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Genes
MDM2
Gene - MDM2
full name
MDM2 proto-oncogene
synonyms
ACTFS, hdm2, HDMX, MDM2, ENSG00000135679
HGNC
HGNC:6973
Entrez Gene
Gene:4193
ENSEMBL
ENSG00000135679
location
chr: 12
start: 69201952
stop: 69239324
strand: +
OMIM
OMIM:164785
: MDM2
OMIM:614401
: {Accelerated tumor formation, susceptibility to}
transcripts
NM_002392.5
NM_001145339.2
NM_001145337.2
NM_001278462.1
NM_001145340.2
pathways
AKT phosphorylates targets in the cytosol
[NCBI:1269189]
[REACTOME:R-HSA-198323]
Adaptive Immune System
[NCBI:1269171]
[REACTOME:R-HSA-1280218]
[PUBMED:16551257]
[PUBMED:21682741]
[PUBMED:11861602]
Aurora A signaling
[NCBI:137925]
[Pathway Interaction Database:aurora_a_pathway]
[PUBMED:17308110]
[PUBMED:16894566]
[PUBMED:16631581]
[PUBMED:17229885]
[PUBMED:15128871]
[PUBMED:14990569]
[PUBMED:12177045]
[PUBMED:14580337]
[PUBMED:14724178]
[PUBMED:17545617]
[PUBMED:15687499]
[PUBMED:11163242]
[PUBMED:14603251]
[PUBMED:17060449]
[PUBMED:12208850]
[PUBMED:12815066]
[PUBMED:17125467]
[PUBMED:13678582]
[PUBMED:15987997]
[PUBMED:15966895]
[PUBMED:11976319]
[PUBMED:14702041]
[PUBMED:16246726]
[PUBMED:17452972]
[PUBMED:12082625]
[PUBMED:11039908]
[PUBMED:14667408]
[PUBMED:12577065]
[PUBMED:14600264]
[PUBMED:11756469]
[PUBMED:16772293]
[PUBMED:12023018]
[PUBMED:15469940]
[PUBMED:16082213]
Bladder cancer
[NCBI:83115]
[KEGG:hsa05219]
[PUBMED:15551095]
[PUBMED:15746962]
[PUBMED:11103787]
[PUBMED:16474624]
[PUBMED:17158541]
[PUBMED:12850530]
[PUBMED:17149381]
[PUBMED:16110317]
Cell Cycle
[NCBI:1269741]
[REACTOME:R-HSA-1640170]
Cell Cycle Checkpoints
[NCBI:1269742]
[REACTOME:R-HSA-69620]
Cell cycle
[NCBI:83054]
[KEGG:hsa04110]
[PUBMED:7973727]
[PUBMED:17568790]
[PUBMED:9832503]
[PUBMED:16936746]
[PUBMED:9029154]
[PUBMED:12573239]
[PUBMED:19020303]
[PUBMED:9618481]
[PUBMED:12809600]
[PUBMED:8242749]
[PUBMED:10385618]
[PUBMED:17426725]
[PUBMED:17018296]
[PUBMED:16212951]
[PUBMED:12925736]
[PUBMED:11099028]
[PUBMED:15568976]
[PUBMED:15838516]
[PUBMED:15838523]
[PUBMED:15876871]
[PUBMED:7908906]
[PUBMED:9889196]
Cellular Senescence
[NCBI:1270426]
[REACTOME:R-HSA-2559583]
[PUBMED:21078816]
[PUBMED:18711403]
[PUBMED:22048312]
[PUBMED:19818705]
[PUBMED:17662938]
[PUBMED:23746838]
[PUBMED:9282108]
[PUBMED:17667954]
[PUBMED:13905658]
Cellular responses to stress
[NCBI:1270414]
[REACTOME:R-HSA-2262752]
[PUBMED:15709958]
Chronic myeloid leukemia
[NCBI:83116]
[KEGG:hsa05220]
[PUBMED:22286129]
[PUBMED:12801837]
[PUBMED:11160144]
[PUBMED:15719031]
[PUBMED:10403855]
[PUBMED:9834202]
[PUBMED:11071626]
[PUBMED:12244301]
[PUBMED:15156182]
[PUBMED:16484590]
[PUBMED:14982876]
Constitutive Signaling by AKT1 E17K in Cancer
[NCBI:1268881]
[REACTOME:R-HSA-5674400]
[PUBMED:17611497]
[PUBMED:18954143]
DAP12 interactions
[NCBI:1269283]
[REACTOME:R-HSA-2172127]
[PUBMED:19120482]
[PUBMED:17220916]
[PUBMED:9490415]
[PUBMED:18192027]
[PUBMED:15884055]
DAP12 signaling
[NCBI:1269284]
[REACTOME:R-HSA-2424491]
[PUBMED:15884055]
[PUBMED:17110943]
[PUBMED:17220916]
Deubiquitination
[NCBI:1427860]
[REACTOME:R-HSA-5688426]
[PUBMED:19243136]
[PUBMED:20074029]
[PUBMED:15571815]
[PUBMED:20418328]
[PUBMED:16325574]
[PUBMED:12944365]
[PUBMED:23845989]
[PUBMED:22201797]
Direct p53 effectors
[NCBI:137939]
[Pathway Interaction Database:p53downstreampathway]
[PUBMED:7479001]
[PUBMED:19626115]
[PUBMED:10692390]
[PUBMED:15289308]
[PUBMED:14688482]
[PUBMED:16301995]
[PUBMED:11850816]
[PUBMED:12370809]
[PUBMED:16260627]
[PUBMED:15186775]
[PUBMED:15580302]
[PUBMED:10748162]
[PUBMED:10919640]
[PUBMED:19011621]
[PUBMED:12438652]
[PUBMED:11559530]
[PUBMED:11641774]
[PUBMED:11971958]
[PUBMED:9659898]
[PUBMED:9343394]
[PUBMED:10716435]
[PUBMED:17146433]
[PUBMED:17719542]
[PUBMED:17938176]
[PUBMED:17409421]
[PUBMED:11032029]
[PUBMED:15781865]
[PUBMED:11463392]
[PUBMED:9736732]
[PUBMED:17268548]
