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Genes
TRAF6
Gene - TRAF6
full name
TNF receptor associated factor 6
synonyms
MGC:3310, RNF85, TRAF6, ENSG00000175104
HGNC
HGNC:12036
Entrez Gene
Gene:7189
ENSEMBL
ENSG00000175104
location
chr: 11
start: 36505317
stop: 36531863
strand: -
transcripts
NM_004620.3
NM_145803.2
pathways
Activated TLR4 signalling
[NCBI:1269236]
[REACTOME:R-HSA-166054]
[PUBMED:15276183]
[PUBMED:15588429]
[PUBMED:15845500]
[PUBMED:15596121]
Adaptive Immune System
[NCBI:1269171]
[REACTOME:R-HSA-1280218]
[PUBMED:16551257]
[PUBMED:21682741]
[PUBMED:11861602]
Autophagy - animal
[NCBI:83058]
[KEGG:hsa04140]
[PUBMED:16200202]
[PUBMED:15325588]
[PUBMED:24343578]
[PUBMED:15978794]
[PUBMED:19802558]
[PUBMED:16099218]
[PUBMED:11099404]
[PUBMED:19653858]
[PUBMED:15325584]
[PUBMED:20034776]
[PUBMED:15928708]
[PUBMED:21801009]
[PUBMED:25948417]
[PUBMED:16125113]
[PUBMED:21187343]
BCR signaling pathway
[NCBI:138058]
[Pathway Interaction Database:bcr_5pathway]
[PUBMED:7687428]
[PUBMED:16200195]
[PUBMED:12730099]
[PUBMED:10770799]
[PUBMED:14563325]
[PUBMED:9763608]
[PUBMED:15541657]
[PUBMED:11781242]
[PUBMED:11102801]
[PUBMED:9586640]
[PUBMED:11279148]
[PUBMED:7499277]
[PUBMED:7542197]
[PUBMED:9820480]
[PUBMED:9221755]
[PUBMED:11909947]
[PUBMED:9360945]
[PUBMED:9058799]
[PUBMED:10339589]
[PUBMED:11226282]
[PUBMED:9271416]
[PUBMED:9620684]
[PUBMED:11163197]
[PUBMED:10820378]
[PUBMED:11356195]
[PUBMED:11080163]
[PUBMED:10755621]
[PUBMED:7717978]
[PUBMED:7618087]
[PUBMED:11577348]
[PUBMED:1279802]
[PUBMED:10640270]
[PUBMED:11356834]
[PUBMED:12867038]
[PUBMED:12780340]
[PUBMED:10430908]
[PUBMED:7528218]
C-type lectin receptors (CLRs)
[NCBI:1269303]
[REACTOME:R-HSA-5621481]
[PUBMED:19521399]
[PUBMED:24330199]
CD40/CD40L signaling
[NCBI:138061]
[Pathway Interaction Database:cd40_pathway]
[PUBMED:11967542]
[PUBMED:11304555]
[PUBMED:11714736]
[PUBMED:17878343]
[PUBMED:12354380]
[PUBMED:11406619]
[PUBMED:9133417]
[PUBMED:7527023]
[PUBMED:18997794]
[PUBMED:1374165]
[PUBMED:1385114]
[PUBMED:12958312]
[PUBMED:10764746]
[PUBMED:11909853]
[PUBMED:10318845]
[PUBMED:7533327]
[PUBMED:16260598]
[PUBMED:18997792]
[PUBMED:12818164]
[PUBMED:10748139]
[PUBMED:9718306]
[PUBMED:10395671]
[PUBMED:17878362]
[PUBMED:7544915]
[PUBMED:12370254]
[PUBMED:8910514]
[PUBMED:17143273]
[PUBMED:10433725]
[PUBMED:14981114]
[PUBMED:16622006]
[PUBMED:12122011]
[PUBMED:12133933]
CLEC7A (Dectin-1) signaling
[NCBI:1269304]
[REACTOME:R-HSA-5607764]
[PUBMED:12719478]
[PUBMED:19223162]
Canonical NF-kappaB pathway
[NCBI:138030]
[Pathway Interaction Database:nfkappabcanonicalpathway]
[PUBMED:7878466]
[PUBMED:10688673]
[PUBMED:16497931]
[PUBMED:10755617]
[PUBMED:9660950]
[PUBMED:9346241]
[PUBMED:10195894]
[PUBMED:10521409]
[PUBMED:12917691]
[PUBMED:15620648]
[PUBMED:14695475]
[PUBMED:14651848]
[PUBMED:11319224]
[PUBMED:9150141]
[PUBMED:9819420]
[PUBMED:15218148]
[PUBMED:7739562]
[PUBMED:12657630]
[PUBMED:12867425]
[PUBMED:16267042]
Cell death signalling via NRAGE, NRIF and NADE
[NCBI:1269447]
[REACTOME:R-HSA-204998]
[PUBMED:12787561]
Chagas disease (American trypanosomiasis)
[NCBI:147809]
[KEGG:hsa05142]
[PUBMED:12377585]
[PUBMED:9794425]
[PUBMED:1717552]
[PUBMED:16238097]
[PUBMED:10066513]
