Home
About
Citations
Statistics
Download
Login
Home
Genes
CHEK1
Gene - CHEK1
full name
checkpoint kinase 1
synonyms
CHK1, CHEK1, ENSG00000149554
HGNC
HGNC:1925
Entrez Gene
Gene:1111
ENSEMBL
ENSG00000149554
location
chr: 11
start: 125495031
stop: 125546150
strand: +
transcripts
NM_001114121.2
NM_001114122.2
NM_001244846.1
NR_045204.1
NR_045205.1
NM_001274.5
pathways
Activation of ATR in response to replication stress
[NCBI:1269757]
[REACTOME:R-HSA-176187]
[PUBMED:12791985]
Cell Cycle
[NCBI:1269741]
[REACTOME:R-HSA-1640170]
Cell Cycle Checkpoints
[NCBI:1269742]
[REACTOME:R-HSA-69620]
Cell cycle
[NCBI:83054]
[KEGG:hsa04110]
[PUBMED:7973727]
[PUBMED:17568790]
[PUBMED:9832503]
[PUBMED:16936746]
[PUBMED:9029154]
[PUBMED:12573239]
[PUBMED:19020303]
[PUBMED:9618481]
[PUBMED:12809600]
[PUBMED:8242749]
[PUBMED:10385618]
[PUBMED:17426725]
[PUBMED:17018296]
[PUBMED:16212951]
[PUBMED:12925736]
[PUBMED:11099028]
[PUBMED:15568976]
[PUBMED:15838516]
[PUBMED:15838523]
[PUBMED:15876871]
[PUBMED:7908906]
[PUBMED:9889196]
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
[NCBI:1269755]
[REACTOME:R-HSA-75035]
Circadian rhythm pathway
[NCBI:137978]
[Pathway Interaction Database:circadianpathway]
[PUBMED:15560782]
[PUBMED:11875063]
[PUBMED:15798197]
[PUBMED:15860628]
[PUBMED:14712925]
[PUBMED:14750904]
DNA Double-Strand Break Repair
[NCBI:1309095]
[REACTOME:R-HSA-5693532]
[PUBMED:12897142]
[PUBMED:20965415]
DNA Repair
[NCBI:1270350]
[REACTOME:R-HSA-73894]
[PUBMED:10583946]
[PUBMED:23175119]
G1/S DNA Damage Checkpoints
[NCBI:1269743]
[REACTOME:R-HSA-69615]
G2/M Checkpoints
[NCBI:1269753]
[REACTOME:R-HSA-69481]
G2/M DNA damage checkpoint
[NCBI:1269754]
[REACTOME:R-HSA-69473]
Gene Expression
[NCBI:1269649]
[REACTOME:R-HSA-74160]
Generic Transcription Pathway
[NCBI:1269650]
[REACTOME:R-HSA-212436]
[PUBMED:15175151]
[PUBMED:14744435]
[PUBMED:15680972]
[PUBMED:11395415]
[PUBMED:15896744]
[PUBMED:10235266]
[PUBMED:14986688]
[PUBMED:12023297]
[PUBMED:15680973]
[PUBMED:16751179]
[PUBMED:11861166]
[PUBMED:16429119]
[PUBMED:16719718]
[PUBMED:16921404]
[PUBMED:15690163]
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)
[NCBI:1309100]
[REACTOME:R-HSA-5693567]
[PUBMED:20965415]
HDR through Homologous Recombination (HRR)
[NCBI:1309102]
[REACTOME:R-HSA-5685942]
[PUBMED:20965415]
HTLV-I infection
[NCBI:373901]
[KEGG:hsa05166]
[PUBMED:17446673]
[PUBMED:16436385]
[PUBMED:14686485]
[PUBMED:19861996]
[PUBMED:19092975]
[PUBMED:11325603]
[PUBMED:16155602]
[PUBMED:12910251]
[PUBMED:16155605]
[PUBMED:16036567]
[PUBMED:11244044]
[PUBMED:18702816]
[PUBMED:15569630]
[PUBMED:21114861]
[PUBMED:16155611]
[PUBMED:17384582]
[PUBMED:16155608]
[PUBMED:10602469]
[PUBMED:19014483]
[PUBMED:9325311]
Homologous DNA Pairing and Strand Exchange
[NCBI:1309103]
[REACTOME:R-HSA-5693579]
[PUBMED:9880493]
[PUBMED:17996710]
[PUBMED:12912992]
[PUBMED:19369211]
[PUBMED:19268590]
[PUBMED:17996711]
[PUBMED:24141787]
[PUBMED:20871615]
[PUBMED:20965415]
[PUBMED:20871616]
[PUBMED:23149936]
Homology Directed Repair
[NCBI:1309099]
[REACTOME:R-HSA-5693538]
[PUBMED:11242102]
[PUBMED:20965415]
[PUBMED:11376695]
[PUBMED:12427531]
Presynaptic phase of homologous DNA pairing and strand exchange
