Logo
full name
MDM2 proto-oncogene

synonyms
ACTFS, hdm2, HDMX, MDM2, ENSG00000135679

HGNC
HGNC:6973

Entrez Gene
Gene:4193

ENSEMBL
ENSG00000135679

location
chr: 12
start: 69201952
stop: 69239324
strand: +

OMIM
OMIM:164785: MDM2
OMIM:614401: {Accelerated tumor formation, susceptibility to}

transcripts
NM_002392.5
NM_001145339.2
NM_001145337.2
NM_001278462.1
NM_001145340.2

pathways
AKT phosphorylates targets in the cytosol [NCBI:1269189] [REACTOME:R-HSA-198323]
Adaptive Immune System [NCBI:1269171] [REACTOME:R-HSA-1280218] [PUBMED:16551257] [PUBMED:21682741] [PUBMED:11861602]
Aurora A signaling [NCBI:137925] [Pathway Interaction Database:aurora_a_pathway] [PUBMED:17308110] [PUBMED:16894566] [PUBMED:16631581] [PUBMED:17229885] [PUBMED:15128871] [PUBMED:14990569] [PUBMED:12177045] [PUBMED:14580337] [PUBMED:14724178] [PUBMED:17545617] [PUBMED:15687499] [PUBMED:11163242] [PUBMED:14603251] [PUBMED:17060449] [PUBMED:12208850] [PUBMED:12815066] [PUBMED:17125467] [PUBMED:13678582] [PUBMED:15987997] [PUBMED:15966895] [PUBMED:11976319] [PUBMED:14702041] [PUBMED:16246726] [PUBMED:17452972] [PUBMED:12082625] [PUBMED:11039908] [PUBMED:14667408] [PUBMED:12577065] [PUBMED:14600264] [PUBMED:11756469] [PUBMED:16772293] [PUBMED:12023018] [PUBMED:15469940] [PUBMED:16082213]
Bladder cancer [NCBI:83115] [KEGG:hsa05219] [PUBMED:15551095] [PUBMED:15746962] [PUBMED:11103787] [PUBMED:16474624] [PUBMED:17158541] [PUBMED:12850530] [PUBMED:17149381] [PUBMED:16110317]
Cell Cycle [NCBI:1269741] [REACTOME:R-HSA-1640170]
Cell Cycle Checkpoints [NCBI:1269742] [REACTOME:R-HSA-69620]
Cell cycle [NCBI:83054] [KEGG:hsa04110] [PUBMED:7973727] [PUBMED:17568790] [PUBMED:9832503] [PUBMED:16936746] [PUBMED:9029154] [PUBMED:12573239] [PUBMED:19020303] [PUBMED:9618481] [PUBMED:12809600] [PUBMED:8242749] [PUBMED:10385618] [PUBMED:17426725] [PUBMED:17018296] [PUBMED:16212951] [PUBMED:12925736] [PUBMED:11099028] [PUBMED:15568976] [PUBMED:15838516] [PUBMED:15838523] [PUBMED:15876871] [PUBMED:7908906] [PUBMED:9889196]
Cellular Senescence [NCBI:1270426] [REACTOME:R-HSA-2559583] [PUBMED:21078816] [PUBMED:18711403] [PUBMED:22048312] [PUBMED:19818705] [PUBMED:17662938] [PUBMED:23746838] [PUBMED:9282108] [PUBMED:17667954] [PUBMED:13905658]
Cellular responses to stress [NCBI:1270414] [REACTOME:R-HSA-2262752] [PUBMED:15709958]
Chronic myeloid leukemia [NCBI:83116] [KEGG:hsa05220] [PUBMED:22286129] [PUBMED:12801837] [PUBMED:11160144] [PUBMED:15719031] [PUBMED:10403855] [PUBMED:9834202] [PUBMED:11071626] [PUBMED:12244301] [PUBMED:15156182] [PUBMED:16484590] [PUBMED:14982876]
Constitutive Signaling by AKT1 E17K in Cancer [NCBI:1268881] [REACTOME:R-HSA-5674400] [PUBMED:17611497] [PUBMED:18954143]
DAP12 interactions [NCBI:1269283] [REACTOME:R-HSA-2172127] [PUBMED:19120482] [PUBMED:17220916] [PUBMED:9490415] [PUBMED:18192027] [PUBMED:15884055]
DAP12 signaling [NCBI:1269284] [REACTOME:R-HSA-2424491] [PUBMED:15884055] [PUBMED:17110943] [PUBMED:17220916]
Deubiquitination [NCBI:1427860] [REACTOME:R-HSA-5688426] [PUBMED:19243136] [PUBMED:20074029] [PUBMED:15571815] [PUBMED:20418328] [PUBMED:16325574] [PUBMED:12944365] [PUBMED:23845989] [PUBMED:22201797]
Direct p53 effectors [NCBI:137939] [Pathway Interaction Database:p53downstreampathway] [PUBMED:7479001] [PUBMED:19626115] [PUBMED:10692390] [PUBMED:15289308] [PUBMED:14688482] [PUBMED:16301995] [PUBMED:11850816] [PUBMED:12370809] [PUBMED:16260627] [PUBMED:15186775] [PUBMED:15580302] [PUBMED:10748162] [PUBMED:10919640] [PUBMED:19011621] [PUBMED:12438652] [PUBMED:11559530] [PUBMED:11641774] [PUBMED:11971958] [PUBMED:9659898] [PUBMED:9343394] [PUBMED:10716435] [PUBMED:17146433] [PUBMED:17719542] [PUBMED:17938176] [PUBMED:17409421] [PUBMED:11032029] [PUBMED:15781865] [PUBMED:11463392] [PUBMED:9736732] [PUBMED:17268548] [PUBMED:8570655] [PUBMED:18046411] [PUBMED:12944