full name
lamin A/C

synonyms
CDCD1, CDDC, CMD1A, CMT2B1, EMD2, FPL, FPLD, FPLD2, HGPS, IDC, LDP1, LFP, LGMD1B, LMN1, LMNC, LMNL1, PRO1, LMNA, ENSG00000160789

HGNC
HGNC:6636

Entrez Gene
Gene:4000

ENSEMBL
ENSG00000160789

location
chr: 1
start: 156052369
stop: 156109880
strand: +

OMIM
OMIM:150330: LMNA (Autosomal dominant inheritance)
OMIM:115200: Cardiomyopathy, dilated, 1A
OMIM:605588: Charcot-Marie-Tooth disease, type 2B1
OMIM:181350: Emery-Dreifuss muscular dystrophy 2, AD
OMIM:616516: Emery-Dreifuss muscular dystrophy 3, AR
OMIM:610140: Heart-hand syndrome, Slovenian type
OMIM:176670: Hutchinson-Gilford progeria
OMIM:151660: Lipodystrophy, familial partial, type 2
OMIM:212112: Malouf syndrome
OMIM:248370: Mandibuloacral dysplasia
OMIM:613205: Muscular dystrophy, congenital
OMIM:159001: Muscular dystrophy, limb-girdle, type 1B
OMIM:275210: Restrictive dermopathy, lethal

transcripts
NR_047544.1
NM_170707.3
NM_170708.3
NM_005572.3
NM_001257374.1
NR_047545.1

