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Genes
CASP1
Gene - CASP1
full name
caspase 1
synonyms
ICE, IL1BC, P45, CASP1, ENSG00000137752
HGNC
HGNC:1499
Entrez Gene
Gene:834
ENSEMBL
ENSG00000137752
location
chr: 11
start: 104896235
stop: 104905884
strand: -
transcripts
NM_033295.3
NM_033294.3
NM_033293.3
NM_001223.4
NM_001257119.1
NM_033292.3
NM_001257118.1
pathways
Amyotrophic lateral sclerosis (ALS)
[NCBI:83099]
[KEGG:hsa05014]
[PUBMED:16026864]
[PUBMED:16924260]
[PUBMED:11513882]
[PUBMED:17015226]
[PUBMED:16723044]
[PUBMED:10970056]
[PUBMED:16909020]
[PUBMED:12531867]
[PUBMED:16713195]
[PUBMED:16603792]
[PUBMED:11870681]
[PUBMED:16050975]
[PUBMED:17409386]
[PUBMED:11239414]
[PUBMED:18519638]
[PUBMED:14569202]
[PUBMED:12728264]
[PUBMED:11715057]
[PUBMED:17566607]
[PUBMED:17434459]
[PUBMED:16909017]
[PUBMED:12595144]
[PUBMED:15310460]
[PUBMED:14739060]
Caspase cascade in apoptosis
[NCBI:137974]
[Pathway Interaction Database:caspase_pathway]
[PUBMED:7774019]
[PUBMED:8626669]
[PUBMED:9850096]
[PUBMED:11803376]
[PUBMED:15189451]
[PUBMED:10564664]
[PUBMED:9642276]
[PUBMED:10567584]
[PUBMED:12419244]
[PUBMED:11423904]
[PUBMED:9422506]
[PUBMED:11438643]
[PUBMED:9070648]
[PUBMED:9588194]
[PUBMED:11085743]
[PUBMED:9298992]
[PUBMED:9933635]
[PUBMED:9528810]
[PUBMED:9323209]
[PUBMED:10809769]
[PUBMED:8700869]
[PUBMED:9463409]
[PUBMED:10497198]
[PUBMED:11953316]
[PUBMED:9422513]
[PUBMED:10409650]
[PUBMED:11463840]
[PUBMED:10611247]
[PUBMED:8605870]
Cellular roles of Anthrax toxin
[NCBI:138076]
[Pathway Interaction Database:anthraxpathway]
[PUBMED:12202685]
[PUBMED:15031715]
[PUBMED:3123387]
[PUBMED:11700562]
[PUBMED:12700348]
[PUBMED:8051159]
[PUBMED:15772169]
[PUBMED:12867985]
[PUBMED:14688124]
[PUBMED:15659071]
[PUBMED:16473908]
[PUBMED:10080100]
[PUBMED:9703991]
[PUBMED:12724519]
[PUBMED:10580119]
[PUBMED:11790132]
[PUBMED:12468536]
[PUBMED:16401723]
[PUBMED:15010463]
[PUBMED:12724328]
[PUBMED:10338520]
[PUBMED:9563949]
[PUBMED:16429160]
[PUBMED:6285339]
[PUBMED:3917427]
[PUBMED:12488448]
[PUBMED:1438214]
[PUBMED:9234799]
[PUBMED:16254597]
[PUBMED:15814721]
[PUBMED:16141341]
[PUBMED:1644824]
[PUBMED:16242117]
[PUBMED:16293226]
Cytokine Signaling in Immune system
[NCBI:1269310]
[REACTOME:R-HSA-1280215]
[PUBMED:12613569]
Cytosolic DNA-sensing pathway
[NCBI:125137]
[KEGG:hsa04623]
[PUBMED:18573338]
[PUBMED:19665965]
[PUBMED:19567913]
[PUBMED:18280611]
[PUBMED:18724932]
[PUBMED:19497760]
[PUBMED:16286919]
[PUBMED:19122387]
[PUBMED:19590578]
[PUBMED:23258413]
[PUBMED:18375758]
[PUBMED:19321146]
[PUBMED:19362700]
[PUBMED:18941233]
[PUBMED:19767723]
Direct p53 effectors
[NCBI:137939]
[Pathway Interaction Database:p53downstreampathway]
[PUBMED:7479001]
[PUBMED:19626115]
[PUBMED:10692390]
