full name
phosphatase and tensin homolog

synonyms
10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1, PTEN, ENSG00000171862

HGNC
HGNC:9588

Entrez Gene
Gene:5728

ENSEMBL
ENSG00000171862

location
chr: 10
start: 89623195
stop: 89728532
strand: +

OMIM
OMIM:601728: PTEN (Autosomal dominant inheritance)
OMIM:153480: Bannayan-Riley-Ruvalcaba syndrome
OMIM:158350: Cowden syndrome 1
OMIM:608089: Endometrial carcinoma, somatic
OMIM:158350: Lhermitte-Duclos syndrome
OMIM:605309: Macrocephaly/autism syndrome
OMIM:155600: Malignant melanoma, somatic
OMIM:275355: Squamous cell carcinoma, head and neck, somatic
OMIM:276950: VATER association with macrocephaly and ventriculomegaly
OMIM:613028: {Glioma susceptibility 2}
OMIM:607174: {Meningioma}
OMIM:176807: {Prostate cancer, somatic}

transcripts
NM_000314.4

pathways
3-phosphoinositide degradation [NCBI:545349] [BIOCYC:HUMAN_PWY-6368]
Adaptive Immune System [NCBI:1269171] [REACTOME:R-HSA-1280218] [PUBMED:21682741] [PUBMED:16551257] [PUBMED:11861602]
Androgen receptor signaling pathway [NCBI:198806] [WikiPathways:WP138]
BCR signaling pathway [NCBI:138058] [Pathway Interaction Database:bcr_5pathway] [PUBMED:7687428] [PUBMED:16200195] [PUBMED:10770799] [PUBMED:9763608] [PUBMED:12730099] [PUBMED:11102801] [PUBMED:15541657] [PUBMED:7499277] [PUBMED:7542197] [PUBMED:9586640] [PUBMED:11279148] [PUBMED:11781242] [PUBMED:9221755] [PUBMED:11909947] [PUBMED:9820480] [PUBMED:10339589] [PUBMED:9271416] [PUBMED:9620684] [PUBMED:9058799] [PUBMED:11226282] [PUBMED:11080163] [PUBMED:11163197] [PUBMED:10755621] [PUBMED:1279802] [PUBMED:7618087] [PUBMED:7717978] [PUBMED:11356195] [PUBMED:11577348] [PUBMED:12780340] [PUBMED:7528218] [PUBMED:10640270] [PUBMED:11356834] [PUBMED:12867038] [PUBMED:14563325] [PUBMED:9360945] [PUBMED:10820378] [PUBMED:10430908]
Central carbon metabolism in cancer [NCBI:1059538] [KEGG:hsa05230] [PUBMED:16982728] [PUBMED:21127244] [PUBMED:22156302] [PUBMED:22349059] [PUBMED:21801601] [PUBMED:15916903] [PUBMED:24113830] [PUBMED:23018234] [PUBMED:22237205] [PUBMED:23897900] [PUBMED:20520704] [PUBMED:18177721] [PUBMED:24398961] [PUBMED:18538731] [PUBMED:24079832] [PUBMED:19460998] [PUBMED:22101401] [PUBMED:22750268] [PUBMED:22307140] [PUBMED:23071355] [PUBMED:21258394] [PUBMED:23279446] [PUBMED:21340684] [PUBMED:19270154] [PUBMED:18766298] [PUBMED:21508971] [PUBMED:24738035]
Class I PI3K signaling events [NCBI:138022] [Pathway Interaction Database:pi3kcipathway] [PUBMED:9072969] [PUBMED:9326591] [PUBMED:10357815] [PUBMED:15296756] [PUBMED:10770799] [PUBMED:10586033] [PUBMED:9824312] [PUBMED:11001876] [PUBMED:9593664] [PUBMED:9442017] [PUBMED:8643691] [PUBMED:7627555] [PUBMED:11102801] [PUBMED:9307042] [PUBMED:11226282] [PUBMED:18024423] [PUBMED:15879121] [PUBMED:9550703] [PUBMED:8629002] [PUBMED:10506192] [PUBMED:11804589] [PUBMED:16418224] [PUBMED:9417041] [PUBMED:14688341] [PUBMED:10333475] [PUBMED:8945478] [PUBMED:10764758] [PUBMED:8052307] [PUBMED:11154281] [PUBMED:12780340]
D-myo-inositol (1,3,4)-trisphosphate biosynthesis [NCBI:545328] [BIOCYC:HUMAN_PWY-6364] [PUBMED:1659392] [PUBMED:3010126] [PUBMED:6285891] [PUBMED:7637787] [PUBMED:6095097] [PUBMED:9038348]
DAP12 interactions [NCBI:1269283] [REACTOME:R-HSA-2172127] [PUBMED:19120482] [PUBMED:17220916] [PUBMED:9490415] [PUBMED:18192027] [PUBMED:15884055]
DAP12 signaling [NCBI:1269284] [REACTOME:R-HSA-2424491] [PUBMED:15884055] [PUBMED:17110943] [PUBMED:17220916]
DNA damage response (only ATM dependent) [NCBI:198827] [WikiPathways:WP710] [PUBMED:15343279] [PUBMED:16921403] [PUBMED:15339658] [PUBMED:17568790] [PUBMED:18004398] [PUBMED:15719025] [PUBMED:14993903] [PUBMED:15545627] [PUBMED:17380161] [PUBMED:16805667] [PUBMED:17943134] [PUBMED:14634621] [PUBMED:15668327] [PUBMED:15688066] [PUBMED:17060944] [PUBMED:17768402] [PUBMED:19111245]