906] [PUBMED:16249378] [PUBMED:15273740] [PUBMED:15598651] [PUBMED:10618379] [PUBMED:15958553] [PUBMED:17189187] [PUBMED:17145718] [PUBMED:11988847] [PUBMED:8119988] [PUBMED:12089322] [PUBMED:16286009] [PUBMED:12890671] [PUBMED:12402042] [PUBMED:10618714] [PUBMED:14730312] [PUBMED:12857899] [PUBMED:14963330] [PUBMED:11278953] [PUBMED:11973653] [PUBMED:12692263] [PUBMED:10984493] [PUBMED:10640990] [PUBMED:11545734] [PUBMED:16151013] [PUBMED:12372430] [PUBMED:16651407] [PUBMED:9891062] [PUBMED:12606722] [PUBMED:12453409] [PUBMED:15377670] [PUBMED:12667443] [PUBMED:17707234] [PUBMED:9920903] [PUBMED:14992722] [PUBMED:15790310] [PUBMED:15831478] [PUBMED:11314010] [PUBMED:10329733] [PUBMED:17264218] [PUBMED:11511362] [PUBMED:11919562] [PUBMED:11814693] [PUBMED:17554199] [PUBMED:18250150] [PUBMED:10518217] [PUBMED:10891498] [PUBMED:10973264] [PUBMED:15077116] [PUBMED:16230375] [PUBMED:18485870] [PUBMED:7796420] [PUBMED:15710382] [PUBMED:17409411] [PUBMED:8319905] [PUBMED:10684646] [PUBMED:7566179] [PUBMED:8887630] [PUBMED:11807984] [PUBMED:9841917] [PUBMED:12654245] [PUBMED:9023107] [PUBMED:15103385] [PUBMED:11684014] [PUBMED:17110336] [PUBMED:11278253] [PUBMED:14576823] [PUBMED:8418500] [PUBMED:11350971] [PUBMED:11840333] [PUBMED:7651818] [PUBMED:7651386] [PUBMED:15378026] [PUBMED:15607964] [PUBMED:11279192] [PUBMED:10777218] [PUBMED:15334053] [PUBMED:12138177] [PUBMED:9619826] [PUBMED:16278683] [PUBMED:17189186] [PUBMED:16140933] [PUBMED:10094469] [PUBMED:9926927] [PUBMED:17719541] [PUBMED:15735003] [PUBMED:12853982] [PUBMED:14707288] [PUBMED:10777207]
Disease [NCBI:1268854] [REACTOME:R-HSA-1643685]
Diseases of signal transduction [NCBI:1268855] [REACTOME:R-HSA-5663202] [PUBMED:12509752]
Downstream signal transduction [NCBI:1269479] [REACTOME:R-HSA-186763] [PUBMED:10508235] [PUBMED:9739761]
Downstream signaling events of B Cell Receptor (BCR) [NCBI:1269185] [REACTOME:R-HSA-1168372] [PUBMED:17052215] [PUBMED:19909372]
Endocrine resistance [NCBI:1404799] [KEGG:hsa01522] [PUBMED:24415977] [PUBMED:23625614] [PUBMED:24841429] [PUBMED:15613444] [PUBMED:23714450] [PUBMED:20960099] [PUBMED:22771991] [PUBMED:19701242] [PUBMED:24289103] [PUBMED:24130921] [PUBMED:23344024] [PUBMED:22015292] [PUBMED:26122181] [PUBMED:26473850] [PUBMED:18804516] [PUBMED:24565562] [PUBMED:26849149] [PUBMED:25907219] [PUBMED:20887199]
Endocytosis [NCBI:102279] [KEGG:hsa04144] [PUBMED:19696797] [PUBMED:19007773] [PUBMED:16203612] [PUBMED:15687999] [PUBMED:19924646] [PUBMED:15261671] [PUBMED:18647649] [PUBMED:19325624] [PUBMED:20110990] [PUBMED:22193161]
Epstein-Barr virus infection [NCBI:585562] [KEGG:hsa05169] [PUBMED:1658397] [PUBMED:10683340] [PUBMED:19375142] [PUBMED:12438576] [PUBMED:12910248] [PUBMED:10400785] [PUBMED:16007144] [PUBMED:14576817] [PUBMED:18559925] [PUBMED:16352731] [PUBMED:7895172] [PUBMED:15510157] [PUBMED:21518914] [PUBMED:10891508] [PUBMED:14673102] [PUBMED:17159145] [PUBMED:15542638] [PUBMED:18786993] [PUBMED:16603506] [PUBMED:10644367] [PUBMED:15021898] [PUBMED:10666279] [PUBMED:9565632]
ErbB4 signaling events [NCBI:137991] [Pathway Interaction Database:erbb4_pathway] [PUBMED:16815842] [PUBMED:8617750] [PUBMED:9663464] [PUBMED:12466964] [PUBMED:15345710] [PUBMED:16061658] [PUBMED:12954715] [PUBMED:17463226] [PUBMED:17646177] [PUBMED:17085783] [PUBMED:18721752] [PUBMED:15023535] [PUBMED:9556621] [PUBMED:12807903] [PUBMED:17486069] [PUBMED:10358079] [PUBMED:12454007] [PUBMED:8702723] [PUBMED:10693928] [PUBMED:18334649] [PUBMED:10725395] [PUBMED:11731109] [PUBMED:7477376] [PUBMED:16837552] [PUBMED:15863494] [PUBMED:19047365] [PUBMED:10722704] [PUBMED:19193720] [PUBMED:10348342] [PUBMED:17018285] [PUBMED:9135143] [PUBMED:9618494] [PUBMED:12716924] [PUBMED:18819924] [PUBMED:10867024] [PUBMED:15985438] [PUBMED:7559778] [PUBMED:7759543] [PUBMED:12824469] [PUBMED:10744726] [PUBMED:15746097] [PUBMED:18653779] [PUBMED:15534001] [PUBMED:17460065] [PUBMED:10508857] [PUBMED:15282549] [PUBMED:9362517] [PUBMED:9685416] [PUBMED:11679632] [PUBMED:10839362] [PUBMED:10353604]