[PUBMED:8570655]
[PUBMED:18046411]
[PUBMED:12944906]
[PUBMED:16249378]
[PUBMED:15273740]
[PUBMED:15598651]
[PUBMED:10618379]
[PUBMED:15958553]
[PUBMED:17189187]
[PUBMED:17145718]
[PUBMED:11988847]
[PUBMED:8119988]
[PUBMED:12089322]
[PUBMED:16286009]
[PUBMED:12890671]
[PUBMED:12402042]
[PUBMED:10618714]
[PUBMED:14730312]
[PUBMED:12857899]
[PUBMED:14963330]
[PUBMED:11278953]
[PUBMED:11973653]
[PUBMED:12692263]
[PUBMED:10984493]
[PUBMED:10640990]
[PUBMED:11545734]
[PUBMED:16151013]
[PUBMED:12372430]
[PUBMED:16651407]
[PUBMED:9891062]
[PUBMED:12606722]
[PUBMED:12453409]
[PUBMED:15377670]
[PUBMED:12667443]
[PUBMED:17707234]
[PUBMED:9920903]
[PUBMED:14992722]
[PUBMED:15790310]
[PUBMED:15831478]
[PUBMED:11314010]
[PUBMED:10329733]
[PUBMED:17264218]
[PUBMED:11511362]
[PUBMED:11919562]
[PUBMED:11814693]
[PUBMED:17554199]
[PUBMED:18250150]
[PUBMED:10518217]
[PUBMED:10891498]
[PUBMED:10973264]
[PUBMED:15077116]
[PUBMED:16230375]
[PUBMED:18485870]
[PUBMED:7796420]
[PUBMED:15710382]
[PUBMED:17409411]
[PUBMED:8319905]
[PUBMED:10684646]
[PUBMED:7566179]
[PUBMED:8887630]
[PUBMED:11807984]
[PUBMED:9841917]
[PUBMED:12654245]
[PUBMED:9023107]
[PUBMED:15103385]
[PUBMED:11684014]
[PUBMED:17110336]
[PUBMED:11278253]
[PUBMED:14576823]
[PUBMED:8418500]
[PUBMED:11350971]
[PUBMED:11840333]
[PUBMED:7651818]
[PUBMED:7651386]
[PUBMED:15378026]
[PUBMED:15607964]
[PUBMED:11279192]
[PUBMED:10777218]
[PUBMED:15334053]
[PUBMED:12138177]
[PUBMED:9619826]
[PUBMED:16278683]
[PUBMED:17189186]
[PUBMED:16140933]
[PUBMED:10094469]
[PUBMED:9926927]
[PUBMED:17719541]
[PUBMED:15735003]
[PUBMED:12853982]
[PUBMED:14707288]
[PUBMED:10777207]
Disease
[NCBI:1268854]
[REACTOME:R-HSA-1643685]
Diseases of signal transduction
[NCBI:1268855]
[REACTOME:R-HSA-5663202]
[PUBMED:12509752]
Downstream signal transduction
[NCBI:1269479]
[REACTOME:R-HSA-186763]
[PUBMED:10508235]
[PUBMED:9739761]
Downstream signaling events of B Cell Receptor (BCR)
[NCBI:1269185]
[REACTOME:R-HSA-1168372]
[PUBMED:17052215]
[PUBMED:19909372]
Endocrine resistance
[NCBI:1404799]
[KEGG:hsa01522]
[PUBMED:24415977]
[PUBMED:23625614]
[PUBMED:24841429]
[PUBMED:15613444]
[PUBMED:23714450]
[PUBMED:20960099]
[PUBMED:22771991]
[PUBMED:19701242]
[PUBMED:24289103]
[PUBMED:24130921]
[PUBMED:23344024]
[PUBMED:22015292]
[PUBMED:26122181]
[PUBMED:26473850]
[PUBMED:18804516]
[PUBMED:24565562]
[PUBMED:26849149]
[PUBMED:25907219]
[PUBMED:20887199]
Endocytosis
[NCBI:102279]
[KEGG:hsa04144]
[PUBMED:19696797]
[PUBMED:19007773]
[PUBMED:16203612]
[PUBMED:15687999]
[PUBMED:19924646]
[PUBMED:15261671]
[PUBMED:18647649]
[PUBMED:19325624]
[PUBMED:20110990]
[PUBMED:22193161]
Epstein-Barr virus infection
[NCBI:585562]
[KEGG:hsa05169]
[PUBMED:1658397]
[PUBMED:10683340]
[PUBMED:19375142]
[PUBMED:12438576]
[PUBMED:12910248]
[PUBMED:10400785]
[PUBMED:16007144]
[PUBMED:14576817]
[PUBMED:18559925]
[PUBMED:16352731]
[PUBMED:7895172]
[PUBMED:15510157]
[PUBMED:21518914]
[PUBMED:10891508]
[PUBMED:14673102]
[PUBMED:17159145]
[PUBMED:15542638]
[PUBMED:18786993]
[PUBMED:16603506]
[PUBMED:10644367]
[PUBMED:15021898]
[PUBMED:10666279]
[PUBMED:9565632]
ErbB4 signaling events
[NCBI:137991]
[Pathway Interaction Database:erbb4_pathway]
[PUBMED:16815842]
[PUBMED:8617750]
[PUBMED:9663464]
[PUBMED:12466964]
[PUBMED:15345710]
[PUBMED:16061658]
[PUBMED:12954715]
[PUBMED:17463226]
[PUBMED:17646177]
[PUBMED:17085783]
[PUBMED:18721752]
[PUBMED:15023535]
[PUBMED:9556621]
[PUBMED:12807903]
[PUBMED:17486069]
[PUBMED:10358079]
[PUBMED:12454007]
[PUBMED:8702723]
[PUBMED:10693928]
[PUBMED:18334649]
[PUBMED:10725395]
[PUBMED:11731109]
[PUBMED:7477376]
[PUBMED:16837552]
[PUBMED:15863494]
[PUBMED:19047365]
[PUBMED:10722704]
[PUBMED:19193720]
[PUBMED:10348342]
[PUBMED:17018285]
[PUBMED:9135143]
[PUBMED:9618494]
[PUBMED:12716924]
[PUBMED:18819924]
[PUBMED:10867024]
[PUBMED:15985438]
[PUBMED:7559778]
