full name
neurotrophic receptor tyrosine kinase 1
synonyms
MTC, p140-TrkA, TRK, Trk-A, TRK1, TRKA, NTRK1, ENSG00000198400
HGNC
HGNC:8031
Entrez Gene
Gene:4914
ENSEMBL
ENSG00000198400
location
chr: 1
start: 156785542
stop: 156851642
strand: +
OMIM
OMIM:191315:
NTRK1
(Autosomal recessive inheritance)
OMIM:256800:
Insensitivity to pain, congenital, with anhidrosis
OMIM:155240:
Medullary thyroid carcinoma, familial
transcripts
NM_001007792.1
NM_002529.3
NM_001012331.1
pathways
ARMS-mediated activation
[NCBI:1269471]
[REACTOME:R-HSA-170984]
[PUBMED:9069267]
Activation of TRKA receptors
[NCBI:1269461]
[REACTOME:R-HSA-187015]
[PUBMED:16939974]
Apoptosis
[NCBI:83060]
[KEGG:hsa04210]
[NCBI:1270262]
[REACTOME:R-HSA-109581]
[PUBMED:12189384]
[PUBMED:20533903]
[PUBMED:18208375]
[PUBMED:22429822]
[PUBMED:15218528]
[PUBMED:24769728]
[PUBMED:18023214]
[PUBMED:25526085]
[PUBMED:23070002]
[PUBMED:15654015]
[PUBMED:15601572]
[PUBMED:14561771]
[PUBMED:24278747]
[PUBMED:21914490]
[PUBMED:22465226]
[PUBMED:21145844]
[PUBMED:12838338]
[PUBMED:18238895]
[PUBMED:12949498]
[PUBMED:18304445]
[PUBMED:14737178]
[PUBMED:26231733]
[PUBMED:9916983]
[PUBMED:14634621]
[PUBMED:19770840]
[PUBMED:22075987]
[PUBMED:4561027]
[PUBMED:20075940]
[PUBMED:9894605]
[PUBMED:26615431]
[PUBMED:12505355]
[PUBMED:11520933]
[PUBMED:19148180]
[PUBMED:16397578]
[PUBMED:15719025]
[PUBMED:15322527]
[PUBMED:15725726]
[PUBMED:12209154]
[PUBMED:23803157]
Central carbon metabolism in cancer
[NCBI:1059538]
[KEGG:hsa05230]
[PUBMED:16982728]
[PUBMED:21127244]
[PUBMED:22349059]
[PUBMED:19270154]
[PUBMED:24113830]
[PUBMED:22156302]
[PUBMED:21801601]
[PUBMED:15916903]
[PUBMED:18177721]
[PUBMED:22237205]
[PUBMED:20520704]
[PUBMED:23018234]
[PUBMED:23897900]
[PUBMED:24398961]
[PUBMED:24079832]
[PUBMED:18538731]
[PUBMED:19460998]
[PUBMED:22307140]
[PUBMED:18766298]
[PUBMED:22101401]
[PUBMED:23071355]
[PUBMED:21508971]
[PUBMED:24738035]
[PUBMED:22750268]
[PUBMED:21258394]
[PUBMED:23279446]
[PUBMED:21340684]
Endocytosis
[NCBI:102279]
[KEGG:hsa04144]
[PUBMED:19696797]
[PUBMED:19007773]
[PUBMED:16203612]
[PUBMED:15687999]
[PUBMED:19924646]
[PUBMED:15261671]
[PUBMED:18647649]
[PUBMED:19325624]
[PUBMED:20110990]
[PUBMED:22193161]
Frs2-mediated activation
[NCBI:1269470]
[REACTOME:R-HSA-170968]
[PUBMED:9069267]
Inflammatory mediator regulation of TRP channels
[NCBI:948277]
[KEGG:hsa04750]
[PUBMED:21841075]
[PUBMED:15820689]
[PUBMED:16776582]
[PUBMED:12838328]
[PUBMED:17548207]
[PUBMED:16319926]
[PUBMED:18427980]
[PUBMED:20932256]
[PUBMED:18615141]
[PUBMED:17124270]
[PUBMED:17684094]
[PUBMED:22470230]
[PUBMED:19074743]