pathways
Adipogenesis [NCBI:198832] [WikiPathways:WP236] [PUBMED:11031233]
Apoptosis [NCBI:83060] [KEGG:hsa04210] [NCBI:198797] [WikiPathways:WP254] [NCBI:1270262] [REACTOME:R-HSA-109581] [PUBMED:20533903] [PUBMED:17914240] [PUBMED:25526085] [PUBMED:22429822] [PUBMED:23070002] [PUBMED:24769728] [PUBMED:15601572] [PUBMED:21914490] [PUBMED:18023214] [PUBMED:12838338] [PUBMED:24278747] [PUBMED:15654015] [PUBMED:21145844] [PUBMED:12949498] [PUBMED:22465226] [PUBMED:14561771] [PUBMED:18238895] [PUBMED:14634621] [PUBMED:14737178] [PUBMED:4561027] [PUBMED:26231733] [PUBMED:9916983] [PUBMED:22075987] [PUBMED:20075940] [PUBMED:19770840] [PUBMED:12505355] [PUBMED:10618704] [PUBMED:12209154] [PUBMED:26615431] [PUBMED:11520933] [PUBMED:16397578] [PUBMED:15322527] [PUBMED:19148180] [PUBMED:23803157] [PUBMED:15719025] [PUBMED:12189384] [PUBMED:18208375] [PUBMED:15218528] [PUBMED:18304445] [PUBMED:9894605] [PUBMED:15725726]
Apoptotic cleavage of cellular proteins [NCBI:1270288] [REACTOME:R-HSA-111465] [PUBMED:17254298] [PUBMED:17599937] [PUBMED:12655297]
Apoptotic execution phase [NCBI:1270287] [REACTOME:R-HSA-75153] [PUBMED:12655297]
Arrhythmogenic right ventricular cardiomyopathy [NCBI:672454] [WikiPathways:WP2118]
Arrhythmogenic right ventricular cardiomyopathy (ARVC) [NCBI:117293] [KEGG:hsa05412] [PUBMED:16823481] [PUBMED:19205777] [PUBMED:11716909] [PUBMED:12270949] [PUBMED:18382419] [PUBMED:16101641] [PUBMED:17413274] [PUBMED:16124859]
Breakdown of the nuclear lamina [NCBI:1270291] [REACTOME:R-HSA-352238] [PUBMED:12655297]
Caspase cascade in apoptosis [NCBI:137974] [Pathway Interaction Database:caspase_pathway] [PUBMED:7774019] [PUBMED:12419244] [PUBMED:9850096] [PUBMED:9422506] [PUBMED:11803376] [PUBMED:15189451] [PUBMED:9642276] [PUBMED:10567584] [PUBMED:11423904] [PUBMED:9070648] [PUBMED:11438643] [PUBMED:9588194] [PUBMED:11085743] [PUBMED:9298992] [PUBMED:10809769] [PUBMED:9528810] [PUBMED:10409650] [PUBMED:9323209] [PUBMED:10497198] [PUBMED:9422513] [PUBMED:9463409] [PUBMED:8700869] [PUBMED:10611247] [PUBMED:11463840] [PUBMED:8626669] [PUBMED:10564664] [PUBMED:9933635] [PUBMED:11953316] [PUBMED:8605870]
Cell Cycle [NCBI:1269741] [REACTOME:R-HSA-1640170]
Cell Cycle, Mitotic [NCBI:1269763] [REACTOME:R-HSA-69278]
Depolymerisation of the Nuclear Lamina [NCBI:1269819] [REACTOME:R-HSA-4419969] [PUBMED:23212477] [PUBMED:22134922] [PUBMED:2188730] [PUBMED:19494126] [PUBMED:21413788] [PUBMED:2188731] [PUBMED:8034666] [PUBMED:19494125] [PUBMED:8463284] [PUBMED:2344612] [PUBMED:22986494]
Dilated cardiomyopathy [NCBI:121494] [KEGG:hsa05414] [PUBMED:11524405] [PUBMED:11805847] [PUBMED:12270949] [PUBMED:15146239] [PUBMED:18672201] [PUBMED:14522402] [PUBMED:19017683] [PUBMED:19273156] [PUBMED:19246813] [PUBMED:11716909] [PUBMED:16817756]
FAS pathway and Stress induction of HSP regulation [NCBI:198894] [WikiPathways:WP314] [PUBMED:10914538]
Hypertrophic cardiomyopathy (HCM) [NCBI:114229] [KEGG:hsa05410] [PUBMED:18572189] [PUBMED:11805847] [PUBMED:14711353] [PUBMED:19136482] [PUBMED:18056765] [PUBMED:11225594] [PUBMED:10615904] [PUBMED:12844200] [PUBMED:11716909] [PUBMED:11371514] [PUBMED:12270949]
IRE1alpha activates chaperones [NCBI:1268759] [REACTOME:R-HSA-381070] [PUBMED:18038217] [PUBMED:18436705] [PUBMED:18048764]
Initiation of Nuclear Envelope Reformation [NCBI:1269828] [REACTOME:R-HSA-2995383] [PUBMED:18628300] [PUBMED:19234477]
M Phase [NCBI:1269810] [REACTOME:R-HSA-68886]
Meiosis [NCBI:1269865] [REACTOME:R-HSA-1500620] [PUBMED:20051984] [PUBMED:20364103] [PUBMED:16543383] [PUBMED:18948708]
Meiotic synapsis [NCBI:1269867] [REACTOME:R-HSA-1221632] [PUBMED:20364103] [PUBMED:18948708]
Metabolism of proteins [NCBI:1268677] [REACTOME:R-HSA-392499]
Mitotic Anaphase [NCBI:1269825] [REACTOME:R-HSA-68882]
Mitotic Metaphase and Anaphase [NCBI:1269823] [REACTOME:R-HSA-2555396]
Mitotic Prophase [NCBI:1269811] [REACTOME:R-HSA-68875]
Nuclear Envelope Breakdown [NCBI:1269815] [REACTOME:R-HSA-2980766] [PUBMED:19234477]
Nuclear Envelope Reassembly [NCBI:1269827] [REACTOME:R-HSA-2995410] [PUBMED:19234477]
Programmed Cell Death [NCBI:1270261] [REACTOME:R-HSA-5357801] [PUBMED:25236395]
Unfolded Protein Response (UPR) [NCBI:1268756] [REACTOME:R-HSA-381119] [PUBMED:18436705] [PUBMED:18038217] [PUBMED:16365312] [PUBMED:15952902] [PUBMED:18048764]
XBP1(S) activates chaperone genes [NCBI:1268760] [REACTOME:R-HSA-381038] [PUBMED:16461360] [PUBMED:14559994] [PUBMED:18664523] [PUBMED:16539657] [PUBMED:17612490]