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Genes
MAP3K11
Gene - MAP3K11
full name
mitogen-activated protein kinase kinase kinase 11
synonyms
MEKK11, MLK-3, MLK3, PTK1, SPRK, MAP3K11, ENSG00000173327
HGNC
HGNC:6850
Entrez Gene
Gene:4296
ENSEMBL
ENSG00000173327
location
chr: 11
start: 65365226
stop: 65381720
strand: -
transcripts
NM_002419.3
pathways
ARMS-mediated activation
[NCBI:1269471]
[REACTOME:R-HSA-170984]
[PUBMED:9069267]
Axon guidance
[NCBI:83065]
[KEGG:hsa04360]
[NCBI:1270303]
[REACTOME:R-HSA-422475]
[PUBMED:14682358]
[PUBMED:15084255]
[PUBMED:11687826]
[PUBMED:15818466]
[PUBMED:15363605]
[PUBMED:12471249]
[PUBMED:15630019]
[PUBMED:11891122]
[PUBMED:15960985]
[PUBMED:12677003]
CDC42 signaling events
[NCBI:137994]
[Pathway Interaction Database:cdc42_pathway]
[PUBMED:7629060]
[PUBMED:7652575]
[PUBMED:8653792]
[PUBMED:18448434]
[PUBMED:19822663]
[PUBMED:19454477]
[PUBMED:18662680]
[PUBMED:15882626]
[PUBMED:11948177]
[PUBMED:9860974]
[PUBMED:15225553]
[PUBMED:8643625]
[PUBMED:8107774]
[PUBMED:8670801]
[PUBMED:8034624]
[PUBMED:10934474]
[PUBMED:10734320]
[PUBMED:17522712]
[PUBMED:11525734]
[PUBMED:15649357]
[PUBMED:10473551]
[PUBMED:16157700]
[PUBMED:9822598]
[PUBMED:15723051]
[PUBMED:7600582]
[PUBMED:18319301]
[PUBMED:9042860]
[PUBMED:10613909]
[PUBMED:17580073]
[PUBMED:12745076]
[PUBMED:16253996]
[PUBMED:10840034]
[PUBMED:10360579]
[PUBMED:11907268]
[PUBMED:10934475]
[PUBMED:10219243]
[PUBMED:17038317]
[PUBMED:8910292]
[PUBMED:9403696]
[PUBMED:11285260]
[PUBMED:10995437]
[PUBMED:9368021]
[PUBMED:14970210]
[PUBMED:9694656]
[PUBMED:14505571]
[PUBMED:17115031]
[PUBMED:9317150]
[PUBMED:14653992]
[PUBMED:17081755]
[PUBMED:12676083]
[PUBMED:18216334]
[PUBMED:19826000]
[PUBMED:8702968]
[PUBMED:11304531]
[PUBMED:10973943]
[PUBMED:11309380]
[PUBMED:18586681]
[PUBMED:15479449]
[PUBMED:19097998]
[PUBMED:16892055]
[PUBMED:17244649]
[PUBMED:8625410]
[PUBMED:8497321]
[PUBMED:15485841]
[PUBMED:16407834]
[PUBMED:11804587]
[PUBMED:9867866]
[PUBMED:10747870]
[PUBMED:7600581]
[PUBMED:12610628]
[PUBMED:19435802]
[PUBMED:15572110]
[PUBMED:7592586]
[PUBMED:11696321]
[PUBMED:10559936]
Cytokine Signaling in Immune system
[NCBI:1269310]
[REACTOME:R-HSA-1280215]
[PUBMED:12613569]
DAP12 interactions
[NCBI:1269283]
[REACTOME:R-HSA-2172127]
[PUBMED:19120482]
[PUBMED:17220916]
[PUBMED:9490415]
[PUBMED:18192027]
[PUBMED:15884055]
DAP12 signaling
[NCBI:1269284]
[REACTOME:R-HSA-2424491]
[PUBMED:15884055]
[PUBMED:17110943]
[PUBMED:17220916]
Developmental Biology
