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Genes
IRAK4
Gene - IRAK4
full name
interleukin 1 receptor associated kinase 4
synonyms
IPD1, IRAK-4, NY-REN-64, REN64, IRAK4, ENSG00000198001
HGNC
HGNC:17967
Entrez Gene
Gene:51135
ENSEMBL
ENSG00000198001
location
chr: 12
start: 44152747
stop: 44183346
strand: +
OMIM
OMIM:606883
: IRAK4
OMIM:607676
: Immunodeficiency 67
transcripts
NM_001114182.2
NM_001145256.1
NM_016123.3
NM_001145257.1
NM_001145258.1
pathways
Activated TLR4 signalling
[NCBI:1269236]
[REACTOME:R-HSA-166054]
[PUBMED:15276183]
[PUBMED:15588429]
[PUBMED:15845500]
[PUBMED:15596121]
Chagas disease (American trypanosomiasis)
[NCBI:147809]
[KEGG:hsa05142]
[PUBMED:12377585]
[PUBMED:9794425]
[PUBMED:1717552]
[PUBMED:16238097]
[PUBMED:10066513]
[PUBMED:12874238]
[PUBMED:12036740]
[PUBMED:15917295]
[PUBMED:12055254]
[PUBMED:17651955]
[PUBMED:1396957]
[PUBMED:16175174]
[PUBMED:2194668]
[PUBMED:9190942]
[PUBMED:12377942]
[PUBMED:12427093]
[PUBMED:10234174]
[PUBMED:16030288]
[PUBMED:15223603]
[PUBMED:17110955]
Cytokine Signaling in Immune system
[NCBI:1269310]
[REACTOME:R-HSA-1280215]
[PUBMED:12613569]
Disease
[NCBI:1268854]
[REACTOME:R-HSA-1643685]
Diseases associated with the TLR signaling cascade
[NCBI:1269157]
[REACTOME:R-HSA-5602358]
[PUBMED:23622315]
[PUBMED:21734245]
[PUBMED:22610250]
[PUBMED:16176658]
Diseases of Immune System
[NCBI:1269156]
[REACTOME:R-HSA-5260271]
[PUBMED:24795713]
[PUBMED:22165913]
IL1-mediated signaling events
[NCBI:137944]
[Pathway Interaction Database:il1pathway]
[PUBMED:10854325]
[PUBMED:11287640]
[PUBMED:10747026]
[PUBMED:11960013]
[PUBMED:12150927]
[PUBMED:1837145]
[PUBMED:17197697]
[PUBMED:9374458]
[PUBMED:12721283]
[PUBMED:8035875]
[PUBMED:9261174]
[PUBMED:9734363]
[PUBMED:11460167]
[PUBMED:7878046]
[PUBMED:10373529]
[PUBMED:2530587]
[PUBMED:12538665]
[PUBMED:10882101]
[PUBMED:9360994]
[PUBMED:9062194]
[PUBMED:12242293]
[PUBMED:8837778]
[PUBMED:9430229]
[PUBMED:7775431]
IRAK4 deficiency (TLR2/4)
[NCBI:1269158]
[REACTOME:R-HSA-5603041]
[PUBMED:18669862]
[PUBMED:12637671]
[PUBMED:24316379]
[PUBMED:15069402]
IRAK4 deficiency (TLR5)
[NCBI:1269159]
[REACTOME:R-HSA-5603037]
[PUBMED:24316379]
[PUBMED:12637671]
[PUBMED:17893200]
Immune System
[NCBI:1269170]
[REACTOME:R-HSA-168256]
Influenza A
[NCBI:217173]
[KEGG:hsa05164]
[PUBMED:17267598]
[PUBMED:18049471]
[PUBMED:16882036]
[PUBMED:11907320]
[PUBMED:17944269]
[PUBMED:20629046]
[PUBMED:17072332]
[PUBMED:18588994]
[PUBMED:19864182]
[PUBMED:19290913]
[PUBMED:19420020]
[PUBMED:17213831]
[PUBMED:9060654]
[PUBMED:19481124]
[PUBMED:16494716]
[PUBMED:21147034]
[PUBMED:18980544]
[PUBMED:20020828]
[PUBMED:15502848]
[PUBMED:19782761]
Innate Immune System
[NCBI:1269203]
[REACTOME:R-HSA-168249]
Interleukin-1 signaling
[NCBI:1269320]