[PUBMED:12874238]
[PUBMED:12036740]
[PUBMED:15917295]
[PUBMED:12055254]
[PUBMED:17651955]
[PUBMED:1396957]
[PUBMED:16175174]
[PUBMED:2194668]
[PUBMED:9190942]
[PUBMED:12377942]
[PUBMED:12427093]
[PUBMED:10234174]
[PUBMED:16030288]
[PUBMED:15223603]
[PUBMED:17110955]
Cytokine Signaling in Immune system
[NCBI:1269310]
[REACTOME:R-HSA-1280215]
[PUBMED:12613569]
Deubiquitination
[NCBI:1427860]
[REACTOME:R-HSA-5688426]
[PUBMED:19243136]
[PUBMED:20074029]
[PUBMED:15571815]
[PUBMED:20418328]
[PUBMED:16325574]
[PUBMED:12944365]
[PUBMED:23845989]
[PUBMED:22201797]
Downstream TCR signaling
[NCBI:1269176]
[REACTOME:R-HSA-202424]
[PUBMED:15084594]
Endocytosis
[NCBI:102279]
[KEGG:hsa04144]
[PUBMED:19696797]
[PUBMED:19007773]
[PUBMED:16203612]
[PUBMED:15687999]
[PUBMED:19924646]
[PUBMED:15261671]
[PUBMED:18647649]
[PUBMED:19325624]
[PUBMED:20110990]
[PUBMED:22193161]
Epstein-Barr virus infection
[NCBI:585562]
[KEGG:hsa05169]
[PUBMED:1658397]
[PUBMED:10683340]
[PUBMED:19375142]
[PUBMED:12438576]
[PUBMED:12910248]
[PUBMED:10400785]
[PUBMED:16007144]
[PUBMED:14576817]
[PUBMED:18559925]
[PUBMED:16352731]
[PUBMED:7895172]
[PUBMED:15510157]
[PUBMED:21518914]
[PUBMED:10891508]
[PUBMED:14673102]
[PUBMED:17159145]
[PUBMED:15542638]
[PUBMED:18786993]
[PUBMED:16603506]
[PUBMED:10644367]
[PUBMED:15021898]
[PUBMED:10666279]
[PUBMED:9565632]
FCERI mediated NF-kB activation
[NCBI:1269301]
[REACTOME:R-HSA-2871837]
[PUBMED:17336609]
[PUBMED:16432253]
Fc epsilon receptor (FCERI) signaling
[NCBI:1269298]
[REACTOME:R-HSA-2454202]
[PUBMED:15099567]
[PUBMED:21799019]
Hepatitis C
[NCBI:173973]
[KEGG:hsa05160]
[PUBMED:19708811]
[PUBMED:16314558]
[PUBMED:17467654]
[PUBMED:19515018]
[PUBMED:18514579]
[PUBMED:16107833]
[PUBMED:19074178]
[PUBMED:12691459]
[PUBMED:15302943]
[PUBMED:20537953]
[PUBMED:11991644]
[PUBMED:19148799]
[PUBMED:19187070]
[PUBMED:12655344]
Herpes simplex infection
[NCBI:377873]
[KEGG:hsa05168]
[PUBMED:12224518]
[PUBMED:17913820]
[PUBMED:12844494]
[PUBMED:10998601]
[PUBMED:15163721]
[PUBMED:19694546]
[PUBMED:16297150]
[PUBMED:14747533]
[PUBMED:12826401]
[PUBMED:14963113]
[PUBMED:15056211]
[PUBMED:12797447]
[PUBMED:21107701]
[PUBMED:10918307]
[PUBMED:10696424]
[PUBMED:16076403]
[PUBMED:10364308]
[PUBMED:17222692]
[PUBMED:9621021]
[PUBMED:12224508]
[PUBMED:19879619]
[PUBMED:11070032]
[PUBMED:9499021]
[PUBMED:18596690]
[PUBMED:12525427]
[PUBMED:12224517]
[PUBMED:10196275]
[PUBMED:15047834]
[PUBMED:18508584]
[PUBMED:20036979]
IKK complex recruitment mediated by RIP1
[NCBI:1269223]
[REACTOME:R-HSA-937041]
[PUBMED:16603398]
[PUBMED:16115877]
[PUBMED:14530355]
IL-17 signaling pathway
[NCBI:1474301]
[KEGG:hsa04657]
[PUBMED:17921324]
[PUBMED:24011563]
[PUBMED:21349428]
[PUBMED:20383173]
[PUBMED:20514051]
[PUBMED:20177959]
[PUBMED:18178098]
[PUBMED:21074482]
[PUBMED:21130872]
[PUBMED:17027518]
[PUBMED:23917206]
[PUBMED:23116200]
[PUBMED:18701318]
[PUBMED:26252407]
[PUBMED:22851696]
[PUBMED:21155836]
[PUBMED:25145755]
[PUBMED:17177681]
[PUBMED:19575028]
[PUBMED:23557798]
[PUBMED:21852080]
[PUBMED:22324470]
IL1-mediated signaling events
[NCBI:137944]
[Pathway Interaction Database:il1pathway]
[PUBMED:10854325]
[PUBMED:11287640]
[PUBMED:10747026]
[PUBMED:11960013]
[PUBMED:12150927]
[PUBMED:1837145]
