full name
G protein-coupled receptor kinase 2

synonyms
BARK1, BETA-ARK1, GRK2, ADRBK1, ENSG00000173020

HGNC
HGNC:289

Entrez Gene
Gene:156

ENSEMBL
ENSG00000173020

location
chr: 11
start: 67033905
stop: 67054029
strand: +

transcripts
NM_001619.3

pathways
Activation of SMO [NCBI:1269642] [REACTOME:R-HSA-5635838] [PUBMED:16339192] [PUBMED:21356043] [PUBMED:20395968] [PUBMED:23719536] [PUBMED:24582806] [PUBMED:14636583] [PUBMED:19081070] [PUBMED:17641202] [PUBMED:17762891] [PUBMED:10966113] [PUBMED:17960137] [PUBMED:22981989] [PUBMED:20412775] [PUBMED:24845016] [PUBMED:23079593] [PUBMED:21801010] [PUBMED:21695114] [PUBMED:15691767] [PUBMED:22986504] [PUBMED:16459297] [PUBMED:14614827] [PUBMED:19906846] [PUBMED:12192414] [PUBMED:20844016]
CXCR4-mediated signaling events [NCBI:137910] [Pathway Interaction Database:cxcr4_pathway] [PUBMED:18799424] [PUBMED:17537990] [PUBMED:10881171] [PUBMED:17675482] [PUBMED:11157475] [PUBMED:12077227] [PUBMED:11544290] [PUBMED:8752280] [PUBMED:12535795] [PUBMED:19380820] [PUBMED:10952719] [PUBMED:16230460] [PUBMED:12682230] [PUBMED:16503409] [PUBMED:10644702] [PUBMED:9722546] [PUBMED:11784854] [PUBMED:10491003] [PUBMED:10521508] [PUBMED:10606629] [PUBMED:15615703] [PUBMED:17568820] [PUBMED:10753828] [PUBMED:12519755] [PUBMED:12032308] [PUBMED:8752281] [PUBMED:10570282] [PUBMED:11369622] [PUBMED:15728464] [PUBMED:12590707] [PUBMED:16038794] [PUBMED:14662753] [PUBMED:18596232] [PUBMED:17056591] [PUBMED:14602072] [PUBMED:15994292] [PUBMED:16919488] [PUBMED:15872091] [PUBMED:10506573] [PUBMED:12036857] [PUBMED:15618472] [PUBMED:14704365] [PUBMED:18227351] [PUBMED:11641392] [PUBMED:18319399] [PUBMED:12133960] [PUBMED:15630457]
Ca-dependent events [NCBI:1269588] [REACTOME:R-HSA-111996] [PUBMED:18083096] [PUBMED:11162741] [PUBMED:17697045] [PUBMED:16076488]
CaM pathway [NCBI:1269292] [REACTOME:R-HSA-111997] [PUBMED:10884684]
Calmodulin induced events [NCBI:1269293] [REACTOME:R-HSA-111933] [PUBMED:15381755]
Cargo recognition for clathrin-mediated endocytosis [NCBI:1427859] [REACTOME:R-HSA-8856825] [PUBMED:24186068] [PUBMED:12952941] [PUBMED:19696796] [PUBMED:14985334] [PUBMED:20448150] [PUBMED:20485680] [PUBMED:16382132] [PUBMED:23482940] [PUBMED:16870701]
Chemokine signaling pathway [NCBI:99051] [KEGG:hsa04062] [PUBMED:17371236] [PUBMED:19159344] [PUBMED:17169327] [PUBMED:10852130] [PUBMED:9765254] [PUBMED:15771581] [PUBMED:14607270] [PUBMED:18662984] [PUBMED:12495636] [PUBMED:15803148] [PUBMED:15046611] [PUBMED:12069927] [PUBMED:18711432] [PUBMED:17675482] [PUBMED:16144840] [PUBMED:17496928] [PUBMED:17537990] [PUBMED:11872087] [PUBMED:12051620] [PUBMED:14625285] [PUBMED:8576262] [PUBMED:11244042]
Clathrin-mediated endocytosis [NCBI:1427858] [REACTOME:R-HSA-8856828] [PUBMED:16516836] [PUBMED:15339664] [PUBMED:19754444] [PUBMED:8552632] [PUBMED:21779028] [PUBMED:12353027] [PUBMED:23891661] [PUBMED:21613550] [PUBMED:20059951] [PUBMED:21447041] [PUBMED:17620409] [PUBMED:16903783] [PUBMED:21445324] [PUBMED:19696798] [PUBMED:26246598] [PUBMED:25085911] [PUBMED:24186068] [PUBMED:26829388] [PUBMED:27092250] [PUBMED:24581490] [PUBMED:26042225] [PUBMED:23823722] [PUBMED:24789820] [PUBMED:9736607] [PUBMED:23637288] [PUBMED:22233676] [PUBMED:19458185] [PUBMED:26403691] [PUBMED:19296720] [PUBMED:15703209] [PUBMED:20428113] [PUBMED:8953040] [PUBMED:1177317] [PUBMED:9092476] [PUBMED:26872272] [PUBMED:19092055]