[PUBMED:23000387]
[PUBMED:24099085]
[PUBMED:17321113]
MAPK signaling pathway
[NCBI:83048]
[KEGG:hsa04010]
[PUBMED:11749383]
[PUBMED:12566928]
[PUBMED:12849693]
[PUBMED:12676795]
[PUBMED:12947395]
[PUBMED:14597384]
[PUBMED:11369511]
[PUBMED:12191611]
[PUBMED:12390245]
NGF signalling via TRKA from the plasma membrane
[NCBI:1269460]
[REACTOME:R-HSA-187037]
[PUBMED:11520933]
[PUBMED:12676795]
[PUBMED:10851172]
[PUBMED:10579918]
NGF-independant TRKA activation
[NCBI:1269463]
[REACTOME:R-HSA-187024]
[PUBMED:16805430]
Neurotrophic factor-mediated Trk receptor signaling
[NCBI:137977]
[Pathway Interaction Database:trkrpathway]
[PUBMED:1849459]
[PUBMED:8226808]
[PUBMED:11163269]
[PUBMED:7510697]
[PUBMED:11027277]
[PUBMED:15758069]
[PUBMED:11425862]
[PUBMED:11238898]
[PUBMED:11251075]
[PUBMED:8344249]
[PUBMED:9356464]
[PUBMED:11150291]
[PUBMED:10092678]
[PUBMED:1280261]
[PUBMED:11150334]
[PUBMED:11244088]
[PUBMED:10985348]
[PUBMED:15753086]
[PUBMED:1653651]
[PUBMED:11466412]
[PUBMED:15167895]
[PUBMED:1831195]
[PUBMED:10490030]
[PUBMED:8384556]
[PUBMED:16697063]
[PUBMED:17003042]
[PUBMED:15520226]
[PUBMED:15632082]
[PUBMED:16611639]
[PUBMED:16187212]
[PUBMED:9182757]
[PUBMED:1604323]
[PUBMED:16284401]
[PUBMED:8356095]
[PUBMED:10329710]
[PUBMED:9927421]
[PUBMED:9856458]
[PUBMED:10691301]
[PUBMED:1375038]
[PUBMED:10679771]
[PUBMED:15122257]
[PUBMED:15513915]
[PUBMED:16701206]
[PUBMED:1710174]
[PUBMED:8155326]
[PUBMED:8288573]
[PUBMED:7972023]
[PUBMED:7512734]
[PUBMED:10601297]
[PUBMED:16203995]
[PUBMED:12510192]
[PUBMED:16481401]
[PUBMED:8106527]
[PUBMED:11278445]
[PUBMED:9099755]
[PUBMED:1850821]
[PUBMED:9632781]
[PUBMED:10235685]
[PUBMED:15917464]
[PUBMED:9285826]
[PUBMED:12446789]
[PUBMED:7657612]
[PUBMED:1850549]
[PUBMED:12879077]
[PUBMED:16157584]
[PUBMED:10207144]
[PUBMED:12006576]
[PUBMED:8052307]
[PUBMED:8382740]
[PUBMED:10629055]
Neurotrophin signaling pathway
[NCBI:101143]
[KEGG:hsa04722]
[PUBMED:16699811]
[PUBMED:10812966]
[PUBMED:12676795]
[PUBMED:16939974]
[PUBMED:10851172]
[PUBMED:15499580]
[PUBMED:14704852]
[PUBMED:11399424]
[PUBMED:10764727]
[PUBMED:10985348]
[PUBMED:16856873]
[PUBMED:11529497]
PI3K/AKT activation
[NCBI:1269473]
[REACTOME:R-HSA-198203]
[PUBMED:10579926]
[PUBMED:12123609]
PLC-gamma1 signalling
[NCBI:1269472]
[REACTOME:R-HSA-167021]
[PUBMED:12676795]
[PUBMED:10579907]
Pathways in cancer
[NCBI:83105]
[KEGG:hsa05200]
[PUBMED:12244301]
[PUBMED:15156182]
[PUBMED:16899407]
[PUBMED:12621137]
[PUBMED:21193867]
[PUBMED:16001072]
[PUBMED:11707511]
[PUBMED:11253051]
[PUBMED:11071626]
[PUBMED:17251915]
[PUBMED:11736900]
[PUBMED:16557281]