Direct p53 effectors [NCBI:137939] [Pathway Interaction Database:p53downstreampathway] [PUBMED:7479001] [PUBMED:15186775] [PUBMED:19626115] [PUBMED:10692390] [PUBMED:15580302] [PUBMED:15289308] [PUBMED:19011621] [PUBMED:12438652] [PUBMED:11641774] [PUBMED:10748162] [PUBMED:10919640] [PUBMED:16301995] [PUBMED:17719542] [PUBMED:17409421] [PUBMED:11850816] [PUBMED:17938176] [PUBMED:11559530] [PUBMED:18046411] [PUBMED:12370809] [PUBMED:8570655] [PUBMED:16260627] [PUBMED:11971958] [PUBMED:11463392] [PUBMED:9659898] [PUBMED:10716435] [PUBMED:15273740] [PUBMED:11032029] [PUBMED:15781865] [PUBMED:11278953] [PUBMED:17145718] [PUBMED:9736732] [PUBMED:11973653] [PUBMED:17189187] [PUBMED:17268548] [PUBMED:16286009] [PUBMED:12944906] [PUBMED:12890671] [PUBMED:12402042] [PUBMED:16249378] [PUBMED:10618714] [PUBMED:15598651] [PUBMED:10984493] [PUBMED:12857899] [PUBMED:17707234] [PUBMED:9920903] [PUBMED:14963330] [PUBMED:8119988] [PUBMED:15790310] [PUBMED:12692263] [PUBMED:9891062] [PUBMED:12372430] [PUBMED:12453409] [PUBMED:17264218] [PUBMED:12606722] [PUBMED:10329733] [PUBMED:15377670] [PUBMED:18485870] [PUBMED:16230375] [PUBMED:14992722] [PUBMED:15710382] [PUBMED:10973264] [PUBMED:17554199] [PUBMED:8319905] [PUBMED:18250150] [PUBMED:11314010] [PUBMED:11919562] [PUBMED:11814693] [PUBMED:10891498] [PUBMED:12654245] [PUBMED:11684014] [PUBMED:7566179] [PUBMED:15103385] [PUBMED:7796420] [PUBMED:15077116] [PUBMED:8887630] [PUBMED:17409411] [PUBMED:11807984] [PUBMED:11840333] [PUBMED:15378026] [PUBMED:9841917] [PUBMED:10684646] [PUBMED:17110336] [PUBMED:9023107] [PUBMED:7651818] [PUBMED:14576823] [PUBMED:11350971] [PUBMED:17189186] [PUBMED:7651386] [PUBMED:14707288] [PUBMED:16278683] [PUBMED:10777218] [PUBMED:11279192] [PUBMED:15607964] [PUBMED:15334053] [PUBMED:15735003] [PUBMED:16140933] [PUBMED:12853982] [PUBMED:10777207] [PUBMED:9926927] [PUBMED:10094469] [PUBMED:17719541] [PUBMED:14688482] [PUBMED:9343394] [PUBMED:17146433] [PUBMED:12089322] [PUBMED:14730312] [PUBMED:10618379] [PUBMED:15958553] [PUBMED:11988847] [PUBMED:16651407] [PUBMED:10640990] [PUBMED:11545734] [PUBMED:16151013] [PUBMED:12667443] [PUBMED:15831478] [PUBMED:11511362] [PUBMED:10518217] [PUBMED:11278253] [PUBMED:8418500] [PUBMED:12138177] [PUBMED:9619826]
Downstream TCR signaling [NCBI:1269176] [REACTOME:R-HSA-202424] [PUBMED:15084594]
Downstream signal transduction [NCBI:1269479] [REACTOME:R-HSA-186763] [PUBMED:10508235] [PUBMED:9739761]
Downstream signaling events of B Cell Receptor (BCR) [NCBI:1269185] [REACTOME:R-HSA-1168372] [PUBMED:17052215] [PUBMED:19909372]
Downstream signaling of activated FGFR1 [NCBI:1269392] [REACTOME:R-HSA-5654687] [PUBMED:8752212]
Downstream signaling of activated FGFR2 [NCBI:1269403] [REACTOME:R-HSA-5654696] [PUBMED:8752212]
Downstream signaling of activated FGFR3 [NCBI:1269413] [REACTOME:R-HSA-5654708] [PUBMED:8752212]
Downstream signaling of activated FGFR4 [NCBI:1269422] [REACTOME:R-HSA-5654716] [PUBMED:8752212]
Endometrial cancer [NCBI:83109] [KEGG:hsa05213] [PUBMED:14747944] [PUBMED:11431710] [PUBMED:7585656] [PUBMED:15284264] [PUBMED:16508724] [PUBMED:17028294] [PUBMED:15947972] [PUBMED:16248975]
Fc epsilon receptor (FCERI) signaling [NCBI:1269298] [REACTOME:R-HSA-2454202] [PUBMED:21799019] [PUBMED:15099567]
Focal Adhesion [NCBI:198795] [WikiPathways:WP306] [PUBMED:15108811] [PUBMED:15459662] [PUBMED:11573199] [PUBMED:12640026] [PUBMED:15179030] [PUBMED:14756624] [PUBMED:15053919] [PUBMED:15688067] [PUBMED:15034601] [PUBMED:11229600] [PUBMED:11146675] [PUBMED:12235283] [PUBMED:11882383] [PUBMED:10698680] [PUBMED:11082269] [PUBMED:14519391] [PUBMED:14744429]
