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Genes
BIRC2
Gene - BIRC2
full name
baculoviral IAP repeat containing 2
synonyms
API1, c-IAP1, cIAP1, Hiap-2, HIAP2, MIHB, RNF48, BIRC2, ENSG00000110330
HGNC
HGNC:590
Entrez Gene
Gene:329
ENSEMBL
ENSG00000110330
location
chr: 11
start: 102217913
stop: 102249401
strand: +
transcripts
NM_001166.4
NM_001256166.1
NM_001256163.1
pathways
Activated TLR4 signalling
[NCBI:1269236]
[REACTOME:R-HSA-166054]
[PUBMED:15276183]
[PUBMED:15588429]
[PUBMED:15845500]
[PUBMED:15596121]
Apoptosis
[NCBI:83060]
[KEGG:hsa04210]
[NCBI:1270262]
[REACTOME:R-HSA-109581]
[PUBMED:12189384]
[PUBMED:20533903]
[PUBMED:18208375]
[PUBMED:22429822]
[PUBMED:15218528]
[PUBMED:24769728]
[PUBMED:18023214]
[PUBMED:25526085]
[PUBMED:23070002]
[PUBMED:15654015]
[PUBMED:15601572]
[PUBMED:14561771]
[PUBMED:24278747]
[PUBMED:21914490]
[PUBMED:22465226]
[PUBMED:21145844]
[PUBMED:12838338]
[PUBMED:18238895]
[PUBMED:12949498]
[PUBMED:18304445]
[PUBMED:14737178]
[PUBMED:26231733]
[PUBMED:9916983]
[PUBMED:14634621]
[PUBMED:19770840]
[PUBMED:22075987]
[PUBMED:4561027]
[PUBMED:20075940]
[PUBMED:9894605]
[PUBMED:26615431]
[PUBMED:12505355]
[PUBMED:11520933]
[PUBMED:19148180]
[PUBMED:16397578]
[PUBMED:15719025]
[PUBMED:15322527]
[PUBMED:15725726]
[PUBMED:12209154]
[PUBMED:23803157]
Apoptosis - multiple species
[NCBI:1384747]
[KEGG:hsa04215]
[PUBMED:23457257]
[PUBMED:11858838]
[PUBMED:15963254]
[PUBMED:20041301]
[PUBMED:24393571]
[PUBMED:21150934]
[PUBMED:15107838]
[PUBMED:10578171]
[PUBMED:15082313]
[PUBMED:19659442]
[PUBMED:20479784]
[PUBMED:22689371]
[PUBMED:20978240]
[PUBMED:25862972]
[PUBMED:20028968]
[PUBMED:25991373]
Apoptotic cleavage of cellular proteins
[NCBI:1270288]
[REACTOME:R-HSA-111465]
[PUBMED:17254298]
[PUBMED:17599937]
[PUBMED:12655297]
Apoptotic execution phase
[NCBI:1270287]
[REACTOME:R-HSA-75153]
[PUBMED:12655297]
CD40/CD40L signaling
[NCBI:138061]
[Pathway Interaction Database:cd40_pathway]
[PUBMED:11967542]
[PUBMED:11304555]
[PUBMED:11714736]
[PUBMED:17878343]
[PUBMED:12354380]
[PUBMED:11406619]
[PUBMED:9133417]
[PUBMED:7527023]
[PUBMED:18997794]
[PUBMED:1374165]
[PUBMED:1385114]
[PUBMED:12958312]
[PUBMED:10764746]
[PUBMED:11909853]
[PUBMED:10318845]
[PUBMED:7533327]
[PUBMED:16260598]
[PUBMED:18997792]
[PUBMED:12818164]
[PUBMED:10748139]
[PUBMED:9718306]
[PUBMED:10395671]
[PUBMED:17878362]
[PUBMED:7544915]
[PUBMED:12370254]
[PUBMED:8910514]
[PUBMED:17143273]
[PUBMED:10433725]
[PUBMED:14981114]
