full name
protein phosphatase 1 catalytic subunit alpha

synonyms
PP-1A, PP1A, PP1alpha, PPP1A, PPP1CA, ENSG00000172531

HGNC
HGNC:9281

Entrez Gene
Gene:5499

ENSEMBL
ENSG00000172531

location
chr: 11
start: 67165652
stop: 67169376
strand: -

transcripts
NM_206873.1
NM_002708.3
NM_001008709.1

pathways
ALK1 signaling events [NCBI:137968] [Pathway Interaction Database:alk1pathway] [PUBMED:9748228] [PUBMED:17071858] [PUBMED:14580334] [PUBMED:9920917] [PUBMED:17911401] [PUBMED:17311849] [PUBMED:8140412] [PUBMED:17068149] [PUBMED:8242742] [PUBMED:16571110] [PUBMED:9872992] [PUBMED:8612709] [PUBMED:18065769] [PUBMED:1326540] [PUBMED:15385967] [PUBMED:8756725] [PUBMED:11927558] [PUBMED:10187774] [PUBMED:8294451] [PUBMED:15702480] [PUBMED:10716993] [PUBMED:17540773] [PUBMED:19592636]
Adrenergic signaling in cardiomyocytes [NCBI:908257] [KEGG:hsa04261] [PUBMED:15232578] [PUBMED:20923637] [PUBMED:10571541] [PUBMED:11604549] [PUBMED:17988210] [PUBMED:11805843] [PUBMED:15142747] [PUBMED:21212391] [PUBMED:20658186] [PUBMED:16765984] [PUBMED:19874988] [PUBMED:19883653] [PUBMED:15979723] [PUBMED:18407781] [PUBMED:22022314] [PUBMED:12439640] [PUBMED:17826821] [PUBMED:15765137]
Alcoholism [NCBI:585563] [KEGG:hsa05034] [PUBMED:16764827] [PUBMED:18616668] [PUBMED:19077056] [PUBMED:18991950] [PUBMED:19756388] [PUBMED:12068305] [PUBMED:16102840] [PUBMED:20947635] [PUBMED:20729980] [PUBMED:16278489] [PUBMED:17270154] [PUBMED:20626732] [PUBMED:18310464] [PUBMED:10774721] [PUBMED:19342616] [PUBMED:12605085] [PUBMED:15500908] [PUBMED:14729391] [PUBMED:12085089] [PUBMED:16776597]
Amphetamine addiction [NCBI:547607] [KEGG:hsa05031] [PUBMED:16776597] [PUBMED:18617632] [PUBMED:16724157] [PUBMED:19222557] [PUBMED:14746512] [PUBMED:18632938] [PUBMED:8630246] [PUBMED:14622123] [PUBMED:21338876] [PUBMED:8753884] [PUBMED:10774721] [PUBMED:14529709] [PUBMED:17728700] [PUBMED:21989194] [PUBMED:16151049] [PUBMED:18440072] [PUBMED:19199083] [PUBMED:10414964]
BMP receptor signaling [NCBI:137948] [Pathway Interaction Database:bmppathway] [PUBMED:9136927] [PUBMED:12857866] [PUBMED:11158580] [PUBMED:10748465] [PUBMED:11401399] [PUBMED:9442019] [PUBMED:10814522] [PUBMED:8752214] [PUBMED:9660951] [PUBMED:17085434] [PUBMED:11714695] [PUBMED:7644468] [PUBMED:15671031] [PUBMED:8065329] [PUBMED:16604073] [PUBMED:8006002] [PUBMED:9436979] [PUBMED:9689081] [PUBMED:9335505] [PUBMED:17289590] [PUBMED:8893010] [PUBMED:16931515] [PUBMED:10748100] [PUBMED:15020244] [PUBMED:11121043] [PUBMED:15975920] [PUBMED:7937936] [PUBMED:11016919] [PUBMED:8752213] [PUBMED:7673243] [PUBMED:10519551] [PUBMED:8662721] [PUBMED:9878061] [PUBMED:17356069] [PUBMED:7791754] [PUBMED:8653785] [PUBMED:10504300] [PUBMED:10458166]
