Logo
full name
RNA polymerase II subunit L

synonyms
hRPB7.6, RBP10, RPABC5, RPB10, RPB10beta, RPB7.6, POLR2L, ENSG00000177700

HGNC
HGNC:9199

Entrez Gene
Gene:5441

ENSEMBL
ENSG00000177700

location
chr: 11
start: 839721
stop: 842529
strand: -

transcripts
NM_021128.4

pathways
Abortive elongation of HIV-1 transcript in the absence of Tat [NCBI:1269078] [REACTOME:R-HSA-167242] [PUBMED:2825027] [PUBMED:9450929] [PUBMED:10199401]
Activation of HOX genes during differentiation [NCBI:1339139] [REACTOME:R-HSA-5619507] [PUBMED:19923920] [PUBMED:25804734] [PUBMED:23973942] [PUBMED:23650639] [PUBMED:20435029] [PUBMED:24529385]
Activation of anterior HOX genes in hindbrain development during early embryogenesis [NCBI:1339140] [REACTOME:R-HSA-5617472] [PUBMED:19575673] [PUBMED:23973942] [PUBMED:18394579] [PUBMED:24529385] [PUBMED:24115586] [PUBMED:18412118] [PUBMED:19651303] [PUBMED:25804734] [PUBMED:22770981] [PUBMED:19923920] [PUBMED:16155570] [PUBMED:18816852] [PUBMED:25560970] [PUBMED:10068641] [PUBMED:10662633] [PUBMED:20435029] [PUBMED:17368312] [PUBMED:21497760] [PUBMED:10668974]
B-WICH complex positively regulates rRNA expression [NCBI:1339126] [REACTOME:R-HSA-5250924] [PUBMED:23555303] [PUBMED:21559432] [PUBMED:16514417] [PUBMED:23667505] [PUBMED:16603771] [PUBMED:16574391]
Cytosolic DNA-sensing pathway [NCBI:125137] [KEGG:hsa04623] [PUBMED:18573338] [PUBMED:19665965] [PUBMED:19567913] [PUBMED:18280611] [PUBMED:18724932] [PUBMED:19497760] [PUBMED:16286919] [PUBMED:19122387] [PUBMED:19590578] [PUBMED:23258413] [PUBMED:18375758] [PUBMED:19321146] [PUBMED:19362700] [PUBMED:18941233] [PUBMED:19767723]
Cytosolic sensors of pathogen-associated DNA [NCBI:1269268] [REACTOME:R-HSA-1834949] [PUBMED:23706668] [PUBMED:21533068] [PUBMED:23706667]
DNA Repair [NCBI:1270350] [REACTOME:R-HSA-73894] [PUBMED:10583946] [PUBMED:23175119]
Developmental Biology [NCBI:1270302] [REACTOME:R-HSA-1266738]
Disease [NCBI:1268854] [REACTOME:R-HSA-1643685]
Diseases of signal transduction [NCBI:1268855] [REACTOME:R-HSA-5663202] [PUBMED:12509752]
Dual incision in TC-NER [NCBI:1309119] [REACTOME:R-HSA-6782135] [PUBMED:19279666] [PUBMED:23906714] [PUBMED:8078911] [PUBMED:16246722] [PUBMED:19023283] [PUBMED:11904382] [PUBMED:24402227]
Epigenetic regulation of gene expression [NCBI:1269734] [REACTOME:R-HSA-212165] [PUBMED:12610534]
Epstein-Barr virus infection [NCBI:585562] [KEGG:hsa05169] [PUBMED:1658397] [PUBMED:10683340] [PUBMED:19375142] [PUBMED:12438576] [PUBMED:12910248] [PUBMED:10400785] [PUBMED:16007144] [PUBMED:14576817] [PUBMED:18559925] [PUBMED:16352731] [PUBMED:7895172] [PUBMED:15510157] [PUBMED:21518914] [PUBMED:10891508] [PUBMED:14673102] [PUBMED:17159145] [PUBMED:15542638] [PUBMED:18786993] [PUBMED:16603506] [PUBMED:10644367] [PUBMED:15021898] [PUBMED:10666279] [PUBMED:9565632]