[PUBMED:16622006]
[PUBMED:12122011]
[PUBMED:12133933]
Canonical NF-kappaB pathway
[NCBI:138030]
[Pathway Interaction Database:nfkappabcanonicalpathway]
[PUBMED:7878466]
[PUBMED:10688673]
[PUBMED:16497931]
[PUBMED:10755617]
[PUBMED:9660950]
[PUBMED:9346241]
[PUBMED:10195894]
[PUBMED:10521409]
[PUBMED:12917691]
[PUBMED:15620648]
[PUBMED:14695475]
[PUBMED:14651848]
[PUBMED:11319224]
[PUBMED:9150141]
[PUBMED:9819420]
[PUBMED:15218148]
[PUBMED:7739562]
[PUBMED:12657630]
[PUBMED:12867425]
[PUBMED:16267042]
Caspase cascade in apoptosis
[NCBI:137974]
[Pathway Interaction Database:caspase_pathway]
[PUBMED:7774019]
[PUBMED:8626669]
[PUBMED:9850096]
[PUBMED:11803376]
[PUBMED:15189451]
[PUBMED:10564664]
[PUBMED:9642276]
[PUBMED:10567584]
[PUBMED:12419244]
[PUBMED:11423904]
[PUBMED:9422506]
[PUBMED:11438643]
[PUBMED:9070648]
[PUBMED:9588194]
[PUBMED:11085743]
[PUBMED:9298992]
[PUBMED:9933635]
[PUBMED:9528810]
[PUBMED:9323209]
[PUBMED:10809769]
[PUBMED:8700869]
[PUBMED:9463409]
[PUBMED:10497198]
[PUBMED:11953316]
[PUBMED:9422513]
[PUBMED:10409650]
[PUBMED:11463840]
[PUBMED:10611247]
[PUBMED:8605870]
Cytokine Signaling in Immune system
[NCBI:1269310]
[REACTOME:R-HSA-1280215]
[PUBMED:12613569]
Death Receptor Signalling
[NCBI:1269644]
[REACTOME:R-HSA-73887]
Deubiquitination
[NCBI:1427860]
[REACTOME:R-HSA-5688426]
[PUBMED:19243136]
[PUBMED:20074029]
[PUBMED:15571815]
[PUBMED:20418328]
[PUBMED:16325574]
[PUBMED:12944365]
[PUBMED:23845989]
[PUBMED:22201797]
FAS (CD95) signaling pathway
[NCBI:138081]
[Pathway Interaction Database:faspathway]
[PUBMED:9765224]
[PUBMED:11717445]
[PUBMED:9727491]
[PUBMED:11279218]
[PUBMED:12110583]
[PUBMED:11739735]
[PUBMED:8521815]
[PUBMED:9184224]
[PUBMED:20153221]
[PUBMED:9126929]
[PUBMED:10200443]
[PUBMED:16033886]
[PUBMED:8681377]
[PUBMED:9880544]
[PUBMED:9501089]
[PUBMED:10535980]
[PUBMED:9727492]
[PUBMED:7523573]
[PUBMED:11101870]
[PUBMED:9321399]
[PUBMED:9362518]
[PUBMED:12724420]
[PUBMED:16498403]
[PUBMED:11583996]
[PUBMED:15557123]
[PUBMED:7536343]
[PUBMED:12832037]
[PUBMED:9576928]
[PUBMED:9228058]
[PUBMED:7538908]
[PUBMED:18635548]
[PUBMED:20038679]
[PUBMED:10894163]
[PUBMED:12545171]
[PUBMED:16619028]
[PUBMED:9351817]
[PUBMED:9045686]
[PUBMED:15289496]
Focal adhesion
[NCBI:83067]
[KEGG:hsa04510]
[PUBMED:10698680]
[PUBMED:15459662]
[PUBMED:14756624]
[PUBMED:11573199]
[PUBMED:12640026]
[PUBMED:15179030]
[PUBMED:15108811]
[PUBMED:15053919]
[PUBMED:11082269]
[PUBMED:15034601]
[PUBMED:12235283]