[PUBMED:15289308]
[PUBMED:14688482]
[PUBMED:16301995]
[PUBMED:11850816]
[PUBMED:12370809]
[PUBMED:16260627]
[PUBMED:15186775]
[PUBMED:15580302]
[PUBMED:10748162]
[PUBMED:10919640]
[PUBMED:19011621]
[PUBMED:12438652]
[PUBMED:11559530]
[PUBMED:11641774]
[PUBMED:11971958]
[PUBMED:9659898]
[PUBMED:9343394]
[PUBMED:10716435]
[PUBMED:17146433]
[PUBMED:17719542]
[PUBMED:17938176]
[PUBMED:17409421]
[PUBMED:11032029]
[PUBMED:15781865]
[PUBMED:11463392]
[PUBMED:9736732]
[PUBMED:17268548]
[PUBMED:8570655]
[PUBMED:18046411]
[PUBMED:12944906]
[PUBMED:16249378]
[PUBMED:15273740]
[PUBMED:15598651]
[PUBMED:10618379]
[PUBMED:15958553]
[PUBMED:17189187]
[PUBMED:17145718]
[PUBMED:11988847]
[PUBMED:8119988]
[PUBMED:12089322]
[PUBMED:16286009]
[PUBMED:12890671]
[PUBMED:12402042]
[PUBMED:10618714]
[PUBMED:14730312]
[PUBMED:12857899]
[PUBMED:14963330]
[PUBMED:11278953]
[PUBMED:11973653]
[PUBMED:12692263]
[PUBMED:10984493]
[PUBMED:10640990]
[PUBMED:11545734]
[PUBMED:16151013]
[PUBMED:12372430]
[PUBMED:16651407]
[PUBMED:9891062]
[PUBMED:12606722]
[PUBMED:12453409]
[PUBMED:15377670]
[PUBMED:12667443]
[PUBMED:17707234]
[PUBMED:9920903]
[PUBMED:14992722]
[PUBMED:15790310]
[PUBMED:15831478]
[PUBMED:11314010]
[PUBMED:10329733]
[PUBMED:17264218]
[PUBMED:11511362]
[PUBMED:11919562]
[PUBMED:11814693]
[PUBMED:17554199]
[PUBMED:18250150]
[PUBMED:10518217]
[PUBMED:10891498]
[PUBMED:10973264]
[PUBMED:15077116]
[PUBMED:16230375]
[PUBMED:18485870]
[PUBMED:7796420]
[PUBMED:15710382]
[PUBMED:17409411]
[PUBMED:8319905]
[PUBMED:10684646]
[PUBMED:7566179]
[PUBMED:8887630]
[PUBMED:11807984]
[PUBMED:9841917]
[PUBMED:12654245]
[PUBMED:9023107]
[PUBMED:15103385]
[PUBMED:11684014]
[PUBMED:17110336]
[PUBMED:11278253]
[PUBMED:14576823]
[PUBMED:8418500]
[PUBMED:11350971]
[PUBMED:11840333]
[PUBMED:7651818]
[PUBMED:7651386]
[PUBMED:15378026]
[PUBMED:15607964]
[PUBMED:11279192]
[PUBMED:10777218]
[PUBMED:15334053]
[PUBMED:12138177]
[PUBMED:9619826]
[PUBMED:16278683]
[PUBMED:17189186]
[PUBMED:16140933]
[PUBMED:10094469]
[PUBMED:9926927]
[PUBMED:17719541]
[PUBMED:15735003]
[PUBMED:12853982]
[PUBMED:14707288]
[PUBMED:10777207]
Gene Expression
[NCBI:1269649]
[REACTOME:R-HSA-74160]
Generic Transcription Pathway
[NCBI:1269650]
[REACTOME:R-HSA-212436]
[PUBMED:15175151]
[PUBMED:14744435]
[PUBMED:15680972]
[PUBMED:11395415]
[PUBMED:15896744]
[PUBMED:10235266]
[PUBMED:14986688]
[PUBMED:12023297]
[PUBMED:15680973]
[PUBMED:16751179]
[PUBMED:11861166]
[PUBMED:16429119]
[PUBMED:16719718]
[PUBMED:16921404]
[PUBMED:15690163]
IFN-gamma pathway
[NCBI:138040]
[Pathway Interaction Database:ifngpathway]
[PUBMED:9724754]
[PUBMED:10657627]
[PUBMED:10067896]
[PUBMED:9271410]
[PUBMED:8608598]
[PUBMED:15878863]
[PUBMED:11971965]
[PUBMED:11438544]