[PUBMED:17197697]
[PUBMED:9374458]
[PUBMED:12721283]
[PUBMED:8035875]
[PUBMED:9261174]
[PUBMED:9734363]
[PUBMED:11460167]
[PUBMED:7878046]
[PUBMED:10373529]
[PUBMED:2530587]
[PUBMED:12538665]
[PUBMED:10882101]
[PUBMED:9360994]
[PUBMED:9062194]
[PUBMED:12242293]
[PUBMED:8837778]
[PUBMED:9430229]
[PUBMED:7775431]
IRAK1 recruits IKK complex
[NCBI:1269208]
[REACTOME:R-HSA-937039]
[PUBMED:14625308]
[PUBMED:12856330]
[PUBMED:16477006]
[PUBMED:15767370]
[PUBMED:18347055]
[PUBMED:15695821]
[PUBMED:14661019]
[PUBMED:18276832]
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
[NCBI:1269230]
[REACTOME:R-HSA-975144]
[PUBMED:16477006]
[PUBMED:15767370]
[PUBMED:18347055]
[PUBMED:15695821]
[PUBMED:14661019]
[PUBMED:18276832]
[PUBMED:14625308]
[PUBMED:12856330]
IRAK2 mediated activation of TAK1 complex
[NCBI:1269209]
[REACTOME:R-HSA-937042]
[PUBMED:21606490]
[PUBMED:12140561]
[PUBMED:16831874]
[PUBMED:17878161]
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
[NCBI:1269231]
[REACTOME:R-HSA-975163]
[PUBMED:12140561]
[PUBMED:16831874]
[PUBMED:17878161]
Immune System
[NCBI:1269170]
[REACTOME:R-HSA-168256]
Innate Immune System
[NCBI:1269203]
[REACTOME:R-HSA-168249]
Interleukin-1 signaling
[NCBI:1269320]
[REACTOME:R-HSA-446652]
[PUBMED:19302047]
[PUBMED:19022706]
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
[NCBI:1269212]
[REACTOME:R-HSA-450321]
[PUBMED:15837794]
[PUBMED:11460167]
Leishmaniasis
[NCBI:144181]
[KEGG:hsa05140]
[PUBMED:11890722]
[PUBMED:7916951]
[PUBMED:10417174]
[PUBMED:11298294]
[PUBMED:10586030]
[PUBMED:15322192]
[PUBMED:15831826]
[PUBMED:11728310]
[PUBMED:15039466]
[PUBMED:10462516]
[PUBMED:10608501]
[PUBMED:15721837]
[PUBMED:15639739]
[PUBMED:14762510]
[PUBMED:18793215]
[PUBMED:7591091]
[PUBMED:12438359]
[PUBMED:18070909]
[PUBMED:17543969]
[PUBMED:15983048]
[PUBMED:16848789]
[PUBMED:10770277]
[PUBMED:9504340]
MAP kinase activation in TLR cascade
[NCBI:1269211]
[REACTOME:R-HSA-450294]
[PUBMED:17637696]
[PUBMED:11861597]
[PUBMED:19196711]
[PUBMED:11242034]
MAPK signaling pathway
[NCBI:83048]
[KEGG:hsa04010]
[PUBMED:11749383]
[PUBMED:12566928]
[PUBMED:12849693]
[PUBMED:12676795]
[PUBMED:12947395]
[PUBMED:14597384]
[PUBMED:11369511]
[PUBMED:12191611]
[PUBMED:12390245]
Measles
[NCBI:213306]
[KEGG:hsa05162]
[PUBMED:16237742]
[PUBMED:12804771]
[PUBMED:19198562]
[PUBMED:20376484]
[PUBMED:11385511]
[PUBMED:16963735]
[PUBMED:19198566]
[PUBMED:18922877]
[PUBMED:19203114]
[PUBMED:12620806]
[PUBMED:16690907]
[PUBMED:17720800]
[PUBMED:20636817]
[PUBMED:12410527]
[PUBMED:11582511]
[PUBMED:19203109]
[PUBMED:19203113]
[PUBMED:14585342]
[PUBMED:12805463]
Metabolism of proteins
[NCBI:1268677]
[REACTOME:R-HSA-392499]
MyD88 cascade initiated on plasma membrane
[NCBI:1269207]
[REACTOME:R-HSA-975871]
[PUBMED:15728506]
[PUBMED:16239509]
MyD88 dependent cascade initiated on endosome
[NCBI:1269228]
[REACTOME:R-HSA-975155]
[PUBMED:20237413]
[PUBMED:15276183]
[PUBMED:18652679]
MyD88-independent TLR3/TLR4 cascade
[NCBI:1269220]
[REACTOME:R-HSA-166166]
[PUBMED:15276183]
MyD88:Mal cascade initiated on plasma membrane
[NCBI:1269237]
[REACTOME:R-HSA-166058]
[PUBMED:15276183]
NF-kB is activated and signals survival
[NCBI:1269454]
[REACTOME:R-HSA-209560]
[PUBMED:16187223]
