full name
alpha-2-macroglobulin

synonyms
A2MD, CPAMD5, FWP007, S863-7, A2M, ENSG00000175899

HGNC
HGNC:7

Entrez Gene
Gene:2

ENSEMBL
ENSG00000175899

location
chr: 12
start: 9220304
stop: 9268558
strand: -

OMIM
OMIM:103950: A2M
OMIM:104300: {Alzheimer disease, susceptibility to}

transcripts
ENST00000318602.7

pathways
Complement and coagulation cascades [NCBI:83073] [KEGG:hsa04610] [PUBMED:23564577] [PUBMED:25309880] [PUBMED:26082779] [PUBMED:23110467] [PUBMED:20027185] [PUBMED:25568220] [PUBMED:26324800] [PUBMED:25705421] [PUBMED:21811895] [PUBMED:23911436] [PUBMED:23564578] [PUBMED:24924409] [PUBMED:26489954] [PUBMED:17635716]
Degradation of the extracellular matrix [NCBI:1270257] [REACTOME:R-HSA-1474228] [PUBMED:21917992]
Extracellular matrix organization [NCBI:1270244] [REACTOME:R-HSA-1474244] [PUBMED:21123617] [PUBMED:21917992] [PUBMED:12845610]
Formation of Fibrin Clot (Clotting Cascade) [NCBI:1269368] [REACTOME:R-HSA-140877] [PUBMED:1931959] [PUBMED:12524220]
HDL-mediated lipid transport [NCBI:1270007] [REACTOME:R-HSA-194223] [PUBMED:16968945] [PUBMED:14592845] [PUBMED:18460328] [PUBMED:10488948] [PUBMED:15738977]
Hemostasis [NCBI:1269340] [REACTOME:R-HSA-109582]
IL6-mediated signaling events [NCBI:137932] [Pathway Interaction Database:il6_7pathway] [PUBMED:8559663] [PUBMED:8662591] [PUBMED:11689697] [PUBMED:11727828] [PUBMED:10383440] [PUBMED:10777583] [PUBMED:16774741] [PUBMED:12754507] [PUBMED:9295319] [PUBMED:15722452] [PUBMED:10859312] [PUBMED:9590172] [PUBMED:9880505] [PUBMED:12445202] [PUBMED:8134389] [PUBMED:10409724] [PUBMED:8164674] [PUBMED:8272872] [PUBMED:9794795] [PUBMED:7678052] [PUBMED:8511589] [PUBMED:8668165] [PUBMED:9724754] [PUBMED:8083235] [PUBMED:12754505] [PUBMED:8621622] [PUBMED:16254248] [PUBMED:12361954] [PUBMED:10605021] [PUBMED:9388184] [PUBMED:15935617] [PUBMED:11120832] [PUBMED:7875298] [PUBMED:9973404] [PUBMED:11335711] [PUBMED:9632795] [PUBMED:11468294] [PUBMED:7898939] [PUBMED:8626374] [PUBMED:8670868] [PUBMED:7537214] [PUBMED:15677447] [PUBMED:2261637] [PUBMED:9874564] [PUBMED:12829785] [PUBMED:8537375] [PUBMED:8272873] [PUBMED:7523403] [PUBMED:11251120] [PUBMED:9163525] [PUBMED:3136546] [PUBMED:10727406] [PUBMED:10023775] [PUBMED:12754506] [PUBMED:12456685] [PUBMED:2788034] [PUBMED:10446219] [PUBMED:15572665] [PUBMED:1662392] [PUBMED:15010462] [PUBMED:8140422] [PUBMED:8467812]
Intrinsic Pathway of Fibrin Clot Formation [NCBI:1269370] [REACTOME:R-HSA-140837] [PUBMED:1931959] [PUBMED:7598447] [PUBMED:12231555] [PUBMED:14691562]
Lipid digestion, mobilization, and transport [NCBI:1270002] [REACTOME:R-HSA-73923]
Lipoprotein metabolism [NCBI:1270005] [REACTOME:R-HSA-174824]
Metabolism [NCBI:1269956] [REACTOME:R-HSA-1430728]
Metabolism of lipids and lipoproteins [NCBI:1270001] [REACTOME:R-HSA-556833]
Platelet activation, signaling and aggregation [NCBI:1269350] [REACTOME:R-HSA-76002] [PUBMED:16543958] [PUBMED:8704248] [PUBMED:2018971] [PUBMED:1672265] [PUBMED:17059469] [PUBMED:12681240] [PUBMED:12411949] [PUBMED:11511514]
Platelet degranulation [NCBI:1269367] [REACTOME:R-HSA-114608] [PUBMED:14630798]
Response to elevated platelet cytosolic Ca2+ [NCBI:1269365] [REACTOME:R-HSA-76005] [PUBMED:8424766]
Rho GTPase cycle [NCBI:1269508] [REACTOME:R-HSA-194840] [PUBMED:17222083] [PUBMED:9308960]
Signal Transduction [NCBI:1269379] [REACTOME:R-HSA-162582] [PUBMED:17604717] [PUBMED:19648010] [PUBMED:16260143] [PUBMED:11742412] [PUBMED:19536106] [PUBMED:15863030] [PUBMED:19379690] [PUBMED:19458711] [PUBMED:19935667] [PUBMED:21252999] [PUBMED:15520807] [PUBMED:17496910] [PUBMED:15450248] [PUBMED:18043707] [PUBMED:16939974] [PUBMED:19762341] [PUBMED:18483217] [PUBMED:17084981] [PUBMED:21781017] [PUBMED:19619488]
Signaling by Rho GTPases [NCBI:1269507] [REACTOME:R-HSA-194315] [PUBMED:16212495] [PUBMED:15630019]