[PUBMED:7759543]
[PUBMED:12824469]
[PUBMED:10744726]
[PUBMED:15746097]
[PUBMED:18653779]
[PUBMED:15534001]
[PUBMED:17460065]
[PUBMED:10508857]
[PUBMED:15282549]
[PUBMED:9362517]
[PUBMED:9685416]
[PUBMED:11679632]
[PUBMED:10839362]
[PUBMED:10353604]
Fc epsilon receptor (FCERI) signaling
[NCBI:1269298]
[REACTOME:R-HSA-2454202]
[PUBMED:15099567]
[PUBMED:21799019]
FoxO signaling pathway
[NCBI:921162]
[KEGG:hsa04068]
[PUBMED:23325358]
[PUBMED:15005655]
[PUBMED:18951090]
[PUBMED:22761423]
[PUBMED:22902436]
[PUBMED:16288288]
[PUBMED:19701188]
[PUBMED:16964248]
[PUBMED:18045156]
[PUBMED:18403263]
[PUBMED:21613825]
[PUBMED:21440011]
[PUBMED:17470511]
[PUBMED:21238503]
[PUBMED:17522590]
[PUBMED:15084259]
[PUBMED:23801966]
[PUBMED:17569704]
[PUBMED:15516968]
G1/S DNA Damage Checkpoints
[NCBI:1269743]
[REACTOME:R-HSA-69615]
GAB1 signalosome
[NCBI:1269384]
[REACTOME:R-HSA-180292]
[PUBMED:15550174]
Gene Expression
[NCBI:1269649]
[REACTOME:R-HSA-74160]
Generic Transcription Pathway
[NCBI:1269650]
[REACTOME:R-HSA-212436]
[PUBMED:15175151]
[PUBMED:14744435]
[PUBMED:15680972]
[PUBMED:11395415]
[PUBMED:15896744]
[PUBMED:10235266]
[PUBMED:14986688]
[PUBMED:12023297]
[PUBMED:15680973]
[PUBMED:16751179]
[PUBMED:11861166]
[PUBMED:16429119]
[PUBMED:16719718]
[PUBMED:16921404]
[PUBMED:15690163]
Glioma
[NCBI:83110]
[KEGG:hsa05214]
[PUBMED:11057895]
[PUBMED:11253051]
[PUBMED:12154354]
[PUBMED:12084351]
[PUBMED:15639402]
[PUBMED:9643506]
[PUBMED:16095998]
[PUBMED:12762887]
[PUBMED:16700615]
Glucocorticoid receptor regulatory network
[NCBI:138014]
[Pathway Interaction Database:reg_gr_pathway]
[PUBMED:8943293]
[PUBMED:1708774]
[PUBMED:15826950]
[PUBMED:11027313]
[PUBMED:12118039]
[PUBMED:9388207]
[PUBMED:11751894]
[PUBMED:12151000]
[PUBMED:9765258]
[PUBMED:9407028]
[PUBMED:19074285]
[PUBMED:2838908]
[PUBMED:15817653]
[PUBMED:9722596]
[PUBMED:12917342]
[PUBMED:1387550]
[PUBMED:10974006]
[PUBMED:15790729]
[PUBMED:10825196]
[PUBMED:10623828]
[PUBMED:2169352]
[PUBMED:9315653]
[PUBMED:7759501]
[PUBMED:8290595]
[PUBMED:2905764]
[PUBMED:12351702]
[PUBMED:11080152]
[PUBMED:8428574]
[PUBMED:9215863]
[PUBMED:15459252]
[PUBMED:10400612]
[PUBMED:9426156]
[PUBMED:17440046]
[PUBMED:18838540]
[PUBMED:2169353]
[PUBMED:10820245]
[PUBMED:12511605]
[PUBMED:2586521]
[PUBMED:1740658]
[PUBMED:11555652]
[PUBMED:11562347]
[PUBMED:9482836]
[PUBMED:18337589]
[PUBMED:10958685]
[PUBMED:9388192]
[PUBMED:15834420]
[PUBMED:15657031]
[PUBMED:8878484]
[PUBMED:10760263]
[PUBMED:12730237]
[PUBMED:8702844]
[PUBMED:2169351]
[PUBMED:17215482]
[PUBMED:8898375]
Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity
[NCBI:1268794]
[REACTOME:R-HSA-399721]
[PUBMED:16904750]
[PUBMED:16713244]
[PUBMED:19217372]
Immune System
[NCBI:1269170]
[REACTOME:R-HSA-168256]
Innate Immune System
[NCBI:1269203]
[REACTOME:R-HSA-168249]
Melanoma
[NCBI:83114]
[KEGG:hsa05218]
[PUBMED:16822996]
[PUBMED:14695152]
[PUBMED:11224709]
[PUBMED:10843728]
[PUBMED:12894244]
[PUBMED:16899407]
[PUBMED:16001072]
[PUBMED:15721476]
[PUBMED:15557758]
[PUBMED:15009714]
[PUBMED:16001050]
[PUBMED:15841168]
[PUBMED:16750612]
Metabolism of proteins
[NCBI:1268677]
[REACTOME:R-HSA-392499]
MicroRNAs in cancer
[NCBI:852705]
[KEGG:hsa05206]
[PUBMED:23075324]
[PUBMED:21742789]
[PUBMED:22351564]
[PUBMED:18817506]
[PUBMED:22345301]
[PUBMED:21402473]
[PUBMED:22926415]
[PUBMED:23165235]
[PUBMED:19630570]
[PUBMED:21565290]
[PUBMED:23091478]
[PUBMED:23462054]
[PUBMED:23316212]
[PUBMED:19773200]
[PUBMED:22035854]
[PUBMED:20221895]
[PUBMED:20345848]
[PUBMED:22580099]
[PUBMED:20128019]
NGF signalling via TRKA from the plasma membrane
[NCBI:1269460]
[REACTOME:R-HSA-187037]
[PUBMED:11520933]
[PUBMED:12676795]
[PUBMED:10851172]
[PUBMED:10579918]
Neuronal System
[NCBI:1268763]
[REACTOME:R-HSA-112316]
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
[NCBI:1268786]
[REACTOME:R-HSA-112314]