FGFR2 alternative splicing [NCBI:1383022] [REACTOME:R-HSA-6803529] [PUBMED:17959601] [PUBMED:9858549] [PUBMED:12393912] [PUBMED:10982855] [PUBMED:11313454] [PUBMED:10938105] [PUBMED:16603716] [PUBMED:16449636] [PUBMED:7651400] [PUBMED:19285943] [PUBMED:18573884] [PUBMED:15863030] [PUBMED:15684416] [PUBMED:8668531] [PUBMED:12419237]
FGFR2 mutant receptor activation [NCBI:1268870] [REACTOME:R-HSA-1839126] [PUBMED:15282208] [PUBMED:17552943] [PUBMED:9266968] [PUBMED:17803937] [PUBMED:9816310] [PUBMED:18757403] [PUBMED:11003564] [PUBMED:20101236] [PUBMED:18337450] [PUBMED:9538690] [PUBMED:17525745] [PUBMED:10626794] [PUBMED:11056689] [PUBMED:18381441] [PUBMED:11325814] [PUBMED:9539778] [PUBMED:19103595] [PUBMED:9154000] [PUBMED:20106510] [PUBMED:17505008] [PUBMED:18552176]
Formation of HIV elongation complex in the absence of HIV Tat [NCBI:1269080] [REACTOME:R-HSA-167152]
Formation of HIV-1 elongation complex containing HIV-1 Tat [NCBI:1269077] [REACTOME:R-HSA-167200] [PUBMED:7853496] [PUBMED:14701750] [PUBMED:9491887] [PUBMED:15564463] [PUBMED:10757782]
Formation of RNA Pol II elongation complex [NCBI:1269684] [REACTOME:R-HSA-112382] [PUBMED:12676794]
Formation of TC-NER Pre-Incision Complex [NCBI:1309118] [REACTOME:R-HSA-6781823] [PUBMED:12208738] [PUBMED:16916636] [PUBMED:17290000] [PUBMED:25435140] [PUBMED:22466611] [PUBMED:10944529] [PUBMED:22902626] [PUBMED:16751180] [PUBMED:22466610] [PUBMED:8876179] [PUBMED:12660172] [PUBMED:25154395] [PUBMED:8078911]
Formation of the Early Elongation Complex [NCBI:1269683] [REACTOME:R-HSA-113418] [PUBMED:11940650] [PUBMED:10916156]
Formation of the HIV-1 Early Elongation Complex [NCBI:1269075] [REACTOME:R-HSA-167158] [PUBMED:12653964] [PUBMED:12370301] [PUBMED:11940650]
Gap-filling DNA repair synthesis and ligation in TC-NER [NCBI:1309120] [REACTOME:R-HSA-6782210] [PUBMED:20227374] [PUBMED:19279666] [PUBMED:17643379]
Gene Expression [NCBI:1269649] [REACTOME:R-HSA-74160]
Gene Silencing by RNA [NCBI:1269719] [REACTOME:R-HSA-211000] [PUBMED:15741316] [PUBMED:25565029] [PUBMED:19165215] [PUBMED:21755468] [PUBMED:16510870] [PUBMED:19412884] [PUBMED:17560368] [PUBMED:19239886]
Generic Transcription Pathway [NCBI:1269650] [REACTOME:R-HSA-212436] [PUBMED:15175151] [PUBMED:14744435] [PUBMED:15680972] [PUBMED:11395415] [PUBMED:15896744] [PUBMED:10235266] [PUBMED:14986688] [PUBMED:12023297] [PUBMED:15680973] [PUBMED:16751179] [PUBMED:11861166] [PUBMED:16429119] [PUBMED:16719718] [PUBMED:16921404] [PUBMED:15690163]