Focal adhesion [NCBI:83067] [KEGG:hsa04510] [PUBMED:14756624] [PUBMED:10698680] [PUBMED:15459662] [PUBMED:15179030] [PUBMED:11573199] [PUBMED:12640026] [PUBMED:15108811] [PUBMED:15053919] [PUBMED:11082269] [PUBMED:11146675] [PUBMED:15034601] [PUBMED:14519391] [PUBMED:12235283] [PUBMED:11229600] [PUBMED:11882383] [PUBMED:14744429] [PUBMED:15688067]
FoxO signaling pathway [NCBI:921162] [KEGG:hsa04068] [PUBMED:23325358] [PUBMED:18951090] [PUBMED:15005655] [PUBMED:22761423] [PUBMED:22902436] [PUBMED:16288288] [PUBMED:19701188] [PUBMED:18403263] [PUBMED:16964248] [PUBMED:21238503] [PUBMED:21613825] [PUBMED:17522590] [PUBMED:17470511] [PUBMED:15084259] [PUBMED:23801966] [PUBMED:17569704] [PUBMED:18045156] [PUBMED:21440011] [PUBMED:15516968]
GAB1 signalosome [NCBI:1269384] [REACTOME:R-HSA-180292] [PUBMED:15550174]
Gene Expression [NCBI:1269649] [REACTOME:R-HSA-74160]
Generic Transcription Pathway [NCBI:1269650] [REACTOME:R-HSA-212436] [PUBMED:15680972] [PUBMED:14744435] [PUBMED:15175151] [PUBMED:15896744] [PUBMED:11395415] [PUBMED:10235266] [PUBMED:12023297] [PUBMED:14986688] [PUBMED:15680973] [PUBMED:16751179] [PUBMED:16719718] [PUBMED:11861166] [PUBMED:16429119] [PUBMED:15690163] [PUBMED:16921404]
Glioma [NCBI:83110] [KEGG:hsa05214] [PUBMED:11253051] [PUBMED:12154354] [PUBMED:11057895] [PUBMED:12084351] [PUBMED:15639402] [PUBMED:9643506] [PUBMED:16095998] [PUBMED:12762887] [PUBMED:16700615]
Hepatitis B [NCBI:694606] [KEGG:hsa05161] [PUBMED:18931690] [PUBMED:16891440] [PUBMED:19854353] [PUBMED:11325602] [PUBMED:11604508] [PUBMED:17158882] [PUBMED:11099494] [PUBMED:9325306] [PUBMED:11483993] [PUBMED:18024894] [PUBMED:11278872] [PUBMED:21647825] [PUBMED:19784739] [PUBMED:11287574] [PUBMED:18481805] [PUBMED:15107488] [PUBMED:17188775] [PUBMED:19263472] [PUBMED:18605975] [PUBMED:10454581] [PUBMED:22504921] [PUBMED:18046710] [PUBMED:21334391] [PUBMED:20657822] [PUBMED:15132991] [PUBMED:15542625] [PUBMED:9843511] [PUBMED:15173177] [PUBMED:8764004] [PUBMED:21994545] [PUBMED:11821950] [PUBMED:16459163] [PUBMED:9738022] [PUBMED:12839924] [PUBMED:16203685] [PUBMED:21618535] [PUBMED:12771941]
Immune System [NCBI:1269170] [REACTOME:R-HSA-168256]
Innate Immune System [NCBI:1269203] [REACTOME:R-HSA-168249]
Inositol phosphate metabolism [NCBI:82987] [KEGG:hsa00562] [NCBI:1269988] [REACTOME:R-HSA-1483249] [PUBMED:17943301] [PUBMED:18310071] [PUBMED:11331907] [PUBMED:20414202] [PUBMED:14993306] [PUBMED:16781889] [PUBMED:20359876]
Insulin Signaling [NCBI:198845] [WikiPathways:WP481] [PUBMED:11742412] [PUBMED:1890850] [PUBMED:11282018]
Insulin resistance [NCBI:1272486] [KEGG:hsa04931] [PUBMED:20466550] [PUBMED:17130651] [PUBMED:16364488] [PUBMED:12765939] [PUBMED:15166380] [PUBMED:7666792] [PUBMED:10923637] [PUBMED:23647930] [PUBMED:16756496] [PUBMED:17141630] [PUBMED:18309108] [PUBMED:20526383] [PUBMED:22675355] [PUBMED:16186396] [PUBMED:15107844] [PUBMED:22360800] [PUBMED:9886945] [PUBMED:8048519] [PUBMED:22677645]
Integrated Breast Cancer Pathway [NCBI:219801] [WikiPathways:WP1984] [PUBMED:16438734] [PUBMED:7859292] [PUBMED:2147360] [PUBMED:16087680] [PUBMED:11003670] [PUBMED:8182145] [PUBMED:16601937] [PUBMED:17623674] [PUBMED:12221076] [PUBMED:10363963] [PUBMED:11356332] [PUBMED:10880455] [PUBMED:16597033] [PUBMED:8758926] [PUBMED:1199706] [PUBMED:9688941] [PUBMED:2828745] [PUBMED:15701627] [PUBMED:7966593] [PUBMED:10022864]
Integrated Cancer pathway [NCBI:672450] [WikiPathways:WP1971]
Integrated Pancreatic Cancer Pathway [NCBI:711360] [WikiPathways:WP2377]