Fc epsilon receptor (FCERI) signaling [NCBI:1269298] [REACTOME:R-HSA-2454202] [PUBMED:15099567] [PUBMED:21799019]
FoxO signaling pathway [NCBI:921162] [KEGG:hsa04068] [PUBMED:23325358] [PUBMED:15005655] [PUBMED:18951090] [PUBMED:22761423] [PUBMED:22902436] [PUBMED:16288288] [PUBMED:19701188] [PUBMED:16964248] [PUBMED:18045156] [PUBMED:18403263] [PUBMED:21613825] [PUBMED:21440011] [PUBMED:17470511] [PUBMED:21238503] [PUBMED:17522590] [PUBMED:15084259] [PUBMED:23801966] [PUBMED:17569704] [PUBMED:15516968]
G1/S DNA Damage Checkpoints [NCBI:1269743] [REACTOME:R-HSA-69615]
GAB1 signalosome [NCBI:1269384] [REACTOME:R-HSA-180292] [PUBMED:15550174]
Gene Expression [NCBI:1269649] [REACTOME:R-HSA-74160]
Generic Transcription Pathway [NCBI:1269650] [REACTOME:R-HSA-212436] [PUBMED:15175151] [PUBMED:14744435] [PUBMED:15680972] [PUBMED:11395415] [PUBMED:15896744] [PUBMED:10235266] [PUBMED:14986688] [PUBMED:12023297] [PUBMED:15680973] [PUBMED:16751179] [PUBMED:11861166] [PUBMED:16429119] [PUBMED:16719718] [PUBMED:16921404] [PUBMED:15690163]
Glioma [NCBI:83110] [KEGG:hsa05214] [PUBMED:11057895] [PUBMED:11253051] [PUBMED:12154354] [PUBMED:12084351] [PUBMED:15639402] [PUBMED:9643506] [PUBMED:16095998] [PUBMED:12762887] [PUBMED:16700615]
Glucocorticoid receptor regulatory network [NCBI:138014] [Pathway Interaction Database:reg_gr_pathway] [PUBMED:8943293] [PUBMED:1708774] [PUBMED:15826950] [PUBMED:11027313] [PUBMED:12118039] [PUBMED:9388207] [PUBMED:11751894] [PUBMED:12151000] [PUBMED:9765258] [PUBMED:9407028] [PUBMED:19074285] [PUBMED:2838908] [PUBMED:15817653] [PUBMED:9722596] [PUBMED:12917342] [PUBMED:1387550] [PUBMED:10974006] [PUBMED:15790729] [PUBMED:10825196] [PUBMED:10623828] [PUBMED:2169352] [PUBMED:9315653] [PUBMED:7759501] [PUBMED:8290595] [PUBMED:2905764] [PUBMED:12351702] [PUBMED:11080152] [PUBMED:8428574] [PUBMED:9215863] [PUBMED:15459252] [PUBMED:10400612] [PUBMED:9426156] [PUBMED:17440046] [PUBMED:18838540] [PUBMED:2169353] [PUBMED:10820245] [PUBMED:12511605] [PUBMED:2586521] [PUBMED:1740658] [PUBMED:11555652] [PUBMED:11562347] [PUBMED:9482836] [PUBMED:18337589] [PUBMED:10958685] [PUBMED:9388192] [PUBMED:15834420] [PUBMED:15657031] [PUBMED:8878484] [PUBMED:10760263] [PUBMED:12730237] [PUBMED:8702844] [PUBMED:2169351] [PUBMED:17215482] [PUBMED:8898375]
Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity [NCBI:1268794] [REACTOME:R-HSA-399721] [PUBMED:16904750] [PUBMED:16713244] [PUBMED:19217372]
Immune System [NCBI:1269170] [REACTOME:R-HSA-168256]
Innate Immune System [NCBI:1269203] [REACTOME:R-HSA-168249]
Melanoma [NCBI:83114] [KEGG:hsa05218] [PUBMED:16822996] [PUBMED:14695152] [PUBMED:11224709] [PUBMED:10843728] [PUBMED:12894244] [PUBMED:16899407] [PUBMED:16001072] [PUBMED:15721476] [PUBMED:15557758] [PUBMED:15009714] [PUBMED:16001050] [PUBMED:15841168] [PUBMED:16750612]
Metabolism of proteins [NCBI:1268677] [REACTOME:R-HSA-392499]
MicroRNAs in cancer [NCBI:852705] [KEGG:hsa05206] [PUBMED:23075324] [PUBMED:21742789] [PUBMED:22351564] [PUBMED:18817506] [PUBMED:22345301] [PUBMED:21402473] [PUBMED:22926415] [PUBMED:23165235] [PUBMED:19630570] [PUBMED:21565290] [PUBMED:23091478] [PUBMED:23462054] [PUBMED:23316212] [PUBMED:19773200] [PUBMED:22035854] [PUBMED:20221895] [PUBMED:20345848] [PUBMED:22580099] [PUBMED:20128019]
NGF signalling via TRKA from the plasma membrane [NCBI:1269460] [REACTOME:R-HSA-187037] [PUBMED:11520933] [PUBMED:12676795] [PUBMED:10851172] [PUBMED:10579918]
Neuronal System [NCBI:1268763] [REACTOME:R-HSA-112316]
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell [NCBI:1268786] [REACTOME:R-HSA-112314]
