full name
eukaryotic translation initiation factor 3 subunit A

synonyms
EIF3, eIF3-p170, eIF3-theta, EIF3S10, P167, p180, p185, TIF32, EIF3A, ENSG00000107581

HGNC
HGNC:3271

Entrez Gene
Gene:8661

ENSEMBL
ENSG00000107581

location
chr: 10
start: 120794541
stop: 120840959
strand: -

transcripts
NM_003750.2

pathways
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S [NCBI:1268683] [REACTOME:R-HSA-72662] [PUBMED:9732867] [PUBMED:592399] [PUBMED:641056] [PUBMED:6853548]
Cap-dependent Translation Initiation [NCBI:1268680] [REACTOME:R-HSA-72737]
Eukaryotic Translation Initiation [NCBI:1268679] [REACTOME:R-HSA-72613] [PUBMED:20444697]
Formation of a pool of free 40S subunits [NCBI:1268681] [REACTOME:R-HSA-72689]
Formation of the ternary complex, and subsequently, the 43S complex [NCBI:1268682] [REACTOME:R-HSA-72695] [PUBMED:641056] [PUBMED:1104615] [PUBMED:592399] [PUBMED:429297]
GTP hydrolysis and joining of the 60S ribosomal subunit [NCBI:1268686] [REACTOME:R-HSA-72706] [PUBMED:11018020] [PUBMED:1095581] [PUBMED:429297] [PUBMED:641056] [PUBMED:1856230] [PUBMED:592398] [PUBMED:10659855] [PUBMED:592399]
Gene Expression [NCBI:1269649] [REACTOME:R-HSA-74160]
IL2 signaling events mediated by PI3K [NCBI:137938] [Pathway Interaction Database:il2_pi3kpathway] [PUBMED:15271800] [PUBMED:8617294] [PUBMED:7543780] [PUBMED:9092570] [PUBMED:9162082] [PUBMED:7737351] [PUBMED:9108028] [PUBMED:11486019] [PUBMED:1614535] [PUBMED:15843522] [PUBMED:7760801] [PUBMED:9029085] [PUBMED:1652056] [PUBMED:11994454] [PUBMED:12393431] [PUBMED:9771966] [PUBMED:10373522] [PUBMED:12525482] [PUBMED:3523754] [PUBMED:7736574] [PUBMED:10982827] [PUBMED:7589144] [PUBMED:7528328]
L13a-mediated translational silencing of Ceruloplasmin expression [NCBI:1268688] [REACTOME:R-HSA-156827] [PUBMED:14567916]
Metabolism of proteins [NCBI:1268677] [REACTOME:R-HSA-392499]
RNA transport [NCBI:177876] [KEGG:hsa03013] [PUBMED:10872469] [PUBMED:17401408] [PUBMED:20733056] [PUBMED:11018020] [PUBMED:15519698] [PUBMED:16314458] [PUBMED:15901496] [PUBMED:9548260] [PUBMED:18313922]
Ribosomal scanning and start codon recognition [NCBI:1268685] [REACTOME:R-HSA-72702] [PUBMED:9732867] [PUBMED:7000367] [PUBMED:592399] [PUBMED:641056]
Translation [NCBI:1268678] [REACTOME:R-HSA-72766]
Translation initiation complex formation [NCBI:1268684] [REACTOME:R-HSA-72649] [PUBMED:6853548] [PUBMED:641056] [PUBMED:9732867] [PUBMED:592399]