full name
protein phosphatase 1 regulatory subunit 12A

synonyms
M130, MBS, MYPT1, PPP1R12A, ENSG00000058272

HGNC
HGNC:7618

Entrez Gene
Gene:4659

ENSEMBL
ENSG00000058272

location
chr: 12
start: 80167343
stop: 80329235
strand: -

transcripts
NM_001244990.1
NM_001143885.1
NM_002480.2
NM_001244992.1
NM_001143886.1

pathways
Cell Cycle [NCBI:1269741] [REACTOME:R-HSA-1640170]
Cell Cycle, Mitotic [NCBI:1269763] [REACTOME:R-HSA-69278]
Focal adhesion [NCBI:83067] [KEGG:hsa04510] [PUBMED:10698680] [PUBMED:15459662] [PUBMED:14756624] [PUBMED:11573199] [PUBMED:12640026] [PUBMED:15179030] [PUBMED:15108811] [PUBMED:15053919] [PUBMED:11082269] [PUBMED:15034601] [PUBMED:12235283] [PUBMED:14519391] [PUBMED:11146675] [PUBMED:11229600] [PUBMED:15688067] [PUBMED:14744429] [PUBMED:11882383]
G2/M Transition [NCBI:1269799] [REACTOME:R-HSA-69275]
Mitotic G2-G2/M phases [NCBI:1269797] [REACTOME:R-HSA-453274]
Oxytocin signaling pathway [NCBI:952859] [KEGG:hsa04921] [PUBMED:23356278] [PUBMED:9219843] [PUBMED:20626426] [PUBMED:18555543] [PUBMED:22190926] [PUBMED:21981277] [PUBMED:9575824] [PUBMED:22227279] [PUBMED:19840865] [PUBMED:11861513] [PUBMED:9326674] [PUBMED:12433531] [PUBMED:18655881] [PUBMED:23335873] [PUBMED:22902539] [PUBMED:16156781] [PUBMED:20141572] [PUBMED:14715914] [PUBMED:12009385] [PUBMED:16787565] [PUBMED:16966388]
PLK1 signaling events [NCBI:138007] [Pathway Interaction Database:plk1_pathway] [PUBMED:15070733] [PUBMED:18418076] [PUBMED:15350223] [PUBMED:16885021] [PUBMED:12167714] [PUBMED:16966375] [PUBMED:18615013] [PUBMED:18662541] [PUBMED:18521620] [PUBMED:7790358] [PUBMED:8428596] [PUBMED:12852857] [PUBMED:18427546] [PUBMED:17446864] [PUBMED:16760428] [PUBMED:15148369] [PUBMED:16885022] [PUBMED:9734353] [PUBMED:18331714] [PUBMED:16980960] [PUBMED:18378770] [PUBMED:16860740] [PUBMED:15964272] [PUBMED:10980711] [PUBMED:11050165] [PUBMED:16580887] [PUBMED:17360533] [PUBMED:15678101] [PUBMED:11897663] [PUBMED:16418575] [PUBMED:17218258] [PUBMED:14734534] [PUBMED:18566290] [PUBMED:17081991] [PUBMED:15469984] [PUBMED:11447294] [PUBMED:17351640] [PUBMED:16934469] [PUBMED:18552834] [PUBMED:17488623] [PUBMED:8991084] [PUBMED:17785528] [PUBMED:18477460] [PUBMED:19351716] [PUBMED:12939256] [PUBMED:12852856] [PUBMED:15737063]
Platelet activation [NCBI:952858] [KEGG:hsa04611] [PUBMED:20002545] [PUBMED:18363565] [PUBMED:18544684] [PUBMED:18174460] [PUBMED:23106920] [PUBMED:18550847] [PUBMED:22119499] [PUBMED:19630797] [PUBMED:19286885] [PUBMED:17158345] [PUBMED:20089227] [PUBMED:22701130] [PUBMED:21071698] [PUBMED:23805129] [PUBMED:16149014] [PUBMED:18641368]
Proteoglycans in cancer [NCBI:782000] [KEGG:hsa05205] [PUBMED:19433454] [PUBMED:20655987] [PUBMED:18798267] [PUBMED:10633082] [PUBMED:10687947] [PUBMED:22735579] [PUBMED:24412155] [PUBMED:9346940] [PUBMED:22087031] [PUBMED:22194599] [PUBMED:14711376] [PUBMED:19255147] [PUBMED:15655247] [PUBMED:11717317] [PUBMED:17971838] [PUBMED:18413366] [PUBMED:20974860] [PUBMED:11830493] [PUBMED:23058688] [PUBMED:18450475] [PUBMED:12748184] [PUBMED:19733083] [PUBMED:18812315] [PUBMED:12509413] [PUBMED:21155971] [PUBMED:11931647] [PUBMED:18949819] [PUBMED:12729888] [PUBMED:15994311] [PUBMED:23305321] [PUBMED:18505598] [PUBMED:22563565] [PUBMED:22033227]
