full name
LDL receptor related protein 6

synonyms
ADCAD2, LRP6, ENSG00000070018

HGNC
HGNC:6698

Entrez Gene
Gene:4040

ENSEMBL
ENSG00000070018

location
chr: 12
start: 12268959
stop: 12419811
strand: -

OMIM
OMIM:603507: LRP6
OMIM:616724: Tooth agenesis, selective, 7
OMIM:610947: {Coronary artery disease, autosomal dominant, 2}

transcripts
NM_002336.2

pathways
Breast cancer [NCBI:1435207] [KEGG:hsa05224] [PUBMED:24649067] [PUBMED:26040571] [PUBMED:11879567] [PUBMED:22722193] [PUBMED:26028978] [PUBMED:25013431] [PUBMED:11737884] [PUBMED:23702927] [PUBMED:21076461] [PUBMED:21898546] [PUBMED:27390604] [PUBMED:24291072] [PUBMED:26968398] [PUBMED:20087430] [PUBMED:23000897] [PUBMED:25544707] [PUBMED:24596345] [PUBMED:23988612] [PUBMED:24111892] [PUBMED:25907219] [PUBMED:15343273] [PUBMED:21965336] [PUBMED:23881035] [PUBMED:23196196] [PUBMED:22178455] [PUBMED:20436504] [PUBMED:19088017] [PUBMED:16113099] [PUBMED:20971825]
Canonical Wnt signaling pathway [NCBI:138032] [Pathway Interaction Database:wnt_canonical_pathway] [PUBMED:16849322] [PUBMED:10228155] [PUBMED:11007767] [PUBMED:10023673] [PUBMED:19061640] [PUBMED:10074433] [PUBMED:9554852] [PUBMED:10196136] [PUBMED:18772438] [PUBMED:19309792] [PUBMED:16263762] [PUBMED:16890161] [PUBMED:16341017] [PUBMED:17569865] [PUBMED:16314428] [PUBMED:17529994] [PUBMED:10421629] [PUBMED:11751573] [PUBMED:20177058] [PUBMED:15024404] [PUBMED:12000790] [PUBMED:19107203] [PUBMED:10684251] [PUBMED:9482734] [PUBMED:16547521] [PUBMED:10092233] [PUBMED:18077588] [PUBMED:16303557] [PUBMED:19556239] [PUBMED:19561074] [PUBMED:11274398] [PUBMED:14966280] [PUBMED:9566905] [PUBMED:11834740] [PUBMED:19801552] [PUBMED:12554650] [PUBMED:16341016] [PUBMED:17510365] [PUBMED:15459103] [PUBMED:18929646] [PUBMED:15327768] [PUBMED:9312064]
Disassembly of the destruction complex and recruitment of AXIN to the membrane [NCBI:1269601] [REACTOME:R-HSA-4641262] [PUBMED:10647780] [PUBMED:10581160] [PUBMED:14551908] [PUBMED:15084453] [PUBMED:19619488] [PUBMED:19759537] [PUBMED:14731402] [PUBMED:18234723] [PUBMED:15459103] [PUBMED:22363759] [PUBMED:17318175] [PUBMED:11336703] [PUBMED:16341017] [PUBMED:10421629] [PUBMED:17569865]
Disease [NCBI:1268854] [REACTOME:R-HSA-1643685]
Diseases of signal transduction [NCBI:1268855] [REACTOME:R-HSA-5663202] [PUBMED:12509752]
Negative regulation of TCF-dependent signaling by WNT ligand antagonists [NCBI:1269608] [REACTOME:R-HSA-3772470] [PUBMED:17143291] [PUBMED:11357136] [PUBMED:15908424] [PUBMED:18322270] [PUBMED:10347172] [PUBMED:12775774] [PUBMED:10383463] [PUBMED:11448771] [PUBMED:9450748]
Presenilin action in Notch and Wnt signaling [NCBI:137914] [Pathway Interaction Database:ps1pathway] [PUBMED:10391247] [PUBMED:11921277] [PUBMED:11357136] [PUBMED:15620650] [PUBMED:11739397] [PUBMED:15747065] [PUBMED:10359821] [PUBMED:15327768] [PUBMED:12554650] [PUBMED:15292388] [PUBMED:11266469] [PUBMED:12794186] [PUBMED:10882062] [PUBMED:8923452] [PUBMED:12050670] [PUBMED:10201374] [PUBMED:12857724] [PUBMED:9171444]
RNF mutants show enhanced WNT signaling and proliferation [NCBI:1268924] [REACTOME:R-HSA-5340588] [PUBMED:22575959] [PUBMED:23847203] [PUBMED:20495530] [PUBMED:22895187]
Regulation of FZD by ubiquitination [NCBI:1269607] [REACTOME:R-HSA-4641263] [PUBMED:17908284] [PUBMED:22575959] [PUBMED:23058807] [PUBMED:22965053] [PUBMED:20495530] [PUBMED:22617469]
Signal Transduction [NCBI:1269379] [REACTOME:R-HSA-162582] [PUBMED:17604717] [PUBMED:19648010] [PUBMED:16260143] [PUBMED:11742412] [PUBMED:19536106] [PUBMED:15863030] [PUBMED:19379690] [PUBMED:19458711] [PUBMED:19935667] [PUBMED:21252999] [PUBMED:15520807] [PUBMED:17496910] [PUBMED:15450248] [PUBMED:18043707] [PUBMED:16939974] [PUBMED:19762341] [PUBMED:18483217] [PUBMED:17084981] [PUBMED:21781017] [PUBMED:19619488]