Oncogene Induced Senescence
[NCBI:1270427]
[REACTOME:R-HSA-2559585]
[PUBMED:10722742]
[PUBMED:20583212]
[PUBMED:8521522]
[PUBMED:20534573]
[PUBMED:11234019]
[PUBMED:14729966]
[PUBMED:12839923]
[PUBMED:8319905]
[PUBMED:18365017]
[PUBMED:15572696]
[PUBMED:9529249]
[PUBMED:10733595]
[PUBMED:9824166]
[PUBMED:11782450]
[PUBMED:8259215]
[PUBMED:7588608]
[PUBMED:8552081]
[PUBMED:9704925]
[PUBMED:22336108]
[PUBMED:11883935]
Oxidative Stress Induced Senescence
[NCBI:1270428]
[REACTOME:R-HSA-2559580]
[PUBMED:17344414]
[PUBMED:17332741]
[PUBMED:8622688]
[PUBMED:7588633]
[PUBMED:15563468]
[PUBMED:15287722]
[PUBMED:11062067]
[PUBMED:16337592]
[PUBMED:14532106]
[PUBMED:17254968]
[PUBMED:15866172]
[PUBMED:9628874]
[PUBMED:12171911]
[PUBMED:7816143]
[PUBMED:22020331]
[PUBMED:11564866]
[PUBMED:9162092]
[PUBMED:8974401]
[PUBMED:19451217]
[PUBMED:12808055]
[PUBMED:17210787]
[PUBMED:8846784]
[PUBMED:19462008]
[PUBMED:12134156]
[PUBMED:8626550]
[PUBMED:8774846]
[PUBMED:12189133]
[PUBMED:9195981]
[PUBMED:8622669]
[PUBMED:8259215]
[PUBMED:19528227]
[PUBMED:9564042]
[PUBMED:9529249]
[PUBMED:16436515]
[PUBMED:19451218]
[PUBMED:17395714]
[PUBMED:9030721]
[PUBMED:12435631]
[PUBMED:22325352]
PI3K-Akt signaling pathway
[NCBI:692234]
[KEGG:hsa04151]
[PUBMED:12048182]
[PUBMED:11357143]
[PUBMED:21440011]
[PUBMED:15209374]
[PUBMED:12669022]
[PUBMED:18842113]
[PUBMED:16847462]
[PUBMED:12660731]
[PUBMED:17360849]
[PUBMED:9838078]
[PUBMED:15505410]
[PUBMED:16248975]
[PUBMED:12531180]
[PUBMED:21779440]
[PUBMED:16187290]
[PUBMED:15784165]
[PUBMED:21620960]
PI3K/AKT Signaling in Cancer
[NCBI:1268879]
[REACTOME:R-HSA-2219528]
[PUBMED:20713702]
[PUBMED:10555148]
[PUBMED:19644473]
[PUBMED:17611497]
[PUBMED:21478295]
[PUBMED:17626883]
[PUBMED:16339315]
[PUBMED:18317450]
[PUBMED:18079394]
[PUBMED:9467011]
[PUBMED:17604717]
[PUBMED:9326929]
[PUBMED:18954143]
[PUBMED:20009532]
[PUBMED:19962665]
[PUBMED:21430697]
[PUBMED:19487573]
[PUBMED:10866302]
PI3K/AKT activation
[NCBI:1269473]
[REACTOME:R-HSA-198203]
[PUBMED:10579926]
[PUBMED:12123609]
PIP3 activates AKT signaling
[NCBI:1269188]
[REACTOME:R-HSA-1257604]
Pathways in cancer
[NCBI:83105]
[KEGG:hsa05200]
[PUBMED:12244301]
[PUBMED:15156182]
[PUBMED:16899407]
[PUBMED:12621137]
[PUBMED:21193867]
[PUBMED:16001072]
[PUBMED:11707511]
[PUBMED:11253051]
[PUBMED:11071626]
[PUBMED:17251915]
[PUBMED:11736900]
[PUBMED:16557281]
[PUBMED:16699851]
[PUBMED:16189702]
[PUBMED:11902573]
[PUBMED:16555243]
[PUBMED:8069858]
[PUBMED:15310786]
[PUBMED:9834202]
[PUBMED:16700615]
[PUBMED:12545153]
[PUBMED:15656799]
[PUBMED:12154354]
[PUBMED:11895903]
[PUBMED:11527574]
[PUBMED:16326109]
[PUBMED:16339096]
[PUBMED:11160144]
[PUBMED:15724144]
[PUBMED:12951584]
[PUBMED:10647931]
[PUBMED:16881963]
[PUBMED:15557758]
[PUBMED:11477132]
[PUBMED:15721476]
[PUBMED:15625120]
[PUBMED:16236521]
[PUBMED:14967450]
[PUBMED:15942304]
[PUBMED:17287871]
[PUBMED:14634372]
[PUBMED:15573119]
[PUBMED:15009714]
[PUBMED:16112428]
[PUBMED:15611513]
[PUBMED:16001050]
[PUBMED:15349822]
[PUBMED:16551846]
[PUBMED:15978322]
[PUBMED:15774796]
[PUBMED:16352814]
[PUBMED:12951588]
[PUBMED:10944551]
[PUBMED:10740269]
[PUBMED:15639402]
[PUBMED:12407699]
[PUBMED:11130178]
[PUBMED:15109562]
[PUBMED:11170304]
[PUBMED:11276000]
[PUBMED:9643506]
[PUBMED:16248975]
[PUBMED:16242838]
[PUBMED:12946833]
[PUBMED:11559746]
[PUBMED:9196022]
[PUBMED:12079267]
[PUBMED:15468170]
[PUBMED:16064138]
[PUBMED:14580692]
[PUBMED:15082523]
[PUBMED:15551095]
[PUBMED:17062879]
[PUBMED:17211469]
[PUBMED:11720739]
[PUBMED:12588368]
[PUBMED:11057895]
[PUBMED:9422516]
[PUBMED:12894244]
[PUBMED:15479695]
[PUBMED:16189154]
[PUBMED:12878745]
[PUBMED:11900250]
[PUBMED:11103787]
[PUBMED:15122209]
[PUBMED:12711111]
[PUBMED:12243753]
[PUBMED:16306523]
[PUBMED:16702400]
[PUBMED:15270885]
[PUBMED:14685170]
[PUBMED:14586404]
[PUBMED:11078609]