NF-kappa B signaling pathway
[NCBI:634527]
[KEGG:hsa04064]
[PUBMED:22119011]
[PUBMED:16264088]
[PUBMED:21187855]
[PUBMED:15546385]
[PUBMED:17607554]
[PUBMED:21135871]
[PUBMED:16984817]
[PUBMED:17047224]
[PUBMED:19203223]
[PUBMED:20300215]
[PUBMED:14657271]
[PUBMED:17431096]
[PUBMED:15134788]
[PUBMED:16356770]
[PUBMED:21772278]
[PUBMED:12654254]
[PUBMED:22390971]
[PUBMED:22017435]
[PUBMED:17183360]
[PUBMED:21173796]
[PUBMED:15905862]
[PUBMED:19302050]
[PUBMED:17098202]
[PUBMED:21872579]
[PUBMED:22152226]
[PUBMED:18613837]
[PUBMED:19489733]
[PUBMED:11875461]
[PUBMED:19726767]
[PUBMED:22017430]
[PUBMED:21232019]
[PUBMED:18832076]
NOD-like receptor signaling pathway
[NCBI:122191]
[KEGG:hsa04621]
[PUBMED:25330206]
[PUBMED:21575908]
[PUBMED:23846113]
[PUBMED:26549800]
[PUBMED:16493424]
[PUBMED:23124073]
[PUBMED:24840700]
[PUBMED:27291964]
[PUBMED:27012466]
[PUBMED:24707857]
[PUBMED:19767725]
[PUBMED:25879280]
[PUBMED:23215645]
[PUBMED:22819539]
[PUBMED:23702978]
[PUBMED:20643110]
[PUBMED:25879288]
[PUBMED:26655628]
[PUBMED:25145756]
[PUBMED:24718315]
[PUBMED:26482951]
[PUBMED:25526305]
[PUBMED:26121197]
[PUBMED:22430786]
NOD1/2 Signaling Pathway
[NCBI:1269252]
[REACTOME:R-HSA-168638]
[PUBMED:18928408]
[PUBMED:18585455]
[PUBMED:18414735]
NRIF signals cell death from the nucleus
[NCBI:1269449]
[REACTOME:R-HSA-205043]
[PUBMED:15721744]
Neurotrophin signaling pathway
[NCBI:101143]
[KEGG:hsa04722]
[PUBMED:16699811]
[PUBMED:10812966]
[PUBMED:12676795]
[PUBMED:16939974]
[PUBMED:10851172]
[PUBMED:15499580]
[PUBMED:14704852]
[PUBMED:11399424]
[PUBMED:10764727]
[PUBMED:10985348]
[PUBMED:16856873]
[PUBMED:11529497]
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
[NCBI:1269251]
[REACTOME:R-HSA-168643]
[PUBMED:18928408]
Osteoclast differentiation
[NCBI:193147]
[KEGG:hsa04380]
[PUBMED:17633024]
[PUBMED:18382763]
[PUBMED:18329366]
[PUBMED:17869613]
[PUBMED:18722561]
[PUBMED:15122243]
[PUBMED:20703218]
[PUBMED:12748652]
[PUBMED:12110142]
[PUBMED:19585227]
[PUBMED:15546140]
[PUBMED:16184196]
[PUBMED:15817678]
[PUBMED:20392226]
[PUBMED:16313349]
[PUBMED:16313342]
[PUBMED:17380158]
[PUBMED:18451259]
Ovarian tumor domain proteases
[NCBI:1427863]
[REACTOME:R-HSA-5689896]
[PUBMED:23827681]
Pathways in cancer
[NCBI:83105]
[KEGG:hsa05200]
[PUBMED:12244301]
[PUBMED:15156182]
[PUBMED:16899407]
[PUBMED:12621137]
[PUBMED:21193867]
[PUBMED:16001072]
[PUBMED:11707511]
[PUBMED:11253051]
[PUBMED:11071626]
[PUBMED:17251915]
[PUBMED:11736900]
[PUBMED:16557281]
[PUBMED:16699851]
[PUBMED:16189702]
[PUBMED:11902573]
[PUBMED:16555243]
[PUBMED:8069858]
[PUBMED:15310786]
[PUBMED:9834202]
[PUBMED:16700615]
[PUBMED:12545153]
[PUBMED:15656799]
[PUBMED:12154354]
[PUBMED:11895903]
[PUBMED:11527574]
[PUBMED:16326109]
[PUBMED:16339096]
[PUBMED:11160144]
[PUBMED:15724144]
[PUBMED:12951584]
[PUBMED:10647931]
[PUBMED:16881963]
[PUBMED:15557758]
[PUBMED:11477132]
[PUBMED:15721476]
[PUBMED:15625120]
[PUBMED:16236521]
[PUBMED:14967450]
[PUBMED:15942304]
[PUBMED:17287871]
[PUBMED:14634372]
[PUBMED:15573119]
[PUBMED:15009714]
[PUBMED:16112428]
[PUBMED:15611513]
[PUBMED:16001050]
[PUBMED:15349822]
[PUBMED:16551846]
[PUBMED:15978322]
[PUBMED:15774796]
[PUBMED:16352814]
[PUBMED:12951588]
[PUBMED:10944551]