Oncogene Induced Senescence [NCBI:1270427] [REACTOME:R-HSA-2559585] [PUBMED:10722742] [PUBMED:20583212] [PUBMED:8521522] [PUBMED:20534573] [PUBMED:11234019] [PUBMED:14729966] [PUBMED:12839923] [PUBMED:8319905] [PUBMED:18365017] [PUBMED:15572696] [PUBMED:9529249] [PUBMED:10733595] [PUBMED:9824166] [PUBMED:11782450] [PUBMED:8259215] [PUBMED:7588608] [PUBMED:8552081] [PUBMED:9704925] [PUBMED:22336108] [PUBMED:11883935]
Oxidative Stress Induced Senescence [NCBI:1270428] [REACTOME:R-HSA-2559580] [PUBMED:17344414] [PUBMED:17332741] [PUBMED:8622688] [PUBMED:7588633] [PUBMED:15563468] [PUBMED:15287722] [PUBMED:11062067] [PUBMED:16337592] [PUBMED:14532106] [PUBMED:17254968] [PUBMED:15866172] [PUBMED:9628874] [PUBMED:12171911] [PUBMED:7816143] [PUBMED:22020331] [PUBMED:11564866] [PUBMED:9162092] [PUBMED:8974401] [PUBMED:19451217] [PUBMED:12808055] [PUBMED:17210787] [PUBMED:8846784] [PUBMED:19462008] [PUBMED:12134156] [PUBMED:8626550] [PUBMED:8774846] [PUBMED:12189133] [PUBMED:9195981] [PUBMED:8622669] [PUBMED:8259215] [PUBMED:19528227] [PUBMED:9564042] [PUBMED:9529249] [PUBMED:16436515] [PUBMED:19451218] [PUBMED:17395714] [PUBMED:9030721] [PUBMED:12435631] [PUBMED:22325352]
PI3K-Akt signaling pathway [NCBI:692234] [KEGG:hsa04151] [PUBMED:12048182] [PUBMED:11357143] [PUBMED:21440011] [PUBMED:15209374] [PUBMED:12669022] [PUBMED:18842113] [PUBMED:16847462] [PUBMED:12660731] [PUBMED:17360849] [PUBMED:9838078] [PUBMED:15505410] [PUBMED:16248975] [PUBMED:12531180] [PUBMED:21779440] [PUBMED:16187290] [PUBMED:15784165] [PUBMED:21620960]
PI3K/AKT Signaling in Cancer [NCBI:1268879] [REACTOME:R-HSA-2219528] [PUBMED:20713702] [PUBMED:10555148] [PUBMED:19644473] [PUBMED:17611497] [PUBMED:21478295] [PUBMED:17626883] [PUBMED:16339315] [PUBMED:18317450] [PUBMED:18079394] [PUBMED:9467011] [PUBMED:17604717] [PUBMED:9326929] [PUBMED:18954143] [PUBMED:20009532] [PUBMED:19962665] [PUBMED:21430697] [PUBMED:19487573] [PUBMED:10866302]
PI3K/AKT activation [NCBI:1269473] [REACTOME:R-HSA-198203] [PUBMED:10579926] [PUBMED:12123609]
PIP3 activates AKT signaling [NCBI:1269188] [REACTOME:R-HSA-1257604]
Pathways in cancer [NCBI:83105] [KEGG:hsa05200] [PUBMED:12244301] [PUBMED:15156182] [PUBMED:16899407] [PUBMED:12621137] [PUBMED:21193867] [PUBMED:16001072] [PUBMED:11707511] [PUBMED:11253051] [PUBMED:11071626] [PUBMED:17251915] [PUBMED:11736900] [PUBMED:16557281] [PUBMED:16699851] [PUBMED:16189702] [PUBMED:11902573] [PUBMED:16555243] [PUBMED:8069858] [PUBMED:15310786] [PUBMED:9834202] [PUBMED:16700615] [PUBMED:12545153] [PUBMED:15656799] [PUBMED:12154354] [PUBMED:11895903] [PUBMED:11527574] [PUBMED:16326109] [PUBMED:16339096] [PUBMED:11160144] [PUBMED:15724144] [PUBMED:12951584] [PUBMED:10647931] [PUBMED:16881963] [PUBMED:15557758] [PUBMED:11477132] [PUBMED:15721476] [PUBMED:15625120] [PUBMED:16236521] [PUBMED:14967450] [PUBMED:15942304] [PUBMED:17287871] [PUBMED:14634372] [PUBMED:15573119] [PUBMED:15009714] [PUBMED:16112428] [PUBMED:15611513] [PUBMED:16001050] [PUBMED:15349822] [PUBMED:16551846] [PUBMED:15978322] [PUBMED:15774796] [PUBMED:16352814] [PUBMED:12951588] [PUBMED:10944551] [PUBMED:10740269] [PUBMED:15639402] [PUBMED:12407699] [PUBMED:11130178] [PUBMED:15109562] [PUBMED:11170304] [PUBMED:11276000] [PUBMED:9643506] [PUBMED:16248975] [PUBMED:16242838] [PUBMED:12946833] [PUBMED:11559746] [PUBMED:9196022] [PUBMED:12079267] [PUBMED:15468170] [PUBMED:16064138] [PUBMED:14580692] [PUBMED:15082523] [PUBMED:15551095] [PUBMED:17062879] [PUBMED:17211469] [PUBMED:11720739] [PUBMED:12588368] [PUBMED:11057895] [PUBMED:9422516] [PUBMED:12894244] [PUBMED:15479695] [PUBMED:16189154] [PUBMED:12878745] [PUBMED:11900250] [PUBMED:11103787] [PUBMED:15122209] [PUBMED:12711111] [PUBMED:12243753] [PUBMED:16306523] [PUBMED:16702400] [PUBMED:15270885] [PUBMED:14685170] [PUBMED:14586404] [PUBMED:11078609] [PUBMED:15284264] [PUBMED:10505543] [