[PUBMED:15284264]
[PUBMED:10505543]
[PUBMED:11223406]
[PUBMED:14982876]
[PUBMED:12648469]
[PUBMED:12867060]
[PUBMED:15711891]
[PUBMED:12094241]
[PUBMED:16642045]
[PUBMED:11463388]
[PUBMED:12762887]
[PUBMED:15746962]
[PUBMED:15823750]
[PUBMED:16750612]
[PUBMED:16484590]
[PUBMED:11459867]
[PUBMED:16146838]
[PUBMED:14556242]
[PUBMED:15947972]
[PUBMED:12563308]
[PUBMED:16946003]
[PUBMED:15948971]
[PUBMED:11407945]
[PUBMED:12737309]
[PUBMED:16095998]
[PUBMED:12351585]
[PUBMED:24508914]
[PUBMED:12084351]
[PUBMED:11807782]
[PUBMED:14695152]
[PUBMED:10453277]
[PUBMED:17554387]
[PUBMED:15841168]
[PUBMED:12616528]
[PUBMED:10403855]
[PUBMED:16054233]
[PUBMED:16474624]
[PUBMED:16822996]
[PUBMED:17028294]
[PUBMED:11224709]
[PUBMED:11750244]
[PUBMED:11905738]
[PUBMED:15719031]
[PUBMED:10843728]
[PUBMED:16110317]
[PUBMED:11721960]
[PUBMED:12741677]
[PUBMED:7585656]
[PUBMED:12801837]
[PUBMED:16551847]
[PUBMED:12459728]
[PUBMED:11431710]
[PUBMED:12468433]
[PUBMED:11165748]
[PUBMED:16042571]
[PUBMED:16508724]
[PUBMED:15000146]
[PUBMED:17149381]
[PUBMED:15948711]
[PUBMED:14747944]
[PUBMED:14737121]
[PUBMED:12379883]
[PUBMED:17158541]
[PUBMED:12850530]
[PUBMED:10835690]
[PUBMED:16870043]
Platinum drug resistance
[NCBI:1404797]
[KEGG:hsa01524]
[PUBMED:24074238]
[PUBMED:26867799]
[PUBMED:14609433]
[PUBMED:26184483]
[PUBMED:24874729]
[PUBMED:15607932]
[PUBMED:25546083]
[PUBMED:25058905]
[PUBMED:19190080]
[PUBMED:14576837]
[PUBMED:20811617]
[PUBMED:21892204]
[PUBMED:20647037]
[PUBMED:17336087]
[PUBMED:26886018]
[PUBMED:23442359]
[PUBMED:17625587]
Post-translational protein modification
[NCBI:1268701]
[REACTOME:R-HSA-597592]
Prostate cancer
[NCBI:83111]
[KEGG:hsa05215]
[PUBMED:12878745]
[PUBMED:11900250]
[PUBMED:11527574]
[PUBMED:11750244]
[PUBMED:16551847]
[PUBMED:10835690]
[PUBMED:8069858]
[PUBMED:15724144]
[PUBMED:10453277]
[PUBMED:15082523]
[PUBMED:9422516]
Proteoglycans in cancer
[NCBI:782000]
[KEGG:hsa05205]
[PUBMED:19433454]
[PUBMED:20655987]
[PUBMED:18798267]
[PUBMED:10633082]
[PUBMED:10687947]
[PUBMED:22735579]
[PUBMED:24412155]
[PUBMED:9346940]
[PUBMED:22087031]
[PUBMED:22194599]
[PUBMED:14711376]
[PUBMED:19255147]
[PUBMED:15655247]
[PUBMED:11717317]
[PUBMED:17971838]
[PUBMED:18413366]
[PUBMED:20974860]
[PUBMED:11830493]
[PUBMED:23058688]
[PUBMED:18450475]
[PUBMED:12748184]
[PUBMED:19733083]
[PUBMED:18812315]
[PUBMED:12509413]
[PUBMED:21155971]
[PUBMED:11931647]
[PUBMED:18949819]
[PUBMED:12729888]
[PUBMED:15994311]
[PUBMED:23305321]
[PUBMED:18505598]
[PUBMED:22563565]
[PUBMED:22033227]
Regulation of Androgen receptor activity
[NCBI:138027]
[Pathway Interaction Database:ar_tf_pathway]
[PUBMED:15650026]
[PUBMED:17045208]
[PUBMED:10364196]
[PUBMED:16860317]
[PUBMED:10611280]
[PUBMED:10930412]
[PUBMED:1525041]
[PUBMED:10779504]
[PUBMED:12514133]
[PUBMED:1985913]
[PUBMED:11931767]
[PUBMED:17011549]
[PUBMED:15640443]
[PUBMED:16322096]
[PUBMED:15923603]
[PUBMED:14985354]
[PUBMED:15743818]
[PUBMED:12949936]
[PUBMED:11994312]
[PUBMED:10567371]
[PUBMED:11875111]
[PUBMED:15604291]
[PUBMED:12890669]
[PUBMED:14729952]
[PUBMED:9211894]
[PUBMED:9162033]
[PUBMED:16705743]
[PUBMED:16849544]
[PUBMED:16923962]
[PUBMED:11591700]
[PUBMED:16051670]
[PUBMED:8643509]
[PUBMED:17108144]
[PUBMED:16914734]
[PUBMED:12682292]
[PUBMED:3353726]
[PUBMED:11585838]
[PUBMED:16282370]
[PUBMED:10381882]
[PUBMED:15199155]
[PUBMED:16455820]
[PUBMED:14612401]
[PUBMED:10625666]
[PUBMED:17679089]
[PUBMED:16461774]
Regulation of TP53 Activity
[NCBI:1383076]
[REACTOME:R-HSA-5633007]
[PUBMED:19450511]
[PUBMED:20457558]
[PUBMED:23825024]
[PUBMED:25641576]
Regulation of TP53 Activity through Methylation
[NCBI:1383082]
[REACTOME:R-HSA-6804760]
[PUBMED:18833288]
[PUBMED:17805299]
[PUBMED:15186775]
[PUBMED:11511361]
[PUBMED:16415881]
[PUBMED:22362889]
[PUBMED:20118233]
[PUBMED:15525938]
[PUBMED:21625555]
[PUBMED:15448695]
