full name
Rho/Rac guanine nucleotide exchange factor 2

synonyms
GEF, GEF-H1, GEFH1, LFP40, P40, ARHGEF2, ENSG00000116584

HGNC
HGNC:682

Entrez Gene
Gene:9181

ENSEMBL
ENSG00000116584

location
chr: 1
start: 155916431
stop: 155953396
strand: -

OMIM
OMIM:607560: ARHGEF2
OMIM:617523: ?Neurodevelopmental disorder with midbrain and hindbrain malformations

transcripts
NM_001162384.1
NM_001162383.1
NM_004723.3

pathways
Cell death signalling via NRAGE, NRIF and NADE [NCBI:1269447] [REACTOME:R-HSA-204998] [PUBMED:12787561]
Fluid shear stress and atherosclerosis [NCBI:1474302] [KEGG:hsa05418] [PUBMED:23429585] [PUBMED:21050140] [PUBMED:17599600] [PUBMED:24190880] [PUBMED:22003002] [PUBMED:24876354] [PUBMED:24947523] [PUBMED:23899566] [PUBMED:26597822] [PUBMED:20353494] [PUBMED:22076424] [PUBMED:20538799] [PUBMED:25165867] [PUBMED:20032497] [PUBMED:23084990] [PUBMED:26822720] [PUBMED:24573382] [PUBMED:23555159] [PUBMED:26212910] [PUBMED:21457103] [PUBMED:19151844] [PUBMED:15388638] [PUBMED:16765337] [PUBMED:27027326] [PUBMED:25638487] [PUBMED:21733876]
G alpha (12/13) signalling events [NCBI:1269579] [REACTOME:R-HSA-416482] [PUBMED:18814923] [PUBMED:19212140]
GPCR downstream signaling [NCBI:1269574] [REACTOME:R-HSA-388396] [PUBMED:12040175]
NRAGE signals death through JNK [NCBI:1269448] [REACTOME:R-HSA-193648] [PUBMED:12376548]
Pathogenic Escherichia coli infection [NCBI:83103] [KEGG:hsa05130] [PUBMED:15318166] [PUBMED:15845459] [PUBMED:19144561] [PUBMED:15694854] [PUBMED:12101285] [PUBMED:15618137] [PUBMED:16582930] [PUBMED:15040260] [PUBMED:16448495]
Reelin signaling pathway [NCBI:137980] [Pathway Interaction Database:reelinpathway] [PUBMED:12526739] [PUBMED:12899622] [PUBMED:14517291] [PUBMED:10939329] [PUBMED:16148228] [PUBMED:15062102] [PUBMED:15987942] [PUBMED:15091337] [PUBMED:12376533] [PUBMED:10827199] [PUBMED:12882964] [PUBMED:15590913] [PUBMED:14724251] [PUBMED:15361067] [PUBMED:14578885]
Regulation of RAC1 activity [NCBI:169346] [Pathway Interaction Database:rac1_reg_pathway] [PUBMED:8297393] [PUBMED:12134164] [PUBMED:15485841] [PUBMED:11707441] [PUBMED:17320046] [PUBMED:9857026] [PUBMED:9497316] [PUBMED:17254573] [PUBMED:15850775] [PUBMED:8352776] [PUBMED:15128856] [PUBMED:17403664] [PUBMED:8491184] [PUBMED:7753201] [PUBMED:9707409] [PUBMED:12432077] [PUBMED:8226937] [PUBMED:19934221] [PUBMED:17196961] [PUBMED:17640372] [PUBMED:11287617] [PUBMED:12515821] [PUBMED:16943182] [PUBMED:19861492] [PUBMED:10220378] [PUBMED:11431473] [PUBMED:10982832] [PUBMED:7673236] [PUBMED:10744696] [PUBMED:17599059] [PUBMED:17116687] [PUBMED:12923183] [PUBMED:10364228] [PUBMED:16628218] [PUBMED:8288572] [PUBMED:15306850] [PUBMED:11396949] [PUBMED:8496137] [PUBMED:11912491] [PUBMED:15649357] [PUBMED:7980444] [PUBMED:18325335] [PUBMED:15242348] [PUBMED:11955434] [PUBMED:15039778] [PUBMED:11685227] [PUBMED:15897194] [PUBMED:11130063] [PUBMED:10559863] [PUBMED:17052214] [PUBMED:11099046] [PUBMED:15728722] [PUBMED:16520382] [PUBMED:16492808] [PUBMED:12547822] [PUBMED:12446789] [PUBMED:11274357] [PUBMED:8419353] [PUBMED:16481401] [PUBMED:8276860] [PUBMED:15005707] [PUBMED:10499589] [PUBMED:11336673] [PUBMED:1903516] [PUBMED:12829596] [PUBMED:17332503] [PUBMED:11146652] [PUBMED:12134158] [PUBMED:8643598] [PUBMED:18212043]
