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Genes
PAK1
Gene - PAK1
full name
p21 (RAC1) activated kinase 1
synonyms
PAKalpha, PAK1, ENSG00000149269
HGNC
HGNC:8590
Entrez Gene
Gene:5058
ENSEMBL
ENSG00000149269
location
chr: 11
start: 77033060
stop: 77185108
strand: -
OMIM
OMIM:602590
: PAK1
OMIM:618158
: Intellectual developmental disorder with macrocephaly, seizures, and speech delay
transcripts
NM_002576.4
NM_001128620.1
pathways
Activation of Rac
[NCBI:1270321]
[REACTOME:R-HSA-428540]
Adaptive Immune System
[NCBI:1269171]
[REACTOME:R-HSA-1280218]
[PUBMED:16551257]
[PUBMED:21682741]
[PUBMED:11861602]
Angiopoietin receptor Tie2-mediated signaling
[NCBI:137917]
[Pathway Interaction Database:angiopoietinreceptor_pathway]
[PUBMED:9204896]
[PUBMED:12609966]
[PUBMED:14726409]
[PUBMED:11157678]
[PUBMED:10347092]
[PUBMED:11967990]
[PUBMED:15162796]
[PUBMED:11289054]
[PUBMED:12759249]
[PUBMED:10051567]
[PUBMED:12824293]
[PUBMED:16895971]
[PUBMED:10807867]
[PUBMED:12933576]
[PUBMED:11513602]
[PUBMED:12074640]
[PUBMED:8980223]
[PUBMED:14665640]
[PUBMED:15132996]
[PUBMED:10944458]
[PUBMED:11230987]
[PUBMED:15242771]
[PUBMED:10585289]
[PUBMED:16061664]
[PUBMED:10376602]
[PUBMED:15350545]
[PUBMED:9632797]
[PUBMED:10625301]
[PUBMED:9926914]
[PUBMED:17189382]
[PUBMED:11139469]
[PUBMED:11689432]
[PUBMED:11416142]
[PUBMED:11166279]
[PUBMED:15284220]
[PUBMED:15985432]
[PUBMED:16049136]
[PUBMED:16157706]
[PUBMED:10521483]
[PUBMED:12816861]
[PUBMED:9478921]
[PUBMED:10376603]
[PUBMED:15769741]
[PUBMED:12890486]
[PUBMED:14749497]
[PUBMED:7561682]
[PUBMED:11801735]
[PUBMED:12665569]
[PUBMED:12117724]
[PUBMED:9764820]
Aurora A signaling
[NCBI:137925]
[Pathway Interaction Database:aurora_a_pathway]
[PUBMED:17308110]
[PUBMED:16894566]
[PUBMED:16631581]
[PUBMED:17229885]
[PUBMED:15128871]
[PUBMED:14990569]
[PUBMED:12177045]
[PUBMED:14580337]
[PUBMED:14724178]
[PUBMED:17545617]
[PUBMED:15687499]
[PUBMED:11163242]
[PUBMED:14603251]
[PUBMED:17060449]
[PUBMED:12208850]
[PUBMED:12815066]
[PUBMED:17125467]
[PUBMED:13678582]
[PUBMED:15987997]
[PUBMED:15966895]
[PUBMED:11976319]
[PUBMED:14702041]
[PUBMED:16246726]
[PUBMED:17452972]
[PUBMED:12082625]
[PUBMED:11039908]
[PUBMED:14667408]
[PUBMED:12577065]
[PUBMED:14600264]
[PUBMED:11756469]
[PUBMED:16772293]
[PUBMED:12023018]
[PUBMED:15469940]
[PUBMED:16082213]
Axon guidance
[NCBI:83065]
[KEGG:hsa04360]
[NCBI:1270303]
[REACTOME:R-HSA-422475]
[PUBMED:14682358]
[PUBMED:15084255]
[PUBMED:11687826]
[PUBMED:15818466]
[PUBMED:15363605]
[PUBMED:12471249]
[PUBMED:15630019]
[PUBMED:11891122]
[PUBMED:15960985]
[PUBMED:12677003]
C-type lectin receptors (CLRs)
[NCBI:1269303]
[REACTOME:R-HSA-5621481]
[PUBMED:19521399]
[PUBMED:24330199]
CD209 (DC-SIGN) signaling
[NCBI:1269309]
[REACTOME:R-HSA-5621575]
[PUBMED:18998127]
[PUBMED:17462920]
[PUBMED:20816209]
CD28 co-stimulation
[NCBI:1269178]
[REACTOME:R-HSA-389356]
[PUBMED:8649453]
[PUBMED:8609386]
[PUBMED:12165654]
CD28 dependent Vav1 pathway
[NCBI:1269180]
[REACTOME:R-HSA-389359]
[PUBMED:15886116]
[PUBMED:12670394]
[PUBMED:10849438]
CDC42 signaling events
[NCBI:137994]
[Pathway Interaction Database:cdc42_pathway]
[PUBMED:7629060]
[PUBMED:7652575]
[PUBMED:8653792]
[PUBMED:18448434]
[PUBMED:19822663]
[PUBMED:19454477]
[PUBMED:18662680]
[PUBMED:15882626]
[PUBMED:11948177]
[PUBMED:9860974]
[PUBMED:15225553]
[PUBMED:8643625]
[PUBMED:8107774]
[PUBMED:8670801]
[PUBMED:8034624]
[PUBMED:10934474]
[PUBMED:10734320]
[PUBMED:17522712]
[PUBMED:11525734]
[PUBMED:15649357]
[PUBMED:10473551]
[PUBMED:16157700]
[PUBMED:9822598]
[PUBMED:15723051]