[PUBMED:15051500]
[PUBMED:17032168]
[PUBMED:11909529]
[PUBMED:11171987]
[PUBMED:7514165]
[PUBMED:12817007]
[PUBMED:8232552]
[PUBMED:10485906]
[PUBMED:8755534]
[PUBMED:10490100]
[PUBMED:8156998]
[PUBMED:11972023]
[PUBMED:8986769]
[PUBMED:12438563]
[PUBMED:10022928]
[PUBMED:12270932]
[PUBMED:7510216]
[PUBMED:15311277]
[PUBMED:14670297]
[PUBMED:12048245]
[PUBMED:10777554]
[PUBMED:12138178]
[PUBMED:9336467]
[PUBMED:7690989]
[PUBMED:1281555]
[PUBMED:17606919]
[PUBMED:10805787]
[PUBMED:12050152]
[PUBMED:8608597]
[PUBMED:15879117]
[PUBMED:12855578]
[PUBMED:10995751]
[PUBMED:10490099]
[PUBMED:7777519]
IL1-mediated signaling events
[NCBI:137944]
[Pathway Interaction Database:il1pathway]
[PUBMED:10854325]
[PUBMED:11287640]
[PUBMED:10747026]
[PUBMED:11960013]
[PUBMED:12150927]
[PUBMED:1837145]
[PUBMED:17197697]
[PUBMED:9374458]
[PUBMED:12721283]
[PUBMED:8035875]
[PUBMED:9261174]
[PUBMED:9734363]
[PUBMED:11460167]
[PUBMED:7878046]
[PUBMED:10373529]
[PUBMED:2530587]
[PUBMED:12538665]
[PUBMED:10882101]
[PUBMED:9360994]
[PUBMED:9062194]
[PUBMED:12242293]
[PUBMED:8837778]
[PUBMED:9430229]
[PUBMED:7775431]
Immune System
[NCBI:1269170]
[REACTOME:R-HSA-168256]
Inflammasomes
[NCBI:1269253]
[REACTOME:R-HSA-622312]
[PUBMED:20303873]
[PUBMED:19120479]
Influenza A
[NCBI:217173]
[KEGG:hsa05164]
[PUBMED:17267598]
[PUBMED:18049471]
[PUBMED:16882036]
[PUBMED:11907320]
[PUBMED:17944269]
[PUBMED:20629046]
[PUBMED:17072332]
[PUBMED:18588994]
[PUBMED:19864182]
[PUBMED:19290913]
[PUBMED:19420020]
[PUBMED:17213831]
[PUBMED:9060654]
[PUBMED:19481124]
[PUBMED:16494716]
[PUBMED:21147034]
[PUBMED:18980544]
[PUBMED:20020828]
[PUBMED:15502848]
[PUBMED:19782761]
Innate Immune System
[NCBI:1269203]
[REACTOME:R-HSA-168249]
Interleukin-1 processing
[NCBI:1269319]
[REACTOME:R-HSA-448706]
[PUBMED:17284521]
Legionellosis
[NCBI:469200]
[KEGG:hsa05134]
[PUBMED:19021631]
[PUBMED:19157961]
[PUBMED:20375353]
[PUBMED:19478083]
[PUBMED:18284575]
[PUBMED:19386084]
[PUBMED:19666608]
[PUBMED:15972519]
[PUBMED:18549456]
[PUBMED:1721820]
[PUBMED:17124169]
[PUBMED:19687203]
[PUBMED:18363881]
[PUBMED:19343209]
[PUBMED:20941588]
[PUBMED:16824952]
[PUBMED:18281405]
[PUBMED:18048909]
[PUBMED:16495539]
[PUBMED:12427954]
NOD-like receptor signaling pathway
[NCBI:122191]
[KEGG:hsa04621]
[PUBMED:25330206]
[PUBMED:21575908]
[PUBMED:23846113]
[PUBMED:26549800]
[PUBMED:16493424]
[PUBMED:23124073]
[PUBMED:24840700]
[PUBMED:27291964]
[PUBMED:27012466]
[PUBMED:24707857]
[PUBMED:19767725]
[PUBMED:25879280]
[PUBMED:23215645]
[PUBMED:22819539]
[PUBMED:23702978]
[PUBMED:20643110]
[PUBMED:25879288]
[PUBMED:26655628]
[PUBMED:25145756]
[PUBMED:24718315]
[PUBMED:26482951]
[PUBMED:25526305]
[PUBMED:26121197]
[PUBMED:22430786]
NOD1/2 Signaling Pathway
[NCBI:1269252]