HIV Infection [NCBI:1269057] [REACTOME:R-HSA-162906] [PUBMED:16354571] [PUBMED:9759480]
HIV Life Cycle [NCBI:1269058] [REACTOME:R-HSA-162587] [PUBMED:9188609] [PUBMED:9759480]
HIV Transcription Elongation [NCBI:1269074] [REACTOME:R-HSA-167169] [PUBMED:10550206] [PUBMED:15049426]
HIV Transcription Initiation [NCBI:1269071] [REACTOME:R-HSA-167161]
HIV elongation arrest and recovery [NCBI:1269079] [REACTOME:R-HSA-167287]
Huntington's disease [NCBI:83100] [KEGG:hsa05016] [PUBMED:15336977] [PUBMED:11738471] [PUBMED:11807533] [PUBMED:15996546] [PUBMED:14526190] [PUBMED:15242639] [PUBMED:17041811] [PUBMED:15996541] [PUBMED:18951640] [PUBMED:15459747] [PUBMED:16288298] [PUBMED:17081970] [PUBMED:15695335] [PUBMED:12372277] [PUBMED:11839795]
Immune System [NCBI:1269170] [REACTOME:R-HSA-168256]
Infectious disease [NCBI:1269056] [REACTOME:R-HSA-5663205]
Influenza Infection [NCBI:1269108] [REACTOME:R-HSA-168254]
Influenza Life Cycle [NCBI:1269109] [REACTOME:R-HSA-168255]
Influenza Viral RNA Transcription and Replication [NCBI:1269115] [REACTOME:R-HSA-168273] [PUBMED:2214032] [PUBMED:6863242] [PUBMED:6616622] [PUBMED:6269803]
Innate Immune System [NCBI:1269203] [REACTOME:R-HSA-168249]
Late Phase of HIV Life Cycle [NCBI:1269069] [REACTOME:R-HSA-162599] [PUBMED:2825027] [PUBMED:10550206] [PUBMED:10562489] [PUBMED:15719065] [PUBMED:15183343] [PUBMED:3031512] [PUBMED:9891806] [PUBMED:2784194]
Metabolic pathways [NCBI:132956] [KEGG:hsa01100]
MicroRNA (miRNA) biogenesis [NCBI:1269720] [REACTOME:R-HSA-203927] [PUBMED:15211354] [PUBMED:8252621] [PUBMED:23511973] [PUBMED:17057362] [PUBMED:19330724] [PUBMED:19165215] [PUBMED:21755468] [PUBMED:24388755] [PUBMED:15944707] [PUBMED:15364901]
Negative epigenetic regulation of rRNA expression [NCBI:1269737] [REACTOME:R-HSA-5250941] [PUBMED:23063748] [PUBMED:23150253] [PUBMED:18616426]
NoRC negatively regulates rRNA expression [NCBI:1269739] [REACTOME:R-HSA-427413] [PUBMED:17439825] [PUBMED:17613545] [PUBMED:23063748] [PUBMED:11583633] [PUBMED:18631128] [PUBMED:18616426]
Nucleotide Excision Repair [NCBI:1309111] [REACTOME:R-HSA-5696398] [PUBMED:11900249] [PUBMED:23906714] [PUBMED:14599765] [PUBMED:10583946] [PUBMED:24954209] [PUBMED:19023283]
PIWI-interacting RNA (piRNA) biogenesis [NCBI:1269724] [REACTOME:R-HSA-5601884] [PUBMED:23980886] [PUBMED:23124062] [PUBMED:23829526] [PUBMED:21427766] [PUBMED:22221002] [PUBMED:23166399] [PUBMED:18282709]
Pausing and recovery of HIV elongation [NCBI:1269081] [REACTOME:R-HSA-167290]
Pausing and recovery of Tat-mediated HIV elongation [NCBI:1269083] [REACTOME:R-HSA-167238]
Positive epigenetic regulation of rRNA expression [NCBI:1339125] [REACTOME:R-HSA-5250913] [PUBMED:23153826] [PUBMED:16574391] [PUBMED:23063748] [PUBMED:23150253] [PUBMED:18616426]