[PUBMED:7600582]
[PUBMED:18319301]
[PUBMED:9042860]
[PUBMED:10613909]
[PUBMED:17580073]
[PUBMED:12745076]
[PUBMED:16253996]
[PUBMED:10840034]
[PUBMED:10360579]
[PUBMED:11907268]
[PUBMED:10934475]
[PUBMED:10219243]
[PUBMED:17038317]
[PUBMED:8910292]
[PUBMED:9403696]
[PUBMED:11285260]
[PUBMED:10995437]
[PUBMED:9368021]
[PUBMED:14970210]
[PUBMED:9694656]
[PUBMED:14505571]
[PUBMED:17115031]
[PUBMED:9317150]
[PUBMED:14653992]
[PUBMED:17081755]
[PUBMED:12676083]
[PUBMED:18216334]
[PUBMED:19826000]
[PUBMED:8702968]
[PUBMED:11304531]
[PUBMED:10973943]
[PUBMED:11309380]
[PUBMED:18586681]
[PUBMED:15479449]
[PUBMED:19097998]
[PUBMED:16892055]
[PUBMED:17244649]
[PUBMED:8625410]
[PUBMED:8497321]
[PUBMED:15485841]
[PUBMED:16407834]
[PUBMED:11804587]
[PUBMED:9867866]
[PUBMED:10747870]
[PUBMED:7600581]
[PUBMED:12610628]
[PUBMED:19435802]
[PUBMED:15572110]
[PUBMED:7592586]
[PUBMED:11696321]
[PUBMED:10559936]
CXCR4-mediated signaling events
[NCBI:137910]
[Pathway Interaction Database:cxcr4_pathway]
[PUBMED:18799424]
[PUBMED:17537990]
[PUBMED:10881171]
[PUBMED:17675482]
[PUBMED:11157475]
[PUBMED:12077227]
[PUBMED:11544290]
[PUBMED:8752280]
[PUBMED:12535795]
[PUBMED:19380820]
[PUBMED:10952719]
[PUBMED:16230460]
[PUBMED:12682230]
[PUBMED:16503409]
[PUBMED:10644702]
[PUBMED:9722546]
[PUBMED:11784854]
[PUBMED:10491003]
[PUBMED:10521508]
[PUBMED:10606629]
[PUBMED:15615703]
[PUBMED:17568820]
[PUBMED:10753828]
[PUBMED:12519755]
[PUBMED:12032308]
[PUBMED:8752281]
[PUBMED:10570282]
[PUBMED:11369622]
[PUBMED:15728464]
[PUBMED:12590707]
[PUBMED:16038794]
[PUBMED:14662753]
[PUBMED:18596232]
[PUBMED:17056591]
[PUBMED:14602072]
[PUBMED:15994292]
[PUBMED:16919488]
[PUBMED:15872091]
[PUBMED:10506573]
[PUBMED:12036857]
[PUBMED:15618472]
[PUBMED:14704365]
[PUBMED:18227351]
[PUBMED:11641392]
[PUBMED:18319399]
[PUBMED:12133960]
[PUBMED:15630457]
Cell-Cell communication
[NCBI:1270231]
[REACTOME:R-HSA-1500931]
[PUBMED:20554646]
[PUBMED:12598678]
[PUBMED:17766183]
[PUBMED:18837673]
[PUBMED:16691243]
[PUBMED:1616050]
Chemokine signaling pathway
[NCBI:99051]
[KEGG:hsa04062]
[PUBMED:17371236]
[PUBMED:19159344]
[PUBMED:17169327]
[PUBMED:10852130]
[PUBMED:9765254]
[PUBMED:15771581]
[PUBMED:14607270]
[PUBMED:18662984]
[PUBMED:12495636]
[PUBMED:15803148]
[PUBMED:15046611]
[PUBMED:12069927]
[PUBMED:18711432]
[PUBMED:17675482]
[PUBMED:16144840]
[PUBMED:17496928]
[PUBMED:17537990]
[PUBMED:11872087]
[PUBMED:12051620]
[PUBMED:14625285]
[PUBMED:8576262]
[PUBMED:11244042]
Costimulation by the CD28 family
[NCBI:1269177]
[REACTOME:R-HSA-388841]
[PUBMED:10374692]
[PUBMED:14647476]
[PUBMED:11905831]
DSCAM interactions
[NCBI:1270242]
[REACTOME:R-HSA-376172]
[PUBMED:10925149]
[PUBMED:18585357]
Developmental Biology
[NCBI:1270302]
[REACTOME:R-HSA-1266738]
EGF receptor (ErbB1) signaling pathway
[NCBI:137970]
[Pathway Interaction Database:erbb1_receptor_proximal_pathway]
[PUBMED:15284024]
[PUBMED:15574420]
[PUBMED:12024020]
[PUBMED:10913131]
[PUBMED:2176151]
[PUBMED:8479540]
[PUBMED:8386805]
[PUBMED:10648629]
[PUBMED:7478566]
[PUBMED:9307968]
[PUBMED:6090944]
[PUBMED:1850098]
[PUBMED:7970708]
[PUBMED:12522133]
[PUBMED:1537335]
[PUBMED:10075741]
[PUBMED:9454735]
[PUBMED:9049300]
[PUBMED:9642214]
[PUBMED:14560030]
[PUBMED:9079708]
[PUBMED:12952932]
[PUBMED:10806474]
[PUBMED:1689011]
[PUBMED:7681824]
[PUBMED:9038217]
[PUBMED:7525285]
[PUBMED:14963038]
[PUBMED:7592690]
[PUBMED:1860884]
[PUBMED:19401591]
[PUBMED:12464621]
[PUBMED:8596638]
[PUBMED:7478553]
[PUBMED:8626525]
[PUBMED:8479541]
[PUBMED:7962064]
[PUBMED:10675331]
[PUBMED:8106552]