[NCBI:1309104]
[REACTOME:R-HSA-5693616]
[PUBMED:20729858]
[PUBMED:15665856]
[PUBMED:20729832]
[PUBMED:23149936]
[PUBMED:23810717]
[PUBMED:15703751]
[PUBMED:18317453]
[PUBMED:20729859]
[PUBMED:11751635]
Processing of DNA double-strand break ends
[NCBI:1309101]
[REACTOME:R-HSA-5693607]
[PUBMED:25122754]
[PUBMED:18171670]
[PUBMED:20965415]
[PUBMED:22231403]
[PUBMED:25558984]
[PUBMED:19357644]
[PUBMED:21325134]
[PUBMED:21240188]
[PUBMED:21659603]
[PUBMED:23468639]
[PUBMED:25659039]
Regulation of TP53 Activity
[NCBI:1383076]
[REACTOME:R-HSA-5633007]
[PUBMED:19450511]
[PUBMED:20457558]
[PUBMED:23825024]
[PUBMED:25641576]
Regulation of TP53 Activity through Phosphorylation
[NCBI:1383080]
[REACTOME:R-HSA-6804756]
[PUBMED:11780126]
[PUBMED:21317932]
[PUBMED:15866171]
[PUBMED:12393879]
[PUBMED:11740489]
[PUBMED:11447225]
[PUBMED:9733515]
[PUBMED:12851404]
[PUBMED:10884347]
[PUBMED:10710310]
[PUBMED:11239457]
[PUBMED:9925639]
[PUBMED:11546806]
[PUBMED:11551930]
[PUBMED:10570149]
[PUBMED:18490454]
[PUBMED:17591690]
[PUBMED:19965871]
[PUBMED:12064478]
[PUBMED:10673501]
[PUBMED:22611192]
[PUBMED:9843217]
[PUBMED:15053879]
[PUBMED:12914926]
[PUBMED:10673500]
[PUBMED:17349958]
[PUBMED:14702041]
[PUBMED:20959462]
[PUBMED:10435622]
[PUBMED:9733514]
Signal Transduction
[NCBI:1269379]
[REACTOME:R-HSA-162582]
[PUBMED:17604717]
[PUBMED:19648010]
[PUBMED:16260143]
[PUBMED:11742412]
[PUBMED:19536106]
[PUBMED:15863030]
[PUBMED:19379690]
[PUBMED:19458711]
[PUBMED:19935667]
[PUBMED:21252999]
[PUBMED:15520807]
[PUBMED:17496910]
[PUBMED:15450248]
[PUBMED:18043707]
[PUBMED:16939974]
[PUBMED:19762341]
[PUBMED:18483217]
[PUBMED:17084981]
[PUBMED:21781017]
[PUBMED:19619488]
Signaling by SCF-KIT
[NCBI:1269487]
[REACTOME:R-HSA-1433557]
[PUBMED:17350321]
[PUBMED:16483568]
[PUBMED:7688988]
[PUBMED:19540337]
[PUBMED:16475976]
[PUBMED:15526160]
TP53 Regulates Transcription of DNA Repair Genes
[NCBI:1383075]
[REACTOME:R-HSA-6796648]
[PUBMED:10984493]
[PUBMED:25712099]
[PUBMED:22988298]
[PUBMED:12771027]
[PUBMED:23139867]
[PUBMED:11971958]
[PUBMED:22012619]
[PUBMED:11988847]
[PUBMED:9858527]
[PUBMED:26773055]
[PUBMED:15781865]
[PUBMED:11350971]
[PUBMED:25429106]
[PUBMED:12170774]
[PUBMED:20096807]
[PUBMED:18187580]
[PUBMED:9063748]
[PUBMED:24662513]
Transcriptional Regulation by TP53
[NCBI:1269654]
[REACTOME:R-HSA-3700989]
[PUBMED:26122615]
[PUBMED:19410540]
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
[NCBI:1269752]
[REACTOME:R-HSA-69601]
[PUBMED:10828887]
Viral carcinogenesis
[NCBI:658418]
[KEGG:hsa05203]
[PUBMED:9990017]
[PUBMED:15173177]
[PUBMED:16036567]
[PUBMED:16581947]
[PUBMED:9060639]
[PUBMED:17457345]
[PUBMED:15956361]
[PUBMED:21421561]
[PUBMED:18391203]
[PUBMED:21040832]
[PUBMED:9837909]
[PUBMED:17645777]
[PUBMED:15967719]
[PUBMED:12686421]
[PUBMED:17049016]
[PUBMED:21152115]
[PUBMED:11160754]
[PUBMED:21966251]
[PUBMED:17979705]
[PUBMED:8617242]
[PUBMED:12925958]
[PUBMED:10873631]
[PUBMED:21250384]
[PUBMED:15614436]
[PUBMED:10354594]
[PUBMED:20494113]
[PUBMED:18702816]
[PUBMED:9651361]
[PUBMED:16459163]
[PUBMED:11278402]
[PUBMED:15510157]
[PUBMED:19956178]
[PUBMED:18251977]
[PUBMED:11766888]
[PUBMED:10824878]
[PUBMED:21372216]
[PUBMED:11244044]
