Logo
full name
neurotrophic receptor tyrosine kinase 1

synonyms
MTC, p140-TrkA, TRK, Trk-A, TRK1, TRKA, NTRK1, ENSG00000198400

HGNC
HGNC:8031

Entrez Gene
Gene:4914

ENSEMBL
ENSG00000198400

location
chr: 1
start: 156785542
stop: 156851642
strand: +

OMIM
OMIM:191315: NTRK1 (Autosomal recessive inheritance)
OMIM:256800: Insensitivity to pain, congenital, with anhidrosis
OMIM:155240: Medullary thyroid carcinoma, familial

transcripts
NM_001007792.1
NM_002529.3
NM_001012331.1

pathways
ARMS-mediated activation [NCBI:1269471] [REACTOME:R-HSA-170984] [PUBMED:9069267]
Activation of TRKA receptors [NCBI:1269461] [REACTOME:R-HSA-187015] [PUBMED:16939974]
Apoptosis [NCBI:83060] [KEGG:hsa04210] [NCBI:198797] [WikiPathways:WP254] [NCBI:1270262] [REACTOME:R-HSA-109581] [PUBMED:20533903] [PUBMED:17914240] [PUBMED:25526085] [PUBMED:22429822] [PUBMED:23070002] [PUBMED:24769728] [PUBMED:15601572] [PUBMED:21914490] [PUBMED:18023214] [PUBMED:12838338] [PUBMED:24278747] [PUBMED:15654015] [PUBMED:21145844] [PUBMED:12949498] [PUBMED:22465226] [PUBMED:14561771] [PUBMED:18238895] [PUBMED:14634621] [PUBMED:14737178] [PUBMED:4561027] [PUBMED:26231733] [PUBMED:9916983] [PUBMED:22075987] [PUBMED:20075940] [PUBMED:19770840] [PUBMED:12505355] [PUBMED:10618704] [PUBMED:12209154] [PUBMED:26615431] [PUBMED:11520933] [PUBMED:16397578] [PUBMED:15322527] [PUBMED:19148180] [PUBMED:23803157] [PUBMED:15719025] [PUBMED:12189384] [PUBMED:18208375] [PUBMED:15218528] [PUBMED:18304445] [PUBMED:9894605] [PUBMED:15725726]
BDNF signaling pathway [NCBI:712093] [WikiPathways:WP2380] [PUBMED:11980901] [PUBMED:8760293] [PUBMED:11922610] [PUBMED:18422784] [PUBMED:7780132] [PUBMED:11054408] [PUBMED:15504554] [PUBMED:12036856] [PUBMED:17658515] [PUBMED:11722433] [PUBMED:22809535] [PUBMED:20870899] [PUBMED:9070265] [PUBMED:9506832] [PUBMED:10979953] [PUBMED:9305885] [PUBMED:15701720] [PUBMED:8695859] [PUBMED:11204567] [PUBMED:15588513] [PUBMED:19261614] [PUBMED:10611229] [PUBMED:7589510] [PUBMED:10651727] [PUBMED:9711904] [PUBMED:10224114] [PUBMED:16123382] [PUBMED:9373250] [PUBMED:12855555] [PUBMED:11085749] [PUBMED:11750880] [PUBMED:10918061] [PUBMED:9257862] [PUBMED:18256550] [PUBMED:10460590] [PUBMED:21898686] [PUBMED:16368886] [PUBMED:18528423] [PUBMED:10415383] [PUBMED:22456226] [PUBMED:11784712] [PUBMED:11278373] [PUBMED:15673499] [PUBMED:14576181] [PUBMED:21304100] [PUBMED:18618018] [PUBMED:14687665] [PUBMED:10438715] [PUBMED:12495897] [PUBMED:19744539] [PUBMED:7795229] [PUBMED:9119889] [PUBMED:8632906] [PUBMED:11402314] [PUBMED:8843545] [PUBMED:21892137] [PUBMED:7545904] [PUBMED:19289146] [PUBMED:20576130] [PUBMED:18804163] [PUBMED:19888469] [PUBMED:8695851] [PUBMED:10419886] [PUBMED:19714753] [PUBMED:11238104] [PUBMED:11266445] [PUBMED:15705785] [PUBMED:16249382] [PUBMED:19038790] [PUBMED:15778351] [PUBMED:22514603] [PUBMED:9632812] [PUBMED:9446641] [PUBMED:9990315] [PUBMED:11861812] [PUBMED:20838657] [PUBMED:19