full name
nuclear receptor subfamily 1 group H member 4
synonyms
BAR, FXR, HRR-1, HRR1, RIP14, NR1H4, ENSG00000012504
HGNC
HGNC:7967
Entrez Gene
Gene:9971
ENSEMBL
ENSG00000012504
location
chr: 12
start: 100867486
stop: 100957645
strand: +
OMIM
OMIM:603826:
NR1H4
OMIM:617049:
Cholestasis, progressive familial intrahepatic, 5
transcripts
NM_001206977.1
NM_001206979.1
NM_005123.3
NM_001206978.1
NM_001206993.1
NM_001206992.1
pathways
Bile acid and bile salt metabolism
[NCBI:1270040]
[REACTOME:R-HSA-194068]
[PUBMED:12543708]
[PUBMED:12663868]
[PUBMED:14699511]
[PUBMED:11969205]
Bile secretion
[NCBI:193146]
[KEGG:hsa04976]
[PUBMED:11826283]
[PUBMED:19273385]
[PUBMED:12663868]
[PUBMED:15758646]
[PUBMED:18837079]
[PUBMED:15975683]
[PUBMED:17404808]
[PUBMED:18377365]
[PUBMED:16706681]
[PUBMED:10728790]
[PUBMED:14659471]
[PUBMED:18670431]
[PUBMED:12483266]
[PUBMED:19273238]
[PUBMED:18668439]
[PUBMED:18371245]
[PUBMED:14999673]
[PUBMED:11316487]
[PUBMED:18081658]
[PUBMED:19482594]
[PUBMED:20103563]
Biological oxidations
[NCBI:1270189]
[REACTOME:R-HSA-211859]
Cytochrome P450 - arranged by substrate type
[NCBI:1270191]
[REACTOME:R-HSA-211897]
[PUBMED:16584116]
[PUBMED:15102545]
[PUBMED:12369887]
Endogenous sterols
[NCBI:1270192]
[REACTOME:R-HSA-211976]
[PUBMED:16872679]
[PUBMED:15102545]
[PUBMED:16584116]
Fatty acid, triacylglycerol, and ketone body metabolism
[NCBI:1270010]
[REACTOME:R-HSA-535734]
Gene Expression
[NCBI:1269649]
[REACTOME:R-HSA-74160]
Generic Transcription Pathway
[NCBI:1269650]
[REACTOME:R-HSA-212436]
[PUBMED:15175151]
[PUBMED:14744435]
[PUBMED:15680972]
[PUBMED:11395415]
[PUBMED:15896744]
[PUBMED:10235266]
[PUBMED:14986688]
[PUBMED:12023297]
[PUBMED:15680973]
[PUBMED:16751179]
[PUBMED:11861166]
[PUBMED:16429119]
[PUBMED:16719718]
[PUBMED:16921404]
[PUBMED:15690163]
Metabolism
[NCBI:1269956]
[REACTOME:R-HSA-1430728]
Metabolism of lipids and lipoproteins
[NCBI:1270001]
[REACTOME:R-HSA-556833]
Nuclear Receptor transcription pathway
[NCBI:1269652]
[REACTOME:R-HSA-383280]
PPARA activates gene expression
[NCBI:1270030]
[REACTOME:R-HSA-1989781]
[PUBMED:10529898]
[PUBMED:18288277]
[PUBMED:11330046]
[PUBMED:20936127]
[PUBMED:14999402]
Phase 1 - Functionalization of compounds
[NCBI:1270190]
[REACTOME:R-HSA-211945]
[PUBMED:12369887]
[PUBMED:17125408]
[PUBMED:16584116]
RXR and RAR heterodimerization with other nuclear receptor
[NCBI:137975]
[Pathway Interaction Database:rxr_vdr_pathway]
[PUBMED:8394351]
[PUBMED:15284334]
[PUBMED:9223286]
[PUBMED:8389594]
[PUBMED:15650024]
[PUBMED:7744246]
[PUBMED:11741944]
[PUBMED:12359143]
[PUBMED:8060315]
[PUBMED:16611854]
[PUBMED:15731112]
[PUBMED:15509776]
[PUBMED:16181625]
[PUBMED:17595322]
[PUBMED:7705655]
[PUBMED:8621574]
[PUBMED:7760852]
[PUBMED:11287605]
[PUBMED:15187081]
[PUBMED:8164684]
[PUBMED:8381967]
[PUBMED:10858438]
[PUBMED:7958963]
Recycling of bile acids and salts
[NCBI:1270045]
[REACTOME:R-HSA-159418]
[PUBMED:621437]
[PUBMED:8034703]
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
[NCBI:1270029]
[REACTOME:R-HSA-400206]
[PUBMED:18288277]
[PUBMED:10529898]
[PUBMED:16476485]
[PUBMED:16503871]
Synthesis of bile acids and bile salts
[NCBI:1270041]
[REACTOME:R-HSA-192105]
[PUBMED:12543708]
[PUBMED:11969205]
Synthesis of bile acids and bile salts via 27-hydroxycholesterol
[NCBI:1270044]
[REACTOME:R-HSA-193807]
[PUBMED:10428977]
[PUBMED:12543708]
[PUBMED:11969205]
[PUBMED:8078928]
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
[NCBI:1270042]
[REACTOME:R-HSA-193368]
[PUBMED:12543708]