[PUBMED:20870725]
[PUBMED:10518217]
[PUBMED:17108971]
Regulation of TP53 Activity through Phosphorylation
[NCBI:1383080]
[REACTOME:R-HSA-6804756]
[PUBMED:11780126]
[PUBMED:21317932]
[PUBMED:15866171]
[PUBMED:12393879]
[PUBMED:11740489]
[PUBMED:11447225]
[PUBMED:9733515]
[PUBMED:12851404]
[PUBMED:10884347]
[PUBMED:10710310]
[PUBMED:11239457]
[PUBMED:9925639]
[PUBMED:11546806]
[PUBMED:11551930]
[PUBMED:10570149]
[PUBMED:18490454]
[PUBMED:17591690]
[PUBMED:19965871]
[PUBMED:12064478]
[PUBMED:10673501]
[PUBMED:22611192]
[PUBMED:9843217]
[PUBMED:15053879]
[PUBMED:12914926]
[PUBMED:10673500]
[PUBMED:17349958]
[PUBMED:14702041]
[PUBMED:20959462]
[PUBMED:10435622]
[PUBMED:9733514]
Regulation of TP53 Degradation
[NCBI:1383079]
[REACTOME:R-HSA-6804757]
[PUBMED:21730132]
[PUBMED:10570149]
[PUBMED:15563468]
[PUBMED:16845383]
[PUBMED:11923872]
[PUBMED:11883935]
[PUBMED:17290220]
[PUBMED:17121812]
[PUBMED:10673500]
[PUBMED:9843217]
[PUBMED:9529249]
[PUBMED:21730163]
[PUBMED:11715018]
[PUBMED:9733514]
[PUBMED:19838211]
[PUBMED:10608892]
[PUBMED:16474402]
[PUBMED:19450511]
[PUBMED:16163388]
[PUBMED:10722742]
[PUBMED:21986495]
[PUBMED:15788536]
[PUBMED:19816404]
[PUBMED:11359766]
[PUBMED:11504915]
[PUBMED:9733515]
[PUBMED:19756449]
[PUBMED:11983168]
[PUBMED:8319905]
[PUBMED:20438709]
Regulation of TP53 Expression and Degradation
[NCBI:1383077]
[REACTOME:R-HSA-6806003]
[PUBMED:11883935]
[PUBMED:11923872]
[PUBMED:19293287]
[PUBMED:23303139]
[PUBMED:17499002]
[PUBMED:15563468]
[PUBMED:17121812]
[PUBMED:21986495]
[PUBMED:15103385]
[PUBMED:9529249]
[PUBMED:21814038]
[PUBMED:19250907]
[PUBMED:8319905]
[PUBMED:7878469]
[PUBMED:12654245]
[PUBMED:16213212]
Regulation of retinoblastoma protein
[NCBI:137916]
[Pathway Interaction Database:rb_1pathway]
[PUBMED:15469821]
[PUBMED:11470869]
[PUBMED:8493578]
[PUBMED:7596417]
[PUBMED:8449399]
[PUBMED:9468140]
[PUBMED:11596110]
[PUBMED:9545246]
[PUBMED:16360038]
[PUBMED:14673169]
[PUBMED:17991896]
[PUBMED:8805225]
[PUBMED:7926730]
[PUBMED:10322110]
[PUBMED:11533237]
[PUBMED:1828393]
[PUBMED:8657117]
[PUBMED:9491888]
[PUBMED:7877691]
[PUBMED:14729964]
[PUBMED:1710781]
[PUBMED:10778858]
[PUBMED:11566021]
[PUBMED:8246996]
[PUBMED:12450794]
[PUBMED:16374512]
[PUBMED:10783144]
[PUBMED:15949438]
[PUBMED:9468139]
[PUBMED:8242749]
[PUBMED:9464541]
[PUBMED:1531329]
[PUBMED:9819434]
[PUBMED:12479814]
[PUBMED:10888886]
[PUBMED:10597288]
[PUBMED:8626527]
[PUBMED:7629134]
[PUBMED:11545733]
[PUBMED:17620057]
[PUBMED:11433299]
[PUBMED:9858607]
[PUBMED:15716956]
[PUBMED:10490602]
[PUBMED:1828392]
[PUBMED:15577944]
[PUBMED:11484059]
[PUBMED:11583618]
[PUBMED:10499802]
Role of LAT2/NTAL/LAB on calcium mobilization
[NCBI:1269302]
[REACTOME:R-HSA-2730905]
[PUBMED:17993265]
[PUBMED:20643813]
[PUBMED:17420272]
SUMO E3 ligases SUMOylate target proteins
[NCBI:1268743]
[REACTOME:R-HSA-3108232]
[PUBMED:20674646]
[PUBMED:17763827]
[PUBMED:19471022]
[PUBMED:23746258]
[PUBMED:24016193]
[PUBMED:23503365]
[PUBMED:21252943]
[PUBMED:17000644]
[PUBMED:24273646]
[PUBMED:22811915]
[PUBMED:21693764]
[PUBMED:23277067]
[PUBMED:21102611]
SUMOylation
[NCBI:1268738]
[REACTOME:R-HSA-2990846]
[PUBMED:21102611]
[PUBMED:20674646]
[PUBMED:23514139]
[PUBMED:19923268]
[PUBMED:20462400]
[PUBMED:17768054]
SUMOylation of transcription factors
[NCBI:1339110]
[REACTOME:R-HSA-3232118]
[PUBMED:16095902]
[PUBMED:21892772]
[PUBMED:19107415]
[PUBMED:19616654]
[PUBMED:15209380]
[PUBMED:18031228]
Signal Transduction
[NCBI:1269379]
[REACTOME:R-HSA-162582]
[PUBMED:17604717]
[PUBMED:19648010]
[PUBMED:16260143]
[PUBMED:11742412]
[PUBMED:19536106]
[PUBMED:15863030]
[PUBMED:19379690]
[PUBMED:19458711]
[PUBMED:19935667]
[PUBMED:21252999]
[PUBMED:15520807]
[PUBMED:17496910]
[PUBMED:15450248]
[PUBMED:18043707]
[PUBMED:16939974]
[PUBMED:19762341]
[PUBMED:18483217]
[PUBMED:17084981]
[PUBMED:21781017]
[PUBMED:19619488]