[PUBMED:14519391]
[PUBMED:11146675]
[PUBMED:11229600]
[PUBMED:15688067]
[PUBMED:14744429]
[PUBMED:11882383]
Hippo signaling pathway
[NCBI:749777]
[KEGG:hsa04390]
[PUBMED:18955139]
[PUBMED:20439427]
[PUBMED:20951342]
[PUBMED:21138973]
[PUBMED:18328423]
[PUBMED:21324984]
[PUBMED:23034192]
[PUBMED:21808241]
[PUBMED:17975546]
[PUBMED:22750148]
[PUBMED:21084559]
[PUBMED:19846288]
[PUBMED:22895435]
[PUBMED:22683405]
[PUBMED:22658639]
[PUBMED:22153608]
[PUBMED:20945341]
[PUBMED:22830020]
[PUBMED:21874053]
[PUBMED:21376238]
IKK complex recruitment mediated by RIP1
[NCBI:1269223]
[REACTOME:R-HSA-937041]
[PUBMED:16603398]
[PUBMED:16115877]
[PUBMED:14530355]
Immune System
[NCBI:1269170]
[REACTOME:R-HSA-168256]
Innate Immune System
[NCBI:1269203]
[REACTOME:R-HSA-168249]
Metabolism of proteins
[NCBI:1268677]
[REACTOME:R-HSA-392499]
MyD88-independent TLR3/TLR4 cascade
[NCBI:1269220]
[REACTOME:R-HSA-166166]
[PUBMED:15276183]
NF-kappa B signaling pathway
[NCBI:634527]
[KEGG:hsa04064]
[PUBMED:22119011]
[PUBMED:16264088]
[PUBMED:21187855]
[PUBMED:15546385]
[PUBMED:17607554]
[PUBMED:21135871]
[PUBMED:16984817]
[PUBMED:17047224]
[PUBMED:19203223]
[PUBMED:20300215]
[PUBMED:14657271]
[PUBMED:17431096]
[PUBMED:15134788]
[PUBMED:16356770]
[PUBMED:21772278]
[PUBMED:12654254]
[PUBMED:22390971]
[PUBMED:22017435]
[PUBMED:17183360]
[PUBMED:21173796]
[PUBMED:15905862]
[PUBMED:19302050]
[PUBMED:17098202]
[PUBMED:21872579]
[PUBMED:22152226]
[PUBMED:18613837]
[PUBMED:19489733]
[PUBMED:11875461]
[PUBMED:19726767]
[PUBMED:22017430]
[PUBMED:21232019]
[PUBMED:18832076]
NOD-like receptor signaling pathway
[NCBI:122191]
[KEGG:hsa04621]
[PUBMED:25330206]
[PUBMED:21575908]
[PUBMED:23846113]
[PUBMED:26549800]
[PUBMED:16493424]
[PUBMED:23124073]
[PUBMED:24840700]
[PUBMED:27291964]
[PUBMED:27012466]
[PUBMED:24707857]
[PUBMED:19767725]
[PUBMED:25879280]
[PUBMED:23215645]
[PUBMED:22819539]
[PUBMED:23702978]
[PUBMED:20643110]
[PUBMED:25879288]
[PUBMED:26655628]
[PUBMED:25145756]
[PUBMED:24718315]
[PUBMED:26482951]
[PUBMED:25526305]
[PUBMED:26121197]
[PUBMED:22430786]
NOD1/2 Signaling Pathway
[NCBI:1269252]
[REACTOME:R-HSA-168638]
[PUBMED:18928408]
[PUBMED:18585455]
[PUBMED:18414735]
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
[NCBI:1269251]
[REACTOME:R-HSA-168643]
[PUBMED:18928408]
Pathways in cancer
[NCBI:83105]
[KEGG:hsa05200]
[PUBMED:12244301]
[PUBMED:15156182]
[PUBMED:16899407]
[PUBMED:12621137]
[PUBMED:21193867]
[PUBMED:16001072]
[PUBMED:11707511]