[PUBMED:9989831]
[PUBMED:10816576]
[PUBMED:7527043]
[PUBMED:2171993]
[PUBMED:12424235]
[PUBMED:7923364]
[PUBMED:2173144]
[PUBMED:7993895]
[PUBMED:8034616]
[PUBMED:9733788]
[PUBMED:2153914]
[PUBMED:1322798]
[PUBMED:14498832]
[PUBMED:8621459]
[PUBMED:7898933]
[PUBMED:9121432]
[PUBMED:11950594]
[PUBMED:7673163]
[PUBMED:7689150]
[PUBMED:1623525]
[PUBMED:8824201]
[PUBMED:8798379]
[PUBMED:8707848]
[PUBMED:15550174]
[PUBMED:8940013]
[PUBMED:10669730]
[PUBMED:8479536]
[PUBMED:17635937]
[PUBMED:18269246]
[PUBMED:10411909]
[PUBMED:7542246]
[PUBMED:7488034]
[PUBMED:2005883]
[PUBMED:1689310]
[PUBMED:7823926]
[PUBMED:16055672]
[PUBMED:2236073]
[PUBMED:8490966]
[PUBMED:18156174]
[PUBMED:8628261]
[PUBMED:8816994]
[PUBMED:8895577]
[PUBMED:11134009]
[PUBMED:9355745]
[PUBMED:1315766]
[PUBMED:1700866]
[PUBMED:9346957]
[PUBMED:7518560]
EPH-Ephrin signaling
[NCBI:1270330]
[REACTOME:R-HSA-2682334]
[PUBMED:18281458]
[PUBMED:22120527]
EPHA2 forward signaling
[NCBI:137961]
[Pathway Interaction Database:epha2_fwdpathway]
[PUBMED:12496371]
[PUBMED:18387945]
[PUBMED:18198190]
[PUBMED:12134157]
[PUBMED:15054110]
[PUBMED:7982920]
[PUBMED:17135240]
[PUBMED:10655584]
[PUBMED:16782872]
[PUBMED:12400011]
[PUBMED:8755474]
[PUBMED:12615978]
[PUBMED:14988728]
EPHB forward signaling
[NCBI:138047]
[Pathway Interaction Database:ephbfwdpathway]
[PUBMED:8808709]
[PUBMED:11780069]
[PUBMED:11585923]
[PUBMED:10644995]
[PUBMED:12223469]
[PUBMED:15351694]
[PUBMED:12973357]
[PUBMED:15107421]
[PUBMED:9233798]
[PUBMED:7973638]
[PUBMED:12389031]
[PUBMED:15536074]
[PUBMED:8755474]
[PUBMED:9430661]
[PUBMED:12546821]
[PUBMED:15107857]
[PUBMED:14500293]
[PUBMED:12925710]
[PUBMED:8878483]
[PUBMED:8918835]
[PUBMED:10669731]
[PUBMED:10570155]
[PUBMED:8761303]
[PUBMED:12408869]
[PUBMED:15821731]
[PUBMED:12475948]
EPHB-mediated forward signaling
[NCBI:1270332]
[REACTOME:R-HSA-3928662]
[PUBMED:12808016]
Endothelins
[NCBI:137958]
[Pathway Interaction Database:endothelinpathway]
[PUBMED:1319997]
[PUBMED:12719447]
[PUBMED:15047866]
[PUBMED:1905483]
[PUBMED:3144974]
[PUBMED:12922939]
[PUBMED:9595433]
[PUBMED:2558572]
[PUBMED:10364236]
[PUBMED:11231316]
[PUBMED:17569879]
[PUBMED:11078350]
[PUBMED:17535295]
[PUBMED:17533154]
[PUBMED:8764613]
[PUBMED:8617878]
[PUBMED:17526654]
[PUBMED:8843717]
[PUBMED:12606754]
[PUBMED:15200122]
[PUBMED:8319594]
[PUBMED:17627891]
[PUBMED:8940174]
[PUBMED:12397581]
[PUBMED:2545198]
Ephrin signaling
[NCBI:1270333]
[REACTOME:R-HSA-3928664]
[PUBMED:19515977]
Epithelial cell signaling in Helicobacter pylori infection
[NCBI:83102]
[KEGG:hsa05120]
[PUBMED:11389469]
[PUBMED:15694859]
[PUBMED:14700549]
[PUBMED:12197905]
ErbB signaling pathway
[NCBI:83049]
[KEGG:hsa04012]
[PUBMED:16377102]
[PUBMED:14967450]
[PUBMED:9642287]
[PUBMED:9872057]
[PUBMED:10880430]
[PUBMED:12851486]
[PUBMED:16729045]
[PUBMED:15863494]
[PUBMED:15864276]
[PUBMED:17000658]
[PUBMED:16729043]
[PUBMED:10490623]
[PUBMED:11252954]
[PUBMED:14744244]
[PUBMED:16829981]
FCERI mediated MAPK activation
[NCBI:1269299]
[REACTOME:R-HSA-2871796]
[PUBMED:19290926]
[PUBMED:19909365]
[PUBMED:17122878]
Fc epsilon receptor (FCERI) signaling
[NCBI:1269298]
[REACTOME:R-HSA-2454202]
[PUBMED:15099567]
[PUBMED:21799019]
Fc gamma R-mediated phagocytosis
[NCBI:114228]
[KEGG:hsa04666]
[PUBMED:11304556]
[PUBMED:11244038]
[PUBMED:10755615]
[PUBMED:17308335]
[PUBMED:12821647]
[PUBMED:15466916]
[PUBMED:17050193]
[PUBMED:11228151]
[PUBMED:12488490]
[PUBMED:10224668]
[PUBMED:11708889]
[PUBMED:9581795]
[PUBMED:10586078]
[PUBMED:9417101]
[PUBMED:15485887]
[PUBMED:18322649]
[PUBMED:10577498]
