full name
B-cell linker

synonyms
AGM4, BASH, bca, BLNK-S, LY57, SLP-65, SLP65, BLNK, ENSG00000095585

HGNC
HGNC:14211

Entrez Gene
Gene:29760

ENSEMBL
ENSG00000095585
ENSG00000262509

location
chr: 10
start: 97951455
stop: 98031333
strand: -

OMIM
OMIM:604515: BLNK (Autosomal recessive inheritance)
OMIM:613502: ?Agammaglobulinemia 4

transcripts
NM_001114094.1
NM_013314.3
NM_001258442.1
NR_047680.1
NR_047682.1
NR_047683.1
NM_001258441.1
NM_001258440.1
NR_047681.1

pathways
Adaptive Immune System [NCBI:1269171] [REACTOME:R-HSA-1280218] [PUBMED:16551257] [PUBMED:21682741] [PUBMED:11861602]
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers [NCBI:1269184] [REACTOME:R-HSA-983695] [PUBMED:8163536] [PUBMED:18818202] [PUBMED:15489917] [PUBMED:20206686] [PUBMED:7592958] [PUBMED:6335036] [PUBMED:8918697] [PUBMED:7688784] [PUBMED:1376928] [PUBMED:1550550] [PUBMED:15509800] [PUBMED:7524079] [PUBMED:7927516] [PUBMED:9341187] [PUBMED:18187424] [PUBMED:803528] [PUBMED:20192804] [PUBMED:7929028] [PUBMED:10770799] [PUBMED:16849466] [PUBMED:8306975] [PUBMED:11606584] [PUBMED:1702903] [PUBMED:2011584] [PUBMED:7538118] [PUBMED:19065780] [PUBMED:1375264] [PUBMED:1081164] [PUBMED:15161916] [PUBMED:11901194] [PUBMED:18596693] [PUBMED:8580068] [PUBMED:19249086] [PUBMED:9468499] [PUBMED:11226282] [PUBMED:12456653] [PUBMED:10648173] [PUBMED:9697839] [PUBMED:4589993]
B cell receptor signaling pathway [NCBI:83081] [KEGG:hsa04662] [PUBMED:15626471] [PUBMED:12119152] [PUBMED:15886119] [PUBMED:12461567] [PUBMED:9697839] [PUBMED:15752555] [PUBMED:11163197] [PUBMED:18086859] [PUBMED:15364057] [PUBMED:15457440] [PUBMED:15322145] [PUBMED:15771577] [PUBMED:12033741] [PUBMED:15886112] [PUBMED:10358768]
BCR signaling pathway [NCBI:138058] [Pathway Interaction Database:bcr_5pathway] [PUBMED:7687428] [PUBMED:16200195] [PUBMED:12730099] [PUBMED:10770799] [PUBMED:14563325] [PUBMED:9763608] [PUBMED:15541657] [PUBMED:11781242] [PUBMED:11102801] [PUBMED:9586640] [PUBMED:11279148] [PUBMED:7499277] [PUBMED:7542197] [PUBMED:9820480] [PUBMED:9221755] [PUBMED:11909947] [PUBMED:9360945] [PUBMED:9058799] [PUBMED:10339589] [PUBMED:11226282] [PUBMED:9271416] [PUBMED:9620684] [PUBMED:11163197] [PUBMED:10820378] [PUBMED:11356195] [PUBMED:11080163] [PUBMED:10755621] [PUBMED:7717978] [PUBMED:7618087] [PUBMED:11577348] [PUBMED:1279802] [PUBMED:10640270] [PUBMED:11356834] [PUBMED:12867038] [PUBMED:12780340] [PUBMED:10430908] [PUBMED:7528218]
Cytokine Signaling in Immune system [NCBI:1269310] [REACTOME:R-HSA-1280215] [PUBMED:12613569]
Immune System [NCBI:1269170] [REACTOME:R-HSA-168256]
Interleukin-3, 5 and GM-CSF signaling [NCBI:1269323] [REACTOME:R-HSA-512988] [PUBMED:10450743] [PUBMED:9766809]
NF-kappa B signaling pathway [NCBI:634527] [KEGG:hsa04064] [PUBMED:22119011] [PUBMED:16264088] [PUBMED:21187855] [PUBMED:15546385] [PUBMED:17607554] [PUBMED:21135871] [PUBMED:16984817] [PUBMED:17047224] [PUBMED:19203223] [PUBMED:20300215] [PUBMED:14657271] [PUBMED:17431096] [PUBMED:15134788] [PUBMED:16356770] [PUBMED:21772278] [PUBMED:12654254] [PUBMED:22390971] [PUBMED:22017435] [PUBMED:17183360] [PUBMED:21173796] [PUBMED:15905862] [PUBMED:19302050] [PUBMED:17098202] [PUBMED:21872579] [PUBMED:22152226] [PUBMED:18613837] [PUBMED:19489733] [PUBMED:11875461] [PUBMED:19726767] [PUBMED:22017430] [PUBMED:21232019] [PUBMED:18832076]
Osteoclast differentiation [NCBI:193147] [KEGG:hsa04380] [PUBMED:17633024] [PUBMED:18382763] [PUBMED:18329366] [PUBMED:17869613] [PUBMED:18722561] [PUBMED:15122243] [PUBMED:20703218] [PUBMED:12748652] [PUBMED:12110142] [PUBMED:19585227] [PUBMED:15546140] [PUBMED:16184196] [PUBMED:15817678] [PUBMED:20392226] [PUBMED:16313349] [PUBMED:16313342] [PUBMED:17380158] [PUBMED:18451259]
Primary immunodeficiency [NCBI:83125] [KEGG:hsa05340] [PUBMED:11941303] [PUBMED:18093537] [PUBMED:11058677] [PUBMED:17952897] [PUBMED:14699405] [PUBMED:15661024] [PUBMED:14647478] [PUBMED:17960151] [PUBMED:16261175]
Regulation of signaling by CBL [NCBI:1269324] [REACTOME:R-HSA-912631] [PUBMED:9590251]
Signaling by Interleukins [NCBI:1269318] [REACTOME:R-HSA-449147] [PUBMED:19302047] [PUBMED:12445398]
Signaling by the B Cell Receptor (BCR) [NCBI:1269183] [REACTOME:R-HSA-983705] [PUBMED:1702903] [PUBMED:2011584] [PUBMED:1081164] [PUBMED:19065780] [PUBMED:16849466] [PUBMED:1375264] [PUBMED:7538118] [PUBMED:11901194] [PUBMED:8580068] [PUBMED:19249086] [PUBMED:18596693] [PUBMED:10648173] [PUBMED:4589993] [PUBMED:8163536] [PUBMED:1376928] [PUBMED:7688784] [PUBMED:6335036] [PUBMED:17052215] [PUBMED:18818202] [PUBMED:20206686] [PUBMED:7592958] [PUBMED:7524079] [PUBMED:15489917] [PUBMED:15509800] [PUBMED:18187424] [PUBMED:7927516] [PUBMED:803528] [PUBMED:19909372] [PUBMED:20192804] [PUBMED:8306975]