[NCBI:1270302]
[REACTOME:R-HSA-1266738]
Disease
[NCBI:1268854]
[REACTOME:R-HSA-1643685]
Diseases of signal transduction
[NCBI:1268855]
[REACTOME:R-HSA-5663202]
[PUBMED:12509752]
Downstream signal transduction
[NCBI:1269479]
[REACTOME:R-HSA-186763]
[PUBMED:10508235]
[PUBMED:9739761]
FCERI mediated MAPK activation
[NCBI:1269299]
[REACTOME:R-HSA-2871796]
[PUBMED:19290926]
[PUBMED:19909365]
[PUBMED:17122878]
Fc epsilon receptor (FCERI) signaling
[NCBI:1269298]
[REACTOME:R-HSA-2454202]
[PUBMED:15099567]
[PUBMED:21799019]
Frs2-mediated activation
[NCBI:1269470]
[REACTOME:R-HSA-170968]
[PUBMED:9069267]
GRB2 events in EGFR signaling
[NCBI:1269382]
[REACTOME:R-HSA-179812]
[PUBMED:11706405]
[PUBMED:11498013]
Gastrin-CREB signalling pathway via PKC and MAPK
[NCBI:1269592]
[REACTOME:R-HSA-881907]
[PUBMED:10413847]
[PUBMED:7491953]
[PUBMED:17698287]
IFN-gamma pathway
[NCBI:138040]
[Pathway Interaction Database:ifngpathway]
[PUBMED:9724754]
[PUBMED:10657627]
[PUBMED:10067896]
[PUBMED:9271410]
[PUBMED:8608598]
[PUBMED:15878863]
[PUBMED:11971965]
[PUBMED:11438544]
[PUBMED:15051500]
[PUBMED:17032168]
[PUBMED:11909529]
[PUBMED:11171987]
[PUBMED:7514165]
[PUBMED:12817007]
[PUBMED:8232552]
[PUBMED:10485906]
[PUBMED:8755534]
[PUBMED:10490100]
[PUBMED:8156998]
[PUBMED:11972023]
[PUBMED:8986769]
[PUBMED:12438563]
[PUBMED:10022928]
[PUBMED:12270932]
[PUBMED:7510216]
[PUBMED:15311277]
[PUBMED:14670297]
[PUBMED:12048245]
[PUBMED:10777554]
[PUBMED:12138178]
[PUBMED:9336467]
[PUBMED:7690989]
[PUBMED:1281555]
[PUBMED:17606919]
[PUBMED:10805787]
[PUBMED:12050152]
[PUBMED:8608597]
[PUBMED:15879117]
[PUBMED:12855578]
[PUBMED:10995751]
[PUBMED:10490099]
[PUBMED:7777519]
IGF1R signaling cascade
[NCBI:1269618]
[REACTOME:R-HSA-2428924]
[PUBMED:17598937]
[PUBMED:20975071]
[PUBMED:22649417]
[PUBMED:21042815]
[PUBMED:18927274]
[PUBMED:20098959]
IRS-mediated signalling
[NCBI:1269431]
[REACTOME:R-HSA-112399]
IRS-related events triggered by IGF1R
[NCBI:1269620]
[REACTOME:R-HSA-2428928]
[PUBMED:17598937]
[PUBMED:20975071]
[PUBMED:22649417]
[PUBMED:18927274]
[PUBMED:21042815]
[PUBMED:20098959]
Immune System
[NCBI:1269170]
[REACTOME:R-HSA-168256]
Innate Immune System
[NCBI:1269203]
[REACTOME:R-HSA-168249]
Insulin receptor signalling cascade
[NCBI:1269429]
[REACTOME:R-HSA-74751]
[PUBMED:9677303]
[PUBMED:11282018]
Interleukin receptor SHC signaling
[NCBI:1269322]
[REACTOME:R-HSA-912526]
[PUBMED:8294403]
Interleukin-2 signaling
[NCBI:1269321]
[REACTOME:R-HSA-451927]
[PUBMED:17936914]
[PUBMED:18817510]