[PUBMED:16699851]
[PUBMED:16189702]
[PUBMED:11902573]
[PUBMED:16555243]
[PUBMED:8069858]
[PUBMED:15310786]
[PUBMED:9834202]
[PUBMED:16700615]
[PUBMED:12545153]
[PUBMED:15656799]
[PUBMED:12154354]
[PUBMED:11895903]
[PUBMED:11527574]
[PUBMED:16326109]
[PUBMED:16339096]
[PUBMED:11160144]
[PUBMED:15724144]
[PUBMED:12951584]
[PUBMED:10647931]
[PUBMED:16881963]
[PUBMED:15557758]
[PUBMED:11477132]
[PUBMED:15721476]
[PUBMED:15625120]
[PUBMED:16236521]
[PUBMED:14967450]
[PUBMED:15942304]
[PUBMED:17287871]
[PUBMED:14634372]
[PUBMED:15573119]
[PUBMED:15009714]
[PUBMED:16112428]
[PUBMED:15611513]
[PUBMED:16001050]
[PUBMED:15349822]
[PUBMED:16551846]
[PUBMED:15978322]
[PUBMED:15774796]
[PUBMED:16352814]
[PUBMED:12951588]
[PUBMED:10944551]
[PUBMED:10740269]
[PUBMED:15639402]
[PUBMED:12407699]
[PUBMED:11130178]
[PUBMED:15109562]
[PUBMED:11170304]
[PUBMED:11276000]
[PUBMED:9643506]
[PUBMED:16248975]
[PUBMED:16242838]
[PUBMED:12946833]
[PUBMED:11559746]
[PUBMED:9196022]
[PUBMED:12079267]
[PUBMED:15468170]
[PUBMED:16064138]
[PUBMED:14580692]
[PUBMED:15082523]
[PUBMED:15551095]
[PUBMED:17062879]
[PUBMED:17211469]
[PUBMED:11720739]
[PUBMED:12588368]
[PUBMED:11057895]
[PUBMED:9422516]
[PUBMED:12894244]
[PUBMED:15479695]
[PUBMED:16189154]
[PUBMED:12878745]
[PUBMED:11900250]
[PUBMED:11103787]
[PUBMED:15122209]
[PUBMED:12711111]
[PUBMED:12243753]
[PUBMED:16306523]
[PUBMED:16702400]
[PUBMED:15270885]
[PUBMED:14685170]
[PUBMED:14586404]
[PUBMED:11078609]
[PUBMED:15284264]
[PUBMED:10505543]
[PUBMED:11223406]
[PUBMED:14982876]
[PUBMED:12648469]
[PUBMED:12867060]
[PUBMED:15711891]
[PUBMED:12094241]
[PUBMED:16642045]
[PUBMED:11463388]
[PUBMED:12762887]
[PUBMED:15746962]
[PUBMED:15823750]
[PUBMED:16750612]
[PUBMED:16484590]
[PUBMED:11459867]
[PUBMED:16146838]
[PUBMED:14556242]
[PUBMED:15947972]
[PUBMED:12563308]
[PUBMED:16946003]
[PUBMED:15948971]
[PUBMED:11407945]
[PUBMED:12737309]
[PUBMED:16095998]
[PUBMED:12351585]
[PUBMED:24508914]
[PUBMED:12084351]
[PUBMED:11807782]
[PUBMED:14695152]
[PUBMED:10453277]
[PUBMED:17554387]
[PUBMED:15841168]
[PUBMED:12616528]
[PUBMED:10403855]
[PUBMED:16054233]
[PUBMED:16474624]
[PUBMED:16822996]
[PUBMED:17028294]
[PUBMED:11224709]
[PUBMED:11750244]
[PUBMED:11905738]
[PUBMED:15719031]
[PUBMED:10843728]
[PUBMED:16110317]
[PUBMED:11721960]
[PUBMED:12741677]
[PUBMED:7585656]
[PUBMED:12801837]
[PUBMED:16551847]
[PUBMED:12459728]
[PUBMED:11431710]
[PUBMED:12468433]
[PUBMED:11165748]
[PUBMED:16042571]
[PUBMED:16508724]
[PUBMED:15000146]
[PUBMED:17149381]
[PUBMED:15948711]
[PUBMED:14747944]
[PUBMED:14737121]
[PUBMED:12379883]
[PUBMED:17158541]
