full name
flap structure-specific endonuclease 1

synonyms
FEN-1, MF1, RAD2, FEN1, ENSG00000168496

HGNC
HGNC:3650

Entrez Gene
Gene:2237

ENSEMBL
ENSG00000168496

location
chr: 11
start: 61560109
stop: 61564716
strand: +

transcripts
NM_004111.5

pathways
Base Excision Repair [NCBI:1270351] [REACTOME:R-HSA-73884] [PUBMED:11937636] [PUBMED:10583946]
Base excision repair [NCBI:83043] [KEGG:hsa03410] [PUBMED:17893748] [PUBMED:11436317] [PUBMED:17337257] [PUBMED:21665970]
Cell Cycle [NCBI:1269741] [REACTOME:R-HSA-1640170]
Cell Cycle, Mitotic [NCBI:1269763] [REACTOME:R-HSA-69278]
Chromosome Maintenance [NCBI:1269853] [REACTOME:R-HSA-73886]
DNA Double-Strand Break Repair [NCBI:1309095] [REACTOME:R-HSA-5693532] [PUBMED:12897142] [PUBMED:20965415]
DNA Repair [NCBI:1270350] [REACTOME:R-HSA-73894] [PUBMED:10583946] [PUBMED:23175119]
DNA Replication [NCBI:1269875] [REACTOME:R-HSA-69306] [PUBMED:11257218] [PUBMED:12045100] [PUBMED:1536007] [PUBMED:10966477] [PUBMED:1579437] [PUBMED:8223461]
DNA replication [NCBI:83039] [KEGG:hsa03030] [PUBMED:9759502] [PUBMED:8087839]
DNA strand elongation [NCBI:1269784] [REACTOME:R-HSA-69190] [PUBMED:9081985] [PUBMED:1976634] [PUBMED:7623835] [PUBMED:1536007] [PUBMED:8594377]
Disease [NCBI:1268854] [REACTOME:R-HSA-1643685]
Early Phase of HIV Life Cycle [NCBI:1269059] [REACTOME:R-HSA-162594] [PUBMED:12091904]
Extension of Telomeres [NCBI:1269857] [REACTOME:R-HSA-180786] [PUBMED:15189140]
HDR through MMEJ (alt-NHEJ) [NCBI:1309109] [REACTOME:R-HSA-5685939] [PUBMED:25642963] [PUBMED:25642960] [PUBMED:25643323] [PUBMED:21816818] [PUBMED:25201414] [PUBMED:20483915] [PUBMED:16012167] [PUBMED:19357644] [PUBMED:25789972]
HIV Infection [NCBI:1269057] [REACTOME:R-HSA-162906] [PUBMED:16354571] [PUBMED:9759480]
HIV Life Cycle [NCBI:1269058] [REACTOME:R-HSA-162587] [PUBMED:9188609] [PUBMED:9759480]
Homology Directed Repair [NCBI:1309099] [REACTOME:R-HSA-5693538] [PUBMED:11242102] [PUBMED:20965415] [PUBMED:11376695] [PUBMED:12427531]
Infectious disease [NCBI:1269056] [REACTOME:R-HSA-5663205]
Lagging Strand Synthesis [NCBI:1269788] [REACTOME:R-HSA-69186] [PUBMED:9081985]
Non-homologous end-joining [NCBI:83047] [KEGG:hsa03450] [PUBMED:17506672] [PUBMED:15578053] [PUBMED:16971555] [PUBMED:17589524] [PUBMED:12215643] [PUBMED:16895466]
PCNA-Dependent Long Patch Base Excision Repair [NCBI:1270366] [REACTOME:R-HSA-5651801] [PUBMED:9780000] [PUBMED:11601988] [PUBMED:9214649] [PUBMED:12200445] [PUBMED:10460157] [PUBMED:10559261] [PUBMED:11250913]
POLB-Dependent Long Patch Base Excision Repair [NCBI:1270365] [REACTOME:R-HSA-110362] [PUBMED:15561706] [PUBMED:11440997] [PUBMED:15135726] [PUBMED:9214649] [PUBMED:11554294] [PUBMED:12200445] [PUBMED:11340072] [PUBMED:9685411]
Processive synthesis on the C-strand of the telomere [NCBI:1269862] [REACTOME:R-HSA-174414] [PUBMED:1671046]
Processive synthesis on the lagging strand [NCBI:1269789] [REACTOME:R-HSA-69183] [PUBMED:1671046]
Removal of the Flap Intermediate [NCBI:1269790] [REACTOME:R-HSA-69166] [PUBMED:7926735] [PUBMED:8131753] [PUBMED:7644470]
Removal of the Flap Intermediate from the C-strand [NCBI:1269863] [REACTOME:R-HSA-174437] [PUBMED:1671046]
Resolution of AP sites via the multiple-nucleotide patch replacement pathway [NCBI:1270364] [REACTOME:R-HSA-110373] [PUBMED:10583946] [PUBMED:9214649] [PUBMED:10559261] [PUBMED:10460157] [PUBMED:11440997] [PUBMED:11601988]
Resolution of Abasic Sites (AP sites) [NCBI:1270359] [REACTOME:R-HSA-73933] [PUBMED:11601988] [PUBMED:15260972] [PUBMED:17395641] [PUBMED:19329425] [PUBMED:9804798] [PUBMED:15556996] [PUBMED:9214649] [PUBMED:7608159] [PUBMED:11440997] [PUBMED:15871698] [PUBMED:9207062] [PUBMED:16982218] [PUBMED:8978692]
S Phase [NCBI:1269777] [REACTOME:R-HSA-69242]
Synthesis of DNA [NCBI:1269779] [REACTOME:R-HSA-69239]
Telomere C-strand (Lagging Strand) Synthesis [NCBI:1269859] [REACTOME:R-HSA-174417] [PUBMED:15189140]
Telomere Maintenance [NCBI:1269856] [REACTOME:R-HSA-157579] [PUBMED:16166375] [PUBMED:4507727] [PUBMED:14685173] [PUBMED:642006] [PUBMED:15189140] [PUBMED:3907856] [PUBMED:2463488] [PUBMED:4754905]