[PUBMED:10740269]
[PUBMED:15639402]
[PUBMED:12407699]
[PUBMED:11130178]
[PUBMED:15109562]
[PUBMED:11170304]
[PUBMED:11276000]
[PUBMED:9643506]
[PUBMED:16248975]
[PUBMED:16242838]
[PUBMED:12946833]
[PUBMED:11559746]
[PUBMED:9196022]
[PUBMED:12079267]
[PUBMED:15468170]
[PUBMED:16064138]
[PUBMED:14580692]
[PUBMED:15082523]
[PUBMED:15551095]
[PUBMED:17062879]
[PUBMED:17211469]
[PUBMED:11720739]
[PUBMED:12588368]
[PUBMED:11057895]
[PUBMED:9422516]
[PUBMED:12894244]
[PUBMED:15479695]
[PUBMED:16189154]
[PUBMED:12878745]
[PUBMED:11900250]
[PUBMED:11103787]
[PUBMED:15122209]
[PUBMED:12711111]
[PUBMED:12243753]
[PUBMED:16306523]
[PUBMED:16702400]
[PUBMED:15270885]
[PUBMED:14685170]
[PUBMED:14586404]
[PUBMED:11078609]
[PUBMED:15284264]
[PUBMED:10505543]
[PUBMED:11223406]
[PUBMED:14982876]
[PUBMED:12648469]
[PUBMED:12867060]
[PUBMED:15711891]
[PUBMED:12094241]
[PUBMED:16642045]
[PUBMED:11463388]
[PUBMED:12762887]
[PUBMED:15746962]
[PUBMED:15823750]
[PUBMED:16750612]
[PUBMED:16484590]
[PUBMED:11459867]
[PUBMED:16146838]
[PUBMED:14556242]
[PUBMED:15947972]
[PUBMED:12563308]
[PUBMED:16946003]
[PUBMED:15948971]
[PUBMED:11407945]
[PUBMED:12737309]
[PUBMED:16095998]
[PUBMED:12351585]
[PUBMED:24508914]
[PUBMED:12084351]
[PUBMED:11807782]
[PUBMED:14695152]
[PUBMED:10453277]
[PUBMED:17554387]
[PUBMED:15841168]
[PUBMED:12616528]
[PUBMED:10403855]
[PUBMED:16054233]
[PUBMED:16474624]
[PUBMED:16822996]
[PUBMED:17028294]
[PUBMED:11224709]
[PUBMED:11750244]
[PUBMED:11905738]
[PUBMED:15719031]
[PUBMED:10843728]
[PUBMED:16110317]
[PUBMED:11721960]
[PUBMED:12741677]
[PUBMED:7585656]
[PUBMED:12801837]
[PUBMED:16551847]
[PUBMED:12459728]
[PUBMED:11431710]
[PUBMED:12468433]
[PUBMED:11165748]
[PUBMED:16042571]
[PUBMED:16508724]
[PUBMED:15000146]
[PUBMED:17149381]
[PUBMED:15948711]
[PUBMED:14747944]
[PUBMED:14737121]
[PUBMED:12379883]
[PUBMED:17158541]
[PUBMED:12850530]
[PUBMED:10835690]
[PUBMED:16870043]
Pertussis
[NCBI:218111]
[KEGG:hsa05133]
[PUBMED:20610650]
[PUBMED:12701623]
[PUBMED:15201703]
[PUBMED:18401006]
[PUBMED:20210554]
[PUBMED:16622221]
[PUBMED:17148436]
[PUBMED:21204863]
[PUBMED:20404851]
[PUBMED:10540218]
[PUBMED:16999837]
[PUBMED:16481212]
[PUBMED:16863919]
[PUBMED:16390441]
[PUBMED:21423776]
[PUBMED:17328678]
[PUBMED:12915094]
Post-translational protein modification
[NCBI:1268701]
[REACTOME:R-HSA-597592]
RIG-I-like receptor signaling pathway
[NCBI:117292]
[KEGG:hsa04622]
[PUBMED:19224920]
[PUBMED:19076341]
[PUBMED:18549796]
[PUBMED:18591413]
[PUBMED:19615405]
[PUBMED:19120475]
[PUBMED:18439848]
[PUBMED:19120476]
[PUBMED:15208624]
[PUBMED:19539500]
[PUBMED:18272355]
[PUBMED:18984593]
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
[NCBI:1269259]
[REACTOME:R-HSA-168928]
[PUBMED:17395582]
[PUBMED:17942531]
[PUBMED:18701081]
[PUBMED:17683970]
[PUBMED:18989317]
[PUBMED:16214811]
Regulated proteolysis of p75NTR
[NCBI:1269459]
[REACTOME:R-HSA-193692]
[PUBMED:17986144]
Regulation of p38-alpha and p38-beta
[NCBI:137964]
[Pathway Interaction Database:p38alphabetapathway]
[PUBMED:16461893]
[PUBMED:7997261]
[PUBMED:16943189]
[PUBMED:14585994]
[PUBMED:10391943]
[PUBMED:14661019]
[PUBMED:11359773]
[PUBMED:7914033]
[PUBMED:8910287]
[PUBMED:7744004]
[PUBMED:10190877]
[PUBMED:7592586]