[PUBMED:10376013]
[PUBMED:10601359]
[PUBMED:9545263]
Fcgamma receptor (FCGR) dependent phagocytosis
[NCBI:1269279]
[REACTOME:R-HSA-2029480]
[PUBMED:8541526]
[PUBMED:12488490]
[PUBMED:16413920]
[PUBMED:17050193]
Focal adhesion
[NCBI:83067]
[KEGG:hsa04510]
[PUBMED:10698680]
[PUBMED:15459662]
[PUBMED:14756624]
[PUBMED:11573199]
[PUBMED:12640026]
[PUBMED:15179030]
[PUBMED:15108811]
[PUBMED:15053919]
[PUBMED:11082269]
[PUBMED:15034601]
[PUBMED:12235283]
[PUBMED:14519391]
[PUBMED:11146675]
[PUBMED:11229600]
[PUBMED:15688067]
[PUBMED:14744429]
[PUBMED:11882383]
Generation of second messenger molecules
[NCBI:1269175]
[REACTOME:R-HSA-202433]
[PUBMED:15084594]
Hippo signaling pathway -multiple species
[NCBI:1393107]
[KEGG:hsa04392]
[PUBMED:21415026]
[PUBMED:21808241]
[PUBMED:24594661]
[PUBMED:22830020]
[PUBMED:23843471]
[PUBMED:23579499]
[PUBMED:25966461]
[PUBMED:20951342]
[PUBMED:19826484]
[PUBMED:21138973]
[PUBMED:23396260]
[PUBMED:20439427]
[PUBMED:24715453]
[PUBMED:22525225]
Immune System
[NCBI:1269170]
[REACTOME:R-HSA-168256]
Innate Immune System
[NCBI:1269203]
[REACTOME:R-HSA-168249]
L1CAM interactions
[NCBI:1270323]
[REACTOME:R-HSA-373760]
[PUBMED:9211984]
[PUBMED:18760361]
[PUBMED:14709786]
[PUBMED:17189949]
[PUBMED:19356150]
MAPK family signaling cascades
[NCBI:1269501]
[REACTOME:R-HSA-5683057]
[PUBMED:21167873]
[PUBMED:17161475]
[PUBMED:22535895]
[PUBMED:21372320]
MAPK signaling pathway
[NCBI:83048]
[KEGG:hsa04010]
[PUBMED:11749383]
[PUBMED:12566928]
[PUBMED:12849693]
[PUBMED:12676795]
[PUBMED:12947395]
[PUBMED:14597384]
[PUBMED:11369511]
[PUBMED:12191611]
[PUBMED:12390245]
MAPK6/MAPK4 signaling
[NCBI:1269506]
[REACTOME:R-HSA-5687128]
[PUBMED:18644862]
[PUBMED:22800433]
[PUBMED:19166925]
[PUBMED:12808096]
[PUBMED:18248330]
[PUBMED:20849292]
[PUBMED:21329875]
[PUBMED:21177870]
[PUBMED:17161475]
[PUBMED:18593949]
[PUBMED:21372320]
[PUBMED:18720373]
[PUBMED:17947239]
[PUBMED:15226418]
[PUBMED:22505454]
Natural killer cell mediated cytotoxicity
[NCBI:83079]
[KEGG:hsa04650]
[PUBMED:12530970]
[PUBMED:15567854]
[PUBMED:8942070]
[PUBMED:11905813]
[PUBMED:9143705]
[PUBMED:9862693]
[PUBMED:11895890]
[PUBMED:12205470]
[PUBMED:11836514]
[PUBMED:15607806]
[PUBMED:16002670]
[PUBMED:15618404]
[PUBMED:11390470]
[PUBMED:11062493]
[PUBMED:14710949]
[PUBMED:12752668]
[PUBMED:15607802]
[PUBMED:16109839]
[PUBMED:12766758]
[PUBMED:16177799]
Neurotrophic factor-mediated Trk receptor signaling
[NCBI:137977]
[Pathway Interaction Database:trkrpathway]
[PUBMED:1849459]
[PUBMED:8226808]
[PUBMED:11163269]
[PUBMED:7510697]
[PUBMED:11027277]
[PUBMED:15758069]
[PUBMED:11425862]
[PUBMED:11238898]
[PUBMED:11251075]
[PUBMED:8344249]
[PUBMED:9356464]
[PUBMED:11150291]
[PUBMED:10092678]
[PUBMED:1280261]
[PUBMED:11150334]
[PUBMED:11244088]
[PUBMED:10985348]
[PUBMED:15753086]
[PUBMED:1653651]
[PUBMED:11466412]
[PUBMED:15167895]
[PUBMED:1831195]
[PUBMED:10490030]
[PUBMED:8384556]
[PUBMED:16697063]
[PUBMED:17003042]
[PUBMED:15520226]
[PUBMED:15632082]
[PUBMED:16611639]
[PUBMED:16187212]
[PUBMED:9182757]
[PUBMED:1604323]
[PUBMED:16284401]
[PUBMED:8356095]
[PUBMED:10329710]
[PUBMED:9927421]
[PUBMED:9856458]
[PUBMED:10691301]
[PUBMED:1375038]
[PUBMED:10679771]
[PUBMED:15122257]
[PUBMED:15513915]
[PUBMED:16701206]
[PUBMED:1710174]
[PUBMED:8155326]
[PUBMED:8288573]
[PUBMED:7972023]
[PUBMED:7512734]
[PUBMED:10601297]
[PUBMED:16203995]
[PUBMED:12510192]
[PUBMED:16481401]
[PUBMED:8106527]
[PUBMED:11278445]
[PUBMED:9099755]
[PUBMED:1850821]
[PUBMED:9632781]
[PUBMED:10235685]
[PUBMED:15917464]
[PUBMED:9285826]
[PUBMED:12446789]