RHO GTPase Effectors [NCBI:1269509] [REACTOME:R-HSA-195258] [PUBMED:9694656] [PUBMED:18066052] [PUBMED:11018042] [PUBMED:10470034] [PUBMED:8702756] [PUBMED:21730051] [PUBMED:8571126] [PUBMED:19513348] [PUBMED:17244649] [PUBMED:11145705] [PUBMED:24128008] [PUBMED:23716662] [PUBMED:8617235] [PUBMED:8543060] [PUBMED:11804587] [PUBMED:24969695] [PUBMED:12635176] [PUBMED:12778124] [PUBMED:18006505] [PUBMED:1660188] [PUBMED:21351730] [PUBMED:16507994] [PUBMED:14595335] [PUBMED:10072071] [PUBMED:10591629] [PUBMED:10753910] [PUBMED:23875749] [PUBMED:17151359] [PUBMED:10652353] [PUBMED:12221077] [PUBMED:10559936] [PUBMED:12783890] [PUBMED:11948177] [PUBMED:18237546] [PUBMED:16079795] [PUBMED:10924361] [PUBMED:14514689] [PUBMED:8107774] [PUBMED:8756646] [PUBMED:16979770] [PUBMED:16636067] [PUBMED:9751706] [PUBMED:10619026] [PUBMED:23444367] [PUBMED:15546864] [PUBMED:12473120] [PUBMED:8816443] [PUBMED:9199170] [PUBMED:12514133] [PUBMED:16762923] [PUBMED:12110184] [PUBMED:16431929] [PUBMED:10975528] [PUBMED:10940294] [PUBMED:9535855] [PUBMED:7559638] [PUBMED:11162552] [PUBMED:19737400] [PUBMED:9988689] [PUBMED:12732141] [PUBMED:8798539] [PUBMED:24914801] [PUBMED:11689693] [PUBMED:8769096] [PUBMED:9368021]
RHO GTPases Activate ROCKs [NCBI:1269510] [REACTOME:R-HSA-5627117] [PUBMED:8662509] [PUBMED:8816443] [PUBMED:11018042] [PUBMED:8702756] [PUBMED:20803696] [PUBMED:8617235] [PUBMED:17151359] [PUBMED:10652353]
RHO GTPases activate PAKs [NCBI:1269511] [REACTOME:R-HSA-5627123] [PUBMED:7559638] [PUBMED:9535855] [PUBMED:19513348] [PUBMED:16204230] [PUBMED:10470034] [PUBMED:22340718] [PUBMED:11804587] [PUBMED:21098037] [PUBMED:11278486] [PUBMED:8107774] [PUBMED:10975528]
RHO GTPases activate PKNs [NCBI:1269512] [REACTOME:R-HSA-5625740] [PUBMED:21351730] [PUBMED:21749319] [PUBMED:10753910] [PUBMED:18429822] [PUBMED:9175763] [PUBMED:12783890] [PUBMED:14514689] [PUBMED:10924361] [PUBMED:7673228] [PUBMED:10619026] [PUBMED:10467162] [PUBMED:11134534] [PUBMED:9030526] [PUBMED:9988689] [PUBMED:19723632] [PUBMED:24128008] [PUBMED:18006505]
Regulation of PLK1 Activity at G2/M Transition [NCBI:1269803] [REACTOME:R-HSA-2565942] [PUBMED:12207013] [PUBMED:18615013] [PUBMED:13678582] [PUBMED:18378770] [PUBMED:18566290] [PUBMED:18477460] [PUBMED:22365832]
Regulation of actin cytoskeleton [NCBI:83089] [KEGG:hsa04810] [PUBMED:11152757] [PUBMED:11082272] [PUBMED:10574699] [PUBMED:11082269] [PUBMED:14657486] [PUBMED:14744429] [PUBMED:12700767]