Signaling by EGFR
[NCBI:1269380]
[REACTOME:R-HSA-177929]
[PUBMED:10459005]
[PUBMED:10404636]
[PUBMED:12297041]
[PUBMED:15142631]
Signaling by PDGF
[NCBI:1269478]
[REACTOME:R-HSA-186797]
[PUBMED:15207811]
[PUBMED:10508235]
[PUBMED:9739761]
Signaling by SCF-KIT
[NCBI:1269487]
[REACTOME:R-HSA-1433557]
[PUBMED:17350321]
[PUBMED:16483568]
[PUBMED:7688988]
[PUBMED:19540337]
[PUBMED:16475976]
[PUBMED:15526160]
Signaling by the B Cell Receptor (BCR)
[NCBI:1269183]
[REACTOME:R-HSA-983705]
[PUBMED:1702903]
[PUBMED:2011584]
[PUBMED:1081164]
[PUBMED:19065780]
[PUBMED:16849466]
[PUBMED:1375264]
[PUBMED:7538118]
[PUBMED:11901194]
[PUBMED:8580068]
[PUBMED:19249086]
[PUBMED:18596693]
[PUBMED:10648173]
[PUBMED:4589993]
[PUBMED:8163536]
[PUBMED:1376928]
[PUBMED:7688784]
[PUBMED:6335036]
[PUBMED:17052215]
[PUBMED:18818202]
[PUBMED:20206686]
[PUBMED:7592958]
[PUBMED:7524079]
[PUBMED:15489917]
[PUBMED:15509800]
[PUBMED:18187424]
[PUBMED:7927516]
[PUBMED:803528]
[PUBMED:19909372]
[PUBMED:20192804]
[PUBMED:8306975]
Signalling by NGF
[NCBI:1269443]
[REACTOME:R-HSA-166520]
Stabilization of p53
[NCBI:1269746]
[REACTOME:R-HSA-69541]
[PUBMED:11331603]
[PUBMED:10673500]
[PUBMED:10673501]
[PUBMED:10710310]
Sumoylation by RanBP2 regulates transcriptional repression
[NCBI:138029]
[Pathway Interaction Database:ranbp2pathway]
[PUBMED:11960997]
[PUBMED:12393906]
[PUBMED:8978815]
[PUBMED:9456312]
[PUBMED:12032081]
[PUBMED:9019411]
[PUBMED:9427648]
[PUBMED:9108047]
[PUBMED:12393750]
[PUBMED:10892746]
[PUBMED:9323132]
[PUBMED:10454574]
Thyroid hormone signaling pathway
[NCBI:946598]
[KEGG:hsa04919]
[PUBMED:20005976]
[PUBMED:17983645]
[PUBMED:15345678]
[PUBMED:16951130]
[PUBMED:16214361]
[PUBMED:18329679]
[PUBMED:20051527]
[PUBMED:17574003]
[PUBMED:19716314]
[PUBMED:19755667]
[PUBMED:20868274]
[PUBMED:21835053]
[PUBMED:16051672]
[PUBMED:19295177]
[PUBMED:23021374]
[PUBMED:22484490]
Trafficking of AMPA receptors
[NCBI:1268795]
[REACTOME:R-HSA-399719]
[PUBMED:19217372]
Transcriptional Regulation by TP53
[NCBI:1269654]
[REACTOME:R-HSA-3700989]
[PUBMED:26122615]
[PUBMED:19410540]
Transcriptional misregulation in cancer
[NCBI:523016]
[KEGG:hsa05202]
[PUBMED:17327229]
[PUBMED:20190806]
[PUBMED:20145147]
[PUBMED:11313274]
[PUBMED:11863357]
[PUBMED:19472090]
[PUBMED:18330902]
[PUBMED:19738075]
[PUBMED:15024077]
[PUBMED:12032780]
[PUBMED:14630078]
[PUBMED:21765642]
[PUBMED:19564705]
[PUBMED:17101797]
[PUBMED:15160934]
[PUBMED:15688424]
[PUBMED:15985538]
[PUBMED:12527902]
[PUBMED:12511414]
[PUBMED:11607818]
[PUBMED:17222504]
[PUBMED:15826838]
[PUBMED:21747944]
[PUBMED:19406209]
[PUBMED:10350329]
[PUBMED:21779514]
[PUBMED:18563191]
[PUBMED:16946003]
[PUBMED:17250957]
[PUBMED:12670461]
[PUBMED:12529654]
[PUBMED:18855877]
[PUBMED:17505060]
[PUBMED:20153925]
[PUBMED:20490326]
[PUBMED:12130514]
[PUBMED:18648544]
[PUBMED:19855079]
[PUBMED:10717473]
[PUBMED:20478527]
[PUBMED:11340171]
[PUBMED:16169901]
[PUBMED:14998494]
[PUBMED:19233641]
[PUBMED:19133982]
[PUBMED:12393465]
[PUBMED:19059936]
[PUBMED:18172298]
[PUBMED:10500199]
[PUBMED:19141473]
[PUBMED:10537274]
[PUBMED:15156184]
[PUBMED:14701735]
[PUBMED:19422821]
[PUBMED:21518926]
[PUBMED:18850010]
[PUBMED:19075677]
[PUBMED:18457914]
[PUBMED:12527906]
[PUBMED:15644444]
[PUBMED:10784387]
[PUBMED:17024155]
[PUBMED:19075268]
[PUBMED:15826834]
[PUBMED:21849159]
[PUBMED:21123453]
[PUBMED:20974671]
[PUBMED:20863376]
Transmission across Chemical Synapses
[NCBI:1268766]
[REACTOME:R-HSA-112315]
Ub-specific processing proteases
[NCBI:1427862]
[REACTOME:R-HSA-5689880]
[PUBMED:16325574]
Ubiquitin mediated proteolysis
[NCBI:83056]
[KEGG:hsa04120]
[PUBMED:16405856]
[PUBMED:12944364]
[PUBMED:16922408]
[PUBMED:17588513]
[PUBMED:16922367]
[PUBMED:16922370]
[PUBMED:16816840]
Viral carcinogenesis
[NCBI:658418]
[KEGG:hsa05203]
[PUBMED:9990017]
[PUBMED:15173177]
[PUBMED:16036567]
