full name
apolipoprotein A1
synonyms
APOA1, ENSG00000118137
HGNC
HGNC:600
Entrez Gene
Gene:335
ENSEMBL
ENSG00000118137
location
chr: 11
start: 116706467
stop: 116708338
strand: -
OMIM
OMIM:107680:
APOA1
(Autosomal dominant inheritance)
OMIM:105200:
Amyloidosis, 3 or more types
OMIM:618463:
ApoA-I and apoC-III deficiency, combined
OMIM:618463:
Hypoalphalipoproteinemia, primary, 2, with or without corneal clouding
transcripts
NM_000039.1
pathways
ABC transporters in lipid homeostasis
[NCBI:1269905]
[REACTOME:R-HSA-1369062]
[PUBMED:22366764]
[PUBMED:21352852]
[PUBMED:11229879]
[PUBMED:21039332]
[PUBMED:11048892]
ABC-family proteins mediated transport
[NCBI:1269904]
[REACTOME:R-HSA-382556]
[PUBMED:11435397]
[PUBMED:12045106]
[PUBMED:19234479]
African trypanosomiasis
[NCBI:194384]
[KEGG:hsa05143]
[PUBMED:9574925]
[PUBMED:12088284]
[PUBMED:19559585]
[PUBMED:20398209]
[PUBMED:17582444]
[PUBMED:19168735]
[PUBMED:19016378]
[PUBMED:11850009]
[PUBMED:16600243]
[PUBMED:19995590]
[PUBMED:19621073]
Amyloid fiber formation
[NCBI:1269169]
[REACTOME:R-HSA-977225]
[PUBMED:16302959]
Binding and Uptake of Ligands by Scavenger Receptors
[NCBI:1269897]
[REACTOME:R-HSA-2173782]
[PUBMED:16511968]
[PUBMED:15904923]
[PUBMED:218198]
[PUBMED:19388903]
[PUBMED:19659436]
Chylomicron-mediated lipid transport
[NCBI:1270006]
[REACTOME:R-HSA-174800]
FOXA2 and FOXA3 transcription factor networks
[NCBI:137911]
[Pathway Interaction Database:hnf3bpathway]
[PUBMED:14500912]
[PUBMED:9632808]
[PUBMED:8668179]
[PUBMED:2786140]
[PUBMED:10748140]
[PUBMED:8662915]
[PUBMED:12865419]
[PUBMED:12145169]
[PUBMED:15314688]
[PUBMED:12911579]
[PUBMED:15123725]
[PUBMED:16098831]
[PUBMED:10455192]
[PUBMED:15616563]
[PUBMED:7524494]
[PUBMED:7565696]
[PUBMED:15959514]
[PUBMED:11278466]
[PUBMED:9369482]
[PUBMED:8813720]
Fat digestion and absorption
[NCBI:194385]
[KEGG:hsa04975]
[PUBMED:11504671]
[PUBMED:15891388]
[PUBMED:20522896]
[PUBMED:10924713]
[PUBMED:15286736]
[PUBMED:12621063]
[PUBMED:14976303]
[PUBMED:19663632]
[PUBMED:19280719]
[PUBMED:18830418]
[PUBMED:19116371]
[PUBMED:17002594]
[PUBMED:20148678]
[PUBMED:20493784]
[PUBMED:19158321]
[PUBMED:17495606]
Fatty acid, triacylglycerol, and ketone body metabolism
[NCBI:1270010]
[REACTOME:R-HSA-535734]
HDL-mediated lipid transport
[NCBI:1270007]
[REACTOME:R-HSA-194223]
[PUBMED:16968945]
[PUBMED:14592845]
[PUBMED:18460328]
[PUBMED:10488948]
[PUBMED:15738977]
Hemostasis
[NCBI:1269340]
[REACTOME:R-HSA-109582]
Lipid digestion, mobilization, and transport
[NCBI:1270002]
[REACTOME:R-HSA-73923]
Lipoprotein metabolism
[NCBI:1270005]
[REACTOME:R-HSA-174824]
Metabolism
[NCBI:1269956]
[REACTOME:R-HSA-1430728]
Metabolism of fat-soluble vitamins
[NCBI:1339147]
[REACTOME:R-HSA-6806667]
[PUBMED:22516726]
[PUBMED:15951480]
[PUBMED:16011460]
Metabolism of lipids and lipoproteins
[NCBI:1270001]
[REACTOME:R-HSA-556833]