[PUBMED:19543225]
[PUBMED:18062768]
Interleukin-3, 5 and GM-CSF signaling
[NCBI:1269323]
[REACTOME:R-HSA-512988]
[PUBMED:10450743]
[PUBMED:9766809]
MAPK family signaling cascades
[NCBI:1269501]
[REACTOME:R-HSA-5683057]
[PUBMED:21167873]
[PUBMED:17161475]
[PUBMED:22535895]
[PUBMED:21372320]
MAPK signaling pathway
[NCBI:83048]
[KEGG:hsa04010]
[PUBMED:11749383]
[PUBMED:12566928]
[PUBMED:12849693]
[PUBMED:12676795]
[PUBMED:12947395]
[PUBMED:14597384]
[PUBMED:11369511]
[PUBMED:12191611]
[PUBMED:12390245]
MAPK1/MAPK3 signaling
[NCBI:1269502]
[REACTOME:R-HSA-5684996]
[PUBMED:25378393]
[PUBMED:18199641]
[PUBMED:17496909]
[PUBMED:21779496]
[PUBMED:15520807]
[PUBMED:16393692]
[PUBMED:19520853]
[PUBMED:17496910]
[PUBMED:22569528]
NCAM signaling for neurite out-growth
[NCBI:1270312]
[REACTOME:R-HSA-375165]
[PUBMED:18760361]
[PUBMED:12587671]
[PUBMED:15662836]
[PUBMED:17975827]
[PUBMED:15153429]
[PUBMED:12700044]
NGF signalling via TRKA from the plasma membrane
[NCBI:1269460]
[REACTOME:R-HSA-187037]
[PUBMED:11520933]
[PUBMED:12676795]
[PUBMED:10851172]
[PUBMED:10579918]
Non-alcoholic fatty liver disease (NAFLD)
[NCBI:862188]
[KEGG:hsa04932]
[PUBMED:21038418]
[PUBMED:17498512]
[PUBMED:19352614]
[PUBMED:23299992]
[PUBMED:22570745]
[PUBMED:9285483]
[PUBMED:12891546]
[PUBMED:18061659]
[PUBMED:22705006]
[PUBMED:16364488]
[PUBMED:18242193]
[PUBMED:16374858]
[PUBMED:22940046]
[PUBMED:20619513]
[PUBMED:20303879]
[PUBMED:14685853]
[PUBMED:16406828]
[PUBMED:23545492]
[PUBMED:21145844]
Oncogenic MAPK signaling
[NCBI:1457781]
[REACTOME:R-HSA-6802957]
[PUBMED:25907612]
[PUBMED:24651010]
[PUBMED:24202393]
[PUBMED:25435214]
[PUBMED:21993244]
[PUBMED:24814062]
[PUBMED:22589270]
Paradoxical activation of RAF signaling by kinase inactive BRAF
[NCBI:1457785]
[REACTOME:R-HSA-6802955]
[PUBMED:25435214]
[PUBMED:20674547]
[PUBMED:24957944]
[PUBMED:23352452]
[PUBMED:20130576]
[PUBMED:23680146]
[PUBMED:16364920]
[PUBMED:25907612]
[PUBMED:15035987]
[PUBMED:20179705]
[PUBMED:19727074]
[PUBMED:20141835]
[PUBMED:22510884]
Prolonged ERK activation events
[NCBI:1269469]
[REACTOME:R-HSA-169893]
[PUBMED:12765839]
[PUBMED:9069267]
RAC1 signaling pathway
[NCBI:169355]
[Pathway Interaction Database:rac1_pathway]
[PUBMED:19158278]
[PUBMED:16702231]
[PUBMED:16440308]
[PUBMED:14765121]
[PUBMED:12453877]
[PUBMED:12657629]
[PUBMED:9799233]
[PUBMED:9694656]
[PUBMED:9317150]
[PUBMED:14970210]
[PUBMED:8305740]
[PUBMED:8805275]
[PUBMED:17178910]
[PUBMED:11060298]
[PUBMED:11304531]
[PUBMED:11804587]