[PUBMED:7657612]
[PUBMED:1850549]
[PUBMED:12879077]
[PUBMED:16157584]
[PUBMED:10207144]
[PUBMED:12006576]
[PUBMED:8052307]
[PUBMED:8382740]
[PUBMED:10629055]
Osteopontin-mediated events
[NCBI:137960]
[Pathway Interaction Database:avb3_opn_pathway]
[PUBMED:9727056]
[PUBMED:9585425]
[PUBMED:16888388]
[PUBMED:16474180]
[PUBMED:15757900]
[PUBMED:9682033]
[PUBMED:12529435]
[PUBMED:15142256]
[PUBMED:14624447]
[PUBMED:15711558]
[PUBMED:9988732]
[PUBMED:12730217]
[PUBMED:11600576]
[PUBMED:8744948]
[PUBMED:16691505]
[PUBMED:11940607]
[PUBMED:16006560]
[PUBMED:10766830]
[PUBMED:10559185]
PLK1 signaling events
[NCBI:138007]
[Pathway Interaction Database:plk1_pathway]
[PUBMED:15070733]
[PUBMED:18418076]
[PUBMED:15350223]
[PUBMED:16885021]
[PUBMED:12167714]
[PUBMED:16966375]
[PUBMED:18615013]
[PUBMED:18662541]
[PUBMED:18521620]
[PUBMED:7790358]
[PUBMED:8428596]
[PUBMED:12852857]
[PUBMED:18427546]
[PUBMED:17446864]
[PUBMED:16760428]
[PUBMED:15148369]
[PUBMED:16885022]
[PUBMED:9734353]
[PUBMED:18331714]
[PUBMED:16980960]
[PUBMED:18378770]
[PUBMED:16860740]
[PUBMED:15964272]
[PUBMED:10980711]
[PUBMED:11050165]
[PUBMED:16580887]
[PUBMED:17360533]
[PUBMED:15678101]
[PUBMED:11897663]
[PUBMED:16418575]
[PUBMED:17218258]
[PUBMED:14734534]
[PUBMED:18566290]
[PUBMED:17081991]
[PUBMED:15469984]
[PUBMED:11447294]
[PUBMED:17351640]
[PUBMED:16934469]
[PUBMED:18552834]
[PUBMED:17488623]
[PUBMED:8991084]
[PUBMED:17785528]
[PUBMED:18477460]
[PUBMED:19351716]
[PUBMED:12939256]
[PUBMED:12852856]
[PUBMED:15737063]
Proteoglycans in cancer
[NCBI:782000]
[KEGG:hsa05205]
[PUBMED:19433454]
[PUBMED:20655987]
[PUBMED:18798267]
[PUBMED:10633082]
[PUBMED:10687947]
[PUBMED:22735579]
[PUBMED:24412155]
[PUBMED:9346940]
[PUBMED:22087031]
[PUBMED:22194599]
[PUBMED:14711376]
[PUBMED:19255147]
[PUBMED:15655247]
[PUBMED:11717317]
[PUBMED:17971838]
[PUBMED:18413366]
[PUBMED:20974860]
[PUBMED:11830493]
[PUBMED:23058688]
[PUBMED:18450475]
[PUBMED:12748184]
[PUBMED:19733083]
[PUBMED:18812315]
[PUBMED:12509413]
[PUBMED:21155971]
[PUBMED:11931647]
[PUBMED:18949819]
[PUBMED:12729888]
[PUBMED:15994311]
[PUBMED:23305321]
[PUBMED:18505598]
[PUBMED:22563565]
[PUBMED:22033227]
RAC1 signaling pathway
[NCBI:169355]
[Pathway Interaction Database:rac1_pathway]
[PUBMED:19158278]
[PUBMED:16702231]
[PUBMED:16440308]
[PUBMED:14765121]
[PUBMED:12453877]
[PUBMED:12657629]
[PUBMED:9799233]
[PUBMED:9694656]
[PUBMED:9317150]
[PUBMED:14970210]
[PUBMED:8305740]
[PUBMED:8805275]
[PUBMED:17178910]
[PUBMED:11060298]
[PUBMED:11304531]
[PUBMED:11804587]
[PUBMED:11470914]
[PUBMED:11309380]
[PUBMED:17244649]
[PUBMED:11021801]
[PUBMED:7592586]
[PUBMED:15681696]
[PUBMED:7744004]
[PUBMED:15225553]
[PUBMED:10559936]
[PUBMED:19917258]
[PUBMED:7600581]
[PUBMED:19363480]
[PUBMED:18423204]
[PUBMED:20097736]
[PUBMED:19852956]
[PUBMED:12181570]
[PUBMED:19822663]
[PUBMED:7652575]
[PUBMED:7629060]
[PUBMED:8107774]
[PUBMED:16636067]
[PUBMED:9042860]
[PUBMED:12213441]
[PUBMED:10679324]
[PUBMED:12682053]
[PUBMED:18198193]
[PUBMED:16542153]
[PUBMED:7600582]
[PUBMED:18948007]
[PUBMED:18319301]
[PUBMED:10559253]
[PUBMED:17115053]
[PUBMED:10473551]
[PUBMED:17682062]
[PUBMED:17164293]
[PUBMED:15557278]
[PUBMED:15677464]
[PUBMED:16837009]
[PUBMED:12796474]
[PUBMED:10559863]
[PUBMED:9535855]
[PUBMED:8910292]
[PUBMED:11432831]
[PUBMED:17981134]
[PUBMED:16762923]
[PUBMED:8798539]
[PUBMED:18160398]
[PUBMED:16099876]
[PUBMED:14681219]
RHO GTPase Effectors
[NCBI:1269509]
[REACTOME:R-HSA-195258]
[PUBMED:9694656]
[PUBMED:18066052]
[PUBMED:11018042]
[PUBMED:10470034]
[PUBMED:8702756]