PUBMED:11223406] [PUBMED:14982876] [PUBMED:12648469] [PUBMED:12867060] [PUBMED:15711891] [PUBMED:12094241] [PUBMED:16642045] [PUBMED:11463388] [PUBMED:12762887] [PUBMED:15746962] [PUBMED:15823750] [PUBMED:16750612] [PUBMED:16484590] [PUBMED:11459867] [PUBMED:16146838] [PUBMED:14556242] [PUBMED:15947972] [PUBMED:12563308] [PUBMED:16946003] [PUBMED:15948971] [PUBMED:11407945] [PUBMED:12737309] [PUBMED:16095998] [PUBMED:12351585] [PUBMED:24508914] [PUBMED:12084351] [PUBMED:11807782] [PUBMED:14695152] [PUBMED:10453277] [PUBMED:17554387] [PUBMED:15841168] [PUBMED:12616528] [PUBMED:10403855] [PUBMED:16054233] [PUBMED:16474624] [PUBMED:16822996] [PUBMED:17028294] [PUBMED:11224709] [PUBMED:11750244] [PUBMED:11905738] [PUBMED:15719031] [PUBMED:10843728] [PUBMED:16110317] [PUBMED:11721960] [PUBMED:12741677] [PUBMED:7585656] [PUBMED:12801837] [PUBMED:16551847] [PUBMED:12459728] [PUBMED:11431710] [PUBMED:12468433] [PUBMED:11165748] [PUBMED:16042571] [PUBMED:16508724] [PUBMED:15000146] [PUBMED:17149381] [PUBMED:15948711] [PUBMED:14747944] [PUBMED:14737121] [PUBMED:12379883] [PUBMED:17158541] [PUBMED:12850530] [PUBMED:10835690] [PUBMED:16870043]
Platinum drug resistance [NCBI:1404797] [KEGG:hsa01524] [PUBMED:24074238] [PUBMED:26867799] [PUBMED:14609433] [PUBMED:26184483] [PUBMED:24874729] [PUBMED:15607932] [PUBMED:25546083] [PUBMED:25058905] [PUBMED:19190080] [PUBMED:14576837] [PUBMED:20811617] [PUBMED:21892204] [PUBMED:20647037] [PUBMED:17336087] [PUBMED:26886018] [PUBMED:23442359] [PUBMED:17625587]
Post-translational protein modification [NCBI:1268701] [REACTOME:R-HSA-597592]
Prostate cancer [NCBI:83111] [KEGG:hsa05215] [PUBMED:12878745] [PUBMED:11900250] [PUBMED:11527574] [PUBMED:11750244] [PUBMED:16551847] [PUBMED:10835690] [PUBMED:8069858] [PUBMED:15724144] [PUBMED:10453277] [PUBMED:15082523] [PUBMED:9422516]
Proteoglycans in cancer [NCBI:782000] [KEGG:hsa05205] [PUBMED:19433454] [PUBMED:20655987] [PUBMED:18798267] [PUBMED:10633082] [PUBMED:10687947] [PUBMED:22735579] [PUBMED:24412155] [PUBMED:9346940] [PUBMED:22087031] [PUBMED:22194599] [PUBMED:14711376] [PUBMED:19255147] [PUBMED:15655247] [PUBMED:11717317] [PUBMED:17971838] [PUBMED:18413366] [PUBMED:20974860] [PUBMED:11830493] [PUBMED:23058688] [PUBMED:18450475] [PUBMED:12748184] [PUBMED:19733083] [PUBMED:18812315] [PUBMED:12509413] [PUBMED:21155971] [PUBMED:11931647] [PUBMED:18949819] [PUBMED:12729888] [PUBMED:15994311] [PUBMED:23305321] [PUBMED:18505598] [PUBMED:22563565] [PUBMED:22033227]
Regulation of Androgen receptor activity [NCBI:138027] [Pathway Interaction Database:ar_tf_pathway] [PUBMED:15650026] [PUBMED:17045208] [PUBMED:10364196] [PUBMED:16860317] [PUBMED:10611280] [PUBMED:10930412] [PUBMED:1525041] [PUBMED:10779504] [PUBMED:12514133] [PUBMED:1985913] [PUBMED:11931767] [PUBMED:17011549] [PUBMED:15640443] [PUBMED:16322096] [PUBMED:15923603] [PUBMED:14985354] [PUBMED:15743818] [PUBMED:12949936] [PUBMED:11994312] [PUBMED:10567371] [PUBMED:11875111] [PUBMED:15604291] [PUBMED:12890669] [PUBMED:14729952] [PUBMED:9211894] [PUBMED:9162033] [PUBMED:16705743] [PUBMED:16849544] [PUBMED:16923962] [PUBMED:11591700] [PUBMED:16051670] [PUBMED:8643509] [PUBMED:17108144] [PUBMED:16914734] [PUBMED:12682292] [PUBMED:3353726] [PUBMED:11585838] [PUBMED:16282370] [PUBMED:10381882] [PUBMED:15199155] [PUBMED:16455820] [PUBMED:14612401] [PUBMED:10625666] [PUBMED:17679089] [PUBMED:16461774]
Regulation of TP53 Activity [NCBI:1383076] [REACTOME:R-HSA-5633007] [PUBMED:19450511] [PUBMED:20457558] [PUBMED:23825024] [PUBMED:25641576]
Regulation of TP53 Activity through Methylation [NCBI:1383082] [REACTOME:R-HSA-6804760] [PUBMED:18833288] [PUBMED:17805299] [PUBMED:15186775] [PUBMED:11511361] [PUBMED:16415881] [PUBMED:22362889] [PUBMED:20118233] [PUBMED:15525938] [PUBMED:21625555] [PUBMED:15448695] [PUBMED:20870725] [PUBMED:10518217] [PUBMED:17108971]