RhoA signaling pathway [NCBI:169356] [Pathway Interaction Database:rhoa_pathway] [PUBMED:8641286] [PUBMED:16705166] [PUBMED:9510209] [PUBMED:18267089] [PUBMED:15866170] [PUBMED:18303050] [PUBMED:17588931] [PUBMED:18941185] [PUBMED:16164598] [PUBMED:11238375] [PUBMED:18559669] [PUBMED:18025109] [PUBMED:16427251] [PUBMED:11122380] [PUBMED:8632828] [PUBMED:15866889] [PUBMED:9707430] [PUBMED:9456324] [PUBMED:8662509] [PUBMED:12429848] [PUBMED:9294169] [PUBMED:9042860] [PUBMED:9582304] [PUBMED:15170389] [PUBMED:10744700] [PUBMED:10893221] [PUBMED:14681219] [PUBMED:9121475] [PUBMED:8858161] [PUBMED:18309323] [PUBMED:9710582] [PUBMED:9265657] [PUBMED:19625450] [PUBMED:15068801] [PUBMED:11278519] [PUBMED:12732141] [PUBMED:9529607] [PUBMED:12600823] [PUBMED:9697773] [PUBMED:10085083] [PUBMED:12802051] [PUBMED:11018042] [PUBMED:7600583] [PUBMED:9693382] [PUBMED:12899698] [PUBMED:8702756] [PUBMED:10556088] [PUBMED:10037681] [PUBMED:1643657] [PUBMED:12034774] [PUBMED:9670022] [PUBMED:12574166] [PUBMED:12584113] [PUBMED:11877391] [PUBMED:9920882] [PUBMED:8995216] [PUBMED:7929302] [PUBMED:10428028] [PUBMED:15793569] [PUBMED:14595335] [PUBMED:10436006] [PUBMED:9482732] [PUBMED:11342553] [PUBMED:9351440]
Signal Transduction [NCBI:1269379] [REACTOME:R-HSA-162582] [PUBMED:17604717] [PUBMED:19648010] [PUBMED:16260143] [PUBMED:11742412] [PUBMED:19536106] [PUBMED:15863030] [PUBMED:19379690] [PUBMED:19458711] [PUBMED:19935667] [PUBMED:21252999] [PUBMED:15520807] [PUBMED:17496910] [PUBMED:15450248] [PUBMED:18043707] [PUBMED:16939974] [PUBMED:19762341] [PUBMED:18483217] [PUBMED:17084981] [PUBMED:21781017] [PUBMED:19619488]
Signaling by Rho GTPases [NCBI:1269507] [REACTOME:R-HSA-194315] [PUBMED:16212495] [PUBMED:15630019]
Vascular smooth muscle contraction [NCBI:96530] [KEGG:hsa04270] [PUBMED:16870827] [PUBMED:10911373] [PUBMED:11679404] [PUBMED:16339747] [PUBMED:10221985] [PUBMED:12689814] [PUBMED:11165670] [PUBMED:18552454] [PUBMED:12060106] [PUBMED:9458738] [PUBMED:15725705] [PUBMED:18040024] [PUBMED:12693609] [PUBMED:11773611] [PUBMED:17158339] [PUBMED:17458653] [PUBMED:15026027] [PUBMED:19120701] [PUBMED:15269340] [PUBMED:18703404] [PUBMED:11709400] [PUBMED:17200683]
cAMP signaling pathway [NCBI:1017634] [KEGG:hsa04024] [PUBMED:10880354] [PUBMED:9204709] [PUBMED:21693691] [PUBMED:24062645] [PUBMED:24450633] [PUBMED:21346730] [PUBMED:24613710] [PUBMED:21744067] [PUBMED:22082266] [PUBMED:16460276] [PUBMED:18176800] [PUBMED:14715909] [PUBMED:7688165] [PUBMED:24281338] [PUBMED:11117527] [PUBMED:16765984] [PUBMED:18323530] [PUBMED:18064650] [PUBMED:21852968] [PUBMED:11493633] [PUBMED:21212391] [PUBMED:15142747] [PUBMED:17077866] [PUBMED:19460777] [PUBMED:19874988] [PUBMED:16571352] [PUBMED:22022314]
cGMP-PKG signaling pathway [NCBI:983748] [KEGG:hsa04022] [PUBMED:18006449] [PUBMED:9003029] [PUBMED:18040025] [PUBMED:19306895] [PUBMED:21666108] [PUBMED:12524221] [PUBMED:16460276] [PUBMED:20716671] [PUBMED:22785374] [PUBMED:11522789] [PUBMED:16439998] [PUBMED:16371594] [PUBMED:20388537] [PUBMED:18757523] [PUBMED:16815627] [PUBMED:23212367] [PUBMED:21685243] [PUBMED:20024580] [PUBMED:15894227] [PUBMED:22965426] [PUBMED:17643091] [PUBMED:19176601] [PUBMED:19961855]