Circadian Clock [NCBI:1269871] [REACTOME:R-HSA-400253] [PUBMED:18775307] [PUBMED:18802415] [PUBMED:18786386] [PUBMED:16987893]
DARPP-32 events [NCBI:1269591] [REACTOME:R-HSA-180024] [PUBMED:14744247] [PUBMED:2908293]
Dopaminergic synapse [NCBI:469199] [KEGG:hsa04728] [PUBMED:20727368] [PUBMED:10433257] [PUBMED:17408758] [PUBMED:15292232] [PUBMED:9457173] [PUBMED:17349698] [PUBMED:15521361] [PUBMED:18353279] [PUBMED:21303898] [PUBMED:19251795] [PUBMED:15381316] [PUBMED:15590733] [PUBMED:20224735] [PUBMED:19138563] [PUBMED:12967774]
Downregulation of TGF-beta receptor signaling [NCBI:1269525] [REACTOME:R-HSA-2173788] [PUBMED:10519551] [PUBMED:16027725] [PUBMED:9215638] [PUBMED:20937913] [PUBMED:20129061] [PUBMED:11158580] [PUBMED:9335507] [PUBMED:15781469] [PUBMED:12519765] [PUBMED:16061177] [PUBMED:10757800] [PUBMED:11278251] [PUBMED:12151385] [PUBMED:20061380] [PUBMED:22045334] [PUBMED:14701756] [PUBMED:15496141] [PUBMED:19758997] [PUBMED:14718519] [PUBMED:22344298] [PUBMED:11163210]
Focal adhesion [NCBI:83067] [KEGG:hsa04510] [PUBMED:10698680] [PUBMED:15459662] [PUBMED:14756624] [PUBMED:11573199] [PUBMED:12640026] [PUBMED:15179030] [PUBMED:15108811] [PUBMED:15053919] [PUBMED:11082269] [PUBMED:15034601] [PUBMED:12235283] [PUBMED:14519391] [PUBMED:11146675] [PUBMED:11229600] [PUBMED:15688067] [PUBMED:14744429] [PUBMED:11882383]
Herpes simplex infection [NCBI:377873] [KEGG:hsa05168] [PUBMED:12224518] [PUBMED:17913820] [PUBMED:12844494] [PUBMED:10998601] [PUBMED:15163721] [PUBMED:19694546] [PUBMED:16297150] [PUBMED:14747533] [PUBMED:12826401] [PUBMED:14963113] [PUBMED:15056211] [PUBMED:12797447] [PUBMED:21107701] [PUBMED:10918307] [PUBMED:10696424] [PUBMED:16076403] [PUBMED:10364308] [PUBMED:17222692] [PUBMED:9621021] [PUBMED:12224508] [PUBMED:19879619] [PUBMED:11070032] [PUBMED:9499021] [PUBMED:18596690] [PUBMED:12525427] [PUBMED:12224517] [PUBMED:10196275] [PUBMED:15047834] [PUBMED:18508584] [PUBMED:20036979]
Hippo signaling pathway [NCBI:749777] [KEGG:hsa04390] [PUBMED:18955139] [PUBMED:20439427] [PUBMED:20951342] [PUBMED:21138973] [PUBMED:18328423] [PUBMED:21324984] [PUBMED:23034192] [PUBMED:21808241] [PUBMED:17975546] [PUBMED:22750148] [PUBMED:21084559] [PUBMED:19846288] [PUBMED:22895435] [PUBMED:22683405] [PUBMED:22658639] [PUBMED:22153608] [PUBMED:20945341] [PUBMED:22830020] [PUBMED:21874053] [PUBMED:21376238]
Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis [NCBI:1270009] [REACTOME:R-HSA-163560] [PUBMED:12364542] [PUBMED:10940339]