[PUBMED:16849316]
[PUBMED:7693711]
[PUBMED:11847341]
[PUBMED:7839144]
[PUBMED:9790884]
[PUBMED:7499279]
[PUBMED:14592977]
[PUBMED:12110590]
[PUBMED:14634666]
[PUBMED:8107774]
[PUBMED:8622669]
[PUBMED:8798750]
[PUBMED:11278799]
[PUBMED:15864310]
[PUBMED:16407200]
Signal Transduction
[NCBI:1269379]
[REACTOME:R-HSA-162582]
[PUBMED:17604717]
[PUBMED:19648010]
[PUBMED:16260143]
[PUBMED:11742412]
[PUBMED:19536106]
[PUBMED:15863030]
[PUBMED:19379690]
[PUBMED:19458711]
[PUBMED:19935667]
[PUBMED:21252999]
[PUBMED:15520807]
[PUBMED:17496910]
[PUBMED:15450248]
[PUBMED:18043707]
[PUBMED:16939974]
[PUBMED:19762341]
[PUBMED:18483217]
[PUBMED:17084981]
[PUBMED:21781017]
[PUBMED:19619488]
Signaling by Interleukins
[NCBI:1269318]
[REACTOME:R-HSA-449147]
[PUBMED:19302047]
[PUBMED:12445398]
Signalling by NGF
[NCBI:1269443]
[REACTOME:R-HSA-166520]
Small cell lung cancer
[NCBI:83118]
[KEGG:hsa05222]
[PUBMED:12711111]
[PUBMED:11463388]
[PUBMED:12741677]
[PUBMED:11905738]
[PUBMED:11807782]
[PUBMED:12379883]
[PUBMED:12243753]
[PUBMED:12616528]
[PUBMED:11720739]
[PUBMED:15109562]
[PUBMED:12407699]
[PUBMED:10944551]
[PUBMED:16112428]
[PUBMED:11559746]
[PUBMED:16064138]
[PUBMED:11902573]
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
[NCBI:1269210]
[REACTOME:R-HSA-445989]
[PUBMED:15837794]
[PUBMED:11460167]
TCR signaling
[NCBI:1269172]
[REACTOME:R-HSA-202403]
[PUBMED:10375551]
[PUBMED:12876557]
[PUBMED:9989491]
TCR signaling in naive CD4+ T cells
[NCBI:137998]
[Pathway Interaction Database:tcr_pathway]
[PUBMED:11376344]
[PUBMED:9094314]
[PUBMED:8083187]
[PUBMED:11994416]
[PUBMED:16365455]
[PUBMED:10072079]
[PUBMED:12361955]
[PUBMED:12755691]
[PUBMED:8642247]
[PUBMED:15125833]
[PUBMED:7509360]
[PUBMED:11353765]
[PUBMED:12941616]
[PUBMED:8700169]
[PUBMED:11120819]
[PUBMED:15899849]
[PUBMED:8990121]
[PUBMED:8702662]
[PUBMED:8164687]
[PUBMED:2141684]
[PUBMED:11567141]
[PUBMED:9846481]
[PUBMED:9489702]
[PUBMED:10811803]
[PUBMED:11368773]
[PUBMED:14557276]
[PUBMED:2548204]
[PUBMED:10318843]
[PUBMED:15536066]
[PUBMED:10652356]
[PUBMED:7568038]
[PUBMED:11175263]
[PUBMED:9438848]
[PUBMED:9692882]
[PUBMED:10209031]
[PUBMED:7509083]
[PUBMED:12874226]
[PUBMED:8673706]
[PUBMED:16733527]
[PUBMED:9822663]
[PUBMED:12738795]
[PUBMED:11904433]
[PUBMED:8084588]
[PUBMED:8114715]
[PUBMED:9312162]
[PUBMED:8790380]
[PUBMED:9677202]
[PUBMED:15802604]
[PUBMED:14702343]
[PUBMED:10903746]
[PUBMED:10807788]
[PUBMED:8176201]
[PUBMED:9207119]
[PUBMED:10790433]
[PUBMED:8892604]
[PUBMED:9665884]
[PUBMED:1639064]
[PUBMED:12421919]
[PUBMED:8246987]
[PUBMED:9710204]
[PUBMED:8146197]
[PUBMED:2190221]
[PUBMED:10229072]
[PUBMED:10021361]
[PUBMED:9924026]
[PUBMED:12186560]
[PUBMED:16649996]
[PUBMED:11287959]
[PUBMED:12917261]
[PUBMED:7545666]
[PUBMED:11250890]
[PUBMED:12842872]
[PUBMED:15879121]
[PUBMED:11567140]
[PUBMED:10209041]
[PUBMED:10556826]
[PUBMED:8183372]
[PUBMED:12397360]
[PUBMED:10506192]
[PUBMED:10861059]
[PUBMED:12507424]
[PUBMED:12845325]
[PUBMED:10745081]
[PUBMED:8195151]
[PUBMED:12024036]
[PUBMED:7524075]
[PUBMED:1464315]
[PUBMED:12138205]
[PUBMED:7544353]
[PUBMED:16906149]
[PUBMED:9637919]
[PUBMED:2470098]
[PUBMED:3919143]
[PUBMED:16005298]
[PUBMED:10918068]
[PUBMED:8636141]
[PUBMED:16921383]