[PUBMED:21730051]
[PUBMED:8571126]
[PUBMED:19513348]
[PUBMED:17244649]
[PUBMED:11145705]
[PUBMED:24128008]
[PUBMED:23716662]
[PUBMED:8617235]
[PUBMED:8543060]
[PUBMED:11804587]
[PUBMED:24969695]
[PUBMED:12635176]
[PUBMED:12778124]
[PUBMED:18006505]
[PUBMED:1660188]
[PUBMED:21351730]
[PUBMED:16507994]
[PUBMED:14595335]
[PUBMED:10072071]
[PUBMED:10591629]
[PUBMED:10753910]
[PUBMED:23875749]
[PUBMED:17151359]
[PUBMED:10652353]
[PUBMED:12221077]
[PUBMED:10559936]
[PUBMED:12783890]
[PUBMED:11948177]
[PUBMED:18237546]
[PUBMED:16079795]
[PUBMED:10924361]
[PUBMED:14514689]
[PUBMED:8107774]
[PUBMED:8756646]
[PUBMED:16979770]
[PUBMED:16636067]
[PUBMED:9751706]
[PUBMED:10619026]
[PUBMED:23444367]
[PUBMED:15546864]
[PUBMED:12473120]
[PUBMED:8816443]
[PUBMED:9199170]
[PUBMED:12514133]
[PUBMED:16762923]
[PUBMED:12110184]
[PUBMED:16431929]
[PUBMED:10975528]
[PUBMED:10940294]
[PUBMED:9535855]
[PUBMED:7559638]
[PUBMED:11162552]
[PUBMED:19737400]
[PUBMED:9988689]
[PUBMED:12732141]
[PUBMED:8798539]
[PUBMED:24914801]
[PUBMED:11689693]
[PUBMED:8769096]
[PUBMED:9368021]
RHO GTPases activate PAKs
[NCBI:1269511]
[REACTOME:R-HSA-5627123]
[PUBMED:7559638]
[PUBMED:9535855]
[PUBMED:19513348]
[PUBMED:16204230]
[PUBMED:10470034]
[PUBMED:22340718]
[PUBMED:11804587]
[PUBMED:21098037]
[PUBMED:11278486]
[PUBMED:8107774]
[PUBMED:10975528]
Ras signaling pathway
[NCBI:868085]
[KEGG:hsa04014]
[PUBMED:23506953]
[PUBMED:18437264]
[PUBMED:15062121]
[PUBMED:22189424]
[PUBMED:22233291]
[PUBMED:12778136]
[PUBMED:11313946]
[PUBMED:17428555]
[PUBMED:19091743]
[PUBMED:18568040]
[PUBMED:20420946]
[PUBMED:12217381]
[PUBMED:14663478]
[PUBMED:21686117]
[PUBMED:12642680]
[PUBMED:21196257]
[PUBMED:16869784]
[PUBMED:21111786]
[PUBMED:16966426]
[PUBMED:10712923]
[PUBMED:22020205]
[PUBMED:17384584]
[PUBMED:15572660]
[PUBMED:18413813]
Regulation of actin cytoskeleton
[NCBI:83089]
[KEGG:hsa04810]
[PUBMED:11152757]
[PUBMED:11082272]
[PUBMED:10574699]
[PUBMED:11082269]
[PUBMED:14657486]
[PUBMED:14744429]
[PUBMED:12700767]
Regulation of actin dynamics for phagocytic cup formation
[NCBI:1269281]
[REACTOME:R-HSA-2029482]
[PUBMED:17477841]
[PUBMED:15452139]
[PUBMED:15981459]
Regulation of p38-alpha and p38-beta
[NCBI:137964]
[Pathway Interaction Database:p38alphabetapathway]
[PUBMED:16461893]
[PUBMED:7997261]
[PUBMED:16943189]
[PUBMED:14585994]
[PUBMED:10391943]
[PUBMED:14661019]
[PUBMED:11359773]
[PUBMED:7914033]
[PUBMED:8910287]
[PUBMED:7744004]
[PUBMED:10190877]
[PUBMED:7592586]
[PUBMED:16849316]
[PUBMED:7693711]
[PUBMED:11847341]
[PUBMED:7839144]
[PUBMED:9790884]
[PUBMED:7499279]
[PUBMED:14592977]
[PUBMED:12110590]
[PUBMED:14634666]
[PUBMED:8107774]
[PUBMED:8622669]
[PUBMED:8798750]
[PUBMED:11278799]
[PUBMED:15864310]
[PUBMED:16407200]
Renal cell carcinoma
[NCBI:83107]
[KEGG:hsa05211]
[PUBMED:12351585]
[PUBMED:17211469]
[PUBMED:16339096]
[PUBMED:17287871]
[PUBMED:14634372]
[PUBMED:15611513]
[PUBMED:14685170]
[PUBMED:15122209]
S1P2 pathway
[NCBI:138059]
[Pathway Interaction Database:s1p_s1p2_pathway]
[PUBMED:9854026]
[PUBMED:10617617]
[PUBMED:17431187]
[PUBMED:12588974]
[PUBMED:11094076]
[PUBMED:15240112]
[PUBMED:11853542]
[PUBMED:12810709]
Sema3A PAK dependent Axon repulsion
[NCBI:1270309]
[REACTOME:R-HSA-399954]
[PUBMED:12593985]
[PUBMED:11276226]
[PUBMED:11604131]
[PUBMED:18374575]
Semaphorin interactions
[NCBI:1270304]
[REACTOME:R-HSA-373755]
[PUBMED:12593985]
[PUBMED:12471249]
[PUBMED:18269210]
[PUBMED:16939971]
[PUBMED:18374575]
Signal Transduction
[NCBI:1269379]
[REACTOME:R-HSA-162582]
[PUBMED:17604717]
[PUBMED:19648010]
[PUBMED:16260143]