[PUBMED:11253051]
[PUBMED:11071626]
[PUBMED:17251915]
[PUBMED:11736900]
[PUBMED:16557281]
[PUBMED:16699851]
[PUBMED:16189702]
[PUBMED:11902573]
[PUBMED:16555243]
[PUBMED:8069858]
[PUBMED:15310786]
[PUBMED:9834202]
[PUBMED:16700615]
[PUBMED:12545153]
[PUBMED:15656799]
[PUBMED:12154354]
[PUBMED:11895903]
[PUBMED:11527574]
[PUBMED:16326109]
[PUBMED:16339096]
[PUBMED:11160144]
[PUBMED:15724144]
[PUBMED:12951584]
[PUBMED:10647931]
[PUBMED:16881963]
[PUBMED:15557758]
[PUBMED:11477132]
[PUBMED:15721476]
[PUBMED:15625120]
[PUBMED:16236521]
[PUBMED:14967450]
[PUBMED:15942304]
[PUBMED:17287871]
[PUBMED:14634372]
[PUBMED:15573119]
[PUBMED:15009714]
[PUBMED:16112428]
[PUBMED:15611513]
[PUBMED:16001050]
[PUBMED:15349822]
[PUBMED:16551846]
[PUBMED:15978322]
[PUBMED:15774796]
[PUBMED:16352814]
[PUBMED:12951588]
[PUBMED:10944551]
[PUBMED:10740269]
[PUBMED:15639402]
[PUBMED:12407699]
[PUBMED:11130178]
[PUBMED:15109562]
[PUBMED:11170304]
[PUBMED:11276000]
[PUBMED:9643506]
[PUBMED:16248975]
[PUBMED:16242838]
[PUBMED:12946833]
[PUBMED:11559746]
[PUBMED:9196022]
[PUBMED:12079267]
[PUBMED:15468170]
[PUBMED:16064138]
[PUBMED:14580692]
[PUBMED:15082523]
[PUBMED:15551095]
[PUBMED:17062879]
[PUBMED:17211469]
[PUBMED:11720739]
[PUBMED:12588368]
[PUBMED:11057895]
[PUBMED:9422516]
[PUBMED:12894244]
[PUBMED:15479695]
[PUBMED:16189154]
[PUBMED:12878745]
[PUBMED:11900250]
[PUBMED:11103787]
[PUBMED:15122209]
[PUBMED:12711111]
[PUBMED:12243753]
[PUBMED:16306523]
[PUBMED:16702400]
[PUBMED:15270885]
[PUBMED:14685170]
[PUBMED:14586404]
[PUBMED:11078609]
[PUBMED:15284264]
[PUBMED:10505543]
[PUBMED:11223406]
[PUBMED:14982876]
[PUBMED:12648469]
[PUBMED:12867060]
[PUBMED:15711891]
[PUBMED:12094241]
[PUBMED:16642045]
[PUBMED:11463388]
[PUBMED:12762887]
[PUBMED:15746962]
[PUBMED:15823750]
[PUBMED:16750612]
[PUBMED:16484590]
[PUBMED:11459867]
[PUBMED:16146838]
[PUBMED:14556242]
[PUBMED:15947972]
[PUBMED:12563308]
[PUBMED:16946003]
[PUBMED:15948971]
[PUBMED:11407945]
[PUBMED:12737309]
[PUBMED:16095998]
[PUBMED:12351585]
[PUBMED:24508914]
[PUBMED:12084351]
[PUBMED:11807782]
[PUBMED:14695152]
[PUBMED:10453277]
[PUBMED:17554387]
[PUBMED:15841168]
[PUBMED:12616528]
[PUBMED:10403855]
[PUBMED:16054233]
[PUBMED:16474624]
[PUBMED:16822996]
[PUBMED:17028294]
[PUBMED:11224709]
[PUBMED:11750244]
[PUBMED:11905738]
[PUBMED:15719031]
[PUBMED:10843728]
[PUBMED:16110317]
[PUBMED:11721960]
[PUBMED:12741677]
[PUBMED:7585656]
[PUBMED:12801837]
[PUBMED:16551847]
[PUBMED:12459728]