[PUBMED:8479536]
[PUBMED:7556092]
[PUBMED:16582901]
[PUBMED:8805223]
[PUBMED:15933714]
[PUBMED:10224278]
[PUBMED:9819387]
[PUBMED:12881521]
[PUBMED:14988727]
[PUBMED:16849481]
[PUBMED:11390650]
TCR signaling in naive CD8+ T cells
[NCBI:138055]
[Pathway Interaction Database:cd8tcrpathway]
[PUBMED:9094314]
[PUBMED:15125833]
[PUBMED:11994416]
[PUBMED:7509360]
[PUBMED:12755691]
[PUBMED:8642247]
[PUBMED:12361955]
[PUBMED:11956228]
[PUBMED:10072079]
[PUBMED:8977171]
[PUBMED:2141684]
[PUBMED:8700169]
[PUBMED:8164687]
[PUBMED:9489702]
[PUBMED:8702662]
[PUBMED:2548204]
[PUBMED:11175263]
[PUBMED:8114715]
[PUBMED:10209031]
[PUBMED:15536066]
[PUBMED:7678351]
[PUBMED:8673703]
[PUBMED:7830771]
[PUBMED:7509083]
[PUBMED:16733527]
[PUBMED:9438848]
[PUBMED:8790380]
[PUBMED:1639064]
[PUBMED:15980863]
[PUBMED:8084588]
[PUBMED:14702343]
[PUBMED:10790433]
[PUBMED:10807788]
[PUBMED:16169499]
[PUBMED:15802604]
[PUBMED:8892604]
[PUBMED:2114552]
[PUBMED:12421919]
[PUBMED:12917261]
[PUBMED:8146197]
[PUBMED:1335364]
[PUBMED:10021361]
[PUBMED:8183372]
[PUBMED:8627172]
[PUBMED:8898939]
[PUBMED:2190221]
[PUBMED:9710204]
[PUBMED:11287959]
[PUBMED:14764585]
[PUBMED:12954628]
[PUBMED:10209041]
[PUBMED:1464315]
[PUBMED:12507424]
[PUBMED:12732656]
[PUBMED:8195151]
[PUBMED:12138205]
[PUBMED:16005298]
[PUBMED:9312149]
[PUBMED:7544353]
[PUBMED:16906149]
[PUBMED:9637919]
[PUBMED:12845325]
[PUBMED:2470098]
[PUBMED:10918068]
[PUBMED:16116204]
[PUBMED:16921383]
[PUBMED:10562325]
[PUBMED:9819387]
[PUBMED:16582901]
[PUBMED:8034711]
[PUBMED:8479536]
[PUBMED:10640739]
[PUBMED:3919143]
[PUBMED:10224278]
[PUBMED:10811865]
TRAF6 mediated IRF7 activation
[NCBI:1269262]
[REACTOME:R-HSA-933541]
[PUBMED:19479062]
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
[NCBI:1269232]
[REACTOME:R-HSA-975110]
[PUBMED:16214811]
[PUBMED:11070172]
TRAF6 mediated NF-kB activation
[NCBI:1269263]
[REACTOME:R-HSA-933542]
[PUBMED:18984593]
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
[NCBI:1269229]
[REACTOME:R-HSA-975138]
[PUBMED:22511786]
[PUBMED:18794297]
TRAF6 mediated induction of TAK1 complex
[NCBI:1269225]
[REACTOME:R-HSA-937072]
[PUBMED:19112497]
[PUBMED:19675569]
TRIF-mediated TLR3/TLR4 signaling
[NCBI:1269221]
[REACTOME:R-HSA-937061]
[PUBMED:15814722]
[PUBMED:12855817]
[PUBMED:14739303]
Toll Like Receptor 10 (TLR10) Cascade
[NCBI:1269206]
[REACTOME:R-HSA-168142]
[PUBMED:15728506]
[PUBMED:18332149]
Toll Like Receptor 2 (TLR2) Cascade
[NCBI:1269238]
[REACTOME:R-HSA-181438]
[PUBMED:10820283]
Toll Like Receptor 3 (TLR3) Cascade
[NCBI:1269219]
[REACTOME:R-HSA-168164]
[PUBMED:19627256]
[PUBMED:15733829]
[PUBMED:18202435]
Toll Like Receptor 4 (TLR4) Cascade
[NCBI:1269234]
[REACTOME:R-HSA-166016]
Toll Like Receptor 5 (TLR5) Cascade
[NCBI:1269226]
[REACTOME:R-HSA-168176]
[PUBMED:11489966]
[PUBMED:11323673]
Toll Like Receptor 7/8 (TLR7/8) Cascade
[NCBI:1269227]
[REACTOME:R-HSA-168181]
[PUBMED:14976262]
Toll Like Receptor 9 (TLR9) Cascade
[NCBI:1269233]
[REACTOME:R-HSA-168138]
[PUBMED:14751759]
Toll Like Receptor TLR1:TLR2 Cascade
[NCBI:1269239]
[REACTOME:R-HSA-168179]
[PUBMED:12975352]
Toll Like Receptor TLR6:TLR2 Cascade
[NCBI:1269240]
[REACTOME:R-HSA-168188]
[PUBMED:14977973]
Toll-Like Receptors Cascades
[NCBI:1269204]