Inflammatory mediator regulation of TRP channels [NCBI:948277] [KEGG:hsa04750] [PUBMED:21841075] [PUBMED:15820689] [PUBMED:16776582] [PUBMED:12838328] [PUBMED:17548207] [PUBMED:16319926] [PUBMED:18427980] [PUBMED:20932256] [PUBMED:18615141] [PUBMED:17124270] [PUBMED:17684094] [PUBMED:22470230] [PUBMED:19074743] [PUBMED:23000387] [PUBMED:24099085] [PUBMED:17321113]
Insulin resistance [NCBI:1272486] [KEGG:hsa04931] [PUBMED:17130651] [PUBMED:20466550] [PUBMED:16364488] [PUBMED:12765939] [PUBMED:15166380] [PUBMED:7666792] [PUBMED:16756496] [PUBMED:23647930] [PUBMED:10923637] [PUBMED:17141630] [PUBMED:9886945] [PUBMED:8048519] [PUBMED:18309108] [PUBMED:15107844] [PUBMED:20526383] [PUBMED:22360800] [PUBMED:16186396] [PUBMED:22675355] [PUBMED:22677645]
Insulin signaling pathway [NCBI:83090] [KEGG:hsa04910] [PUBMED:11742412] [PUBMED:11343120] [PUBMED:15733744] [PUBMED:11282018] [PUBMED:10196204] [PUBMED:18291668] [PUBMED:9609110] [PUBMED:10567225] [PUBMED:12791379] [PUBMED:9748166] [PUBMED:15624019] [PUBMED:9445476] [PUBMED:9346240] [PUBMED:14635525] [PUBMED:16288289] [PUBMED:12867054] [PUBMED:15229476] [PUBMED:17344645] [PUBMED:9609111]
Lipid digestion, mobilization, and transport [NCBI:1270002] [REACTOME:R-HSA-73923]
Long-term potentiation [NCBI:83085] [KEGG:hsa04720] [PUBMED:9697848] [PUBMED:15652868] [PUBMED:15803158] [PUBMED:11378299] [PUBMED:10652548] [PUBMED:15857686] [PUBMED:14715912]
Metabolism [NCBI:1269956] [REACTOME:R-HSA-1430728]
Metabolism of lipids and lipoproteins [NCBI:1270001] [REACTOME:R-HSA-556833]
Oocyte meiosis [NCBI:126909] [KEGG:hsa04114] [PUBMED:16760654] [PUBMED:17480229] [PUBMED:15136768] [PUBMED:18946022] [PUBMED:18598214] [PUBMED:16518630] [PUBMED:18631137] [PUBMED:15182704] [PUBMED:15182701] [PUBMED:16554437] [PUBMED:14691134] [PUBMED:18550795] [PUBMED:18096427] [PUBMED:14517314] [PUBMED:18311174]
Opioid Signalling [NCBI:1269584] [REACTOME:R-HSA-111885] [PUBMED:9422713] [PUBMED:9218123] [PUBMED:16612131]
Oxytocin signaling pathway [NCBI:952859] [KEGG:hsa04921] [PUBMED:23356278] [PUBMED:9219843] [PUBMED:20626426] [PUBMED:18555543] [PUBMED:22190926] [PUBMED:21981277] [PUBMED:9575824] [PUBMED:22227279] [PUBMED:19840865] [PUBMED:11861513] [PUBMED:9326674] [PUBMED:12433531] [PUBMED:18655881] [PUBMED:23335873] [PUBMED:22902539] [PUBMED:16156781] [PUBMED:20141572] [PUBMED:14715914] [PUBMED:12009385] [PUBMED:16787565] [PUBMED:16966388]