Regulation of TP53 Activity through Phosphorylation [NCBI:1383080] [REACTOME:R-HSA-6804756] [PUBMED:11780126] [PUBMED:21317932] [PUBMED:15866171] [PUBMED:12393879] [PUBMED:11740489] [PUBMED:11447225] [PUBMED:9733515] [PUBMED:12851404] [PUBMED:10884347] [PUBMED:10710310] [PUBMED:11239457] [PUBMED:9925639] [PUBMED:11546806] [PUBMED:11551930] [PUBMED:10570149] [PUBMED:18490454] [PUBMED:17591690] [PUBMED:19965871] [PUBMED:12064478] [PUBMED:10673501] [PUBMED:22611192] [PUBMED:9843217] [PUBMED:15053879] [PUBMED:12914926] [PUBMED:10673500] [PUBMED:17349958] [PUBMED:14702041] [PUBMED:20959462] [PUBMED:10435622] [PUBMED:9733514]
Regulation of TP53 Degradation [NCBI:1383079] [REACTOME:R-HSA-6804757] [PUBMED:21730132] [PUBMED:10570149] [PUBMED:15563468] [PUBMED:16845383] [PUBMED:11923872] [PUBMED:11883935] [PUBMED:17290220] [PUBMED:17121812] [PUBMED:10673500] [PUBMED:9843217] [PUBMED:9529249] [PUBMED:21730163] [PUBMED:11715018] [PUBMED:9733514] [PUBMED:19838211] [PUBMED:10608892] [PUBMED:16474402] [PUBMED:19450511] [PUBMED:16163388] [PUBMED:10722742] [PUBMED:21986495] [PUBMED:15788536] [PUBMED:19816404] [PUBMED:11359766] [PUBMED:11504915] [PUBMED:9733515] [PUBMED:19756449] [PUBMED:11983168] [PUBMED:8319905] [PUBMED:20438709]
Regulation of TP53 Expression and Degradation [NCBI:1383077] [REACTOME:R-HSA-6806003] [PUBMED:11883935] [PUBMED:11923872] [PUBMED:19293287] [PUBMED:23303139] [PUBMED:17499002] [PUBMED:15563468] [PUBMED:17121812] [PUBMED:21986495] [PUBMED:15103385] [PUBMED:9529249] [PUBMED:21814038] [PUBMED:19250907] [PUBMED:8319905] [PUBMED:7878469] [PUBMED:12654245] [PUBMED:16213212]
Regulation of retinoblastoma protein [NCBI:137916] [Pathway Interaction Database:rb_1pathway] [PUBMED:15469821] [PUBMED:11470869] [PUBMED:8493578] [PUBMED:7596417] [PUBMED:8449399] [PUBMED:9468140] [PUBMED:11596110] [PUBMED:9545246] [PUBMED:16360038] [PUBMED:14673169] [PUBMED:17991896] [PUBMED:8805225] [PUBMED:7926730] [PUBMED:10322110] [PUBMED:11533237] [PUBMED:1828393] [PUBMED:8657117] [PUBMED:9491888] [PUBMED:7877691] [PUBMED:14729964] [PUBMED:1710781] [PUBMED:10778858] [PUBMED:11566021] [PUBMED:8246996] [PUBMED:12450794] [PUBMED:16374512] [PUBMED:10783144] [PUBMED:15949438] [PUBMED:9468139] [PUBMED:8242749] [PUBMED:9464541] [PUBMED:1531329] [PUBMED:9819434] [PUBMED:12479814] [PUBMED:10888886] [PUBMED:10597288] [PUBMED:8626527] [PUBMED:7629134] [PUBMED:11545733] [PUBMED:17620057] [PUBMED:11433299] [PUBMED:9858607] [PUBMED:15716956] [PUBMED:10490602] [PUBMED:1828392] [PUBMED:15577944] [PUBMED:11484059] [PUBMED:11583618] [PUBMED:10499802]
Role of LAT2/NTAL/LAB on calcium mobilization [NCBI:1269302] [REACTOME:R-HSA-2730905] [PUBMED:17993265] [PUBMED:20643813] [PUBMED:17420272]
SUMO E3 ligases SUMOylate target proteins [NCBI:1268743] [REACTOME:R-HSA-3108232] [PUBMED:20674646] [PUBMED:17763827] [PUBMED:19471022] [PUBMED:23746258] [PUBMED:24016193] [PUBMED:23503365] [PUBMED:21252943] [PUBMED:17000644] [PUBMED:24273646] [PUBMED:22811915] [PUBMED:21693764] [PUBMED:23277067] [PUBMED:21102611]
SUMOylation [NCBI:1268738] [REACTOME:R-HSA-2990846] [PUBMED:21102611] [PUBMED:20674646] [PUBMED:23514139] [PUBMED:19923268] [PUBMED:20462400] [PUBMED:17768054]
SUMOylation of transcription factors [NCBI:1339110] [REACTOME:R-HSA-3232118] [PUBMED:16095902] [PUBMED:21892772] [PUBMED:19107415] [PUBMED:19616654] [PUBMED:15209380] [PUBMED:18031228]
Signal Transduction [NCBI:1269379] [REACTOME:R-HSA-162582] [PUBMED:17604717] [PUBMED:19648010] [PUBMED:16260143] [PUBMED:11742412] [PUBMED:19536106] [PUBMED:15863030] [PUBMED:19379690] [PUBMED:19458711] [PUBMED:19935667] [PUBMED:21252999] [PUBMED:15520807] [PUBMED:17496910] [PUBMED:15450248] [PUBMED:18043707] [PUBMED:16939974] [PUBMED:19762341] [PUBMED:18483217] [PUBMED:17084981] [PUBMED:21781017] [PUBMED:19619488]