Melanoma [NCBI:83114] [KEGG:hsa05218] [PUBMED:16822996] [PUBMED:11224709] [PUBMED:10843728] [PUBMED:16899407] [PUBMED:15557758] [PUBMED:15721476] [PUBMED:16001072] [PUBMED:16001050] [PUBMED:16750612] [PUBMED:15841168] [PUBMED:14695152] [PUBMED:12894244] [PUBMED:15009714]
Metabolism [NCBI:1269956] [REACTOME:R-HSA-1430728]
Metabolism of lipids and lipoproteins [NCBI:1270001] [REACTOME:R-HSA-556833]
MicroRNAs in cancer [NCBI:852705] [KEGG:hsa05206] [PUBMED:23075324] [PUBMED:22351564] [PUBMED:21742789] [PUBMED:21402473] [PUBMED:21565290] [PUBMED:23091478] [PUBMED:23316212] [PUBMED:19630570] [PUBMED:19773200] [PUBMED:23462054] [PUBMED:20345848] [PUBMED:22035854] [PUBMED:20221895] [PUBMED:22580099] [PUBMED:20128019] [PUBMED:18817506] [PUBMED:22345301] [PUBMED:22926415] [PUBMED:23165235]
NGF signalling via TRKA from the plasma membrane [NCBI:1269460] [REACTOME:R-HSA-187037] [PUBMED:11520933] [PUBMED:12676795] [PUBMED:10851172] [PUBMED:10579918]
Negative regulation of the PI3K/AKT network [NCBI:1269191] [REACTOME:R-HSA-199418]
PDGFR-beta signaling pathway [NCBI:138071] [Pathway Interaction Database:pdgfrbpathway] [PUBMED:9742401] [PUBMED:8086421] [PUBMED:7545675] [PUBMED:16769879] [PUBMED:10463951] [PUBMED:12652307] [PUBMED:15753096] [PUBMED:10391677] [PUBMED:7739538] [PUBMED:9989826] [PUBMED:11489946] [PUBMED:10734138] [PUBMED:7692233] [PUBMED:10821867] [PUBMED:10837138] [PUBMED:11709084] [PUBMED:10229199] [PUBMED:11389443] [PUBMED:12958184] [PUBMED:15161943] [PUBMED:8619809] [PUBMED:16456542] [PUBMED:10734113] [PUBMED:15494217] [PUBMED:12149261] [PUBMED:1849073] [PUBMED:7622571] [PUBMED:16224065] [PUBMED:11085978] [PUBMED:15944146] [PUBMED:10779329] [PUBMED:1708307] [PUBMED:8940081] [PUBMED:11854295] [PUBMED:12424235] [PUBMED:16537894] [PUBMED:14966296] [PUBMED:11027258] [PUBMED:7935392] [PUBMED:8195171] [PUBMED:2544881]
PI Metabolism [NCBI:1270073] [REACTOME:R-HSA-1483255] [PUBMED:17035995] [PUBMED:18216768] [PUBMED:17330069] [PUBMED:15170460] [PUBMED:16828287] [PUBMED:18726176] [PUBMED:20861159] [PUBMED:19196647] [PUBMED:20043944] [PUBMED:20192774] [PUBMED:18784754] [PUBMED:20559318] [PUBMED:18216767] [PUBMED:17605038] [PUBMED:15269334]
PI-3K cascade:FGFR1 [NCBI:1269396] [REACTOME:R-HSA-5654689] [PUBMED:11057895] [PUBMED:12089343] [PUBMED:12558974] [PUBMED:10918587] [PUBMED:15863030]
PI-3K cascade:FGFR2 [NCBI:1269407] [REACTOME:R-HSA-5654695] [PUBMED:15863030] [PUBMED:11057895] [PUBMED:12558974] [PUBMED:12089343] [PUBMED:10918587]
PI-3K cascade:FGFR3 [NCBI:1269417] [REACTOME:R-HSA-5654710] [PUBMED:10918587] [PUBMED:15863030] [PUBMED:11057895] [PUBMED:12558974] [PUBMED:12089343]
PI-3K cascade:FGFR4 [NCBI:1269426] [REACTOME:R-HSA-5654720] [PUBMED:15863030] [PUBMED:10918587] [PUBMED:11057895] [PUBMED:12558974] [PUBMED:12089343]
PI3K events in ERBB4 signaling [NCBI:1269498] [REACTOME:R-HSA-1250342]
PI3K-Akt signaling pathway [NCBI:692234] [KEGG:hsa04151] [PUBMED:11357143] [PUBMED:12048182] [PUBMED:12669022] [PUBMED:15209374] [PUBMED:18842113] [PUBMED:16847462] [PUBMED:12660731] [PUBMED:15505410] [PUBMED:21779440] [PUBMED:12531180] [PUBMED:21620960] [PUBMED:16187290] [PUBMED:15784165] [PUBMED:21440011] [PUBMED:17360849] [PUBMED:16248975] [PUBMED:9838078]
PI3K/AKT activation [NCBI:1269473] [REACTOME:R-HSA-198203] [PUBMED:10579926] [PUBMED:12123609]
PIP3 activates AKT signaling [NCBI:1269188] [REACTOME:R-HSA-1257604]