Metabolism of proteins
[NCBI:1268677]
[REACTOME:R-HSA-392499]
Metabolism of vitamins and cofactors
[NCBI:1270144]
[REACTOME:R-HSA-196854]
PPAR signaling pathway
[NCBI:83042]
[KEGG:hsa03320]
[PUBMED:15673477]
[PUBMED:15828221]
[PUBMED:14999402]
[PUBMED:15828222]
[PUBMED:16601267]
[PUBMED:15828220]
[PUBMED:10529898]
[PUBMED:15828223]
[PUBMED:16476485]
[PUBMED:11921433]
[PUBMED:16511590]
[PUBMED:16360030]
PPARA activates gene expression
[NCBI:1270030]
[REACTOME:R-HSA-1989781]
[PUBMED:10529898]
[PUBMED:18288277]
[PUBMED:11330046]
[PUBMED:20936127]
[PUBMED:14999402]
Platelet activation, signaling and aggregation
[NCBI:1269350]
[REACTOME:R-HSA-76002]
[PUBMED:16543958]
[PUBMED:8704248]
[PUBMED:2018971]
[PUBMED:1672265]
[PUBMED:17059469]
[PUBMED:12681240]
[PUBMED:12411949]
[PUBMED:11511514]
Platelet degranulation
[NCBI:1269367]
[REACTOME:R-HSA-114608]
[PUBMED:14630798]
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
[NCBI:1270029]
[REACTOME:R-HSA-400206]
[PUBMED:18288277]
[PUBMED:10529898]
[PUBMED:16476485]
[PUBMED:16503871]
Response to elevated platelet cytosolic Ca2+
[NCBI:1269365]
[REACTOME:R-HSA-76005]
[PUBMED:8424766]
Retinoid metabolism and transport
[NCBI:1269624]
[REACTOME:R-HSA-975634]
[PUBMED:16011460]
[PUBMED:11340090]
Scavenging by Class A Receptors
[NCBI:1269899]
[REACTOME:R-HSA-3000480]
[PUBMED:19120472]
[PUBMED:11820786]
[PUBMED:8429029]
[PUBMED:2300208]
[PUBMED:19388903]
Scavenging by Class B Receptors
[NCBI:1269900]
[REACTOME:R-HSA-3000471]
[PUBMED:19388903]
[PUBMED:16712941]
Scavenging of heme from plasma
[NCBI:1269898]
[REACTOME:R-HSA-2168880]
[PUBMED:19659436]
[PUBMED:19650691]
[PUBMED:16511968]
[PUBMED:12042069]
[PUBMED:2485589]
[PUBMED:11865982]
[PUBMED:19659435]
Signal Transduction
[NCBI:1269379]
[REACTOME:R-HSA-162582]
[PUBMED:17604717]
[PUBMED:19648010]
[PUBMED:16260143]
[PUBMED:11742412]
[PUBMED:19536106]
[PUBMED:15863030]
[PUBMED:19379690]
[PUBMED:19458711]
[PUBMED:19935667]
[PUBMED:21252999]
[PUBMED:15520807]
[PUBMED:17496910]
[PUBMED:15450248]
[PUBMED:18043707]
[PUBMED:16939974]
[PUBMED:19762341]
[PUBMED:18483217]
[PUBMED:17084981]
[PUBMED:21781017]
[PUBMED:19619488]
Transmembrane transport of small molecules
[NCBI:1269903]
[REACTOME:R-HSA-382551]
Vesicle-mediated transport
[NCBI:1269876]
[REACTOME:R-HSA-5653656]
Visual phototransduction
[NCBI:1269623]
[REACTOME:R-HSA-2187338]
[PUBMED:15384919]
[PUBMED:22074928]
[PUBMED:20188572]
[PUBMED:21111842]
[PUBMED:16688755]
[PUBMED:8382952]
[PUBMED:22658984]
[PUBMED:20430952]
[PUBMED:21350678]
[PUBMED:22074927]
[PUBMED:16011460]
[PUBMED:11340090]
Vitamin digestion and absorption
[NCBI:199556]
[KEGG:hsa04977]
[PUBMED:19173758]
[PUBMED:16206251]
[PUBMED:14977409]
[PUBMED:14642860]
[PUBMED:16688755]
[PUBMED:19056639]
[PUBMED:18841274]
[PUBMED:20185591]
[PUBMED:16462170]
[PUBMED:20724488]
[PUBMED:11340090]
[PUBMED:11984580]
[PUBMED:20166147]