[PUBMED:11431710]
[PUBMED:12468433]
[PUBMED:11165748]
[PUBMED:16042571]
[PUBMED:16508724]
[PUBMED:15000146]
[PUBMED:17149381]
[PUBMED:15948711]
[PUBMED:14747944]
[PUBMED:14737121]
[PUBMED:12379883]
[PUBMED:17158541]
[PUBMED:12850530]
[PUBMED:10835690]
[PUBMED:16870043]
Platinum drug resistance
[NCBI:1404797]
[KEGG:hsa01524]
[PUBMED:24074238]
[PUBMED:26867799]
[PUBMED:14609433]
[PUBMED:26184483]
[PUBMED:24874729]
[PUBMED:15607932]
[PUBMED:25546083]
[PUBMED:25058905]
[PUBMED:19190080]
[PUBMED:14576837]
[PUBMED:20811617]
[PUBMED:21892204]
[PUBMED:20647037]
[PUBMED:17336087]
[PUBMED:26886018]
[PUBMED:23442359]
[PUBMED:17625587]
Post-translational protein modification
[NCBI:1268701]
[REACTOME:R-HSA-597592]
Programmed Cell Death
[NCBI:1270261]
[REACTOME:R-HSA-5357801]
[PUBMED:25236395]
RIPK1-mediated regulated necrosis
[NCBI:1270299]
[REACTOME:R-HSA-5213460]
[PUBMED:24773756]
[PUBMED:24452471]
Regulated Necrosis
[NCBI:1270298]
[REACTOME:R-HSA-5218859]
[PUBMED:23770045]
[PUBMED:24563506]
[PUBMED:24452471]
Regulation of TNFR1 signaling
[NCBI:1309094]
[REACTOME:R-HSA-5357905]
[PUBMED:22435550]
[PUBMED:11432772]
[PUBMED:12724336]
Regulation of necroptotic cell death
[NCBI:1270300]
[REACTOME:R-HSA-5675482]
[PUBMED:18570872]
[PUBMED:21737330]
[PUBMED:18621737]
[PUBMED:12110583]
[PUBMED:20218968]
[PUBMED:15701649]
Signal Transduction
[NCBI:1269379]
[REACTOME:R-HSA-162582]
[PUBMED:17604717]
[PUBMED:19648010]
[PUBMED:16260143]
[PUBMED:11742412]
[PUBMED:19536106]
[PUBMED:15863030]
[PUBMED:19379690]
[PUBMED:19458711]
[PUBMED:19935667]
[PUBMED:21252999]
[PUBMED:15520807]
[PUBMED:17496910]
[PUBMED:15450248]
[PUBMED:18043707]
[PUBMED:16939974]
[PUBMED:19762341]
[PUBMED:18483217]
[PUBMED:17084981]
[PUBMED:21781017]
[PUBMED:19619488]
Small cell lung cancer
[NCBI:83118]
[KEGG:hsa05222]
[PUBMED:12711111]
[PUBMED:11463388]
[PUBMED:12741677]
[PUBMED:11905738]
[PUBMED:11807782]
[PUBMED:12379883]
[PUBMED:12243753]
[PUBMED:12616528]
[PUBMED:11720739]
[PUBMED:15109562]
[PUBMED:12407699]
[PUBMED:10944551]
[PUBMED:16112428]
[PUBMED:11559746]
[PUBMED:16064138]
[PUBMED:11902573]
TNF receptor signaling pathway
[NCBI:138053]
[Pathway Interaction Database:tnfpathway]
[PUBMED:17024246]
[PUBMED:7923351]
[PUBMED:9774977]
[PUBMED:15258597]
[PUBMED:11429546]
[PUBMED:10848577]
[PUBMED:12917689]
[PUBMED:11031259]
[PUBMED:8974401]
[PUBMED:7758105]
[PUBMED:10510344]
[PUBMED:15793306]
[PUBMED:12391233]
[PUBMED:18450452]
[PUBMED:15218148]
[PUBMED:8692885]