Pathways in cancer [NCBI:83105] [KEGG:hsa05200] [PUBMED:12244301] [PUBMED:16001072] [PUBMED:16699851] [PUBMED:11902573] [PUBMED:16555243] [PUBMED:15156182] [PUBMED:15310786] [PUBMED:21193867] [PUBMED:11707511] [PUBMED:11253051] [PUBMED:12951584] [PUBMED:11071626] [PUBMED:9834202] [PUBMED:15721476] [PUBMED:11895903] [PUBMED:17251915] [PUBMED:11736900] [PUBMED:11477132] [PUBMED:15724144] [PUBMED:10647931] [PUBMED:16700615] [PUBMED:11527574] [PUBMED:16339096] [PUBMED:12545153] [PUBMED:15942304] [PUBMED:16352814] [PUBMED:15656799] [PUBMED:10740269] [PUBMED:16881963] [PUBMED:15978322] [PUBMED:15774796] [PUBMED:17287871] [PUBMED:15557758] [PUBMED:10944551] [PUBMED:11170304] [PUBMED:12154354] [PUBMED:15639402] [PUBMED:16326109] [PUBMED:11276000] [PUBMED:15573119] [PUBMED:15625120] [PUBMED:15109562] [PUBMED:11160144] [PUBMED:15611513] [PUBMED:15349822] [PUBMED:16236521] [PUBMED:14967450] [PUBMED:16551846] [PUBMED:9196022] [PUBMED:12079267] [PUBMED:11130178] [PUBMED:14580692] [PUBMED:14634372] [PUBMED:12407699] [PUBMED:12588368] [PUBMED:15009714] [PUBMED:16001050] [PUBMED:16112428] [PUBMED:9643506] [PUBMED:15468170] [PUBMED:16248975] [PUBMED:12946833] [PUBMED:11057895] [PUBMED:11559746] [PUBMED:16306523] [PUBMED:16064138] [PUBMED:15479695] [PUBMED:11900250] [PUBMED:9422516] [PUBMED:15551095] [PUBMED:17062879] [PUBMED:12894244] [PUBMED:11103787] [PUBMED:12878745] [PUBMED:16702400] [PUBMED:14685170] [PUBMED:16189154] [PUBMED:11720739] [PUBMED:15122209] [PUBMED:11078609] [PUBMED:12243753] [PUBMED:14982876] [PUBMED:16642045] [PUBMED:12563308] [PUBMED:11407945] [PUBMED:14586404] [PUBMED:15270885] [PUBMED:16095998] [PUBMED:15948971] [PUBMED:16484590] [PUBMED:24508914] [PUBMED:12084351] [PUBMED:11459867] [PUBMED:10505543] [PUBMED:15746962] [PUBMED:16146838] [PUBMED:15947972] [PUBMED:15711891] [PUBMED:12094241] [PUBMED:15841168] [PUBMED:11463388] [PUBMED:16474624] [PUBMED:15719031] [PUBMED:10843728] [PUBMED:14556242] [PUBMED:10453277] [PUBMED:11721960] [PUBMED:11905738] [PUBMED:10403855] [PUBMED:12741677] [PUBMED:12616528] [PUBMED:15823750] [PUBMED:12737309] [PUBMED:14695152] [PUBMED:16750612] [PUBMED:11807782] [PUBMED:12351585] [PUBMED:14737121] [PUBMED:12801837] [PUBMED:11431710] [PUBMED:11165748] [PUBMED:11750244] [PUBMED:11224709] [PUBMED:16110317] [PUBMED:16508724] [PUBMED:15948711] [PUBMED:16870043] [PUBMED:7585656] [PUBMED:12379883] [PUBMED:12850530] [PUBMED:10835690] [PUBMED:16551847] [PUBMED:12459728] [PUBMED:14747944] [PUBMED:15000146] [PUBMED:17149381] [PUBMED:17158541] [PUBMED:12468433] [PUBMED:16042571] [PUBMED:16557281] [PUBMED:16899407] [PUBMED:12621137] [PUBMED:16189702] [PUBMED:8069858] [PUBMED:12951588] [PUBMED:16242838] [PUBMED:15082523] [PUBMED:17211469] [PUBMED:12711111] [PUBMED:15284264] [PUBMED:11223406] [PUBMED:12648469] [PUBMED:12867060] [PUBMED:16946003] [PUBMED:12762887] [PUBMED:16054233] [PUBMED:16822996] [PUBMED:17554387] [PUBMED:17028294]
Phosphatidylinositol signaling system [NCBI:83052] [KEGG:hsa04070] [PUBMED:19439500] [PUBMED:19580826]
Phospholipid metabolism [NCBI:1270053] [REACTOME:R-HSA-1483257] [PUBMED:9242906]
Prostate Cancer [NCBI:755440] [WikiPathways:WP2263] [PUBMED:18538735]
Prostate cancer [NCBI:83111] [KEGG:hsa05215] [PUBMED:12878745] [PUBMED:11900250] [PUBMED:11750244] [PUBMED:16551847] [PUBMED:10835690] [PUBMED:8069858] [PUBMED:15724144] [PUBMED:10453277] [PUBMED:15082523] [PUBMED:9422516] [PUBMED:11527574]
Regulation of Microtubule Cytoskeleton [NCBI:755439] [WikiPathways:WP2038]
RhoA signaling pathway [NCBI:169356] [Pathway Interaction