[PUBMED:11470914]
[PUBMED:11309380]
[PUBMED:17244649]
[PUBMED:11021801]
[PUBMED:7592586]
[PUBMED:15681696]
[PUBMED:7744004]
[PUBMED:15225553]
[PUBMED:10559936]
[PUBMED:19917258]
[PUBMED:7600581]
[PUBMED:19363480]
[PUBMED:18423204]
[PUBMED:20097736]
[PUBMED:19852956]
[PUBMED:12181570]
[PUBMED:19822663]
[PUBMED:7652575]
[PUBMED:7629060]
[PUBMED:8107774]
[PUBMED:16636067]
[PUBMED:9042860]
[PUBMED:12213441]
[PUBMED:10679324]
[PUBMED:12682053]
[PUBMED:18198193]
[PUBMED:16542153]
[PUBMED:7600582]
[PUBMED:18948007]
[PUBMED:18319301]
[PUBMED:10559253]
[PUBMED:17115053]
[PUBMED:10473551]
[PUBMED:17682062]
[PUBMED:17164293]
[PUBMED:15557278]
[PUBMED:15677464]
[PUBMED:16837009]
[PUBMED:12796474]
[PUBMED:10559863]
[PUBMED:9535855]
[PUBMED:8910292]
[PUBMED:11432831]
[PUBMED:17981134]
[PUBMED:16762923]
[PUBMED:8798539]
[PUBMED:18160398]
[PUBMED:16099876]
[PUBMED:14681219]
RAF activation
[NCBI:1269286]
[REACTOME:R-HSA-5673000]
[PUBMED:9689060]
[PUBMED:16364920]
[PUBMED:23993095]
[PUBMED:17555829]
[PUBMED:12865432]
[PUBMED:11782426]
[PUBMED:11296227]
[PUBMED:12068308]
[PUBMED:11447113]
[PUBMED:11950876]
[PUBMED:21779496]
[PUBMED:20141835]
[PUBMED:11296228]
[PUBMED:15710605]
[PUBMED:2993863]
[PUBMED:11821947]
[PUBMED:24937142]
[PUBMED:11579234]
RAF/MAP kinase cascade
[NCBI:1269285]
[REACTOME:R-HSA-5673001]
[PUBMED:21167873]
[PUBMED:24937142]
[PUBMED:20674547]
[PUBMED:17496910]
[PUBMED:22177953]
[PUBMED:17496919]
[PUBMED:22569528]
[PUBMED:22535895]
[PUBMED:12068308]
[PUBMED:17496923]
[PUBMED:19091303]
[PUBMED:21372320]
[PUBMED:21388974]
[PUBMED:15520807]
RET signaling
[NCBI:1427866]
[REACTOME:R-HSA-8853659]
[PUBMED:15013219]
[PUBMED:17036197]
Reelin signaling pathway
[NCBI:137980]
[Pathway Interaction Database:reelinpathway]
[PUBMED:12526739]
[PUBMED:12899622]
[PUBMED:14517291]
[PUBMED:10939329]
[PUBMED:16148228]
[PUBMED:15062102]
[PUBMED:15987942]
[PUBMED:15091337]
[PUBMED:12376533]
[PUBMED:10827199]
[PUBMED:12882964]
[PUBMED:15590913]
[PUBMED:14724251]
[PUBMED:15361067]
[PUBMED:14578885]
SHC1 events in EGFR signaling
[NCBI:1269383]
[REACTOME:R-HSA-180336]
[PUBMED:11498013]
[PUBMED:8755247]
SOS-mediated signalling
[NCBI:1269440]
[REACTOME:R-HSA-112412]
Signal Transduction
[NCBI:1269379]
[REACTOME:R-HSA-162582]
[PUBMED:17604717]
[PUBMED:19648010]
[PUBMED:16260143]
[PUBMED:11742412]
[PUBMED:19536106]
[PUBMED:15863030]
[PUBMED:19379690]
[PUBMED:19458711]
[PUBMED:19935667]
[PUBMED:21252999]
[PUBMED:15520807]
[PUBMED:17496910]
[PUBMED:15450248]
[PUBMED:18043707]