Processing of Capped Intron-Containing Pre-mRNA [NCBI:1269688] [REACTOME:R-HSA-72203]
Purine metabolism [NCBI:82944] [KEGG:hsa00230] [NCBI:1270134] [REACTOME:R-HSA-73847] [PUBMED:4620886] [PUBMED:10986234] [PUBMED:10601204]
Pyrimidine metabolism [NCBI:82946] [KEGG:hsa00240] [NCBI:1270138] [REACTOME:R-HSA-73848] [PUBMED:16098809]
RNA Pol II CTD phosphorylation and interaction with CE [NCBI:1269681] [REACTOME:R-HSA-77075]
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection [NCBI:1269073] [REACTOME:R-HSA-167160]
RNA Polymerase I Chain Elongation [NCBI:1269662] [REACTOME:R-HSA-73777]
RNA Polymerase I Promoter Clearance [NCBI:1269658] [REACTOME:R-HSA-73854]
RNA Polymerase I Promoter Escape [NCBI:1269661] [REACTOME:R-HSA-73772]
RNA Polymerase I Transcription [NCBI:1269657] [REACTOME:R-HSA-73864]
RNA Polymerase I Transcription Initiation [NCBI:1269660] [REACTOME:R-HSA-73762]
RNA Polymerase I Transcription Termination [NCBI:1269663] [REACTOME:R-HSA-73863]
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription [NCBI:1269656] [REACTOME:R-HSA-504046]
RNA Polymerase II HIV Promoter Escape [NCBI:1269072] [REACTOME:R-HSA-167162]
RNA Polymerase II Pre-transcription Events [NCBI:1269676] [REACTOME:R-HSA-674695]
RNA Polymerase II Promoter Escape [NCBI:1269680] [REACTOME:R-HSA-73776] [PUBMED:9405375]
RNA Polymerase II Transcription [NCBI:1269675] [REACTOME:R-HSA-73857]
RNA Polymerase II Transcription Elongation [NCBI:1269682] [REACTOME:R-HSA-75955] [PUBMED:11018013] [PUBMED:12676794] [PUBMED:14550628]
RNA Polymerase II Transcription Initiation [NCBI:1269679] [REACTOME:R-HSA-75953] [PUBMED:7601352] [PUBMED:8612591] [PUBMED:11784853] [PUBMED:3667620] [PUBMED:9405375]
RNA Polymerase II Transcription Initiation And Promoter Clearance [NCBI:1269678] [REACTOME:R-HSA-76042]
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening [NCBI:1269677] [REACTOME:R-HSA-73779] [PUBMED:8946909]
RNA Polymerase III Abortive And Retractive Initiation [NCBI:1269665] [REACTOME:R-HSA-749476]
RNA Polymerase III Chain Elongation [NCBI:1269670] [REACTOME:R-HSA-73780]
RNA Polymerase III Transcription [NCBI:1269664] [REACTOME:R-HSA-74158] [PUBMED:9308965] [PUBMED:11121026] [PUBMED:11040218]
RNA Polymerase III Transcription Initiation [NCBI:1269666] [REACTOME:R-HSA-76046] [PUBMED:7357599] [PUBMED:7312050] [PUBMED:6947245] [PUBMED:7357604] [PUBMED:2308839] [PUBMED:2752422]
RNA Polymerase III Transcription Initiation From Type 1 Promoter [NCBI:1269667] [REACTOME:R-HSA-76061] [PUBMED:7226225] [PUBMED:6153931] [PUBMED:3967290] [PUBMED:3972795] [PUBMED:6356356]
