full name
calpain 1

synonyms
CANP, CANP1, CANPL1, muCANP, muCL, CAPN1, ENSG00000014216

HGNC
HGNC:1476

Entrez Gene
Gene:823

ENSEMBL
ENSG00000014216

location
chr: 11
start: 64948686
stop: 64979477
strand: +

OMIM
OMIM:114220: CAPN1
OMIM:616907: Spastic paraplegia 76, autosomal recessive

transcripts
NM_001198868.1
NM_001198869.1
NM_005186.3
NR_040008.1

pathways
Alzheimer's disease [NCBI:83097] [KEGG:hsa05010] [PUBMED:18782350] [PUBMED:18035450] [PUBMED:15177383] [PUBMED:10527810] [PUBMED:15363492] [PUBMED:16677790] [PUBMED:15295589] [PUBMED:17055782] [PUBMED:15864339] [PUBMED:15750290] [PUBMED:18675468] [PUBMED:15232608] [PUBMED:9848086] [PUBMED:11484003] [PUBMED:10830966] [PUBMED:16529745] [PUBMED:17568632]
Apoptosis [NCBI:83060] [KEGG:hsa04210] [NCBI:1270262] [REACTOME:R-HSA-109581] [PUBMED:12189384] [PUBMED:20533903] [PUBMED:18208375] [PUBMED:22429822] [PUBMED:15218528] [PUBMED:24769728] [PUBMED:18023214] [PUBMED:25526085] [PUBMED:23070002] [PUBMED:15654015] [PUBMED:15601572] [PUBMED:14561771] [PUBMED:24278747] [PUBMED:21914490] [PUBMED:22465226] [PUBMED:21145844] [PUBMED:12838338] [PUBMED:18238895] [PUBMED:12949498] [PUBMED:18304445] [PUBMED:14737178] [PUBMED:26231733] [PUBMED:9916983] [PUBMED:14634621] [PUBMED:19770840] [PUBMED:22075987] [PUBMED:4561027] [PUBMED:20075940] [PUBMED:9894605] [PUBMED:26615431] [PUBMED:12505355] [PUBMED:11520933] [PUBMED:19148180] [PUBMED:16397578] [PUBMED:15719025] [PUBMED:15322527] [PUBMED:15725726] [PUBMED:12209154] [PUBMED:23803157]
Degradation of the extracellular matrix [NCBI:1270257] [REACTOME:R-HSA-1474228] [PUBMED:21917992]
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models [NCBI:1457789] [REACTOME:R-HSA-8862803] [PUBMED:8090221] [PUBMED:12684440] [PUBMED:22899714] [PUBMED:10830966] [PUBMED:7592934] [PUBMED:19519302]
Developmental Biology [NCBI:1270302] [REACTOME:R-HSA-1266738]
Disease [NCBI:1268854] [REACTOME:R-HSA-1643685]
Extracellular matrix organization [NCBI:1270244] [REACTOME:R-HSA-1474244] [PUBMED:21123617] [PUBMED:21917992] [PUBMED:12845610]
Formation of the cornified envelope [NCBI:1457791] [REACTOME:R-HSA-6809371] [PUBMED:15803139]
Immune System [NCBI:1269170] [REACTOME:R-HSA-168256]
Innate Immune System [NCBI:1269203] [REACTOME:R-HSA-168249]
Keratinization [NCBI:1457790] [REACTOME:R-HSA-6805567] [PUBMED:18461349]
Neurodegenerative Diseases [NCBI:1457788] [REACTOME:R-HSA-8863678] [PUBMED:26848654]
Neutrophil degranulation [NCBI:1457780] [REACTOME:R-HSA-6798695] [PUBMED:20338884] [PUBMED:1378856] [PUBMED:17627888] [PUBMED:23650620] [PUBMED:8692836]
Protein processing in endoplasmic reticulum [NCBI:167325] [KEGG:hsa04141] [PUBMED:20347046] [PUBMED:18023214] [PUBMED:20219571] [PUBMED:19491040] [PUBMED:20112977]
Signaling events mediated by PTP1B [NCBI:138017] [Pathway Interaction Database:ptp1bpathway] [PUBMED:12414790] [PUBMED:8223493] [PUBMED:12857726] [PUBMED:8999839] [PUBMED:14766979] [PUBMED:9355745] [PUBMED:11579209] [PUBMED:8940134] [PUBMED:12802338] [PUBMED:10807907] [PUBMED:15866871] [PUBMED:10751417] [PUBMED:11346638] [PUBMED:11970899] [PUBMED:9083103] [PUBMED:7693694] [PUBMED:11900546] [PUBMED:7983051] [PUBMED:11694501] [PUBMED:10514492] [PUBMED:12176037] [PUBMED:16644720] [PUBMED:16388599] [PUBMED:9624118] [PUBMED:9786960] [PUBMED:14966267] [PUBMED:15894168] [PUBMED:11773439] [PUBMED:11864611] [PUBMED:8548812] [PUBMED:16477024] [PUBMED:9418872] [PUBMED:9050838] [PUBMED:12424235] [PUBMED:12748279] [PUBMED:1383688] [PUBMED:8782827] [PUBMED:8626723] [PUBMED:11007774] [PUBMED:10993888] [PUBMED:15226396] [PUBMED:10066179] [PUBMED:10660596] [PUBMED:12554649] [PUBMED:11970898] [PUBMED:9566916]