[REACTOME:R-HSA-168638]
[PUBMED:18928408]
[PUBMED:18585455]
[PUBMED:18414735]
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
[NCBI:1269251]
[REACTOME:R-HSA-168643]
[PUBMED:18928408]
Pertussis
[NCBI:218111]
[KEGG:hsa05133]
[PUBMED:20610650]
[PUBMED:12701623]
[PUBMED:15201703]
[PUBMED:18401006]
[PUBMED:20210554]
[PUBMED:16622221]
[PUBMED:17148436]
[PUBMED:21204863]
[PUBMED:20404851]
[PUBMED:10540218]
[PUBMED:16999837]
[PUBMED:16481212]
[PUBMED:16863919]
[PUBMED:16390441]
[PUBMED:21423776]
[PUBMED:17328678]
[PUBMED:12915094]
Salmonella infection
[NCBI:375172]
[KEGG:hsa05132]
[PUBMED:18407067]
[PUBMED:18411289]
[PUBMED:18778407]
[PUBMED:20123714]
[PUBMED:20158475]
[PUBMED:19779561]
[PUBMED:18026123]
[PUBMED:19930040]
[PUBMED:12675800]
[PUBMED:11755407]
[PUBMED:11489966]
[PUBMED:19775254]
[PUBMED:20943123]
[PUBMED:17690885]
[PUBMED:16938850]
[PUBMED:20526845]
[PUBMED:11567004]
[PUBMED:17074883]
[PUBMED:11825778]
[PUBMED:17071592]
[PUBMED:16800847]
[PUBMED:16611232]
[PUBMED:10499590]
Signaling by Interleukins
[NCBI:1269318]
[REACTOME:R-HSA-449147]
[PUBMED:19302047]
[PUBMED:12445398]
TP53 Regulates Transcription of Caspase Activators and Caspases
[NCBI:1383069]
[REACTOME:R-HSA-6803207]
[PUBMED:15580302]
[PUBMED:14688482]
[PUBMED:10973264]
[PUBMED:11278253]
[PUBMED:12089322]
[PUBMED:11559530]
[PUBMED:17284521]
TP53 Regulates Transcription of Cell Death Genes
[NCBI:1383066]
[REACTOME:R-HSA-5633008]
[PUBMED:20353938]
[PUBMED:18676979]
[PUBMED:11511362]
[PUBMED:11919562]
[PUBMED:10973264]
[PUBMED:15797384]
[PUBMED:17442733]
[PUBMED:15607964]
[PUBMED:11278253]
[PUBMED:23059823]
[PUBMED:19549844]
[PUBMED:11684014]
[PUBMED:7566179]
[PUBMED:17349958]
[PUBMED:24739573]
[PUBMED:18719709]
[PUBMED:17284521]
[PUBMED:23703390]
[PUBMED:10807576]
[PUBMED:10733530]
[PUBMED:12402042]
[PUBMED:12851404]
[PUBMED:14729977]
[PUBMED:18431400]
[PUBMED:15377670]
[PUBMED:12089322]
[PUBMED:15273740]
[PUBMED:11382926]
[PUBMED:12606722]
[PUBMED:14623878]
[PUBMED:15577913]
[PUBMED:16230375]
[PUBMED:26122615]
[PUBMED:11559530]
[PUBMED:11054413]
[PUBMED:22766503]
[PUBMED:11463392]
[PUBMED:16249378]
[PUBMED:9326928]
[PUBMED:14614825]
[PUBMED:19615968]
[PUBMED:16140933]
[PUBMED:7834749]
[PUBMED:16135520]
[PUBMED:15126337]
[PUBMED:15580302]
[PUBMED:15289308]
[PUBMED:10777207]
[PUBMED:23365256]
[PUBMED:19040420]
[PUBMED:15735003]
[PUBMED:14688482]
The AIM2 inflammasome
[NCBI:1269257]
[REACTOME:R-HSA-844615]
[PUBMED:20303873]
The IPAF inflammasome
[NCBI:1269256]
[REACTOME:R-HSA-844623]
[PUBMED:20303873]
The NLRP3 inflammasome
[NCBI:1269254]
[REACTOME:R-HSA-844456]
[PUBMED:19501527]
[PUBMED:20303873]
Transcriptional Regulation by TP53
[NCBI:1269654]
[REACTOME:R-HSA-3700989]
[PUBMED:26122615]
[PUBMED:19410540]