RNA Polymerase III Transcription Initiation From Type 2 Promoter [NCBI:1269668] [REACTOME:R-HSA-76066]
RNA Polymerase III Transcription Initiation From Type 3 Promoter [NCBI:1269669] [REACTOME:R-HSA-76071] [PUBMED:2853685] [PUBMED:1535687] [PUBMED:8979085] [PUBMED:8339931] [PUBMED:8336708] [PUBMED:9705341] [PUBMED:9776743] [PUBMED:1868835] [PUBMED:2905684]
RNA Polymerase III Transcription Termination [NCBI:1269671] [REACTOME:R-HSA-73980]
RNA polymerase [NCBI:83037] [KEGG:hsa03020] [PUBMED:19880312] [PUBMED:10499798] [PUBMED:18573085] [PUBMED:10784442]
RNA polymerase II transcribes snRNA genes [NCBI:1383088] [REACTOME:R-HSA-6807505] [PUBMED:23932780] [PUBMED:18482001] [PUBMED:20659008] [PUBMED:3837185] [PUBMED:18442490] [PUBMED:24097444] [PUBMED:18631122] [PUBMED:18378697] [PUBMED:6201719] [PUBMED:22622228] [PUBMED:11390411] [PUBMED:25882383]
Signal Transduction [NCBI:1269379] [REACTOME:R-HSA-162582] [PUBMED:17604717] [PUBMED:19648010] [PUBMED:16260143] [PUBMED:11742412] [PUBMED:19536106] [PUBMED:15863030] [PUBMED:19379690] [PUBMED:19458711] [PUBMED:19935667] [PUBMED:21252999] [PUBMED:15520807] [PUBMED:17496910] [PUBMED:15450248] [PUBMED:18043707] [PUBMED:16939974] [PUBMED:19762341] [PUBMED:18483217] [PUBMED:17084981] [PUBMED:21781017] [PUBMED:19619488]
Signaling by FGFR [NCBI:1269386] [REACTOME:R-HSA-190236] [PUBMED:15863038] [PUBMED:12080084] [PUBMED:20602996] [PUBMED:15863030] [PUBMED:15567848] [PUBMED:7917292] [PUBMED:19247306] [PUBMED:16597617]
Signaling by FGFR in disease [NCBI:1268863] [REACTOME:R-HSA-1226099] [PUBMED:17552943] [PUBMED:10053006] [PUBMED:8640234] [PUBMED:9865713] [PUBMED:21367659] [PUBMED:10471491] [PUBMED:21711248] [PUBMED:9538690] [PUBMED:20094046] [PUBMED:9539778] [PUBMED:12461689] [PUBMED:9438390] [PUBMED:8841188] [PUBMED:11055896] [PUBMED:8599935] [PUBMED:21160078] [PUBMED:9207791] [PUBMED:9154000] [PUBMED:18381441] [PUBMED:20179196] [PUBMED:8755573] [PUBMED:20226962] [PUBMED:8798788] [PUBMED:19066716] [PUBMED:17505008] [PUBMED:11429702]
Signaling by FGFR2 [NCBI:1269399] [REACTOME:R-HSA-5654738] [PUBMED:19247306] [PUBMED:16597617] [PUBMED:15863038] [PUBMED:12080084] [PUBMED:15863030] [PUBMED:20602996] [PUBMED:15567848] [PUBMED:7917292]
Signaling by FGFR2 IIIa TM [NCBI:1383045] [REACTOME:R-HSA-8851708] [PUBMED:21355848]
Signaling by FGFR2 in disease [NCBI:1268869] [REACTOME:R-HSA-5655253] [PUBMED:9154000] [PUBMED:17505008] [PUBMED:17552943] [PUBMED:21367659] [PUBMED:21711248] [PUBMED:9538690] [PUBMED:18381441] [PUBMED:19147536]