619605] [PUBMED:11830463] [PUBMED:17244674] [PUBMED:8877093] [PUBMED:11418622] [PUBMED:9654143] [PUBMED:9111365] [PUBMED:21490406] [PUBMED:9396763] [PUBMED:15001470] [PUBMED:10477685] [PUBMED:11567993] [PUBMED:11376873] [PUBMED:15863506] [PUBMED:10090948] [PUBMED:21900501] [PUBMED:11429396] [PUBMED:18060035] [PUBMED:19631713] [PUBMED:11756417] [PUBMED:9120001] [PUBMED:8628315] [PUBMED:11110685] [PUBMED:11500082] [PUBMED:21630326] [PUBMED:15271795] [PUBMED:17021950] [PUBMED:10194437] [PUBMED:11389697] [PUBMED:10361118] [PUBMED:11535599] [PUBMED:9475764] [PUBMED:7649975] [PUBMED:22649382] [PUBMED:9002950] [PUBMED:10803464] [PUBMED:16418722] [PUBMED:18796624] [PUBMED:15671147] [PUBMED:11446731] [PUBMED:19996410] [PUBMED:20502002] [PUBMED:17284614] [PUBMED:9679986] [PUBMED:20586925] [PUBMED:12032335] [PUBMED:20335227] [PUBMED:8549784] [PUBMED:20976181] [PUBMED:10321988] [PUBMED:17827152] [PUBMED:18288130] [PUBMED:9108397] [PUBMED:18456388] [PUBMED:14617636] [PUBMED:10681535] [PUBMED:11934880] [PUBMED:7488109] [PUBMED:17925492] [PUBMED:15642952] [PUBMED:12359731] [PUBMED:10205146] [PUBMED:21853157] [PUBMED:12145691] [PUBMED:16115772] [PUBMED:21325822] [PUBMED:11012189] [PUBMED:9663467] [PUBMED:9108383] [PUBMED:21933853] [PUBMED:8978680] [PUBMED:18487512] [PUBMED:22005786] [PUBMED:11309383] [PUBMED:11964286] [PUBMED:15085152] [PUBMED:17980909] [PUBMED:9731041] [PUBMED:22528490] [PUBMED:10515871] [PUBMED:21527831] [PUBMED:17525997] [PUBMED:6325330] [PUBMED:20113333] [PUBMED:11283246] [PUBMED:17637498] [PUBMED:14662334] [PUBMED:10050883] [PUBMED:14576068] [PUBMED:7492761] [PUBMED:22128142] [PUBMED:9122198] [PUBMED:8555464] [PUBMED:10397715] [PUBMED:11478766] [PUBMED:11356906] [PUBMED:18632638] [PUBMED:10720694] [PUBMED:17550780] [PUBMED:8943867] [PUBMED:12101178] [PUBMED:17389006] [PUBMED:9845531] [PUBMED:18773906] [PUBMED:10216087] [PUBMED:7537762] [PUBMED:15271793] [PUBMED:12389630] [PUBMED:8639892] [PUBMED:8202160] [PUBMED:15337790] [PUBMED:16449323] [PUBMED:22101255] [PUBMED:22628264] [PUBMED:17455223] [PUBMED:7796811] [PUBMED:18075837] [PUBMED:14693160] [PUBMED:14500680] [PUBMED:9012841] [PUBMED:6286773] [PUBMED:2830276] [PUBMED:9630621] [PUBMED:11097834] [PUBMED:9166841] [PUBMED:14726379] [PUBMED:9657746] [PUBMED:12006617] [PUBMED:19844195] [PUBMED:9028319] [PUBMED:7534285] [PUBMED:11012190] [PUBMED:11376875] [PUBMED:8950973] [PUBMED:10517496] [PUBMED:8541543] [PUBMED:10736563] [PUBMED:12372629] [PUBMED:19262695] [PUBMED:9600081] [PUBMED:16317100] [PUBMED:10891439] [PUBMED:17693582] [PUBMED:16150872] [PUBMED:6313047] [PUBMED:14645506] [PUBMED:15693793] [PUBMED:19620302]
Central carbon metabolism in cancer [NCBI:1059538] [KEGG:hsa05230] [PUBMED:16982728] [PUBMED:21127244] [PUBMED:22156302] [PUBMED:22349059] [PUBMED:21801601] [PUBMED:15916903] [PUBMED:24113830] [PUBMED:23018234] [PUBMED:22237205] [PUBMED:23897900] [PUBMED:20520704] [PUBMED:18177721] [PUBMED:24398961] [PUBMED:18538731] [PUBMED:24079832] [PUBMED:19460998] [PUBMED:22101401] [PUBMED:22750268] [PUBMED:22307140] [PUBMED:23071355] [PUBMED:21258394] [PUBMED:23279446] [PUBMED:21340684] [PUBMED:19270154] [PUBMED:18766298] [PUBMED:21508971] [PUBMED:24738035]
