full name
transient receptor potential cation channel subfamily C member 6

synonyms
FSGS2, TRP6, TRPC6, ENSG00000137672

HGNC
HGNC:12338

Entrez Gene
Gene:7225

ENSEMBL
ENSG00000137672

location
chr: 11
start: 101322295
stop: 101454687
strand: -

OMIM
OMIM:603652: TRPC6
OMIM:603965: Glomerulosclerosis, focal segmental, 2

transcripts
NM_004621.5

pathways
Axon guidance [NCBI:83065] [KEGG:hsa04360] [NCBI:1270303] [REACTOME:R-HSA-422475] [PUBMED:14682358] [PUBMED:15084255] [PUBMED:11687826] [PUBMED:15818466] [PUBMED:15363605] [PUBMED:12471249] [PUBMED:15630019] [PUBMED:11891122] [PUBMED:15960985] [PUBMED:12677003]
Developmental Biology [NCBI:1270302] [REACTOME:R-HSA-1266738]
EPO signaling pathway [NCBI:138051] [Pathway Interaction Database:epopathway] [PUBMED:14699131] [PUBMED:7889566] [PUBMED:8537396] [PUBMED:11124936] [PUBMED:9344843] [PUBMED:12504103] [PUBMED:7528577] [PUBMED:15329338] [PUBMED:15254422] [PUBMED:7537740] [PUBMED:9334184] [PUBMED:10882725] [PUBMED:15007095] [PUBMED:15705783] [PUBMED:10910907] [PUBMED:8343951] [PUBMED:8034732]
Effects of PIP2 hydrolysis [NCBI:1269363] [REACTOME:R-HSA-114508] [PUBMED:17157506] [PUBMED:9601053]
Elevation of cytosolic Ca2+ levels [NCBI:1269346] [REACTOME:R-HSA-139853] [PUBMED:17703229] [PUBMED:19422456] [PUBMED:18308196]
Endothelins [NCBI:137958] [Pathway Interaction Database:endothelinpathway] [PUBMED:1319997] [PUBMED:12719447] [PUBMED:15047866] [PUBMED:1905483] [PUBMED:3144974] [PUBMED:12922939] [PUBMED:9595433] [PUBMED:2558572] [PUBMED:10364236] [PUBMED:11231316] [PUBMED:17569879] [PUBMED:11078350] [PUBMED:17535295] [PUBMED:17533154] [PUBMED:8764613] [PUBMED:8617878] [PUBMED:17526654] [PUBMED:8843717] [PUBMED:12606754] [PUBMED:15200122] [PUBMED:8319594] [PUBMED:17627891] [PUBMED:8940174] [PUBMED:12397581] [PUBMED:2545198]
G alpha (q) signalling events [NCBI:1269578] [REACTOME:R-HSA-416476] [PUBMED:19212139]
GPCR downstream signaling [NCBI:1269574] [REACTOME:R-HSA-388396] [PUBMED:12040175]
Gastrin-CREB signalling pathway via PKC and MAPK [NCBI:1269592] [REACTOME:R-HSA-881907] [PUBMED:10413847] [PUBMED:7491953] [PUBMED:17698287]
Hemostasis [NCBI:1269340] [REACTOME:R-HSA-109582]
Ion channel transport [NCBI:1269950] [REACTOME:R-HSA-983712] [PUBMED:15071553]
Nephrin/Neph1 signaling in the kidney podocyte [NCBI:138072] [Pathway Interaction Database:nephrin_neph1_pathway] [PUBMED:12660326] [PUBMED:18212058] [PUBMED:12832477] [PUBMED:10504499] [PUBMED:12846735] [PUBMED:18385666] [PUBMED:12668668] [PUBMED:19142224] [PUBMED:14633607] [PUBMED:16525419] [PUBMED:10514378] [PUBMED:17923684] [PUBMED:18274541] [PUBMED:17079490] [PUBMED:11733557] [PUBMED:16968782] [PUBMED:15200416] [PUBMED:12424224] [PUBMED:11562357] [PUBMED:18715943] [PUBMED:11549599] [PUBMED:15339792] [PUBMED:10742096] [PUBMED:14570703] [PUBMED:19179337] [PUBMED:19497968] [PUBMED:12578837] [PUBMED:18562307] [PUBMED:18046313] [PUBMED:12646566] [PUBMED:15579503] [PUBMED:18033240] [PUBMED:16543952]
Netrin-1 signaling [NCBI:1270314] [REACTOME:R-HSA-373752] [PUBMED:18269208] [PUBMED:10499167]
Platelet activation, signaling and aggregation [NCBI:1269350] [REACTOME:R-HSA-76002] [PUBMED:16543958] [PUBMED:8704248] [PUBMED:2018971] [PUBMED:1672265] [PUBMED:17059469] [PUBMED:12681240] [PUBMED:12411949] [PUBMED:11511514]
Platelet calcium homeostasis [NCBI:1269345] [REACTOME:R-HSA-418360] [PUBMED:18308196] [PUBMED:19422456]
Platelet homeostasis [NCBI:1269341] [REACTOME:R-HSA-418346] [PUBMED:10798271]
Role of second messengers in netrin-1 signaling [NCBI:1270317] [REACTOME:R-HSA-418890] [PUBMED:15880110] [PUBMED:15758951]
Signal Transduction [NCBI:1269379] [REACTOME:R-HSA-162582] [PUBMED:17604717] [PUBMED:19648010] [PUBMED:16260143] [PUBMED:11742412] [PUBMED:19536106] [PUBMED:15863030] [PUBMED:19379690] [PUBMED:19458711] [PUBMED:19935667] [PUBMED:21252999] [PUBMED:15520807] [PUBMED:17496910] [PUBMED:15450248] [PUBMED:18043707] [PUBMED:16939974] [PUBMED:19762341] [PUBMED:18483217] [PUBMED:17084981] [PUBMED:21781017] [PUBMED:19619488]
Signaling by GPCR [NCBI:1269543] [REACTOME:R-HSA-372790] [PUBMED:16902930] [PUBMED:10202136] [PUBMED:18043707]
Stimuli-sensing channels [NCBI:1269953] [REACTOME:R-HSA-2672351] [PUBMED:15728426] [PUBMED:16460286] [PUBMED:12907679] [PUBMED:18391176] [PUBMED:19278523] [PUBMED:11904445] [PUBMED:22934072] [PUBMED:20807551] [PUBMED:19783045] [PUBMED:16219661] [PUBMED:21932071] [PUBMED:22277752]
TRP channels [NCBI:1269954] [REACTOME:R-HSA-3295583] [PUBMED:20716668] [PUBMED:20347603] [PUBMED:20025796] [PUBMED:20127491]
Transmembrane transport of small molecules [NCBI:1269903] [REACTOME:R-HSA-382551]
cGMP-PKG signaling pathway [NCBI:983748] [KEGG:hsa04022] [PUBMED:18006449] [PUBMED:9003029] [PUBMED:18040025] [PUBMED:19306895] [PUBMED:21666108] [PUBMED:12524221] [PUBMED:16460276] [PUBMED:20716671] [PUBMED:22785374] [PUBMED:11522789] [PUBMED:16439998] [PUBMED:16371594] [PUBMED:20388537] [PUBMED:18757523] [PUBMED:16815627] [PUBMED:23212367] [PUBMED:21685243] [PUBMED:20024580] [PUBMED:15894227] [PUBMED:22965426] [PUBMED:17643091] [PUBMED:19176601] [PUBMED:19961855]