Database:rhoa_pathway] [PUBMED:8641286] [PUBMED:18941185] [PUBMED:17588931] [PUBMED:15866170] [PUBMED:9510209] [PUBMED:16705166] [PUBMED:18303050] [PUBMED:18267089] [PUBMED:16427251] [PUBMED:11238375] [PUBMED:18559669] [PUBMED:15866889] [PUBMED:9707430] [PUBMED:9294169] [PUBMED:12429848] [PUBMED:8632828] [PUBMED:9456324] [PUBMED:8662509] [PUBMED:9582304] [PUBMED:9042860] [PUBMED:15170389] [PUBMED:9121475] [PUBMED:8858161] [PUBMED:19625450] [PUBMED:10893221] [PUBMED:15068801] [PUBMED:10744700] [PUBMED:9697773] [PUBMED:14681219] [PUBMED:18309323] [PUBMED:9265657] [PUBMED:12600823] [PUBMED:11278519] [PUBMED:12732141] [PUBMED:9710582] [PUBMED:11018042] [PUBMED:9529607] [PUBMED:10085083] [PUBMED:12899698] [PUBMED:9693382] [PUBMED:12034774] [PUBMED:12802051] [PUBMED:8995216] [PUBMED:9670022] [PUBMED:8702756] [PUBMED:10428028] [PUBMED:10556088] [PUBMED:10037681] [PUBMED:9482732] [PUBMED:11342553] [PUBMED:1643657] [PUBMED:14595335] [PUBMED:12574166] [PUBMED:12584113] [PUBMED:9920882] [PUBMED:11877391] [PUBMED:7929302] [PUBMED:10436006] [PUBMED:9351440] [PUBMED:15793569] [PUBMED:16164598] [PUBMED:18025109] [PUBMED:11122380] [PUBMED:7600583]
Role of LAT2/NTAL/LAB on calcium mobilization [NCBI:1269302] [REACTOME:R-HSA-2730905] [PUBMED:20643813] [PUBMED:17993265] [PUBMED:17420272]
Senescence and Autophagy [NCBI:198780] [WikiPathways:WP615] [PUBMED:18555778]
Signal Transduction [NCBI:1269379] [REACTOME:R-HSA-162582] [PUBMED:19648010] [PUBMED:17604717] [PUBMED:16260143] [PUBMED:11742412] [PUBMED:15863030] [PUBMED:21252999] [PUBMED:19379690] [PUBMED:19536106] [PUBMED:19458711] [PUBMED:19935667] [PUBMED:15450248] [PUBMED:15520807] [PUBMED:16939974] [PUBMED:18483217] [PUBMED:18043707] [PUBMED:19762341] [PUBMED:21781017] [PUBMED:17084981] [PUBMED:19619488] [PUBMED:17496910]
Signaling Pathways in Glioblastoma [NCBI:672458] [WikiPathways:WP2261] [PUBMED:18772890]
Signaling by EGFR [NCBI:1269380] [REACTOME:R-HSA-177929] [PUBMED:10459005] [PUBMED:10404636] [PUBMED:15142631] [PUBMED:12297041]
Signaling by ERBB4 [NCBI:1269496] [REACTOME:R-HSA-1236394] [PUBMED:9275162] [PUBMED:9168115] [PUBMED:19193720] [PUBMED:16914727] [PUBMED:17545517] [PUBMED:7929212] [PUBMED:17018285] [PUBMED:9135143] [PUBMED:11679632] [PUBMED:15534001] [PUBMED:10744726] [PUBMED:8665853] [PUBMED:18653779] [PUBMED:7565730] [PUBMED:16978839] [PUBMED:15023535] [PUBMED:16061658] [PUBMED:17463226] [PUBMED:9556621] [PUBMED:18721752] [PUBMED:19047365] [PUBMED:12807903] [PUBMED:12869563] [PUBMED:10867024] [PUBMED:16778220] [PUBMED:16912174] [PUBMED:1706616] [PUBMED:8617750] [PUBMED:10722704]
Signaling by FGFR [NCBI:1269386] [REACTOME:R-HSA-190236] [PUBMED:12080084] [PUBMED:20602996] [PUBMED:15863030] [PUBMED:15567848] [PUBMED:7917292] [PUBMED:19247306] [PUBMED:16597617] [PUBMED:15863038]
Signaling by FGFR1 [NCBI:1269387] [REACTOME:R-HSA-5654736] [PUBMED:16597617] [PUBMED:19247306] [PUBMED:12080084] [PUBMED:15863038] [PUBMED:20602996] [PUBMED:15567848] [PUBMED:15863030] [PUBMED:7917292]
Signaling by FGFR2 [NCBI:1269399] [REACTOME:R-HSA-5654738] [PUBMED:16597617] [PUBMED:19247306] [PUBMED:15863038] [PUBMED:12080084] [PUBMED:15863030] [PUBMED:20602996] [PUBMED:15567848] [PUBMED:7917292]
Signaling by FGFR3 [NCBI:1269409] [REACTOME:R-HSA-5654741] [PUBMED:19247306] [PUBMED:16597617] [PUBMED:15863038] [PUBMED:12080084] [PUBMED:20602996] [PUBMED:15567848] [PUBMED:15863030] [PUBMED:7917292]
Signaling by FGFR4 [NCBI:1269419] [REACTOME:R-HSA-5654743] [PUBMED:12080084] [PUBMED:15863038] [PUBMED:7917292] [PUBMED:15863030] [PUBMED:19247306] [PUBMED:16597617] [PUBMED:15567848] [PUBMED:20602996]
Signaling by PDGF [NCBI:1269478] [REACTOME:R-HSA-186797] [PUBMED:15207811] [PUBMED:10508235] [PUBMED:9739761]
Signaling by SCF-KIT [NCBI:1269487] [REACTOME:R-HSA-1433557] [PUBMED:16483568] [PUBMED:7688988] [PUBMED:16475976] [PUBMED:19540337] [PUBMED:15526160] [PUBMED:17350321]
Signaling by the B Cell Receptor (BCR) [NCBI:1269183] [REACTOME:R-HSA-983705] [PUBMED:1702903] [PUBMED:19065780] [PUBMED:16849466] [PUBMED:1081164] [PUBMED:2011584] [PUBMED:18596693] [PUBMED:1375264] [PUBMED:8580068] [PUBMED:4589993] [PUBMED:10648173] [PUBMED:7538118] [PUBMED:11901194] [PUBMED:8163536] [PUBMED:7688784] [PUBMED:1376928] [PUBMED:15489917] [PUBMED:7592958] [PUBMED:17052215] [PUBMED:7927516] [PUBMED:15509800] [PUBMED:7524079] [PUBMED:18818202] [PUBMED:18187424] [PUBMED:803528] [PUBMED:19909372] [PUBMED:20192804] [PUBMED:8306975] [PUBMED:19249086] [PUBMED:6335036] [PUBMED:20206686]