[PUBMED:16581947]
[PUBMED:9060639]
[PUBMED:17457345]
[PUBMED:15956361]
[PUBMED:21421561]
[PUBMED:18391203]
[PUBMED:21040832]
[PUBMED:9837909]
[PUBMED:17645777]
[PUBMED:15967719]
[PUBMED:12686421]
[PUBMED:17049016]
[PUBMED:21152115]
[PUBMED:11160754]
[PUBMED:21966251]
[PUBMED:17979705]
[PUBMED:8617242]
[PUBMED:12925958]
[PUBMED:10873631]
[PUBMED:21250384]
[PUBMED:15614436]
[PUBMED:10354594]
[PUBMED:20494113]
[PUBMED:18702816]
[PUBMED:9651361]
[PUBMED:16459163]
[PUBMED:11278402]
[PUBMED:15510157]
[PUBMED:19956178]
[PUBMED:18251977]
[PUBMED:11766888]
[PUBMED:10824878]
[PUBMED:21372216]
[PUBMED:11244044]
[PUBMED:17894800]
[PUBMED:11905817]
[PUBMED:21347341]
[PUBMED:12186904]
[PUBMED:9374493]
[PUBMED:16352731]
[PUBMED:12770701]
[PUBMED:17384582]
[PUBMED:14506283]
[PUBMED:11091847]
[PUBMED:17267064]
[PUBMED:11886269]
[PUBMED:21177815]
[PUBMED:10400746]
[PUBMED:19156753]
[PUBMED:9882379]
[PUBMED:14559998]
[PUBMED:15767449]
[PUBMED:22110506]
[PUBMED:20534855]
[PUBMED:15542638]
[PUBMED:9343405]
[PUBMED:10405893]
[PUBMED:19400863]
[PUBMED:9349482]
[PUBMED:14747563]
[PUBMED:21647825]
[PUBMED:12970441]
[PUBMED:11669605]
[PUBMED:15795286]
[PUBMED:21994562]
[PUBMED:14530271]
[PUBMED:9594662]
[PUBMED:22566809]
[PUBMED:19651473]
[PUBMED:8756622]
[PUBMED:15105524]
[PUBMED:15452270]
[PUBMED:18948197]
[PUBMED:16760382]
[PUBMED:10793105]
[PUBMED:21084867]
[PUBMED:16308315]
[PUBMED:16155604]
[PUBMED:16381817]
[PUBMED:16828973]
[PUBMED:15342967]
[PUBMED:15692053]
[PUBMED:10855768]
[PUBMED:19078975]
[PUBMED:12379483]
[PUBMED:15310405]
[PUBMED:8223437]
[PUBMED:16939421]
[PUBMED:12910250]
[PUBMED:16039586]
[PUBMED:18201576]
[PUBMED:21102637]
[PUBMED:21743832]
[PUBMED:20592731]
[PUBMED:10644344]
[PUBMED:10074132]
[PUBMED:19715458]
[PUBMED:16155601]
[PUBMED:11604508]
[PUBMED:15919895]
[PUBMED:11099494]
[PUBMED:18385245]
[PUBMED:19854353]
[PUBMED:12101418]
p53 pathway
[NCBI:138067]
[Pathway Interaction Database:p53regulationpathway]
[PUBMED:9153395]
[PUBMED:15448695]
[PUBMED:10734067]
[PUBMED:11340074]
[PUBMED:15525938]
[PUBMED:17189186]
[PUBMED:18454141]
[PUBMED:11715018]
[PUBMED:9733514]
[PUBMED:12963717]
[PUBMED:15989956]
[PUBMED:10581258]
[PUBMED:18566590]
[PUBMED:15029243]
[PUBMED:14612427]
[PUBMED:19011621]
[PUBMED:12842086]
[PUBMED:16377624]
[PUBMED:17268548]
[PUBMED:16845383]
[PUBMED:17534149]
[PUBMED:12397361]
[PUBMED:11740489]
[PUBMED:12110584]
[PUBMED:11713287]
[PUBMED:17646389]
[PUBMED:14654783]
[PUBMED:9153396]
[PUBMED:18243116]
[PUBMED:10673501]
[PUBMED:17719542]
[PUBMED:11983168]
[PUBMED:12397362]
[PUBMED:17189187]
[PUBMED:16757976]
[PUBMED:12667443]
[PUBMED:9733515]
[PUBMED:9878046]
[PUBMED:9363941]
[PUBMED:11504915]
[PUBMED:11359766]
[PUBMED:9529248]
[PUBMED:17936559]
[PUBMED:15210108]
[PUBMED:17293853]
[PUBMED:16107876]
[PUBMED:9724636]
[PUBMED:17707234]
[PUBMED:10606744]
[PUBMED:11780126]
[PUBMED:10821866]
[PUBMED:18485870]
[PUBMED:17110336]
[PUBMED:11046142]
[PUBMED:11331603]
[PUBMED:19597489]
[PUBMED:16163388]
[PUBMED:14671306]
[PUBMED:17108971]
[PUBMED:15242646]
[PUBMED:15314173]
[PUBMED:12654245]
[PUBMED:15308643]
[PUBMED:9744860]
[PUBMED:17906639]
[PUBMED:9891054]
[PUBMED:17098746]
[PUBMED:17349958]
[PUBMED:11030628]
[PUBMED:15103385]
[PUBMED:14744935]
[PUBMED:9529249]
[PUBMED:11283254]
[PUBMED:11606419]
[PUBMED:11078726]
[PUBMED:10611322]
[PUBMED:9288740]
[PUBMED:11127820]
[PUBMED:19357310]
[PUBMED:9450543]
p53 signaling pathway
[NCBI:83055]
[KEGG:hsa04115]
[PUBMED:16557269]
[PUBMED:10714958]
[PUBMED:12505356]
[PUBMED:16915296]
[PUBMED:16697662]
[PUBMED:15116721]
[PUBMED:11313928]
[PUBMED:11747320]
[PUBMED:17409411]
[PUBMED:15838523]
p53-Dependent G1 DNA Damage Response
[NCBI:1269745]
[REACTOME:R-HSA-69563]
[PUBMED:9153396]
[PUBMED:8247533]
[PUBMED:1423616]
[PUBMED:9153395]
p53-Dependent G1/S DNA damage checkpoint
[NCBI:1269744]
[REACTOME:R-HSA-69580]
[PUBMED:1323840]