full name
apolipoprotein A1

synonyms
APOA1, ENSG00000118137

HGNC
HGNC:600

Entrez Gene
Gene:335

ENSEMBL
ENSG00000118137

location
chr: 11
start: 116706467
stop: 116708338
strand: -

OMIM
OMIM:107680: APOA1 (Autosomal dominant inheritance)
OMIM:105200: Amyloidosis, 3 or more types
OMIM:604091: Hypoalphalipoproteinemia

transcripts
NM_000039.1

pathways
ABC transporters in lipid homeostasis [NCBI:1269905] [REACTOME:R-HSA-1369062] [PUBMED:22366764] [PUBMED:21352852] [PUBMED:11229879] [PUBMED:21039332] [PUBMED:11048892]
ABC-family proteins mediated transport [NCBI:1269904] [REACTOME:R-HSA-382556] [PUBMED:11435397] [PUBMED:12045106] [PUBMED:19234479]
African trypanosomiasis [NCBI:194384] [KEGG:hsa05143] [PUBMED:9574925] [PUBMED:12088284] [PUBMED:19559585] [PUBMED:20398209] [PUBMED:17582444] [PUBMED:19168735] [PUBMED:19016378] [PUBMED:11850009] [PUBMED:16600243] [PUBMED:19995590] [PUBMED:19621073]
Amyloid fiber formation [NCBI:1269169] [REACTOME:R-HSA-977225] [PUBMED:16302959]
Binding and Uptake of Ligands by Scavenger Receptors [NCBI:1269897] [REACTOME:R-HSA-2173782] [PUBMED:16511968] [PUBMED:15904923] [PUBMED:218198] [PUBMED:19388903] [PUBMED:19659436]
Chylomicron-mediated lipid transport [NCBI:1270006] [REACTOME:R-HSA-174800]
FOXA2 and FOXA3 transcription factor networks [NCBI:137911] [Pathway Interaction Database:hnf3bpathway] [PUBMED:14500912] [PUBMED:9632808] [PUBMED:8668179] [PUBMED:2786140] [PUBMED:10748140] [PUBMED:8662915] [PUBMED:12865419] [PUBMED:12145169] [PUBMED:15314688] [PUBMED:12911579] [PUBMED:15123725] [PUBMED:16098831] [PUBMED:10455192] [PUBMED:15616563] [PUBMED:7524494] [PUBMED:7565696] [PUBMED:15959514] [PUBMED:11278466] [PUBMED:9369482] [PUBMED:8813720]
Fat digestion and absorption [NCBI:194385] [KEGG:hsa04975] [PUBMED:11504671] [PUBMED:15891388] [PUBMED:20522896] [PUBMED:10924713] [PUBMED:15286736] [PUBMED:12621063] [PUBMED:14976303] [PUBMED:19663632] [PUBMED:19280719] [PUBMED:18830418] [PUBMED:19116371] [PUBMED:17002594] [PUBMED:20148678] [PUBMED:20493784] [PUBMED:19158321] [PUBMED:17495606]
Fatty acid, triacylglycerol, and ketone body metabolism [NCBI:1270010] [REACTOME:R-HSA-535734]
HDL-mediated lipid transport [NCBI:1270007] [REACTOME:R-HSA-194223] [PUBMED:16968945] [PUBMED:14592845] [PUBMED:18460328] [PUBMED:10488948] [PUBMED:15738977]
Hemostasis [NCBI:1269340] [REACTOME:R-HSA-109582]
Lipid digestion, mobilization, and transport [NCBI:1270002] [REACTOME:R-HSA-73923]
Lipoprotein metabolism [NCBI:1270005] [REACTOME:R-HSA-174824]
Metabolism [NCBI:1269956] [REACTOME:R-HSA-1430728]
Metabolism of fat-soluble vitamins [NCBI:1339147] [REACTOME:R-HSA-6806667] [PUBMED:22516726] [PUBMED:15951480] [PUBMED:16011460]
Metabolism of lipids and lipoproteins [NCBI:1270001] [REACTOME:R-HSA-556833]
Metabolism of proteins [NCBI:1268677] [REACTOME:R-HSA-392499]