Signaling by EGFR [NCBI:1269380] [REACTOME:R-HSA-177929] [PUBMED:10459005] [PUBMED:10404636] [PUBMED:12297041] [PUBMED:15142631]
Signaling by PDGF [NCBI:1269478] [REACTOME:R-HSA-186797] [PUBMED:15207811] [PUBMED:10508235] [PUBMED:9739761]
Signaling by SCF-KIT [NCBI:1269487] [REACTOME:R-HSA-1433557] [PUBMED:17350321] [PUBMED:16483568] [PUBMED:7688988] [PUBMED:19540337] [PUBMED:16475976] [PUBMED:15526160]
Signaling by the B Cell Receptor (BCR) [NCBI:1269183] [REACTOME:R-HSA-983705] [PUBMED:1702903] [PUBMED:2011584] [PUBMED:1081164] [PUBMED:19065780] [PUBMED:16849466] [PUBMED:1375264] [PUBMED:7538118] [PUBMED:11901194] [PUBMED:8580068] [PUBMED:19249086] [PUBMED:18596693] [PUBMED:10648173] [PUBMED:4589993] [PUBMED:8163536] [PUBMED:1376928] [PUBMED:7688784] [PUBMED:6335036] [PUBMED:17052215] [PUBMED:18818202] [PUBMED:20206686] [PUBMED:7592958] [PUBMED:7524079] [PUBMED:15489917] [PUBMED:15509800] [PUBMED:18187424] [PUBMED:7927516] [PUBMED:803528] [PUBMED:19909372] [PUBMED:20192804] [PUBMED:8306975]
Signalling by NGF [NCBI:1269443] [REACTOME:R-HSA-166520]
Stabilization of p53 [NCBI:1269746] [REACTOME:R-HSA-69541] [PUBMED:11331603] [PUBMED:10673500] [PUBMED:10673501] [PUBMED:10710310]
Sumoylation by RanBP2 regulates transcriptional repression [NCBI:138029] [Pathway Interaction Database:ranbp2pathway] [PUBMED:11960997] [PUBMED:12393906] [PUBMED:8978815] [PUBMED:9456312] [PUBMED:12032081] [PUBMED:9019411] [PUBMED:9427648] [PUBMED:9108047] [PUBMED:12393750] [PUBMED:10892746] [PUBMED:9323132] [PUBMED:10454574]
Thyroid hormone signaling pathway [NCBI:946598] [KEGG:hsa04919] [PUBMED:20005976] [PUBMED:17983645] [PUBMED:15345678] [PUBMED:16951130] [PUBMED:16214361] [PUBMED:18329679] [PUBMED:20051527] [PUBMED:17574003] [PUBMED:19716314] [PUBMED:19755667] [PUBMED:20868274] [PUBMED:21835053] [PUBMED:16051672] [PUBMED:19295177] [PUBMED:23021374] [PUBMED:22484490]
Trafficking of AMPA receptors [NCBI:1268795] [REACTOME:R-HSA-399719] [PUBMED:19217372]
Transcriptional Regulation by TP53 [NCBI:1269654] [REACTOME:R-HSA-3700989] [PUBMED:26122615] [PUBMED:19410540]
Transcriptional misregulation in cancer [NCBI:523016] [KEGG:hsa05202] [PUBMED:17327229] [PUBMED:20190806] [PUBMED:20145147] [PUBMED:11313274] [PUBMED:11863357] [PUBMED:19472090] [PUBMED:18330902] [PUBMED:19738075] [PUBMED:15024077] [PUBMED:12032780] [PUBMED:14630078] [PUBMED:21765642] [PUBMED:19564705] [PUBMED:17101797] [PUBMED:15160934] [PUBMED:15688424] [PUBMED:15985538] [PUBMED:12527902] [PUBMED:12511414] [PUBMED:11607818] [PUBMED:17222504] [PUBMED:15826838] [PUBMED:21747944] [PUBMED:19406209] [PUBMED:10350329] [PUBMED:21779514] [PUBMED:18563191] [PUBMED:16946003] [PUBMED:17250957] [PUBMED:12670461] [PUBMED:12529654] [PUBMED:18855877] [PUBMED:17505060] [PUBMED:20153925] [PUBMED:20490326] [PUBMED:12130514] [PUBMED:18648544] [PUBMED:19855079] [PUBMED:10717473] [PUBMED:20478527] [PUBMED:11340171] [PUBMED:16169901] [PUBMED:14998494] [PUBMED:19233641] [PUBMED:19133982] [PUBMED:12393465] [PUBMED:19059936] [PUBMED:18172298] [PUBMED:10500199] [PUBMED:19141473] [PUBMED:10537274] [PUBMED:15156184] [PUBMED:14701735] [PUBMED:19422821] [PUBMED:21518926] [PUBMED:18850010] [PUBMED:19075677] [PUBMED:18457914] [PUBMED:12527906] [PUBMED:15644444] [PUBMED:10784387] [PUBMED:17024155] [PUBMED:19075268] [PUBMED:15826834] [PUBMED:21849159] [PUBMED:21123453] [PUBMED:20974671] [PUBMED:20863376]
Transmission across Chemical Synapses [NCBI:1268766] [REACTOME:R-HSA-112315]
Ub-specific processing proteases [NCBI:1427862] [REACTOME:R-HSA-5689880] [PUBMED:16325574]
Ubiquitin mediated proteolysis [NCBI:83056] [KEGG:hsa04120] [PUBMED:16405856] [PUBMED:12944364] [PUBMED:16922408] [PUBMED:17588513] [PUBMED:16922367] [PUBMED:16922370] [PUBMED:16816840]