Signaling events mediated by Stem cell factor receptor (c-Kit) [NCBI:138068] [Pathway Interaction Database:kitpathway] [PUBMED:10364466] [PUBMED:10673502] [PUBMED:8950973] [PUBMED:11071635] [PUBMED:12149208] [PUBMED:15504549] [PUBMED:15315962] [PUBMED:12192036] [PUBMED:12444928] [PUBMED:11369651] [PUBMED:10523831] [PUBMED:15676208] [PUBMED:10679268] [PUBMED:8611693] [PUBMED:9872323] [PUBMED:15465815] [PUBMED:11805142] [PUBMED:12356726] [PUBMED:11520784] [PUBMED:12691919] [PUBMED:15611091] [PUBMED:10397721] [PUBMED:10849422] [PUBMED:9651683] [PUBMED:9355737] [PUBMED:12909618] [PUBMED:9038210] [PUBMED:10637471] [PUBMED:11809791] [PUBMED:1381360] [PUBMED:9528781]
Signaling of Hepatocyte Growth Factor Receptor [NCBI:198836] [WikiPathways:WP313]
Signalling by NGF [NCBI:1269443] [REACTOME:R-HSA-166520]
Small cell lung cancer [NCBI:83118] [KEGG:hsa05222] [PUBMED:11463388] [PUBMED:12711111] [PUBMED:11807782] [PUBMED:11905738] [PUBMED:12741677] [PUBMED:12243753] [PUBMED:12616528] [PUBMED:11559746] [PUBMED:10944551] [PUBMED:12407699] [PUBMED:11720739] [PUBMED:16112428] [PUBMED:16064138] [PUBMED:11902573] [PUBMED:12379883] [PUBMED:15109562]
Sphingolipid signaling pathway [NCBI:1144995] [KEGG:hsa04071] [PUBMED:23919551] [PUBMED:20534702] [PUBMED:16470226] [PUBMED:18675379] [PUBMED:17913601] [PUBMED:17161984] [PUBMED:17438574] [PUBMED:18216770] [PUBMED:22654878] [PUBMED:10880336] [PUBMED:11418646] [PUBMED:25309325] [PUBMED:15451787] [PUBMED:18403224] [PUBMED:21705677] [PUBMED:15999095] [PUBMED:11001563]
Synthesis of IP3 and IP4 in the cytosol [NCBI:1269989] [REACTOME:R-HSA-1855204] [PUBMED:20414202] [PUBMED:11331907]
Synthesis of PIPs at the plasma membrane [NCBI:1270077] [REACTOME:R-HSA-1660499] [PUBMED:16399794] [PUBMED:12646134] [PUBMED:9113989] [PUBMED:9211928] [PUBMED:10224048] [PUBMED:12536145] [PUBMED:22647598] [PUBMED:11733541] [PUBMED:19896968] [PUBMED:9660759]
TCR signaling [NCBI:1269172] [REACTOME:R-HSA-202403] [PUBMED:10375551] [PUBMED:12876557] [PUBMED:9989491]
TCR signaling in naive CD4+ T cells [NCBI:137998] [Pathway Interaction Database:tcr_pathway] [PUBMED:12755691] [PUBMED:9094314] [PUBMED:8642247] [PUBMED:8083187] [PUBMED:15125833] [PUBMED:11994416] [PUBMED:7509360] [PUBMED:11353765] [PUBMED:12361955] [PUBMED:8700169] [PUBMED:11120819] [PUBMED:9846481] [PUBMED:16365455] [PUBMED:15899849] [PUBMED:8990121] [PUBMED:12941616] [PUBMED:11368773] [PUBMED:9438848] [PUBMED:10318843] [PUBMED:8702662] [PUBMED:15536066] [PUBMED:12874226] [PUBMED:2141684] [PUBMED:14557276] [PUBMED:2548204] [PUBMED:16733527] [PUBMED:9692882] [PUBMED:7509083] [PUBMED:10209031] [PUBMED:12738795] [PUBMED:7568038] [PUBMED:9312162] [PUBMED:8673706] [PUBMED:11175263] [PUBMED:9677202] [PUBMED:8114715] [PUBMED:9822663] [PUBMED:10903746] [PUBMED:10790433] [PUBMED:12421919] [PUBMED:8084588] [PUBMED:10807788] [PUBMED:8176201] [PUBMED:1639064] [PUBMED:8246987] [PUBMED:8892604] [PUBMED:9665884] [PUBMED:2190221] [PUBMED:14702343] [PUBMED:12186560] [PUBMED:10021361] [PUBMED:9924026] [PUBMED:7545666] [PUBMED:11250890] [PUBMED:12024036] [PUBMED:9710204] [PUBMED:8146197] [PUBMED:7524075] [PUBMED:12397360] [PUBMED:11287959] [PUBMED:10861059] [PUBMED:12917261] [PUBMED:16906149] [PUBMED:12507424] [PUBMED:10745081] [PUBMED:10224278] [PUBMED:12845325] [PUBMED:15879121] [PUBMED:12842872] [PUBMED:3919143] [PUBMED:8636141] [PUBMED:12881521] [PUBMED:11567140] [PUBMED:8195151] [PUBMED:10506192] [PUBMED:8805