Endocytosis [NCBI:102279] [KEGG:hsa04144] [PUBMED:19696797] [PUBMED:19007773] [PUBMED:16203612] [PUBMED:15687999] [PUBMED:19924646] [PUBMED:15261671] [PUBMED:19325624] [PUBMED:22193161] [PUBMED:18647649] [PUBMED:20110990]
Frs2-mediated activation [NCBI:1269470] [REACTOME:R-HSA-170968] [PUBMED:9069267]
Inflammatory mediator regulation of TRP channels [NCBI:948277] [KEGG:hsa04750] [PUBMED:21841075] [PUBMED:15820689] [PUBMED:16776582] [PUBMED:17548207] [PUBMED:12838328] [PUBMED:16319926] [PUBMED:18427980] [PUBMED:17124270] [PUBMED:17684094] [PUBMED:20932256] [PUBMED:18615141] [PUBMED:22470230] [PUBMED:17321113] [PUBMED:24099085] [PUBMED:23000387] [PUBMED:19074743]
Integrated Pancreatic Cancer Pathway [NCBI:711360] [WikiPathways:WP2377]
MAPK signaling pathway [NCBI:83048] [KEGG:hsa04010] [NCBI:198779] [WikiPathways:WP382] [PUBMED:11749383] [PUBMED:12849693] [PUBMED:12676795] [PUBMED:14597384] [PUBMED:11369511] [PUBMED:22539006] [PUBMED:12947395] [PUBMED:12390245] [PUBMED:12191611] [PUBMED:17726008] [PUBMED:12566928]
NGF signalling via TRKA from the plasma membrane [NCBI:1269460] [REACTOME:R-HSA-187037] [PUBMED:11520933] [PUBMED:12676795] [PUBMED:10851172] [PUBMED:10579918]
NGF-independant TRKA activation [NCBI:1269463] [REACTOME:R-HSA-187024] [PUBMED:16805430]
Neurotrophic factor-mediated Trk receptor signaling [NCBI:137977] [Pathway Interaction Database:trkrpathway] [PUBMED:11425862] [PUBMED:11251075] [PUBMED:8226808] [PUBMED:15758069] [PUBMED:11244088] [PUBMED:7510697] [PUBMED:11027277] [PUBMED:11150334] [PUBMED:9356464] [PUBMED:11150291] [PUBMED:11466412] [PUBMED:10985348] [PUBMED:10092678] [PUBMED:15167895] [PUBMED:1653651] [PUBMED:15520226] [PUBMED:10490030] [PUBMED:17003042] [PUBMED:8384556] [PUBMED:16697063] [PUBMED:9927421] [PUBMED:10691301] [PUBMED:16284401] [PUBMED:15632082] [PUBMED:16611639] [PUBMED:9856458] [PUBMED:8356095] [PUBMED:15513915] [PUBMED:10329710] [PUBMED:1604323] [PUBMED:16701206] [PUBMED:16187212] [PUBMED:10679771] [PUBMED:10601297] [PUBMED:8106527] [PUBMED:9182757] [PUBMED:1375038] [PUBMED:12510192] [PUBMED:1850821] [PUBMED:15122257] [PUBMED:7972023] [PUBMED:9099755] [PUBMED:16203995] [PUBMED:16481401] [PUBMED:1850549] [PUBMED:12446789] [PUBMED:8155326] [PUBMED:9285826] [PUBMED:10235685] [PUBMED:9632781] [PUBMED:8382740] [PUBMED:10629055] [PUBMED:12006576] [PUBMED:8052307] [PUBMED:15917464] [PUBMED:7657612] [PUBMED:16157584] [PUBMED:10207144] [PUBMED:12879077] [PUBMED:1849459] [PUBMED:11238898] [PUBMED:11163269] [PUBMED:8344249] [PUBMED:1280261] [PUBMED:15753086] [PUBMED:1831195] [PUBMED:8288573] [PUBMED:7512734] [PUBMED:1710174] [PUBMED:11278445]