[PUBMED:17894800]
[PUBMED:11905817]
[PUBMED:21347341]
[PUBMED:12186904]
[PUBMED:9374493]
[PUBMED:16352731]
[PUBMED:12770701]
[PUBMED:17384582]
[PUBMED:14506283]
[PUBMED:11091847]
[PUBMED:17267064]
[PUBMED:11886269]
[PUBMED:21177815]
[PUBMED:10400746]
[PUBMED:19156753]
[PUBMED:9882379]
[PUBMED:14559998]
[PUBMED:15767449]
[PUBMED:22110506]
[PUBMED:20534855]
[PUBMED:15542638]
[PUBMED:9343405]
[PUBMED:10405893]
[PUBMED:19400863]
[PUBMED:9349482]
[PUBMED:14747563]
[PUBMED:21647825]
[PUBMED:12970441]
[PUBMED:11669605]
[PUBMED:15795286]
[PUBMED:21994562]
[PUBMED:14530271]
[PUBMED:9594662]
[PUBMED:22566809]
[PUBMED:19651473]
[PUBMED:8756622]
[PUBMED:15105524]
[PUBMED:15452270]
[PUBMED:18948197]
[PUBMED:16760382]
[PUBMED:10793105]
[PUBMED:21084867]
[PUBMED:16308315]
[PUBMED:16155604]
[PUBMED:16381817]
[PUBMED:16828973]
[PUBMED:15342967]
[PUBMED:15692053]
[PUBMED:10855768]
[PUBMED:19078975]
[PUBMED:12379483]
[PUBMED:15310405]
[PUBMED:8223437]
[PUBMED:16939421]
[PUBMED:12910250]
[PUBMED:16039586]
[PUBMED:18201576]
[PUBMED:21102637]
[PUBMED:21743832]
[PUBMED:20592731]
[PUBMED:10644344]
[PUBMED:10074132]
[PUBMED:19715458]
[PUBMED:16155601]
[PUBMED:11604508]
[PUBMED:15919895]
[PUBMED:11099494]
[PUBMED:18385245]
[PUBMED:19854353]
[PUBMED:12101418]
p53 pathway
[NCBI:138067]
[Pathway Interaction Database:p53regulationpathway]
[PUBMED:9153395]
[PUBMED:15448695]
[PUBMED:10734067]
[PUBMED:11340074]
[PUBMED:15525938]
[PUBMED:17189186]
[PUBMED:18454141]
[PUBMED:11715018]
[PUBMED:9733514]
[PUBMED:12963717]
[PUBMED:15989956]
[PUBMED:10581258]
[PUBMED:18566590]
[PUBMED:15029243]
[PUBMED:14612427]
[PUBMED:19011621]
[PUBMED:12842086]
[PUBMED:16377624]
[PUBMED:17268548]
[PUBMED:16845383]
[PUBMED:17534149]
[PUBMED:12397361]
[PUBMED:11740489]
[PUBMED:12110584]
[PUBMED:11713287]
[PUBMED:17646389]
[PUBMED:14654783]
[PUBMED:9153396]
[PUBMED:18243116]
[PUBMED:10673501]
[PUBMED:17719542]
[PUBMED:11983168]
[PUBMED:12397362]
[PUBMED:17189187]
[PUBMED:16757976]
[PUBMED:12667443]
[PUBMED:9733515]
[PUBMED:9878046]
[PUBMED:9363941]
[PUBMED:11504915]
[PUBMED:11359766]
[PUBMED:9529248]
[PUBMED:17936559]
[PUBMED:15210108]
[PUBMED:17293853]
[PUBMED:16107876]
[PUBMED:9724636]
[PUBMED:17707234]
[PUBMED:10606744]
[PUBMED:11780126]
[PUBMED:10821866]
[PUBMED:18485870]
[PUBMED:17110336]
[PUBMED:11046142]
[PUBMED:11331603]
[PUBMED:19597489]
[PUBMED:16163388]
[PUBMED:14671306]
[PUBMED:17108971]
[PUBMED:15242646]
[PUBMED:15314173]
[PUBMED:12654245]
[PUBMED:15308643]
[PUBMED:9744860]
[PUBMED:17906639]
[PUBMED:9891054]
[PUBMED:17098746]
[PUBMED:17349958]
[PUBMED:11030628]
[PUBMED:15103385]
[PUBMED:14744935]
[PUBMED:9529249]
[PUBMED:11283254]
[PUBMED:11606419]
[PUBMED:11078726]
[PUBMED:10611322]
[PUBMED:9288740]
[PUBMED:11127820]
[PUBMED:19357310]
[PUBMED:9450543]
p53 signaling pathway
[NCBI:83055]
[KEGG:hsa04115]
[PUBMED:16557269]
[PUBMED:10714958]
[PUBMED:12505356]
[PUBMED:16915296]
[PUBMED:16697662]
[PUBMED:15116721]
[PUBMED:11313928]
[PUBMED:11747320]
[PUBMED:17409411]
[PUBMED:15838523]
p53-Independent DNA Damage Response
[NCBI:1269751]
[REACTOME:R-HSA-69610]
[PUBMED:11298456]
p53-Independent G1/S DNA damage checkpoint
[NCBI:1269750]
[REACTOME:R-HSA-69613]
[PUBMED:10827953]