[REACTOME:R-HSA-446652]
[PUBMED:19302047]
[PUBMED:19022706]
Leishmaniasis
[NCBI:144181]
[KEGG:hsa05140]
[PUBMED:11890722]
[PUBMED:7916951]
[PUBMED:10417174]
[PUBMED:11298294]
[PUBMED:10586030]
[PUBMED:15322192]
[PUBMED:15831826]
[PUBMED:11728310]
[PUBMED:15039466]
[PUBMED:10462516]
[PUBMED:10608501]
[PUBMED:15721837]
[PUBMED:15639739]
[PUBMED:14762510]
[PUBMED:18793215]
[PUBMED:7591091]
[PUBMED:12438359]
[PUBMED:18070909]
[PUBMED:17543969]
[PUBMED:15983048]
[PUBMED:16848789]
[PUBMED:10770277]
[PUBMED:9504340]
Measles
[NCBI:213306]
[KEGG:hsa05162]
[PUBMED:16237742]
[PUBMED:12804771]
[PUBMED:19198562]
[PUBMED:20376484]
[PUBMED:11385511]
[PUBMED:16963735]
[PUBMED:19198566]
[PUBMED:18922877]
[PUBMED:19203114]
[PUBMED:12620806]
[PUBMED:16690907]
[PUBMED:17720800]
[PUBMED:20636817]
[PUBMED:12410527]
[PUBMED:11582511]
[PUBMED:19203109]
[PUBMED:19203113]
[PUBMED:14585342]
[PUBMED:12805463]
MyD88 cascade initiated on plasma membrane
[NCBI:1269207]
[REACTOME:R-HSA-975871]
[PUBMED:15728506]
[PUBMED:16239509]
MyD88 deficiency (TLR2/4)
[NCBI:1269160]
[REACTOME:R-HSA-5602498]
[PUBMED:18669862]
[PUBMED:24316379]
[PUBMED:15069402]
MyD88 deficiency (TLR5)
[NCBI:1269161]
[REACTOME:R-HSA-5602680]
[PUBMED:18669862]
MyD88 dependent cascade initiated on endosome
[NCBI:1269228]
[REACTOME:R-HSA-975155]
[PUBMED:20237413]
[PUBMED:15276183]
[PUBMED:18652679]
MyD88:Mal cascade initiated on plasma membrane
[NCBI:1269237]
[REACTOME:R-HSA-166058]
[PUBMED:15276183]
NF-kappa B signaling pathway
[NCBI:634527]
[KEGG:hsa04064]
[PUBMED:22119011]
[PUBMED:16264088]
[PUBMED:21187855]
[PUBMED:15546385]
[PUBMED:17607554]
[PUBMED:21135871]
[PUBMED:16984817]
[PUBMED:17047224]
[PUBMED:19203223]
[PUBMED:20300215]
[PUBMED:14657271]
[PUBMED:17431096]
[PUBMED:15134788]
[PUBMED:16356770]
[PUBMED:21772278]
[PUBMED:12654254]
[PUBMED:22390971]
[PUBMED:22017435]
[PUBMED:17183360]
[PUBMED:21173796]
[PUBMED:15905862]
[PUBMED:19302050]
[PUBMED:17098202]
[PUBMED:21872579]
[PUBMED:22152226]
[PUBMED:18613837]
[PUBMED:19489733]
[PUBMED:11875461]
[PUBMED:19726767]
[PUBMED:22017430]
[PUBMED:21232019]
[PUBMED:18832076]
NOD-like receptor signaling pathway
[NCBI:122191]
[KEGG:hsa04621]
[PUBMED:25330206]
[PUBMED:21575908]
[PUBMED:23846113]
[PUBMED:26549800]
[PUBMED:16493424]
[PUBMED:23124073]
[PUBMED:24840700]
[PUBMED:27291964]
[PUBMED:27012466]
[PUBMED:24707857]
[PUBMED:19767725]
[PUBMED:25879280]
[PUBMED:23215645]
[PUBMED:22819539]
[PUBMED:23702978]
[PUBMED:20643110]
[PUBMED:25879288]
[PUBMED:26655628]
[PUBMED:25145756]
[PUBMED:24718315]
[PUBMED:26482951]
[PUBMED:25526305]
[PUBMED:26121197]
[PUBMED:22430786]
Neurotrophin signaling pathway
[NCBI:101143]
[KEGG:hsa04722]
[PUBMED:16699811]
[PUBMED:10812966]
[PUBMED:12676795]
[PUBMED:16939974]
[PUBMED:10851172]
[PUBMED:15499580]