Regulation of RhoA activity [NCBI:138070] [Pathway Interaction Database:rhoa_reg_pathway] [PUBMED:10579713] [PUBMED:15039571] [PUBMED:19605563] [PUBMED:19755152] [PUBMED:16954208] [PUBMED:10744696] [PUBMED:17702745] [PUBMED:10837491] [PUBMED:12454018] [PUBMED:15023524] [PUBMED:11396949] [PUBMED:10523675] [PUBMED:10026210] [PUBMED:18948007] [PUBMED:16112081] [PUBMED:19713215] [PUBMED:9425278] [PUBMED:11085924] [PUBMED:9582072] [PUBMED:12071859] [PUBMED:19066281] [PUBMED:14512443] [PUBMED:18851832] [PUBMED:12775584] [PUBMED:15632174] [PUBMED:8356058] [PUBMED:1907371] [PUBMED:11058585] [PUBMED:9032261] [PUBMED:18211802] [PUBMED:12414125] [PUBMED:17971419] [PUBMED:19625450] [PUBMED:15069594] [PUBMED:12221096] [PUBMED:17804252] [PUBMED:8276860] [PUBMED:19635168] [PUBMED:8910315] [PUBMED:18096806] [PUBMED:12183458] [PUBMED:15601624] [PUBMED:9464532] [PUBMED:11336673] [PUBMED:16721066] [PUBMED:12215546] [PUBMED:15078817] [PUBMED:12196628] [PUBMED:11553710] [PUBMED:7479768] [PUBMED:8643598] [PUBMED:10699171] [PUBMED:9490638] [PUBMED:8491184] [PUBMED:8352776] [PUBMED:20018869] [PUBMED:12944407] [PUBMED:11804590] [PUBMED:8297393] [PUBMED:11672528] [PUBMED:15296756] [PUBMED:17488622] [PUBMED:9670022] [PUBMED:8537347] [PUBMED:19261619] [PUBMED:16896804] [PUBMED:11094164] [PUBMED:15691829] [PUBMED:19103606] [PUBMED:9641916]
Rho GTPase cycle [NCBI:1269508] [REACTOME:R-HSA-194840] [PUBMED:17222083] [PUBMED:9308960]
Signal Transduction [NCBI:1269379] [REACTOME:R-HSA-162582] [PUBMED:17604717] [PUBMED:19648010] [PUBMED:16260143] [PUBMED:11742412] [PUBMED:19536106] [PUBMED:15863030] [PUBMED:19379690] [PUBMED:19458711] [PUBMED:19935667] [PUBMED:21252999] [PUBMED:15520807] [PUBMED:17496910] [PUBMED:15450248] [PUBMED:18043707] [PUBMED:16939974] [PUBMED:19762341] [PUBMED:18483217] [PUBMED:17084981] [PUBMED:21781017] [PUBMED:19619488]
Signaling by GPCR [NCBI:1269543] [REACTOME:R-HSA-372790] [PUBMED:16902930] [PUBMED:10202136] [PUBMED:18043707]
Signaling by Rho GTPases [NCBI:1269507] [REACTOME:R-HSA-194315] [PUBMED:16212495] [PUBMED:15630019]
Signalling by NGF [NCBI:1269443] [REACTOME:R-HSA-166520]
Tight junction [NCBI:83071] [KEGG:hsa04530] [PUBMED:25152334] [PUBMED:16650994] [PUBMED:22892070] [PUBMED:18946474] [PUBMED:12042308] [PUBMED:23885123] [PUBMED:16771626] [PUBMED:17182900] [PUBMED:21283798] [PUBMED:25757376] [PUBMED:22928510] [PUBMED:22169974] [PUBMED:25469537] [PUBMED:24651541] [PUBMED:15820555] [PUBMED:17525755] [PUBMED:27353478] [PUBMED:17950242] [PUBMED:18005931] [PUBMED:24548561] [PUBMED:21781017] [PUBMED:20094051] [PUBMED:20134025] [PUBMED:22896795] [PUBMED:18094055] [PUBMED:25483301]
p75 NTR receptor-mediated signalling [NCBI:1269445] [REACTOME:R-HSA-193704] [PUBMED:16699811] [PUBMED:16939974] [PUBMED:12671646]