[REACTOME:R-HSA-168898]
[PUBMED:15950447]
[PUBMED:12893815]
[PUBMED:15976490]
[PUBMED:15585605]
[PUBMED:14751757]
Toll-like receptor signaling pathway
[NCBI:83076]
[KEGG:hsa04620]
[PUBMED:16924467]
[PUBMED:17395581]
[PUBMED:17637696]
[PUBMED:12734364]
[PUBMED:17507094]
[PUBMED:14698224]
[PUBMED:11101877]
[PUBMED:16497588]
[PUBMED:14751764]
[PUBMED:17275323]
[PUBMED:17457343]
[PUBMED:16932750]
Toxoplasmosis
[NCBI:169642]
[KEGG:hsa05145]
[PUBMED:18617274]
[PUBMED:19400868]
[PUBMED:17024357]
[PUBMED:19744886]
[PUBMED:19891610]
[PUBMED:17110955]
[PUBMED:12106793]
[PUBMED:12580944]
[PUBMED:12857995]
[PUBMED:10234174]
[PUBMED:18327664]
[PUBMED:10525166]
[PUBMED:18059289]
[PUBMED:18775432]
[PUBMED:14642303]
[PUBMED:15361242]
[PUBMED:16339966]
[PUBMED:14987366]
[PUBMED:15639739]
Tuberculosis
[NCBI:213780]
[KEGG:hsa05152]
[PUBMED:20199890]
[PUBMED:21274449]
[PUBMED:17359235]
[PUBMED:20415982]
[PUBMED:18541216]
[PUBMED:19369951]
[PUBMED:15083155]
[PUBMED:11378475]
[PUBMED:15228522]
[PUBMED:19634703]
[PUBMED:21274433]
[PUBMED:19563525]
[PUBMED:18407066]
[PUBMED:18288961]
[PUBMED:16200082]
[PUBMED:17785780]
[PUBMED:11932234]
Ub-specific processing proteases
[NCBI:1427862]
[REACTOME:R-HSA-5689880]
[PUBMED:16325574]
Ubiquitin mediated proteolysis
[NCBI:83056]
[KEGG:hsa04120]
[PUBMED:16405856]
[PUBMED:12944364]
[PUBMED:16922408]
[PUBMED:17588513]
[PUBMED:16922367]
[PUBMED:16922370]
[PUBMED:16816840]
activated TAK1 mediates p38 MAPK activation
[NCBI:1269213]
[REACTOME:R-HSA-450302]
[PUBMED:10878576]
[PUBMED:8533096]
[PUBMED:15837794]
p38 MAPK signaling pathway
[NCBI:137943]
[Pathway Interaction Database:p38_mkk3_6pathway]
[PUBMED:9564042]
[PUBMED:12052864]
[PUBMED:8663074]
[PUBMED:17242196]
[PUBMED:10688666]
[PUBMED:9774977]
[PUBMED:8974401]
[PUBMED:9827804]
[PUBMED:16129676]
[PUBMED:14592977]
[PUBMED:17143273]
[PUBMED:14634666]
[PUBMED:15836773]
[PUBMED:14749717]
[PUBMED:9305639]
[PUBMED:8638164]
[PUBMED:10848581]
[PUBMED:15864310]
[PUBMED:9639556]
[PUBMED:17396146]
[PUBMED:11460167]
[PUBMED:17210579]
[PUBMED:9786855]
p75 NTR receptor-mediated signalling
[NCBI:1269445]
[REACTOME:R-HSA-193704]
[PUBMED:16699811]
[PUBMED:16939974]
[PUBMED:12671646]
p75(NTR)-mediated signaling
[NCBI:138019]
[Pathway Interaction Database:p75ntrpathway]
[PUBMED:14673001]
[PUBMED:14593116]
[PUBMED:10545116]
[PUBMED:11729324]
[PUBMED:16252010]
[PUBMED:11756426]
[PUBMED:12414813]
[PUBMED:2157470]
[PUBMED:11777929]
[PUBMED:1547788]
[PUBMED:10764727]
[PUBMED:8614802]
[PUBMED:14960584]
[PUBMED:12376548]
[PUBMED:11756498]
[PUBMED:8079174]
[PUBMED:16498402]
[PUBMED:15051733]
[PUBMED:12682012]
[PUBMED:14638693]
[PUBMED:14966521]
[PUBMED:9915784]
[PUBMED:11487608]
[PUBMED:10485890]
[PUBMED:16630834]
[PUBMED:11312266]
[PUBMED:10985348]
[PUBMED:11244088]
[PUBMED:6093111]
[PUBMED:10595511]
[PUBMED:14985763]
[PUBMED:12097334]
[PUBMED:15548667]
[PUBMED:15470142]
[PUBMED:11279271]
[PUBMED:8878481]
[PUBMED:12422217]
[PUBMED:15987945]
[PUBMED:15668238]
[PUBMED:10433815]
[PUBMED:12692556]
[PUBMED:2025430]
[PUBMED:15930396]
[PUBMED:11278287]
[PUBMED:12034707]
p75NTR recruits signalling complexes
[NCBI:1269453]
[REACTOME:R-HSA-209543]
p75NTR signals via NF-kB
[NCBI:1269452]
[REACTOME:R-HSA-193639]
[PUBMED:16997282]