[PUBMED:12850530]
[PUBMED:10835690]
[PUBMED:16870043]
Prolonged ERK activation events
[NCBI:1269469]
[REACTOME:R-HSA-169893]
[PUBMED:12765839]
[PUBMED:9069267]
Retrograde neurotrophin signalling
[NCBI:1269476]
[REACTOME:R-HSA-177504]
Signal Transduction
[NCBI:1269379]
[REACTOME:R-HSA-162582]
[PUBMED:17604717]
[PUBMED:19648010]
[PUBMED:16260143]
[PUBMED:11742412]
[PUBMED:19536106]
[PUBMED:15863030]
[PUBMED:19379690]
[PUBMED:19458711]
[PUBMED:19935667]
[PUBMED:21252999]
[PUBMED:15520807]
[PUBMED:17496910]
[PUBMED:15450248]
[PUBMED:18043707]
[PUBMED:16939974]
[PUBMED:19762341]
[PUBMED:18483217]
[PUBMED:17084981]
[PUBMED:21781017]
[PUBMED:19619488]
Signalling by NGF
[NCBI:1269443]
[REACTOME:R-HSA-166520]
Signalling to ERKs
[NCBI:1269464]
[REACTOME:R-HSA-187687]
[PUBMED:10508738]
Signalling to RAS
[NCBI:1269465]
[REACTOME:R-HSA-167044]
[PUBMED:11520933]
Signalling to STAT3
[NCBI:1269474]
[REACTOME:R-HSA-198745]
Signalling to p38 via RIT and RIN
[NCBI:1269468]
[REACTOME:R-HSA-187706]
[PUBMED:10712923]
TRKA activation by NGF
[NCBI:1269462]
[REACTOME:R-HSA-187042]
[PUBMED:1844238]
[PUBMED:1315923]
Thyroid cancer
[NCBI:83112]
[KEGG:hsa05216]
[PUBMED:16189702]
[PUBMED:17062879]
[PUBMED:16557281]
[PUBMED:16242838]
[PUBMED:12094241]
[PUBMED:16551846]
[PUBMED:16946003]
[PUBMED:11165748]
Transcriptional misregulation in cancer
[NCBI:523016]
[KEGG:hsa05202]
[PUBMED:17327229]
[PUBMED:20190806]
[PUBMED:20145147]
[PUBMED:11313274]
[PUBMED:11863357]
[PUBMED:19472090]
[PUBMED:18330902]
[PUBMED:19738075]
[PUBMED:15024077]
[PUBMED:12032780]
[PUBMED:14630078]
[PUBMED:21765642]
[PUBMED:19564705]
[PUBMED:17101797]
[PUBMED:15160934]
[PUBMED:15688424]
[PUBMED:15985538]
[PUBMED:12527902]
[PUBMED:12511414]
[PUBMED:11607818]
[PUBMED:17222504]
[PUBMED:15826838]
[PUBMED:21747944]
[PUBMED:19406209]
[PUBMED:10350329]
[PUBMED:21779514]
[PUBMED:18563191]
[PUBMED:16946003]
[PUBMED:17250957]
[PUBMED:12670461]
[PUBMED:12529654]
[PUBMED:18855877]
[PUBMED:17505060]
[PUBMED:20153925]
[PUBMED:20490326]
[PUBMED:12130514]
[PUBMED:18648544]
[PUBMED:19855079]
[PUBMED:10717473]
[PUBMED:20478527]
[PUBMED:11340171]
[PUBMED:16169901]
[PUBMED:14998494]
[PUBMED:19233641]
[PUBMED:19133982]
[PUBMED:12393465]
[PUBMED:19059936]
[PUBMED:18172298]
[PUBMED:10500199]
[PUBMED:19141473]
[PUBMED:10537274]
[PUBMED:15156184]
[PUBMED:14701735]
[PUBMED:19422821]
[PUBMED:21518926]
[PUBMED:18850010]
[PUBMED:19075677]
[PUBMED:18457914]
[PUBMED:12527906]
[PUBMED:15644444]
[PUBMED:10784387]
[PUBMED:17024155]
[PUBMED:19075268]
[PUBMED:15826834]
[PUBMED:21849159]
[PUBMED:21123453]
[PUBMED:20974671]
[PUBMED:20863376]