Neurotrophin signaling pathway [NCBI:101143] [KEGG:hsa04722] [PUBMED:16699811] [PUBMED:10812966] [PUBMED:16939974] [PUBMED:12676795] [PUBMED:15499580] [PUBMED:14704852] [PUBMED:10764727] [PUBMED:11399424] [PUBMED:16856873] [PUBMED:11529497] [PUBMED:10985348] [PUBMED:10851172]
PI3K/AKT activation [NCBI:1269473] [REACTOME:R-HSA-198203] [PUBMED:10579926] [PUBMED:12123609]
PLC-gamma1 signalling [NCBI:1269472] [REACTOME:R-HSA-167021] [PUBMED:12676795] [PUBMED:10579907]
Pathways in cancer [NCBI:83105] [KEGG:hsa05200] [PUBMED:12244301] [PUBMED:16001072] [PUBMED:16699851] [PUBMED:11902573] [PUBMED:16555243] [PUBMED:15156182] [PUBMED:15310786] [PUBMED:21193867] [PUBMED:11707511] [PUBMED:11253051] [PUBMED:12951584] [PUBMED:11071626] [PUBMED:9834202] [PUBMED:15721476] [PUBMED:11895903] [PUBMED:17251915] [PUBMED:11736900] [PUBMED:11477132] [PUBMED:15724144] [PUBMED:10647931] [PUBMED:16700615] [PUBMED:11527574] [PUBMED:16339096] [PUBMED:12545153] [PUBMED:15942304] [PUBMED:16352814] [PUBMED:15656799] [PUBMED:10740269] [PUBMED:16881963] [PUBMED:15978322] [PUBMED:15774796] [PUBMED:17287871] [PUBMED:15557758] [PUBMED:10944551] [PUBMED:11170304] [PUBMED:12154354] [PUBMED:15639402] [PUBMED:16326109] [PUBMED:11276000] [PUBMED:15573119] [PUBMED:15625120] [PUBMED:15109562] [PUBMED:11160144] [PUBMED:15611513] [PUBMED:15349822] [PUBMED:16236521] [PUBMED:14967450] [PUBMED:16551846] [PUBMED:9196022] [PUBMED:12079267] [PUBMED:11130178] [PUBMED:14580692] [PUBMED:14634372] [PUBMED:12407699] [PUBMED:12588368] [PUBMED:15009714] [PUBMED:16001050] [PUBMED:16112428] [PUBMED:9643506] [PUBMED:15468170] [PUBMED:16248975] [PUBMED:12946833] [PUBMED:11057895] [PUBMED:11559746] [PUBMED:16306523] [PUBMED:16064138] [PUBMED:15479695] [PUBMED:11900250] [PUBMED:9422516] [PUBMED:15551095] [PUBMED:17062879] [PUBMED:12894244] [PUBMED:11103787] [PUBMED:12878745] [PUBMED:16702400] [PUBMED:14685170] [PUBMED:16189154] [PUBMED:11720739] [PUBMED:15122209] [PUBMED:11078609] [PUBMED:12243753] [PUBMED:14982876] [PUBMED:16642045] [PUBMED:12563308] [PUBMED:11407945] [PUBMED:14586404] [PUBMED:15270885] [PUBMED:16095998] [PUBMED:15948971] [PUBMED:16484590] [PUBMED:24508914] [PUBMED:12084351] [PUBMED:11459867] [PUBMED:10505543] [PUBMED:15746962] [PUBMED:16146838] [PUBMED:15947972] [PUBMED:15711891] [PUBMED:12094241] [PUBMED:15841168] [PUBMED:11463388] [PUBMED:16474624] [PUBMED:15719031] [PUBMED:10843728] [PUBMED:14556242] [PUBMED:10453277] [PUBMED:11721960] [PUBMED:11905738] [PUBMED:10403855] [PUBMED:12741677] [PUBMED:12616528] [PUBMED:15823750] [PUBMED:12737309] [PUBMED:14695152] [PUBMED:16750612] [PUBMED:11807782] [PUBMED:12351585] [PUBMED:14737121] [PUBMED:12801837] [PUBMED:11431710] [PUBMED:11165748] [PUBMED:11750244] [PUBMED:11224709] [PUBMED:16110317] [PUBMED:16508724] [PUBMED:15948711] [PUBMED:16870043] [PUBMED:7585656] [PUBMED:12379883] [PUBMED:12850530] [PUBMED:10835690] [PUBMED:16551847] [PUBMED:12459728] [PUBMED:14747944] [PUBMED:15000146] [PUBMED:17149381] [PUBMED:17158541] [PUBMED:12468433] [PUBMED:16042571] [PUBMED:16557281] [PUBMED:16899407] [PUBMED:12621137] [PUBMED:16189702] [PUBMED:8069858] [PUBMED:12951588] [PUBMED:16242838] [PUBMED:15082523] [PUBMED:17211469] [PUBMED:12711111] [PUBMED:15284264] [PUBMED:11223406] [PUBMED:12648469] [PUBMED:12867060] [PUBMED:16946003] [PUBMED:12762887] [PUBMED:16054233] [PUBMED:16822996] [PUBMED:17554387] [PUBMED:17028294]