[PUBMED:14704852]
[PUBMED:11399424]
[PUBMED:10764727]
[PUBMED:10985348]
[PUBMED:16856873]
[PUBMED:11529497]
Pertussis
[NCBI:218111]
[KEGG:hsa05133]
[PUBMED:20610650]
[PUBMED:12701623]
[PUBMED:15201703]
[PUBMED:18401006]
[PUBMED:20210554]
[PUBMED:16622221]
[PUBMED:17148436]
[PUBMED:21204863]
[PUBMED:20404851]
[PUBMED:10540218]
[PUBMED:16999837]
[PUBMED:16481212]
[PUBMED:16863919]
[PUBMED:16390441]
[PUBMED:21423776]
[PUBMED:17328678]
[PUBMED:12915094]
Signaling by Interleukins
[NCBI:1269318]
[REACTOME:R-HSA-449147]
[PUBMED:19302047]
[PUBMED:12445398]
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
[NCBI:1269232]
[REACTOME:R-HSA-975110]
[PUBMED:16214811]
[PUBMED:11070172]
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
[NCBI:1269229]
[REACTOME:R-HSA-975138]
[PUBMED:22511786]
[PUBMED:18794297]
Toll Like Receptor 10 (TLR10) Cascade
[NCBI:1269206]
[REACTOME:R-HSA-168142]
[PUBMED:15728506]
[PUBMED:18332149]
Toll Like Receptor 2 (TLR2) Cascade
[NCBI:1269238]
[REACTOME:R-HSA-181438]
[PUBMED:10820283]
Toll Like Receptor 4 (TLR4) Cascade
[NCBI:1269234]
[REACTOME:R-HSA-166016]
Toll Like Receptor 5 (TLR5) Cascade
[NCBI:1269226]
[REACTOME:R-HSA-168176]
[PUBMED:11489966]
[PUBMED:11323673]
Toll Like Receptor 7/8 (TLR7/8) Cascade
[NCBI:1269227]
[REACTOME:R-HSA-168181]
[PUBMED:14976262]
Toll Like Receptor 9 (TLR9) Cascade
[NCBI:1269233]
[REACTOME:R-HSA-168138]
[PUBMED:14751759]
Toll Like Receptor TLR1:TLR2 Cascade
[NCBI:1269239]
[REACTOME:R-HSA-168179]
[PUBMED:12975352]
Toll Like Receptor TLR6:TLR2 Cascade
[NCBI:1269240]
[REACTOME:R-HSA-168188]
[PUBMED:14977973]
Toll-Like Receptors Cascades
[NCBI:1269204]
[REACTOME:R-HSA-168898]
[PUBMED:15950447]
[PUBMED:12893815]
[PUBMED:15976490]
[PUBMED:15585605]
[PUBMED:14751757]
Toll-like receptor signaling pathway
[NCBI:83076]
[KEGG:hsa04620]
[PUBMED:16924467]
[PUBMED:17395581]
[PUBMED:17637696]
[PUBMED:12734364]
[PUBMED:17507094]
[PUBMED:14698224]
[PUBMED:11101877]
[PUBMED:16497588]
[PUBMED:14751764]
[PUBMED:17275323]
[PUBMED:17457343]
[PUBMED:16932750]
Toxoplasmosis
[NCBI:169642]
[KEGG:hsa05145]
[PUBMED:18617274]
[PUBMED:19400868]
[PUBMED:17024357]
[PUBMED:19744886]
[PUBMED:19891610]
[PUBMED:17110955]
[PUBMED:12106793]
[PUBMED:12580944]
[PUBMED:12857995]
[PUBMED:10234174]
[PUBMED:18327664]
[PUBMED:10525166]
[PUBMED:18059289]
[PUBMED:18775432]
[PUBMED:14642303]
[PUBMED:15361242]
[PUBMED:16339966]
[PUBMED:14987366]
[PUBMED:15639739]
Tuberculosis
[NCBI:213780]
[KEGG:hsa05152]
[PUBMED:20199890]
[PUBMED:21274449]
[PUBMED:17359235]
[PUBMED:20415982]
[PUBMED:18541216]
[PUBMED:19369951]
[PUBMED:15083155]
[PUBMED:11378475]
[PUBMED:15228522]
[PUBMED:19634703]
[PUBMED:21274433]
[PUBMED:19563525]
[PUBMED:18407066]
[PUBMED:18288961]
[PUBMED:16200082]
[PUBMED:17785780]
[PUBMED:11932234]