TP53 Regulates Transcription of DNA Repair Genes [NCBI:1383075] [REACTOME:R-HSA-6796648] [PUBMED:10984493] [PUBMED:25712099] [PUBMED:22988298] [PUBMED:12771027] [PUBMED:23139867] [PUBMED:11971958] [PUBMED:22012619] [PUBMED:11988847] [PUBMED:9858527] [PUBMED:26773055] [PUBMED:15781865] [PUBMED:11350971] [PUBMED:25429106] [PUBMED:12170774] [PUBMED:20096807] [PUBMED:18187580] [PUBMED:9063748] [PUBMED:24662513]
Tat-mediated HIV elongation arrest and recovery [NCBI:1269082] [REACTOME:R-HSA-167243]
Tat-mediated elongation of the HIV-1 transcript [NCBI:1269076] [REACTOME:R-HSA-167246] [PUBMED:2825027] [PUBMED:9450929] [PUBMED:11940650] [PUBMED:2476805] [PUBMED:10866664] [PUBMED:10757782] [PUBMED:10550206] [PUBMED:10199401] [PUBMED:15719065] [PUBMED:10562489] [PUBMED:15183343] [PUBMED:14701750] [PUBMED:7853496] [PUBMED:9491887]
Transcription of the HIV genome [NCBI:1269070] [REACTOME:R-HSA-167172] [PUBMED:10550206] [PUBMED:9791012]
Transcription-Coupled Nucleotide Excision Repair (TC-NER) [NCBI:1309117] [REACTOME:R-HSA-6781827] [PUBMED:24954209] [PUBMED:11823795] [PUBMED:19023283] [PUBMED:23906714] [PUBMED:3466163]
Transcriptional Regulation by TP53 [NCBI:1269654] [REACTOME:R-HSA-3700989] [PUBMED:26122615] [PUBMED:19410540]
Transcriptional regulation by small RNAs [NCBI:1269723] [REACTOME:R-HSA-5578749] [PUBMED:19771207] [PUBMED:18852463] [PUBMED:25131816] [PUBMED:22283730] [PUBMED:22445173] [PUBMED:24388755] [PUBMED:15963934] [PUBMED:24468964] [PUBMED:22961379] [PUBMED:22722852] [PUBMED:21948593] [PUBMED:22053081] [PUBMED:15643423] [PUBMED:16373483] [PUBMED:24384674] [PUBMED:23150874] [PUBMED:20373265] [PUBMED:22336708] [PUBMED:16936726] [PUBMED:24680896] [PUBMED:23882114]
Transcriptional regulation of pluripotent stem cells [NCBI:1270346] [REACTOME:R-HSA-452723] [PUBMED:17093407] [PUBMED:17204602] [PUBMED:17068183] [PUBMED:22394165] [PUBMED:19128516] [PUBMED:19604364] [PUBMED:23166394] [PUBMED:20300647] [PUBMED:22443931] [PUBMED:22909387] [PUBMED:16153702] [PUBMED:19480567] [PUBMED:18029452] [PUBMED:22122341] [PUBMED:16819296] [PUBMED:12923055] [PUBMED:19755485] [PUBMED:22083510] [PUBMED:17572666] [PUBMED:17183653] [PUBMED:16978057] [PUBMED:16846370] [PUBMED:18923680] [PUBMED:23306458] [PUBMED:15493035] [PUBMED:20207225] [PUBMED:18035408] [PUBMED:20027182] [PUBMED:15110706] [PUBMED:22463982] [PUBMED:21044011] [PUBMED:23248145]
Viral Messenger RNA Synthesis [NCBI:1269117] [REACTOME:R-HSA-168325] [PUBMED:16933365] [PUBMED:16806605] [PUBMED:15298169]
mRNA Capping [NCBI:1269687] [REACTOME:R-HSA-72086] [PUBMED:11909521] [PUBMED:3326038] [PUBMED:10395561] [PUBMED:11017188]
mRNA Splicing [NCBI:1269689] [REACTOME:R-HSA-72172] [PUBMED:12226669]
mRNA Splicing - Major Pathway [NCBI:1269690] [REACTOME:R-HSA-72163]
mRNA Splicing - Minor Pathway [NCBI:1269691] [REACTOME:R-HSA-72165] [PUBMED:10207048] [PUBMED:9149533]