Prolonged ERK activation events [NCBI:1269469] [REACTOME:R-HSA-169893] [PUBMED:12765839] [PUBMED:9069267]
Retrograde neurotrophin signalling [NCBI:1269476] [REACTOME:R-HSA-177504]
Signal Transduction [NCBI:1269379] [REACTOME:R-HSA-162582] [PUBMED:19648010] [PUBMED:17604717] [PUBMED:16260143] [PUBMED:11742412] [PUBMED:15863030] [PUBMED:21252999] [PUBMED:19379690] [PUBMED:19536106] [PUBMED:19458711] [PUBMED:19935667] [PUBMED:15450248] [PUBMED:15520807] [PUBMED:16939974] [PUBMED:18483217] [PUBMED:18043707] [PUBMED:19762341] [PUBMED:21781017] [PUBMED:17084981] [PUBMED:19619488] [PUBMED:17496910]
Signalling by NGF [NCBI:1269443] [REACTOME:R-HSA-166520]
Signalling to ERKs [NCBI:1269464] [REACTOME:R-HSA-187687] [PUBMED:10508738]
Signalling to RAS [NCBI:1269465] [REACTOME:R-HSA-167044] [PUBMED:11520933]
Signalling to STAT3 [NCBI:1269474] [REACTOME:R-HSA-198745]
Signalling to p38 via RIT and RIN [NCBI:1269468] [REACTOME:R-HSA-187706] [PUBMED:10712923]
TRKA activation by NGF [NCBI:1269462] [REACTOME:R-HSA-187042] [PUBMED:1844238] [PUBMED:1315923]
Thyroid cancer [NCBI:83112] [KEGG:hsa05216] [PUBMED:16189702] [PUBMED:16557281] [PUBMED:16242838] [PUBMED:12094241] [PUBMED:16551846] [PUBMED:11165748] [PUBMED:16946003] [PUBMED:17062879]
Transcriptional misregulation in cancer [NCBI:523016] [KEGG:hsa05202] [PUBMED:20190806] [PUBMED:11313274] [PUBMED:20145147] [PUBMED:19472090] [PUBMED:11863357] [PUBMED:18330902] [PUBMED:12032780] [PUBMED:19564705] [PUBMED:19738075] [PUBMED:15160934] [PUBMED:15024077] [PUBMED:21765642] [PUBMED:14630078] [PUBMED:17101797] [PUBMED:12511414] [PUBMED:15688424] [PUBMED:15985538] [PUBMED:21747944] [PUBMED:19406209] [PUBMED:15826838] [PUBMED:12527902] [PUBMED:10350329] [PUBMED:16946003] [PUBMED:17250957] [PUBMED:18563191] [PUBMED:17505060] [PUBMED:21779514] [PUBMED:11340171] [PUBMED:12529654] [PUBMED:18855877] [PUBMED:12393465] [PUBMED:20153925] [PUBMED:19855079] [PUBMED:18648544] [PUBMED:10717473] [PUBMED:12130514] [PUBMED:19059936] [PUBMED:18172298] [PUBMED:16169901] [PUBMED:18850010] [PUBMED:19422821] [PUBMED:19233641] [PUBMED:14701735] [PUBMED:10500199] [PUBMED:19141473] [PUBMED:10537274] [PUBMED:18457914] [PUBMED:15826834] [PUBMED:15156184] [PUBMED:10784387] [PUBMED:17024155] [PUBMED:20974671] [PUBMED:19075677] [PUBMED:12527906] [PUBMED:15644444] [PUBMED:21849159] [PUBMED:19075268] [PUBMED:20863376] [PUBMED:21123453] [PUBMED:17327229] [PUBMED:17222504] [PUBMED:11607818] [PUBMED:12670461] [PUBMED:20490326] [PUBMED:20478527] [PUBMED:14998494] [PUBMED:19133982] [PUBMED:21518926]