DAG and IP3 signaling [NCBI:1269291] [REACTOME:R-HSA-1489509] [PUBMED:16260143]
DAP12 interactions [NCBI:1269283] [REACTOME:R-HSA-2172127] [PUBMED:19120482] [PUBMED:17220916] [PUBMED:9490415] [PUBMED:18192027] [PUBMED:15884055]
DAP12 signaling [NCBI:1269284] [REACTOME:R-HSA-2424491] [PUBMED:15884055] [PUBMED:17110943] [PUBMED:17220916]
Downstream signal transduction [NCBI:1269479] [REACTOME:R-HSA-186763] [PUBMED:10508235] [PUBMED:9739761]
EGFR interacts with phospholipase C-gamma [NCBI:1269381] [REACTOME:R-HSA-212718] [PUBMED:1501243]
Endocytosis [NCBI:102279] [KEGG:hsa04144] [PUBMED:19696797] [PUBMED:19007773] [PUBMED:16203612] [PUBMED:15687999] [PUBMED:19924646] [PUBMED:15261671] [PUBMED:18647649] [PUBMED:19325624] [PUBMED:20110990] [PUBMED:22193161]
G alpha (q) signalling events [NCBI:1269578] [REACTOME:R-HSA-416476] [PUBMED:19212139]
G alpha (s) signalling events [NCBI:1269575] [REACTOME:R-HSA-418555] [PUBMED:12036966]
G-protein mediated events [NCBI:1269586] [REACTOME:R-HSA-112040] [PUBMED:9422713] [PUBMED:9218123]
GPCR downstream signaling [NCBI:1269574] [REACTOME:R-HSA-388396] [PUBMED:12040175]
Gastrin-CREB signalling pathway via PKC and MAPK [NCBI:1269592] [REACTOME:R-HSA-881907] [PUBMED:10413847] [PUBMED:7491953] [PUBMED:17698287]
Glutamatergic synapse [NCBI:213818] [KEGG:hsa04724] [PUBMED:10481192] [PUBMED:11561058] [PUBMED:18425072] [PUBMED:17706608] [PUBMED:20055706] [PUBMED:19112153] [PUBMED:17663464] [PUBMED:19110202] [PUBMED:19559598] [PUBMED:9665875] [PUBMED:11672421] [PUBMED:18464791] [PUBMED:12399578] [PUBMED:14684436]
Hedgehog 'on' state [NCBI:1269640] [REACTOME:R-HSA-5632684] [PUBMED:23719536] [PUBMED:21502959] [PUBMED:21801010] [PUBMED:20395968]
Hedgehog signaling pathway [NCBI:83063] [KEGG:hsa04340] [PUBMED:22534646] [PUBMED:26077918] [PUBMED:24925320] [PUBMED:23719536] [PUBMED:26064136] [PUBMED:26366162] [PUBMED:20708941] [PUBMED:22056910] [PUBMED:18583599] [PUBMED:23799571] [PUBMED:26875496]
Immune System [NCBI:1269170] [REACTOME:R-HSA-168256]
Innate Immune System [NCBI:1269203] [REACTOME:R-HSA-168249]
Membrane Trafficking [NCBI:1269877] [REACTOME:R-HSA-199991] [PUBMED:11031247]
Morphine addiction [NCBI:552665] [KEGG:hsa05032] [PUBMED:8785060] [PUBMED:16581089] [PUBMED:21872647] [PUBMED:14625081] [PUBMED:20962224] [PUBMED:15661627] [PUBMED:1346804] [PUBMED:12859419] [PUBMED:8096779] [PUBMED:18349442] [PUBMED:21930931] [PUBMED:10066284] [PUBMED:14969742] [PUBMED:8987801] [PUBMED:12217944] [PUBMED:11750924] [PUBMED:11152760]
NGF signalling via TRKA from the plasma membrane [NCBI:1269460] [REACTOME:R-HSA-187037] [PUBMED:11520933] [PUBMED:12676795] [PUBMED:10851172] [PUBMED:10579918]
Olfactory transduction [NCBI:83087] [KEGG:hsa04740] [PUBMED:19652915] [PUBMED:22735517] [PUBMED:11557990] [PUBMED:19306880] [PUBMED:16269360] [PUBMED:19941039] [PUBMED:20145624] [PUBMED:12488531] [PUBMED:22875451] [PUBMED:24733839] [PUBMED:10944513]
Opioid Signalling [NCBI:1269584] [REACTOME:R-HSA-111885] [PUBMED:9422713] [PUBMED:9218123] [PUBMED:16612131]
PLC beta mediated events [NCBI:1269587] [REACTOME:R-HSA-112043] [PUBMED:9218123] [PUBMED:16183910] [PUBMED:1335363]
