full name
glutamate ionotropic receptor AMPA type subunit 4

synonyms
GluA4, GLUR4, GLUR4C, GLURD, GRIA4, ENSG00000152578

HGNC
HGNC:4574

Entrez Gene
Gene:2893

ENSEMBL
ENSG00000152578

location
chr: 11
start: 105480800
stop: 105852819
strand: +

OMIM
OMIM:138246: GRIA4
OMIM:617864: Neurodevelopmental disorder with or without seizures and gait abnormalities

transcripts
ENST00000393127.2
ENST00000282499.5
NM_001077244.1
NR_046356.1
NM_001112812.1

pathways
Activation of AMPA receptors [NCBI:1268797] [REACTOME:R-HSA-399710] [PUBMED:7973663] [PUBMED:17256974] [PUBMED:16723221]
Activation of NMDA receptor upon glutamate binding and postsynaptic events [NCBI:1268798] [REACTOME:R-HSA-442755] [PUBMED:18616423]
Amphetamine addiction [NCBI:547607] [KEGG:hsa05031] [PUBMED:16776597] [PUBMED:18617632] [PUBMED:16724157] [PUBMED:19222557] [PUBMED:14746512] [PUBMED:18632938] [PUBMED:8630246] [PUBMED:14622123] [PUBMED:21338876] [PUBMED:8753884] [PUBMED:10774721] [PUBMED:14529709] [PUBMED:17728700] [PUBMED:21989194] [PUBMED:16151049] [PUBMED:18440072] [PUBMED:19199083] [PUBMED:10414964]
Circadian entrainment [NCBI:698773] [KEGG:hsa04713] [PUBMED:15016477] [PUBMED:12700026] [PUBMED:20605968] [PUBMED:15813931] [PUBMED:15930378] [PUBMED:12573527] [PUBMED:17586087] [PUBMED:20664079] [PUBMED:17646042] [PUBMED:17167088] [PUBMED:16217123] [PUBMED:11294753] [PUBMED:19109992] [PUBMED:10446325] [PUBMED:10208575] [PUBMED:11086993] [PUBMED:19449447]
Dopaminergic synapse [NCBI:469199] [KEGG:hsa04728] [PUBMED:20727368] [PUBMED:10433257] [PUBMED:17408758] [PUBMED:15292232] [PUBMED:9457173] [PUBMED:17349698] [PUBMED:15521361] [PUBMED:18353279] [PUBMED:21303898] [PUBMED:19251795] [PUBMED:15381316] [PUBMED:15590733] [PUBMED:20224735] [PUBMED:19138563] [PUBMED:12967774]
Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity [NCBI:1268794] [REACTOME:R-HSA-399721] [PUBMED:16904750] [PUBMED:16713244] [PUBMED:19217372]
Glutamatergic synapse [NCBI:213818] [KEGG:hsa04724] [PUBMED:10481192] [PUBMED:11561058] [PUBMED:18425072] [PUBMED:17706608] [PUBMED:20055706] [PUBMED:19112153] [PUBMED:17663464] [PUBMED:19110202] [PUBMED:19559598] [PUBMED:9665875] [PUBMED:11672421] [PUBMED:18464791] [PUBMED:12399578] [PUBMED:14684436]
Neuroactive ligand-receptor interaction [NCBI:83053] [KEGG:hsa04080]
Neuronal System [NCBI:1268763] [REACTOME:R-HSA-112316]
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell [NCBI:1268786] [REACTOME:R-HSA-112314]
Nicotine addiction [NCBI:583255] [KEGG:hsa05033] [PUBMED:19498417] [PUBMED:15661626] [PUBMED:12436424] [PUBMED:19669944] [PUBMED:19434058] [PUBMED:19184650] [PUBMED:15165747] [PUBMED:12716925] [PUBMED:18723034] [PUBMED:18640919] [PUBMED:11906697] [PUBMED:14708004] [PUBMED:17009926] [PUBMED:14747518] [PUBMED:20485364] [PUBMED:16251989] [PUBMED:20833261]
Protein-protein interactions at synapses [NCBI:1427849] [REACTOME:R-HSA-6794362] [PUBMED:18923512] [PUBMED:16337696] [PUBMED:17299456]
Retrograde endocannabinoid signaling [NCBI:537443] [KEGG:hsa04723] [PUBMED:16085309] [PUBMED:18515270] [PUBMED:15340387] [PUBMED:17636069] [PUBMED:17553427] [PUBMED:17404373] [PUBMED:19640475] [PUBMED:21117095] [PUBMED:18084639] [PUBMED:21187849] [PUBMED:18801434] [PUBMED:14978245] [PUBMED:21531987] [PUBMED:19553483] [PUBMED:19126760] [PUBMED:17419048] [PUBMED:18948642] [PUBMED:16968947]
SALM protein interactions at the synapses [NCBI:1383059] [REACTOME:R-HSA-8849932] [PUBMED:22046028] [PUBMED:16630835] [PUBMED:21736948]
Trafficking of AMPA receptors [NCBI:1268795] [REACTOME:R-HSA-399719] [PUBMED:19217372]
Trafficking of GluR2-containing AMPA receptors [NCBI:1268796] [REACTOME:R-HSA-416993] [PUBMED:18547676]
Transmission across Chemical Synapses [NCBI:1268766] [REACTOME:R-HSA-112315]
Unblocking of NMDA receptor, glutamate binding and activation [NCBI:1268799] [REACTOME:R-HSA-438066] [PUBMED:9481670]
cAMP signaling pathway [NCBI:1017634] [KEGG:hsa04024] [PUBMED:10880354] [PUBMED:9204709] [PUBMED:21693691] [PUBMED:24062645] [PUBMED:24450633] [PUBMED:21346730] [PUBMED:24613710] [PUBMED:21744067] [PUBMED:22082266] [PUBMED:16460276] [PUBMED:18176800] [PUBMED:14715909] [PUBMED:7688165] [PUBMED:24281338] [PUBMED:11117527] [PUBMED:16765984] [PUBMED:18323530] [PUBMED:18064650] [PUBMED:21852968] [PUBMED:11493633] [PUBMED:21212391] [PUBMED:15142747] [PUBMED:17077866] [PUBMED:19460777] [PUBMED:19874988] [PUBMED:16571352] [PUBMED:22022314]