full name
TIR domain containing adaptor protein

synonyms
BACTS1, Mal, MyD88-2, wyatt, TIRAP, ENSG00000150455

HGNC
HGNC:17192

Entrez Gene
Gene:114609

ENSEMBL
ENSG00000150455

location
chr: 11
start: 126152800
stop: 126164828
strand: +

OMIM
OMIM:606252: TIRAP
OMIM:614382: {Bacteremia, protection against}
OMIM:611162: {Malaria, protection against}
OMIM:610799: {Pneumococcal disease, invasive, protection against}
OMIM:607948: {Tuberculosis, protection against}

transcripts
NM_001039661.1
NM_148910.2

pathways
Activated TLR4 signalling [NCBI:1269236] [REACTOME:R-HSA-166054] [PUBMED:15276183] [PUBMED:15588429] [PUBMED:15845500] [PUBMED:15596121]
Adaptive Immune System [NCBI:1269171] [REACTOME:R-HSA-1280218] [PUBMED:16551257] [PUBMED:21682741] [PUBMED:11861602]
Antigen processing-Cross presentation [NCBI:1269195] [REACTOME:R-HSA-1236975] [PUBMED:17157489] [PUBMED:20171863] [PUBMED:16181333] [PUBMED:15761154] [PUBMED:16181335] [PUBMED:19218463]
Class I MHC mediated antigen processing & presentation [NCBI:1269192] [REACTOME:R-HSA-983169] [PUBMED:8717519] [PUBMED:17145306] [PUBMED:18926908] [PUBMED:17055423] [PUBMED:12495737] [PUBMED:18641646] [PUBMED:18243674]
Disease [NCBI:1268854] [REACTOME:R-HSA-1643685]
Diseases associated with the TLR signaling cascade [NCBI:1269157] [REACTOME:R-HSA-5602358] [PUBMED:23622315] [PUBMED:21734245] [PUBMED:22610250] [PUBMED:16176658]
Diseases of Immune System [NCBI:1269156] [REACTOME:R-HSA-5260271] [PUBMED:24795713] [PUBMED:22165913]
ER-Phagosome pathway [NCBI:1269197] [REACTOME:R-HSA-1236974] [PUBMED:16213220] [PUBMED:20171863] [PUBMED:14508490] [PUBMED:17027300] [PUBMED:14561893] [PUBMED:15845646] [PUBMED:22915823] [PUBMED:18006660] [PUBMED:14508489] [PUBMED:12151002] [PUBMED:15728715]
Hepatitis B [NCBI:694606] [KEGG:hsa05161] [PUBMED:19854353] [PUBMED:11604508] [PUBMED:11325602] [PUBMED:18931690] [PUBMED:16891440] [PUBMED:17158882] [PUBMED:11099494] [PUBMED:9325306] [PUBMED:18024894] [PUBMED:11483993] [PUBMED:15107488] [PUBMED:11278872] [PUBMED:21647825] [PUBMED:11287574] [PUBMED:18481805] [PUBMED:17188775] [PUBMED:19784739] [PUBMED:19263472] [PUBMED:16203685] [PUBMED:18605975] [PUBMED:10454581] [PUBMED:22504921] [PUBMED:21334391] [PUBMED:20657822] [PUBMED:18046710] [PUBMED:9843511] [PUBMED:15542625] [PUBMED:21618535] [PUBMED:15132991] [PUBMED:15173177] [PUBMED:12771941] [PUBMED:21994545] [PUBMED:8764004] [PUBMED:16459163] [PUBMED:9738022] [PUBMED:11821950] [PUBMED:12839924]
IRAK4 deficiency (TLR2/4) [NCBI:1269158] [REACTOME:R-HSA-5603041] [PUBMED:18669862] [PUBMED:12637671] [PUBMED:24316379] [PUBMED:15069402]
Immune System [NCBI:1269170] [REACTOME:R-HSA-168256]
Innate Immune System [NCBI:1269203] [REACTOME:R-HSA-168249]
MyD88 deficiency (TLR2/4) [NCBI:1269160] [REACTOME:R-HSA-5602498] [PUBMED:18669862] [PUBMED:24316379] [PUBMED:15069402]
MyD88:Mal cascade initiated on plasma membrane [NCBI:1269237] [REACTOME:R-HSA-166058] [PUBMED:15276183]
NF-kappa B signaling pathway [NCBI:634527] [KEGG:hsa04064] [PUBMED:22119011] [PUBMED:16264088] [PUBMED:21187855] [PUBMED:15546385] [PUBMED:17607554] [PUBMED:21135871] [PUBMED:16984817] [PUBMED:17047224] [PUBMED:19203223] [PUBMED:20300215] [PUBMED:14657271] [PUBMED:17431096] [PUBMED:15134788] [PUBMED:16356770] [PUBMED:21772278] [PUBMED:12654254] [PUBMED:22390971] [PUBMED:22017435] [PUBMED:17183360] [PUBMED:21173796] [PUBMED:15905862] [PUBMED:19302050] [PUBMED:17098202] [PUBMED:21872579] [PUBMED:22152226] [PUBMED:18613837] [PUBMED:19489733] [PUBMED:11875461] [PUBMED:19726767] [PUBMED:22017430] [PUBMED:21232019] [PUBMED:18832076]
Pertussis [NCBI:218111] [KEGG:hsa05133] [PUBMED:20610650] [PUBMED:12701623] [PUBMED:15201703] [PUBMED:18401006] [PUBMED:20210554] [PUBMED:16622221] [PUBMED:17148436] [PUBMED:21204863] [PUBMED:20404851] [PUBMED:10540218] [PUBMED:16999837] [PUBMED:16481212] [PUBMED:16863919] [PUBMED:16390441] [PUBMED:21423776] [PUBMED:17328678] [PUBMED:12915094]
Toll Like Receptor 2 (TLR2) Cascade [NCBI:1269238] [REACTOME:R-HSA-181438] [PUBMED:10820283]
Toll Like Receptor 4 (TLR4) Cascade [NCBI:1269234] [REACTOME:R-HSA-166016]
Toll Like Receptor TLR1:TLR2 Cascade [NCBI:1269239] [REACTOME:R-HSA-168179] [PUBMED:12975352]
Toll Like Receptor TLR6:TLR2 Cascade [NCBI:1269240] [REACTOME:R-HSA-168188] [PUBMED:14977973]
Toll-Like Receptors Cascades [NCBI:1269204] [REACTOME:R-HSA-168898] [PUBMED:15950447] [PUBMED:12893815] [PUBMED:15976490] [PUBMED:15585605] [PUBMED:14751757]
Toll-like receptor signaling pathway [NCBI:83076] [KEGG:hsa04620] [PUBMED:16924467] [PUBMED:17395581] [PUBMED:17637696] [PUBMED:12734364] [PUBMED:17507094] [PUBMED:14698224] [PUBMED:11101877] [PUBMED:16497588] [PUBMED:14751764] [PUBMED:17275323] [PUBMED:17457343] [PUBMED:16932750]
Tuberculosis [NCBI:213780] [KEGG:hsa05152] [PUBMED:20199890] [PUBMED:21274449] [PUBMED:17359235] [PUBMED:20415982] [PUBMED:18541216] [PUBMED:19369951] [PUBMED:15083155] [PUBMED:11378475] [PUBMED:15228522] [PUBMED:19634703] [PUBMED:21274433] [PUBMED:19563525] [PUBMED:18407066] [PUBMED:18288961] [PUBMED:16200082] [PUBMED:17785780] [PUBMED:11932234]