Viral carcinogenesis [NCBI:658418] [KEGG:hsa05203] [PUBMED:9990017] [PUBMED:15173177] [PUBMED:16036567] [PUBMED:16581947] [PUBMED:9060639] [PUBMED:17457345] [PUBMED:15956361] [PUBMED:21421561] [PUBMED:18391203] [PUBMED:21040832] [PUBMED:9837909] [PUBMED:17645777] [PUBMED:15967719] [PUBMED:12686421] [PUBMED:17049016] [PUBMED:21152115] [PUBMED:11160754] [PUBMED:21966251] [PUBMED:17979705] [PUBMED:8617242] [PUBMED:12925958] [PUBMED:10873631] [PUBMED:21250384] [PUBMED:15614436] [PUBMED:10354594] [PUBMED:20494113] [PUBMED:18702816] [PUBMED:9651361] [PUBMED:16459163] [PUBMED:11278402] [PUBMED:15510157] [PUBMED:19956178] [PUBMED:18251977] [PUBMED:11766888] [PUBMED:10824878] [PUBMED:21372216] [PUBMED:11244044] [PUBMED:17894800] [PUBMED:11905817] [PUBMED:21347341] [PUBMED:12186904] [PUBMED:9374493] [PUBMED:16352731] [PUBMED:12770701] [PUBMED:17384582] [PUBMED:14506283] [PUBMED:11091847] [PUBMED:17267064] [PUBMED:11886269] [PUBMED:21177815] [PUBMED:10400746] [PUBMED:19156753] [PUBMED:9882379] [PUBMED:14559998] [PUBMED:15767449] [PUBMED:22110506] [PUBMED:20534855] [PUBMED:15542638] [PUBMED:9343405] [PUBMED:10405893] [PUBMED:19400863] [PUBMED:9349482] [PUBMED:14747563] [PUBMED:21647825] [PUBMED:12970441] [PUBMED:11669605] [PUBMED:15795286] [PUBMED:21994562] [PUBMED:14530271] [PUBMED:9594662] [PUBMED:22566809] [PUBMED:19651473] [PUBMED:8756622] [PUBMED:15105524] [PUBMED:15452270] [PUBMED:18948197] [PUBMED:16760382] [PUBMED:10793105] [PUBMED:21084867] [PUBMED:16308315] [PUBMED:16155604] [PUBMED:16381817] [PUBMED:16828973] [PUBMED:15342967] [PUBMED:15692053] [PUBMED:10855768] [PUBMED:19078975] [PUBMED:12379483] [PUBMED:15310405] [PUBMED:8223437] [PUBMED:16939421] [PUBMED:12910250] [PUBMED:16039586] [PUBMED:18201576] [PUBMED:21102637] [PUBMED:21743832] [PUBMED:20592731] [PUBMED:10644344] [PUBMED:10074132] [PUBMED:19715458] [PUBMED:16155601] [PUBMED:11604508] [PUBMED:15919895] [PUBMED:11099494] [PUBMED:18385245] [PUBMED:19854353] [PUBMED:12101418]
p53 pathway [NCBI:138067] [Pathway Interaction Database:p53regulationpathway] [PUBMED:9153395] [PUBMED:15448695] [PUBMED:10734067] [PUBMED:11340074] [PUBMED:15525938] [PUBMED:17189186] [PUBMED:18454141] [PUBMED:11715018] [PUBMED:9733514] [PUBMED:12963717] [PUBMED:15989956] [PUBMED:10581258] [PUBMED:18566590] [PUBMED:15029243] [PUBMED:14612427] [PUBMED:19011621] [PUBMED:12842086] [PUBMED:16377624] [PUBMED:17268548] [PUBMED:16845383] [PUBMED:17534149] [PUBMED:12397361] [PUBMED:11740489] [PUBMED:12110584] [PUBMED:11713287] [PUBMED:17646389] [PUBMED:14654783] [PUBMED:9153396] [PUBMED:18243116] [PUBMED:10673501] [PUBMED:17719542] [PUBMED:11983168] [PUBMED:12397362] [PUBMED:17189187] [PUBMED:16757976] [PUBMED:12667443] [PUBMED:9733515] [PUBMED:9878046] [PUBMED:9363941] [PUBMED:11504915] [PUBMED:11359766] [PUBMED:9529248] [PUBMED:17936559] [PUBMED:15210108] [PUBMED:17293853] [PUBMED:16107876] [PUBMED:9724636] [PUBMED:17707234] [PUBMED:10606744] [PUBMED:11780126] [PUBMED:10821866] [PUBMED:18485870] [PUBMED:17110336] [PUBMED:11046142] [PUBMED:11331603] [PUBMED:19597489] [PUBMED:16163388] [PUBMED:14671306] [PUBMED:17108971] [PUBMED:15242646] [PUBMED:15314173] [PUBMED:12654245] [PUBMED:15308643] [PUBMED:9744860] [PUBMED:17906639] [PUBMED:9891054] [PUBMED:17098746] [PUBMED:17349958] [PUBMED:11030628] [PUBMED:15103385] [PUBMED:14744935] [PUBMED:9529249] [PUBMED:11283254] [PUBMED:11606419] [PUBMED:11078726] [PUBMED:10611322] [PUBMED:9288740] [PUBMED:11127820] [PUBMED:19357310] [PUBMED:9450543]
p53 signaling pathway [NCBI:83055] [KEGG:hsa04115] [PUBMED:16557269] [PUBMED:10714958] [PUBMED:12505356] [PUBMED:16915296] [PUBMED:16697662] [PUBMED:15116721] [PUBMED:11313928] [PUBMED:11747320] [PUBMED:17409411] [PUBMED:15838523]
p53-Dependent G1 DNA Damage Response [NCBI:1269745] [REACTOME:R-HSA-69563] [PUBMED:9153396] [PUBMED:8247533] [PUBMED:1423616] [PUBMED:9153395]
p53-Dependent G1/S DNA damage checkpoint [NCBI:1269744] [REACTOME:R-HSA-69580] [PUBMED:1323840]