[PUBMED:11742412]
[PUBMED:19536106]
[PUBMED:15863030]
[PUBMED:19379690]
[PUBMED:19458711]
[PUBMED:19935667]
[PUBMED:21252999]
[PUBMED:15520807]
[PUBMED:17496910]
[PUBMED:15450248]
[PUBMED:18043707]
[PUBMED:16939974]
[PUBMED:19762341]
[PUBMED:18483217]
[PUBMED:17084981]
[PUBMED:21781017]
[PUBMED:19619488]
Signal transduction by L1
[NCBI:1270326]
[REACTOME:R-HSA-445144]
[PUBMED:15597056]
[PUBMED:12721290]
[PUBMED:10608864]
[PUBMED:17189949]
[PUBMED:16597699]
[PUBMED:10818153]
Signaling by Rho GTPases
[NCBI:1269507]
[REACTOME:R-HSA-194315]
[PUBMED:16212495]
[PUBMED:15630019]
Signaling by Robo receptor
[NCBI:1270318]
[REACTOME:R-HSA-376176]
[PUBMED:18363568]
Signaling by VEGF
[NCBI:1269480]
[REACTOME:R-HSA-194138]
[PUBMED:15585754]
[PUBMED:13678960]
[PUBMED:16336962]
[PUBMED:16835467]
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
[NCBI:137930]
[Pathway Interaction Database:met_pathway]
[PUBMED:10793146]
[PUBMED:8906793]
[PUBMED:11929826]
[PUBMED:10022866]
[PUBMED:11532961]
[PUBMED:12475979]
[PUBMED:1718989]
[PUBMED:1846706]
[PUBMED:10970810]
[PUBMED:10516287]
[PUBMED:12138161]
[PUBMED:11046147]
[PUBMED:18073207]
[PUBMED:12951049]
[PUBMED:15494312]
[PUBMED:9001234]
[PUBMED:11352916]
[PUBMED:11896055]
[PUBMED:9440692]
[PUBMED:8607979]
[PUBMED:12244132]
[PUBMED:11162460]
[PUBMED:11809798]
[PUBMED:9693375]
[PUBMED:14636584]
[PUBMED:17297451]
[PUBMED:17682062]
[PUBMED:19628037]
[PUBMED:11069926]
[PUBMED:18819921]
[PUBMED:16423831]
[PUBMED:10558875]
[PUBMED:16858414]
[PUBMED:10995442]
[PUBMED:20332103]
[PUBMED:11146548]
[PUBMED:18346875]
[PUBMED:17894413]
[PUBMED:9252406]
[PUBMED:17635922]
[PUBMED:11134526]
[PUBMED:2005882]
[PUBMED:19609305]
[PUBMED:8380735]
[PUBMED:16537482]
[PUBMED:10618718]
[PUBMED:9591773]
[PUBMED:12894582]
[PUBMED:9748249]
[PUBMED:11741535]
[PUBMED:17881575]
[PUBMED:10713050]
[PUBMED:1655790]
[PUBMED:11784715]
[PUBMED:10753869]
[PUBMED:10713700]
[PUBMED:11118451]
[PUBMED:16952352]
[PUBMED:15314156]
[PUBMED:19272169]
[PUBMED:12802068]
[PUBMED:17363898]
[PUBMED:7513258]
[PUBMED:1827664]
[PUBMED:2541345]
[PUBMED:8387483]
[PUBMED:16620780]
[PUBMED:11445578]
[PUBMED:10734310]
[PUBMED:16227611]
[PUBMED:12941962]
[PUBMED:15735664]
[PUBMED:19071214]
[PUBMED:7731718]
[PUBMED:19289496]
[PUBMED:11438654]
[PUBMED:11896612]
[PUBMED:11894096]
[PUBMED:11896575]
[PUBMED:7499247]
[PUBMED:12147692]
[PUBMED:11948414]
[PUBMED:19881549]
[PUBMED:19525225]
[PUBMED:14684163]
[PUBMED:17055484]
[PUBMED:9668053]
[PUBMED:10531383]
[PUBMED:9681449]
[PUBMED:1655405]
[PUBMED:12686592]
[PUBMED:19109251]
[PUBMED:10679787]
[PUBMED:9487126]
[PUBMED:9886295]
[PUBMED:12058075]
[PUBMED:15452053]
[PUBMED:9184210]
[PUBMED:10871282]
[PUBMED:17329361]
[PUBMED:2554238]
Signaling events mediated by VEGFR1 and VEGFR2
[NCBI:137940]
[Pathway Interaction Database:vegfr1_2_pathway]
[PUBMED:9398617]
[PUBMED:9405464]
[PUBMED:11494124]
[PUBMED:12963813]
[PUBMED:11756651]
[PUBMED:10744763]
[PUBMED:15060076]
[PUBMED:9600074]
[PUBMED:10376603]
[PUBMED:11425855]
[PUBMED:16337972]
[PUBMED:12154000]
[PUBMED:11978735]
[PUBMED:10692392]
[PUBMED:16763158]
[PUBMED:10361126]
[PUBMED:10748121]
[PUBMED:12598525]
[PUBMED:15026417]
[PUBMED:11948691]
[PUBMED:16966330]
[PUBMED:16835467]
[PUBMED:10409677]
[PUBMED:10908731]
[PUBMED:8903320]
[PUBMED:15962004]
[PUBMED:16633338]
[PUBMED:11387210]
[PUBMED:16839566]
[PUBMED:11312102]
[PUBMED:10207622]
[PUBMED:16787925]
[PUBMED:12171920]
[PUBMED:12509223]
[PUBMED:16760434]
[PUBMED:14724572]
[PUBMED:11704645]
[PUBMED:12821150]
[PUBMED:12881528]
[PUBMED:9790910]
[PUBMED:10376602]
