full name
thymine DNA glycosylase

synonyms
hTDG, TDG, ENSG00000139372

HGNC
HGNC:11700

Entrez Gene
Gene:6996

ENSEMBL
ENSG00000139372

location
chr: 12
start: 104359593
stop: 104382656
strand: +

transcripts
NM_003211.4

pathways
Base Excision Repair [NCBI:1270351] [REACTOME:R-HSA-73884] [PUBMED:11937636] [PUBMED:10583946]
Base excision repair [NCBI:83043] [KEGG:hsa03410] [PUBMED:17893748] [PUBMED:11436317] [PUBMED:17337257] [PUBMED:21665970]
Base-Excision Repair, AP Site Formation [NCBI:1270352] [REACTOME:R-HSA-73929] [PUBMED:10583946] [PUBMED:11937636]
Cleavage of the damaged pyrimidine [NCBI:1270358] [REACTOME:R-HSA-110329] [PUBMED:10583946]
DNA Repair [NCBI:1270350] [REACTOME:R-HSA-73894] [PUBMED:10583946] [PUBMED:23175119]
Depyrimidination [NCBI:1270356] [REACTOME:R-HSA-73928] [PUBMED:10583946]
Displacement of DNA glycosylase by APEX1 [NCBI:1270360] [REACTOME:R-HSA-110357] [PUBMED:9724657]
Epigenetic regulation of gene expression [NCBI:1269734] [REACTOME:R-HSA-212165] [PUBMED:12610534]
Gene Expression [NCBI:1269649] [REACTOME:R-HSA-74160]
Metabolism of proteins [NCBI:1268677] [REACTOME:R-HSA-392499]
Post-translational protein modification [NCBI:1268701] [REACTOME:R-HSA-597592]
Recognition and association of DNA glycosylase with site containing an affected pyrimidine [NCBI:1270357] [REACTOME:R-HSA-110328] [PUBMED:11937636]
Resolution of Abasic Sites (AP sites) [NCBI:1270359] [REACTOME:R-HSA-73933] [PUBMED:11601988] [PUBMED:15260972] [PUBMED:17395641] [PUBMED:19329425] [PUBMED:9804798] [PUBMED:15556996] [PUBMED:9214649] [PUBMED:7608159] [PUBMED:11440997] [PUBMED:15871698] [PUBMED:9207062] [PUBMED:16982218] [PUBMED:8978692]
SUMO E3 ligases SUMOylate target proteins [NCBI:1268743] [REACTOME:R-HSA-3108232] [PUBMED:20674646] [PUBMED:17763827] [PUBMED:19471022] [PUBMED:23746258] [PUBMED:24016193] [PUBMED:23503365] [PUBMED:21252943] [PUBMED:17000644] [PUBMED:24273646] [PUBMED:22811915] [PUBMED:21693764] [PUBMED:23277067] [PUBMED:21102611]
SUMOylation [NCBI:1268738] [REACTOME:R-HSA-2990846] [PUBMED:21102611] [PUBMED:20674646] [PUBMED:23514139] [PUBMED:19923268] [PUBMED:20462400] [PUBMED:17768054]
SUMOylation of DNA damage response and repair proteins [NCBI:1268744] [REACTOME:R-HSA-3108214] [PUBMED:22018829] [PUBMED:24926426] [PUBMED:23122649] [PUBMED:23781231] [PUBMED:23416108] [PUBMED:21486569] [PUBMED:23746258] [PUBMED:21896653] [PUBMED:22357966] [PUBMED:21664912]
TET1,2,3 and TDG demethylate DNA [NCBI:1269736] [REACTOME:R-HSA-5221030] [PUBMED:23770080] [PUBMED:22974304] [PUBMED:20639862] [PUBMED:21321204] [PUBMED:21295276] [PUBMED:24153300] [PUBMED:23727577] [PUBMED:21817016] [PUBMED:24045206] [PUBMED:21778364] [PUBMED:22156206] [PUBMED:19372391] [PUBMED:22956496] [PUBMED:21460836] [PUBMED:21451524] [PUBMED:24050399] [PUBMED:21496894]