Platelet activation [NCBI:952858] [KEGG:hsa04611] [PUBMED:20002545] [PUBMED:18363565] [PUBMED:18544684] [PUBMED:18174460] [PUBMED:23106920] [PUBMED:18550847] [PUBMED:22119499] [PUBMED:19630797] [PUBMED:19286885] [PUBMED:17158345] [PUBMED:20089227] [PUBMED:22701130] [PUBMED:21071698] [PUBMED:23805129] [PUBMED:16149014] [PUBMED:18641368]
Proteoglycans in cancer [NCBI:782000] [KEGG:hsa05205] [PUBMED:19433454] [PUBMED:20655987] [PUBMED:18798267] [PUBMED:10633082] [PUBMED:10687947] [PUBMED:22735579] [PUBMED:24412155] [PUBMED:9346940] [PUBMED:22087031] [PUBMED:22194599] [PUBMED:14711376] [PUBMED:19255147] [PUBMED:15655247] [PUBMED:11717317] [PUBMED:17971838] [PUBMED:18413366] [PUBMED:20974860] [PUBMED:11830493] [PUBMED:23058688] [PUBMED:18450475] [PUBMED:12748184] [PUBMED:19733083] [PUBMED:18812315] [PUBMED:12509413] [PUBMED:21155971] [PUBMED:11931647] [PUBMED:18949819] [PUBMED:12729888] [PUBMED:15994311] [PUBMED:23305321] [PUBMED:18505598] [PUBMED:22563565] [PUBMED:22033227]
Regulation of actin cytoskeleton [NCBI:83089] [KEGG:hsa04810] [PUBMED:11152757] [PUBMED:11082272] [PUBMED:10574699] [PUBMED:11082269] [PUBMED:14657486] [PUBMED:14744429] [PUBMED:12700767]
Signal Transduction [NCBI:1269379] [REACTOME:R-HSA-162582] [PUBMED:17604717] [PUBMED:19648010] [PUBMED:16260143] [PUBMED:11742412] [PUBMED:19536106] [PUBMED:15863030] [PUBMED:19379690] [PUBMED:19458711] [PUBMED:19935667] [PUBMED:21252999] [PUBMED:15520807] [PUBMED:17496910] [PUBMED:15450248] [PUBMED:18043707] [PUBMED:16939974] [PUBMED:19762341] [PUBMED:18483217] [PUBMED:17084981] [PUBMED:21781017] [PUBMED:19619488]
Signaling by GPCR [NCBI:1269543] [REACTOME:R-HSA-372790] [PUBMED:16902930] [PUBMED:10202136] [PUBMED:18043707]
Signaling by TGF-beta Receptor Complex [NCBI:1269523] [REACTOME:R-HSA-170834] [PUBMED:19648010]
TGF-beta receptor signaling [NCBI:138024] [Pathway Interaction Database:tgfbrpathway] [PUBMED:12118366] [PUBMED:8242743] [PUBMED:15221015] [PUBMED:9335507] [PUBMED:11278302] [PUBMED:16601693] [PUBMED:8391934] [PUBMED:1333888] [PUBMED:11438668] [PUBMED:17327236] [PUBMED:2879635] [PUBMED:11483955] [PUBMED:12717440] [PUBMED:8047140] [PUBMED:8576253] [PUBMED:9865696] [PUBMED:9346908] [PUBMED:17197390] [PUBMED:8533096] [PUBMED:8756725] [PUBMED:10615055] [PUBMED:10934479] [PUBMED:16251192] [PUBMED:7706248] [PUBMED:15946939] [PUBMED:7774578] [PUBMED:7988555] [PUBMED:11278251] [PUBMED:11027280] [PUBMED:17420258] [PUBMED:9169454] [PUBMED:12151385] [PUBMED:10757800] [PUBMED:12543979] [PUBMED:12475967] [PUBMED:9679059] [PUBMED:17673906] [PUBMED:9774674] [PUBMED:8893010] [PUBMED:1544886] [PUBMED:12958365] [PUBMED:12110587] [PUBMED:9233797] [PUBMED:11163210] [PUBMED:15496141] [PUBMED:7693660] [PUBMED:14657019] [PUBMED:12429842] [PUBMED:11124802] [PUBMED:11389444] [PUBMED:8798398] [PUBMED:15356634] [PUBMED:17272273] [PUBMED:1657407] [PUBMED:12589052] [PUBMED:11016919] [PUBMED:14718519] [PUBMED:10777621] [PUBMED:17384642] [PUBMED:1310899] [PUBMED:9856985] [PUBMED:10519551] [PUBMED:9155023] [PUBMED:12134160] [PUBMED:9215638] [PUBMED:12134149] [PUBMED:16157589] [PUBMED:12356868] [PUBMED:11387212] [PUBMED:12034739] [PUBMED:11739411] [PUBMED:15761148] [PUBMED:9463378] [PUBMED:11583628] [PUBMED:15684397] [PUBMED:8947046] [PUBMED:11781097]
TGF-beta receptor signaling activates SMADs [NCBI:1269524] [REACTOME:R-HSA-2173789] [PUBMED:9346966] [PUBMED:15350224] [PUBMED:7737999] [PUBMED:11100470] [PUBMED:7693660] [PUBMED:9670020] [PUBMED:15564041] [PUBMED:9233797] [PUBMED:20207738] [PUBMED:11779505] [PUBMED:18243111] [PUBMED:8947046] [PUBMED:1333888] [PUBMED:9311995] [PUBMED:12482908] [PUBMED:8980228] [PUBMED:8242743] [PUBMED:9865696] [PUBMED:8047140] [PUBMED:21423151]
Vascular smooth muscle contraction [NCBI:96530] [KEGG:hsa04270] [PUBMED:16870827] [PUBMED:10911373] [PUBMED:11679404] [PUBMED:16339747] [PUBMED:10221985] [PUBMED:12689814] [PUBMED:11165670] [PUBMED:18552454] [PUBMED:12060106] [PUBMED:9458738] [PUBMED:15725705] [PUBMED:18040024] [PUBMED:12693609] [PUBMED:11773611] [PUBMED:17158339] [PUBMED:17458653] [PUBMED:15026027] [PUBMED:19120701] [PUBMED:15269340] [PUBMED:18703404] [PUBMED:11709400] [PUBMED:17200683]
cAMP signaling pathway [NCBI:1017634] [KEGG:hsa04024] [PUBMED:10880354] [PUBMED:9204709] [PUBMED:21693691] [PUBMED:24062645] [PUBMED:24450633] [PUBMED:21346730] [PUBMED:24613710] [PUBMED:21744067] [PUBMED:22082266] [PUBMED:16460276] [PUBMED:18176800] [PUBMED:14715909] [PUBMED:7688165] [PUBMED:24281338] [PUBMED:11117527] [PUBMED:16765984] [PUBMED:18323530] [PUBMED:18064650] [PUBMED:21852968] [PUBMED:11493633] [PUBMED:21212391] [PUBMED:15142747] [PUBMED:17077866] [PUBMED:19460777] [PUBMED:19874988] [PUBMED:16571352] [PUBMED:22022314]
cGMP-PKG signaling pathway [NCBI:983748] [KEGG:hsa04022] [PUBMED:18006449] [PUBMED:9003029] [PUBMED:18040025] [PUBMED:19306895] [PUBMED:21666108] [PUBMED:12524221] [PUBMED:16460276] [PUBMED:20716671] [PUBMED:22785374] [PUBMED:11522789] [PUBMED:16439998] [PUBMED:16371594] [PUBMED:20388537] [PUBMED:18757523] [PUBMED:16815627] [PUBMED:23212367] [PUBMED:21685243] [PUBMED:20024580] [PUBMED:15894227] [PUBMED:22965426] [PUBMED:17643091] [PUBMED:19176601] [PUBMED:19961855]
mRNA surveillance pathway [NCBI:193328] [KEGG:hsa03015] [PUBMED:16723977] [PUBMED:18158581] [PUBMED:16715045] [PUBMED:17183357] [PUBMED:15040442]