PLC-gamma1 signalling [NCBI:1269472] [REACTOME:R-HSA-167021] [PUBMED:12676795] [PUBMED:10579907]
Signal Transduction [NCBI:1269379] [REACTOME:R-HSA-162582] [PUBMED:17604717] [PUBMED:19648010] [PUBMED:16260143] [PUBMED:11742412] [PUBMED:19536106] [PUBMED:15863030] [PUBMED:19379690] [PUBMED:19458711] [PUBMED:19935667] [PUBMED:21252999] [PUBMED:15520807] [PUBMED:17496910] [PUBMED:15450248] [PUBMED:18043707] [PUBMED:16939974] [PUBMED:19762341] [PUBMED:18483217] [PUBMED:17084981] [PUBMED:21781017] [PUBMED:19619488]
Signaling by EGFR [NCBI:1269380] [REACTOME:R-HSA-177929] [PUBMED:10459005] [PUBMED:10404636] [PUBMED:12297041] [PUBMED:15142631]
Signaling by GPCR [NCBI:1269543] [REACTOME:R-HSA-372790] [PUBMED:16902930] [PUBMED:10202136] [PUBMED:18043707]
Signaling by Hedgehog [NCBI:1269633] [REACTOME:R-HSA-5358351] [PUBMED:19081070] [PUBMED:21801010] [PUBMED:15549094] [PUBMED:23719536]
Signaling by PDGF [NCBI:1269478] [REACTOME:R-HSA-186797] [PUBMED:15207811] [PUBMED:10508235] [PUBMED:9739761]
Signaling events mediated by HDAC Class II [NCBI:138062] [Pathway Interaction Database:hdac_classii_pathway] [PUBMED:15916966] [PUBMED:10869435] [PUBMED:10898795] [PUBMED:16051668] [PUBMED:12032081] [PUBMED:12606581] [PUBMED:11804585] [PUBMED:11466315] [PUBMED:11567998] [PUBMED:16767219] [PUBMED:12024216] [PUBMED:16166628] [PUBMED:16221676] [PUBMED:11948178] [PUBMED:10220385] [PUBMED:12663674] [PUBMED:14668799] [PUBMED:16236793]
Signaling events mediated by the Hedgehog family [NCBI:137950] [Pathway Interaction Database:hedgehog_2pathway] [PUBMED:8906794] [PUBMED:16647303] [PUBMED:12917290] [PUBMED:12192414] [PUBMED:12421714] [PUBMED:7891723] [PUBMED:16136078] [PUBMED:10984056] [PUBMED:16229832] [PUBMED:15019948] [PUBMED:11934857] [PUBMED:11572986] [PUBMED:16537363] [PUBMED:16647304] [PUBMED:9811851] [PUBMED:11668681] [PUBMED:9593755] [PUBMED:15618519] [PUBMED:16895439] [PUBMED:12123571] [PUBMED:10050855] [PUBMED:11517919] [PUBMED:12372301] [PUBMED:16284117] [PUBMED:10465785] [PUBMED:11964399] [PUBMED:11027307] [PUBMED:8824192] [PUBMED:11486055]
Signalling by NGF [NCBI:1269443] [REACTOME:R-HSA-166520]
Thromboxane A2 receptor signaling [NCBI:138060] [Pathway Interaction Database:txa2pathway] [PUBMED:15100160] [PUBMED:11160627] [PUBMED:16859489] [PUBMED:7476920] [PUBMED:12193606] [PUBMED:8474027] [PUBMED:16595906] [PUBMED:11748077] [PUBMED:8948507] [PUBMED:11055976] [PUBMED:15884057] [PUBMED:1825698] [PUBMED:9054415] [PUBMED:1851174] [PUBMED:9862451] [PUBMED:11901221] [PUBMED:14976202] [PUBMED:9915793] [PUBMED:12796499] [PUBMED:16212421] [PUBMED:16956790] [PUBMED:8034687] [PUBMED:17466390] [PUBMED:12183468] [PUBMED:10085139] [PUBMED:9649216] [PUBMED:11873244] [PUBMED:12038794] [PUBMED:10771086] [PUBMED:11015313] [PUBMED:9417126] [PUBMED:12626493] [PUBMED:10827090] [PUBMED:7969066] [PUBMED:8119906] [PUBMED:11389977] [PUBMED:16876780] [PUBMED:16126723] [PUBMED:8636072] [PUBMED:8894620] [PUBMED:11526402] [PUBMED:17229546] [PUBMED:10037795] [PUBMED:15845539] [PUBMED:10670835] [PUBMED:14530262] [PUBMED:8290554] [PUBMED:11443056] [PUBMED:10800962] [PUBMED:9560198] [PUBMED:11389883] [PUBMED:7961988] [PUBMED:10212262] [PUBMED:8245033] [PUBMED:8613548] [PUBMED:7591017] [PUBMED:12187125] [PUBMED:11516166] [PUBMED:10318854]
Vesicle-mediated transport [NCBI:1269876] [REACTOME:R-HSA-5653656]