223] [PUBMED:1464315] [PUBMED:9819387] [PUBMED:12138205] [PUBMED:16005298] [PUBMED:10918068] [PUBMED:16921383] [PUBMED:8479536] [PUBMED:9637919] [PUBMED:7556092] [PUBMED:15933714] [PUBMED:11390650] [PUBMED:14988727] [PUBMED:16849481] [PUBMED:11376344] [PUBMED:10072079] [PUBMED:11567141] [PUBMED:9489702] [PUBMED:10811803] [PUBMED:8164687] [PUBMED:10652356] [PUBMED:11904433] [PUBMED:8790380] [PUBMED:9207119] [PUBMED:15802604] [PUBMED:10229072] [PUBMED:16649996] [PUBMED:10209041] [PUBMED:10556826] [PUBMED:8183372] [PUBMED:7544353] [PUBMED:16582901] [PUBMED:2470098]
TP53 Regulates Metabolic Genes [NCBI:1269655] [REACTOME:R-HSA-5628897] [PUBMED:18344994] [PUBMED:12453409] [PUBMED:20399660] [PUBMED:11545734] [PUBMED:15105503] [PUBMED:16839880] [PUBMED:17409411] [PUBMED:18198340] [PUBMED:18692468] [PUBMED:13298683] [PUBMED:15665293] [PUBMED:16728594] [PUBMED:23484829] [PUBMED:11959846] [PUBMED:17486094] [PUBMED:22682249] [PUBMED:9926927] [PUBMED:19696408] [PUBMED:22864287] [PUBMED:18391940] [PUBMED:17540029] [PUBMED:24366874] [PUBMED:20378837] [PUBMED:15059920] [PUBMED:19439913] [PUBMED:19822145] [PUBMED:12203114] [PUBMED:10716435]
Tight junction [NCBI:83071] [KEGG:hsa04530] [PUBMED:12612641] [PUBMED:12270945] [PUBMED:15551862] [PUBMED:15269339] [PUBMED:12791297] [PUBMED:15151915] [PUBMED:12475568] [PUBMED:11283726]
Transcriptional Regulation by TP53 [NCBI:1269654] [REACTOME:R-HSA-3700989] [PUBMED:26122615] [PUBMED:19410540]
mTOR signaling pathway [NCBI:83059] [KEGG:hsa04150] [NCBI:138001] [Pathway Interaction Database:mtor_4pathway] [PUBMED:15306821] [PUBMED:17277771] [PUBMED:15988001] [PUBMED:15341740] [PUBMED:19963289] [PUBMED:14651849] [PUBMED:12869586] [PUBMED:15268862] [PUBMED:17928295] [PUBMED:15718470] [PUBMED:15681023] [PUBMED:17709744] [PUBMED:15928081] [PUBMED:16288292] [PUBMED:16919458] [PUBMED:9427642] [PUBMED:18046414] [PUBMED:12912918] [PUBMED:16286006] [PUBMED:16962653] [PUBMED:15928708] [PUBMED:19100909] [PUBMED:15780593] [PUBMED:17599906] [PUBMED:10364159] [PUBMED:15659337] [PUBMED:11500364] [PUBMED:12482958] [PUBMED:16109716] [PUBMED:16226444] [PUBMED:15276465] [PUBMED:11729323] [PUBMED:16244323] [PUBMED:18952604] [PUBMED:19114562] [PUBMED:17510057] [PUBMED:9465032] [PUBMED:16469695] [PUBMED:10567431] [PUBMED:9445476] [PUBMED:15851026] [PUBMED:18925875] [PUBMED:17461779] [PUBMED:15004009] [PUBMED:18604198] [PUBMED:15261137] [PUBMED:11287630] [PUBMED:18497260] [PUBMED:15071500] [PUBMED:12820960] [PUBMED:12604610] [PUBMED:18198340] [PUBMED:18411301] [PUBMED:15467718] [PUBMED:17053147] [PUBMED:17043309] [PUBMED:11500365] [PUBMED:12906785] [PUBMED:16452501] [PUBMED:18762023] [PUBMED:19225151] [PUBMED:11418588] [PUBMED:16341064] [PUBMED:15509864] [PUBMED:18439900] [PUBMED:18598780] [PUBMED:11175345] [PUBMED:16099218] [PUBMED:10357815] [PUBMED:18423201] [PUBMED:9271440] [PUBMED:19258318] [PUBMED:19446321] [PUBMED:17141160] [PUBMED:9204908] [PUBMED:15249583] [PUBMED:17386266] [PUBMED:12912989] [PUBMED:16404421] [PUBMED:18566587] [PUBMED:19211835] [PUBMED:16915281] [PUBMED:16288294] [PUBMED:12172553] [PUBMED:16002336] [PUBMED:15342917] [PUBMED:16288290] [PUBMED:1496022] [PUBMED:15545625] [PUBMED:11914378] [PUBMED:15624019] [PUBMED:12747827] [PUBMED:17693255] [PUBMED:14684182] [PUBMED:12231510]
p53 signaling pathway [NCBI:83055] [KEGG:hsa04115] [PUBMED:16557269] [PUBMED:12505356] [PUBMED:16915296] [PUBMED:15116721] [PUBMED:10714958] [PUBMED:11313928] [PUBMED:17409411] [PUBMED:15838523] [PUBMED:16697662] [PUBMED:11747320]
superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism [NCBI:545325] [BIOCYC:HUMAN_PWY-6358]
superpathway of inositol phosphate compounds [NCBI:547492] [BIOCYC:HUMAN_PWY-6371]