[PUBMED:16939974]
[PUBMED:19762341]
[PUBMED:18483217]
[PUBMED:17084981]
[PUBMED:21781017]
[PUBMED:19619488]
Signaling by EGFR
[NCBI:1269380]
[REACTOME:R-HSA-177929]
[PUBMED:10459005]
[PUBMED:10404636]
[PUBMED:12297041]
[PUBMED:15142631]
Signaling by GPCR
[NCBI:1269543]
[REACTOME:R-HSA-372790]
[PUBMED:16902930]
[PUBMED:10202136]
[PUBMED:18043707]
Signaling by Insulin receptor
[NCBI:1269428]
[REACTOME:R-HSA-74752]
[PUBMED:8276779]
Signaling by Interleukins
[NCBI:1269318]
[REACTOME:R-HSA-449147]
[PUBMED:19302047]
[PUBMED:12445398]
Signaling by Leptin
[NCBI:1269632]
[REACTOME:R-HSA-2586552]
[PUBMED:22211890]
[PUBMED:23562747]
[PUBMED:20600241]
[PUBMED:21622208]
[PUBMED:23579596]
[PUBMED:22458591]
[PUBMED:21489811]
[PUBMED:19724019]
[PUBMED:21331644]
[PUBMED:22448029]
[PUBMED:21147620]
[PUBMED:20198122]
[PUBMED:21677426]
[PUBMED:20029269]
[PUBMED:22249808]
[PUBMED:22991412]
[PUBMED:21527729]
[PUBMED:17937601]
[PUBMED:20553370]
[PUBMED:21713385]
[PUBMED:23565489]
[PUBMED:22289780]
Signaling by PDGF
[NCBI:1269478]
[REACTOME:R-HSA-186797]
[PUBMED:15207811]
[PUBMED:10508235]
[PUBMED:9739761]
Signaling by RAS mutants
[NCBI:1457782]
[REACTOME:R-HSA-6802949]
[PUBMED:21993244]
[PUBMED:22589270]
[PUBMED:24651010]
Signaling by SCF-KIT
[NCBI:1269487]
[REACTOME:R-HSA-1433557]
[PUBMED:17350321]
[PUBMED:16483568]
[PUBMED:7688988]
[PUBMED:19540337]
[PUBMED:16475976]
[PUBMED:15526160]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
[NCBI:1269617]
[REACTOME:R-HSA-2404192]
[PUBMED:21042815]
[PUBMED:18927274]
[PUBMED:20098959]
[PUBMED:17598937]
[PUBMED:20975071]
[PUBMED:22044904]
[PUBMED:22649417]
Signaling by VEGF
[NCBI:1269480]
[REACTOME:R-HSA-194138]
[PUBMED:15585754]
[PUBMED:13678960]
[PUBMED:16336962]
[PUBMED:16835467]
Signaling by moderate kinase activity BRAF mutants
[NCBI:1457784]
[REACTOME:R-HSA-6802946]
[PUBMED:25907612]
[PUBMED:15035987]
[PUBMED:24202393]
[PUBMED:22510884]
[PUBMED:25355519]
[PUBMED:23352452]
Signalling by NGF
[NCBI:1269443]
[REACTOME:R-HSA-166520]
Signalling to ERKs
[NCBI:1269464]
[REACTOME:R-HSA-187687]
[PUBMED:10508738]
Signalling to RAS
[NCBI:1269465]
[REACTOME:R-HSA-167044]
[PUBMED:11520933]
Signalling to p38 via RIT and RIN
[NCBI:1269468]
[REACTOME:R-HSA-187706]
[PUBMED:10712923]
VEGFA-VEGFR2 Pathway
[NCBI:1269483]
[REACTOME:R-HSA-4420097]
[PUBMED:17344076]
[PUBMED:16633338]
[PUBMED:19230644]
[PUBMED:13678960]
VEGFR2 mediated cell proliferation
[NCBI:1269485]
[REACTOME:R-HSA-5218921]
[PUBMED:22866201]
[PUBMED:22180219]
[PUBMED:22762016]