[PUBMED:10026132]
[PUBMED:9275185]
[PUBMED:11684013]
[PUBMED:8521496]
[PUBMED:12917690]
[PUBMED:10795740]
[PUBMED:16603398]
[PUBMED:9405407]
[PUBMED:2158863]
[PUBMED:16260783]
[PUBMED:8808629]
[PUBMED:9034190]
[PUBMED:16543241]
[PUBMED:12077366]
[PUBMED:9384583]
[PUBMED:8612133]
[PUBMED:9712898]
[PUBMED:1313189]
[PUBMED:8069916]
[PUBMED:11907583]
[PUBMED:9639556]
[PUBMED:12917691]
[PUBMED:9115275]
[PUBMED:8681376]
[PUBMED:10356400]
[PUBMED:10801798]
[PUBMED:10097111]
[PUBMED:8565075]
[PUBMED:10187805]
[PUBMED:15357952]
[PUBMED:9915703]
[PUBMED:9564042]
[PUBMED:8943045]
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
[NCBI:1269330]
[REACTOME:R-HSA-5676594]
[PUBMED:18997794]
[PUBMED:21173796]
[PUBMED:22017430]
TNF signaling
[NCBI:1269646]
[REACTOME:R-HSA-75893]
[PUBMED:12040173]
TNF signaling pathway
[NCBI:812256]
[KEGG:hsa04668]
[PUBMED:20489699]
[PUBMED:14532286]
[PUBMED:21232019]
[PUBMED:11897488]
[PUBMED:22296764]
[PUBMED:10581243]
[PUBMED:23085193]
[PUBMED:23531747]
TNFR1-induced NFkappaB signaling pathway
[NCBI:1309092]
[REACTOME:R-HSA-5357956]
[PUBMED:16603398]
[PUBMED:17306544]
TNFR2 non-canonical NF-kB pathway
[NCBI:1269329]
[REACTOME:R-HSA-5668541]
[PUBMED:19680262]
[PUBMED:24298274]
[PUBMED:21173796]
[PUBMED:20489699]
[PUBMED:24432023]
[PUBMED:21232019]
[PUBMED:22017430]
TRIF-mediated TLR3/TLR4 signaling
[NCBI:1269221]
[REACTOME:R-HSA-937061]
[PUBMED:15814722]
[PUBMED:12855817]
[PUBMED:14739303]
Toll Like Receptor 3 (TLR3) Cascade
[NCBI:1269219]
[REACTOME:R-HSA-168164]
[PUBMED:19627256]
[PUBMED:15733829]
[PUBMED:18202435]
Toll Like Receptor 4 (TLR4) Cascade
[NCBI:1269234]
[REACTOME:R-HSA-166016]
Toll-Like Receptors Cascades
[NCBI:1269204]
[REACTOME:R-HSA-168898]
[PUBMED:15950447]
[PUBMED:12893815]
[PUBMED:15976490]
[PUBMED:15585605]
[PUBMED:14751757]
Toxoplasmosis
[NCBI:169642]
[KEGG:hsa05145]
[PUBMED:18617274]
[PUBMED:19400868]
[PUBMED:17024357]
[PUBMED:19744886]
[PUBMED:19891610]
[PUBMED:17110955]
[PUBMED:12106793]
[PUBMED:12580944]
[PUBMED:12857995]
[PUBMED:10234174]
[PUBMED:18327664]
[PUBMED:10525166]
[PUBMED:18059289]
[PUBMED:18775432]
[PUBMED:14642303]
[PUBMED:15361242]
[PUBMED:16339966]
[PUBMED:14987366]
[PUBMED:15639739]
Ub-specific processing proteases
[NCBI:1427862]
[REACTOME:R-HSA-5689880]
[PUBMED:16325574]
Ubiquitin mediated proteolysis
[NCBI:83056]
[KEGG:hsa04120]
[PUBMED:16405856]
[PUBMED:12944364]
[PUBMED:16922408]
[PUBMED:17588513]
[PUBMED:16922367]
[PUBMED:16922370]
[PUBMED:16816840]