Signaling by WNT in cancer [NCBI:1268906] [REACTOME:R-HSA-4791275] [PUBMED:7749328] [PUBMED:6318122] [PUBMED:22438566] [PUBMED:17510365] [PUBMED:10700176] [PUBMED:10733430] [PUBMED:17143297] [PUBMED:18311776] [PUBMED:11375957]
Signaling by Wnt [NCBI:1269594] [REACTOME:R-HSA-195721] [PUBMED:19530173] [PUBMED:23256519] [PUBMED:22952392] [PUBMED:19204114] [PUBMED:19365405] [PUBMED:19619488] [PUBMED:17143292] [PUBMED:17230199] [PUBMED:18710302] [PUBMED:16099039] [PUBMED:20576942] [PUBMED:10858654] [PUBMED:12967557]
TCF dependent signaling in response to WNT [NCBI:1269599] [REACTOME:R-HSA-201681] [PUBMED:19619488] [PUBMED:23256519] [PUBMED:23343194]
Wnt signaling network [NCBI:137962] [Pathway Interaction Database:wnt_signaling_pathway] [PUBMED:18505822] [PUBMED:18502762] [PUBMED:15908424] [PUBMED:18948417] [PUBMED:18667433] [PUBMED:10557084] [PUBMED:20053636] [PUBMED:18077588] [PUBMED:19379695] [PUBMED:18187455] [PUBMED:19910923] [PUBMED:17804805] [PUBMED:10395542] [PUBMED:16602827] [PUBMED:12839624] [PUBMED:17101698] [PUBMED:16880514] [PUBMED:17507554] [PUBMED:17276019] [PUBMED:19477926] [PUBMED:14731402] [PUBMED:9389482] [PUBMED:15923619] [PUBMED:17002572] [PUBMED:18606138] [PUBMED:20359476] [PUBMED:12857724] [PUBMED:11433302] [PUBMED:17117926] [PUBMED:20224554] [PUBMED:12050670] [PUBMED:12138115] [PUBMED:18615587] [PUBMED:18528331] [PUBMED:11448771] [PUBMED:12897152] [PUBMED:18505732] [PUBMED:19883499] [PUBMED:16890161] [PUBMED:11336703] [PUBMED:12527209] [PUBMED:18096705] [PUBMED:17569865] [PUBMED:11029007] [PUBMED:19038973] [PUBMED:15509575] [PUBMED:20093360] [PUBMED:15454084] [PUBMED:20215527] [PUBMED:11357136] [PUBMED:18606139] [PUBMED:20093472] [PUBMED:19755491] [PUBMED:12482967]
Wnt signaling pathway [NCBI:83061] [KEGG:hsa04310] [PUBMED:12446114] [PUBMED:14745971] [PUBMED:14530294] [PUBMED:15102436] [PUBMED:14635791] [PUBMED:19482104] [PUBMED:23256519] [PUBMED:12967557] [PUBMED:11433294] [PUBMED:18838381]
mTOR signaling pathway [NCBI:83059] [KEGG:hsa04150] [NCBI:138001] [Pathway Interaction Database:mtor_4pathway] [PUBMED:17277771] [PUBMED:15341740] [PUBMED:12172553] [PUBMED:15718470] [PUBMED:14651849] [PUBMED:15268862] [PUBMED:15306821] [PUBMED:26046644] [PUBMED:12869586] [PUBMED:24556838] [PUBMED:17928295] [PUBMED:9427642] [PUBMED:18046414] [PUBMED:12912918] [PUBMED:16286006] [PUBMED:26658722] [PUBMED:24842496] [PUBMED:23465396] [PUBMED:17709744] [PUBMED:17599906] [PUBMED:16919458] [PUBMED:10364159] [PUBMED:15342917] [PUBMED:11500364] [PUBMED:19812304] [PUBMED:12482958] [PUBMED:11729323] [PUBMED:16962653] [PUBMED:18952604] [PUBMED:9465032] [PUBMED:1496022] [PUBMED:10567431] [PUBMED:19114562] [PUBMED:17510057] [PUBMED:18604198] [PUBMED:15545625] [PUBMED:11914378] [PUBMED:17461779] [PUBMED:9445476] [PUBMED:18497260] [PUBMED:12604610] [PUBMED:15071500] [PUBMED:18925875] [PUBMED:12906785] [PUBMED:11287630] [PUBMED:15004009] [PUBMED:16756488] [PUBMED:17043309] [PUBMED:18198340] [PUBMED:12820960] [PUBMED:12747827] [PUBMED:17053147] [PUBMED:15851026] [PUBMED:15467718] [PUBMED:18762023] [PUBMED:25242279] [PUBMED:24698685] [PUBMED:11175345] [PUBMED:27304501] [PUBMED:18411301] [PUBMED:11500365] [PUBMED:17693255] [PUBMED:23694989] [PUBMED:12231510] [PUBMED:19446321] [PUBMED:11418588] [PUBMED:19258318] [PUBMED:18439900] [PUBMED:19225151] [PUBMED:26185979] [PUBMED:10357815] [PUBMED:26269525] [PUBMED:23421405] [PUBMED:9271440] [PUBMED:16915281] [PUBMED:17141160] [PUBMED:15249583] [PUBMED:12912989] [PUBMED:27027448] [PUBMED:18423201] [PUBMED:19211835] [PUBMED:9204908] [PUBMED:26700098] [PUBMED:18566587] [PUBMED:17386266]