Metabolism of vitamins and cofactors [NCBI:1270144] [REACTOME:R-HSA-196854]
PPAR signaling pathway [NCBI:83042] [KEGG:hsa03320] [PUBMED:15673477] [PUBMED:15828221] [PUBMED:14999402] [PUBMED:15828222] [PUBMED:16601267] [PUBMED:15828220] [PUBMED:10529898] [PUBMED:15828223] [PUBMED:16476485] [PUBMED:11921433] [PUBMED:16511590] [PUBMED:16360030]
PPARA activates gene expression [NCBI:1270030] [REACTOME:R-HSA-1989781] [PUBMED:10529898] [PUBMED:18288277] [PUBMED:11330046] [PUBMED:20936127] [PUBMED:14999402]
Platelet activation, signaling and aggregation [NCBI:1269350] [REACTOME:R-HSA-76002] [PUBMED:16543958] [PUBMED:8704248] [PUBMED:2018971] [PUBMED:1672265] [PUBMED:17059469] [PUBMED:12681240] [PUBMED:12411949] [PUBMED:11511514]
Platelet degranulation [NCBI:1269367] [REACTOME:R-HSA-114608] [PUBMED:14630798]
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) [NCBI:1270029] [REACTOME:R-HSA-400206] [PUBMED:18288277] [PUBMED:10529898] [PUBMED:16476485] [PUBMED:16503871]
Response to elevated platelet cytosolic Ca2+ [NCBI:1269365] [REACTOME:R-HSA-76005] [PUBMED:8424766]
Retinoid metabolism and transport [NCBI:1269624] [REACTOME:R-HSA-975634] [PUBMED:16011460] [PUBMED:11340090]
Scavenging by Class A Receptors [NCBI:1269899] [REACTOME:R-HSA-3000480] [PUBMED:19120472] [PUBMED:11820786] [PUBMED:8429029] [PUBMED:2300208] [PUBMED:19388903]
Scavenging by Class B Receptors [NCBI:1269900] [REACTOME:R-HSA-3000471] [PUBMED:19388903] [PUBMED:16712941]
Scavenging of heme from plasma [NCBI:1269898] [REACTOME:R-HSA-2168880] [PUBMED:19659436] [PUBMED:19650691] [PUBMED:16511968] [PUBMED:12042069] [PUBMED:2485589] [PUBMED:11865982] [PUBMED:19659435]
Signal Transduction [NCBI:1269379] [REACTOME:R-HSA-162582] [PUBMED:17604717] [PUBMED:19648010] [PUBMED:16260143] [PUBMED:11742412] [PUBMED:19536106] [PUBMED:15863030] [PUBMED:19379690] [PUBMED:19458711] [PUBMED:19935667] [PUBMED:21252999] [PUBMED:15520807] [PUBMED:17496910] [PUBMED:15450248] [PUBMED:18043707] [PUBMED:16939974] [PUBMED:19762341] [PUBMED:18483217] [PUBMED:17084981] [PUBMED:21781017] [PUBMED:19619488]
Transmembrane transport of small molecules [NCBI:1269903] [REACTOME:R-HSA-382551]
Vesicle-mediated transport [NCBI:1269876] [REACTOME:R-HSA-5653656]
Visual phototransduction [NCBI:1269623] [REACTOME:R-HSA-2187338] [PUBMED:15384919] [PUBMED:22074928] [PUBMED:20188572] [PUBMED:21111842] [PUBMED:16688755] [PUBMED:8382952] [PUBMED:22658984] [PUBMED:20430952] [PUBMED:21350678] [PUBMED:22074927] [PUBMED:16011460] [PUBMED:11340090]
Vitamin digestion and absorption [NCBI:199556] [KEGG:hsa04977] [PUBMED:19173758] [PUBMED:16206251] [PUBMED:14977409] [PUBMED:14642860] [PUBMED:16688755] [PUBMED:19056639] [PUBMED:18841274] [PUBMED:20185591] [PUBMED:16462170] [PUBMED:20724488] [PUBMED:11340090] [PUBMED:11984580] [PUBMED:20166147]