[PUBMED:15247219]
[PUBMED:11333271]
[PUBMED:12214271]
[PUBMED:9804796]
[PUBMED:11986311]
[PUBMED:9182576]
[PUBMED:15217908]
[PUBMED:10749680]
[PUBMED:16763549]
Signaling events mediated by focal adhesion kinase
[NCBI:169348]
[Pathway Interaction Database:fak_pathway]
[PUBMED:18793427]
[PUBMED:15340073]
[PUBMED:16054026]
[PUBMED:12932330]
[PUBMED:20038548]
[PUBMED:7542255]
[PUBMED:8939916]
[PUBMED:16000375]
[PUBMED:10856236]
[PUBMED:17164291]
[PUBMED:9148935]
[PUBMED:10893408]
[PUBMED:10512882]
[PUBMED:11839772]
[PUBMED:11553710]
[PUBMED:7566154]
[PUBMED:20018869]
[PUBMED:12839996]
[PUBMED:11799111]
[PUBMED:16308318]
[PUBMED:11331870]
[PUBMED:12681445]
[PUBMED:11369769]
[PUBMED:11739801]
[PUBMED:9860979]
[PUBMED:8947559]
[PUBMED:11017882]
[PUBMED:7509446]
[PUBMED:10791986]
[PUBMED:9128257]
[PUBMED:19297531]
[PUBMED:17325207]
[PUBMED:17093062]
[PUBMED:10593973]
[PUBMED:20308429]
[PUBMED:8922390]
[PUBMED:19776348]
[PUBMED:9374537]
[PUBMED:10976102]
[PUBMED:10373530]
[PUBMED:19883375]
[PUBMED:10430888]
[PUBMED:12820964]
[PUBMED:9425168]
[PUBMED:14743221]
[PUBMED:18854312]
[PUBMED:12952943]
[PUBMED:15962308]
[PUBMED:11927607]
[PUBMED:15657076]
[PUBMED:15039571]
[PUBMED:18303050]
[PUBMED:11799401]
[PUBMED:15247219]
[PUBMED:12702722]
[PUBMED:10998418]
[PUBMED:7615549]
[PUBMED:18195107]
[PUBMED:9032297]
[PUBMED:10873807]
[PUBMED:10777511]
[PUBMED:12502711]
[PUBMED:9566877]
[PUBMED:8649427]
[PUBMED:19473962]
[PUBMED:9808620]
[PUBMED:15914540]
[PUBMED:1385445]
[PUBMED:18223254]
[PUBMED:11909938]
[PUBMED:15166238]
[PUBMED:7622520]
[PUBMED:8824286]
[PUBMED:8662921]
[PUBMED:8707856]
[PUBMED:10330411]
[PUBMED:10446223]
[PUBMED:20150423]
[PUBMED:11604500]
[PUBMED:9234699]
[PUBMED:18773890]
[PUBMED:18757826]
[PUBMED:9864370]
[PUBMED:7983066]
[PUBMED:18322799]
[PUBMED:12006652]
[PUBMED:16461767]
[PUBMED:10385525]
[PUBMED:14676198]
[PUBMED:9858476]
[PUBMED:18070912]
[PUBMED:11058585]
[PUBMED:12890755]
[PUBMED:9184223]
[PUBMED:12058076]
[PUBMED:12226752]
[PUBMED:19435801]
[PUBMED:10212207]
[PUBMED:10521463]
[PUBMED:16159962]
[PUBMED:7579684]
[PUBMED:18362184]
[PUBMED:7997267]
[PUBMED:8816475]
[PUBMED:11279163]
[PUBMED:7537852]
[PUBMED:11418135]
[PUBMED:12167697]
[PUBMED:12615911]
[PUBMED:12876277]
T cell receptor signaling pathway
[NCBI:83080]
[KEGG:hsa04660]
[PUBMED:17395537]
[PUBMED:15308211]
[PUBMED:15928679]
[PUBMED:14656980]
[PUBMED:17187070]
[PUBMED:15084594]
[PUBMED:16799472]
[PUBMED:12669022]
[PUBMED:15286727]
[PUBMED:15122199]
[PUBMED:19132916]
[PUBMED:15489916]
[PUBMED:11905831]
[PUBMED:12195013]
[PUBMED:15343367]
[PUBMED:12133805]
[PUBMED:14647476]
[PUBMED:15771581]
[PUBMED:15099566]
[PUBMED:14617194]
[PUBMED:19290929]
[PUBMED:15345216]
TCR signaling
[NCBI:1269172]
[REACTOME:R-HSA-202403]
[PUBMED:10375551]
[PUBMED:12876557]
[PUBMED:9989491]
VEGFA-VEGFR2 Pathway
[NCBI:1269483]
[REACTOME:R-HSA-4420097]
[PUBMED:17344076]
[PUBMED:16633338]
[PUBMED:19230644]
[PUBMED:13678960]
VEGFR2 mediated vascular permeability
[NCBI:1269484]
[REACTOME:R-HSA-5218920]
[PUBMED:17008595]
cAMP signaling pathway
[NCBI:1017634]
[KEGG:hsa04024]
[PUBMED:10880354]
[PUBMED:9204709]
[PUBMED:21693691]
[PUBMED:24062645]
[PUBMED:24450633]
[PUBMED:21346730]
[PUBMED:24613710]
[PUBMED:21744067]
[PUBMED:22082266]
[PUBMED:16460276]
[PUBMED:18176800]
[PUBMED:14715909]
[PUBMED:7688165]
[PUBMED:24281338]
[PUBMED:11117527]
[PUBMED:16765984]
[PUBMED:18323530]
[PUBMED:18064650]
[PUBMED:21852968]
[PUBMED:11493633]
[PUBMED:21212391]
[PUBMED:15142747]
[PUBMED:17077866]
[PUBMED:19460777]
[PUBMED:19874988]
[PUBMED:16571352]
[PUBMED:22022314]