full name
cytochrome P450 family 2 subfamily C member 19

synonyms
CPCJ, CYP2C, P450C2C, P450IIC19, CYP2C19, ENSG00000165841

HGNC
HGNC:2621

Entrez Gene
Gene:1557

ENSEMBL
ENSG00000165841

location
chr: 10
start: 96522463
stop: 96612671
strand: +

OMIM
OMIM:124020: CYP2C19 (Autosomal recessive inheritance)
OMIM:609535: Clopidogrel, impaired responsiveness to
OMIM:609535: Mephenytoin poor metabolizer
OMIM:609535: Omeprazole poor metabolizer
OMIM:609535: Proguanil poor metabolizer

transcripts
ENST00000371321.3

pathways
Arachidonic acid metabolism [NCBI:82991] [KEGG:hsa00590] [NCBI:1270087] [REACTOME:R-HSA-2142753] [PUBMED:14622984] [PUBMED:15292194] [PUBMED:10908295] [PUBMED:15205388] [PUBMED:9812980] [PUBMED:14660610] [PUBMED:11328810] [PUBMED:14636671] [PUBMED:14626496] [PUBMED:11679404] [PUBMED:19244215]
Biological oxidations [NCBI:1270189] [REACTOME:R-HSA-211859]
CYP2E1 reactions [NCBI:1270196] [REACTOME:R-HSA-211999] [PUBMED:15603755] [PUBMED:10397283] [PUBMED:14744237]
Chemical carcinogenesis [NCBI:673221] [KEGG:hsa05204] [PUBMED:21473878] [PUBMED:15489140] [PUBMED:21255676] [PUBMED:11376689] [PUBMED:15298956] [PUBMED:17445838] [PUBMED:22705365] [PUBMED:9152590] [PUBMED:8759017] [PUBMED:20570348] [PUBMED:11275476] [PUBMED:9202760] [PUBMED:21163908] [PUBMED:10753215] [PUBMED:10913381] [PUBMED:21217854] [PUBMED:15582261] [PUBMED:16959879] [PUBMED:11092599] [PUBMED:20159989] [PUBMED:21234336] [PUBMED:17459420] [PUBMED:9275165] [PUBMED:17292678] [PUBMED:11978484] [PUBMED:11222868] [PUBMED:15660110] [PUBMED:8702479] [PUBMED:9356303] [PUBMED:20232918] [PUBMED:12435844] [PUBMED:19657920] [PUBMED:8951235] [PUBMED:15532073] [PUBMED:16084004] [PUBMED:18066431] [PUBMED:14570033] [PUBMED:16421178] [PUBMED:21154658] [PUBMED:12928348] [PUBMED:19531241] [PUBMED:20669524] [PUBMED:11467078] [PUBMED:22178655] [PUBMED:21456541]
Cytochrome P450 - arranged by substrate type [NCBI:1270191] [REACTOME:R-HSA-211897] [PUBMED:16584116] [PUBMED:15102545] [PUBMED:12369887]
Drug metabolism - cytochrome P450 [NCBI:83032] [KEGG:hsa00982] [PUBMED:16550168] [PUBMED:10575324] [PUBMED:11226815] [PUBMED:16393888] [PUBMED:12399158] [PUBMED:11504799] [PUBMED:16038189] [PUBMED:10901707] [PUBMED:18043895] [PUBMED:18463198] [PUBMED:9698084] [PUBMED:12386121] [PUBMED:10859160]
Linoleic acid metabolism [NCBI:82992] [KEGG:hsa00591] [PUBMED:12226220] [PUBMED:1634517] [PUBMED:11302930] [PUBMED:8765137] [PUBMED:12909723] [PUBMED:9694817] [PUBMED:14757320] [PUBMED:12324235]
Metabolic pathways [NCBI:132956] [KEGG:hsa01100]
Metabolism [NCBI:1269956] [REACTOME:R-HSA-1430728]
Metabolism of lipids and lipoproteins [NCBI:1270001] [REACTOME:R-HSA-556833]
Phase 1 - Functionalization of compounds [NCBI:1270190] [REACTOME:R-HSA-211945] [PUBMED:12369887] [PUBMED:17125408] [PUBMED:16584116]
Serotonergic synapse [NCBI:525336] [KEGG:hsa04726] [PUBMED:9658404] [PUBMED:15034221] [PUBMED:11043573] [PUBMED:9651340] [PUBMED:9542727] [PUBMED:18676031] [PUBMED:12543273] [PUBMED:15710402] [PUBMED:16826372] [PUBMED:19545642] [PUBMED:11916537] [PUBMED:11701344] [PUBMED:12676358] [PUBMED:20561690] [PUBMED:16896947]
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) [NCBI:1270095] [REACTOME:R-HSA-2142816] [PUBMED:19244215] [PUBMED:10681399]
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) [NCBI:1270096] [REACTOME:R-HSA-2142670] [PUBMED:10681399] [PUBMED:19244215]
Xenobiotics [NCBI:1270194] [REACTOME:R-HSA-211981] [PUBMED:12369887] [PUBMED:15102545] [PUBMED:16584116]
melatonin degradation I [NCBI:545356] [BIOCYC:HUMAN_PWY-6398] [PUBMED:18344019] [PUBMED:18717775] [PUBMED:12899443] [PUBMED:17198536] [PUBMED:16219483] [PUBMED:9181522] [PUBMED:15981996] [PUBMED:12662344] [PUBMED:11485009] [PUBMED:18155917] [PUBMED:15616152] [PUBMED:16793870]
superpathway of melatonin degradation [NCBI:545359] [BIOCYC:HUMAN_PWY-6402]
superpathway of tryptophan utilization [NCBI:835392] [BIOCYC:HUMAN_PWY66-401]