full name
SH2B adaptor protein 3

synonyms
IDDM20, LNK, SH2B3, ENSG00000111252

HGNC
HGNC:29605

Entrez Gene
Gene:10019

ENSEMBL
ENSG00000111252

location
chr: 12
start: 111843720
stop: 111889427
strand: +

OMIM
OMIM:605093: SH2B3 (Autosomal dominant inheritance)
OMIM:133100: Erythrocytosis, somatic
OMIM:254450: Myelofibrosis, somatic
OMIM:187950: Thrombocythemia, somatic

transcripts
NM_005475.2

pathways
EPO signaling pathway [NCBI:138051] [Pathway Interaction Database:epopathway] [PUBMED:14699131] [PUBMED:7889566] [PUBMED:8537396] [PUBMED:11124936] [PUBMED:9344843] [PUBMED:12504103] [PUBMED:7528577] [PUBMED:15329338] [PUBMED:15254422] [PUBMED:7537740] [PUBMED:9334184] [PUBMED:10882725] [PUBMED:15007095] [PUBMED:15705783] [PUBMED:10910907] [PUBMED:8343951] [PUBMED:8034732]
Factors involved in megakaryocyte development and platelet production [NCBI:1269377] [REACTOME:R-HSA-983231] [PUBMED:16856888] [PUBMED:17635743] [PUBMED:17934486]
Hemostasis [NCBI:1269340] [REACTOME:R-HSA-109582]
Neurotrophin signaling pathway [NCBI:101143] [KEGG:hsa04722] [PUBMED:16699811] [PUBMED:10812966] [PUBMED:12676795] [PUBMED:16939974] [PUBMED:10851172] [PUBMED:15499580] [PUBMED:14704852] [PUBMED:11399424] [PUBMED:10764727] [PUBMED:10985348] [PUBMED:16856873] [PUBMED:11529497]
Regulation of KIT signaling [NCBI:1269488] [REACTOME:R-HSA-1433559] [PUBMED:10582339] [PUBMED:16483568]
Signal Transduction [NCBI:1269379] [REACTOME:R-HSA-162582] [PUBMED:17604717] [PUBMED:19648010] [PUBMED:16260143] [PUBMED:11742412] [PUBMED:19536106] [PUBMED:15863030] [PUBMED:19379690] [PUBMED:19458711] [PUBMED:19935667] [PUBMED:21252999] [PUBMED:15520807] [PUBMED:17496910] [PUBMED:15450248] [PUBMED:18043707] [PUBMED:16939974] [PUBMED:19762341] [PUBMED:18483217] [PUBMED:17084981] [PUBMED:21781017] [PUBMED:19619488]
Signaling by SCF-KIT [NCBI:1269487] [REACTOME:R-HSA-1433557] [PUBMED:17350321] [PUBMED:16483568] [PUBMED:7688988] [PUBMED:19540337] [PUBMED:16475976] [PUBMED:15526160]
Signaling events mediated by Stem cell factor receptor (c-Kit) [NCBI:138068] [Pathway Interaction Database:kitpathway] [PUBMED:12909618] [PUBMED:10364466] [PUBMED:10673502] [PUBMED:15315962] [PUBMED:12192036] [PUBMED:12444928] [PUBMED:15504549] [PUBMED:8950973] [PUBMED:11071635] [PUBMED:12149208] [PUBMED:11369651] [PUBMED:9038210] [PUBMED:10679268] [PUBMED:15465815] [PUBMED:10523831] [PUBMED:8611693] [PUBMED:15676208] [PUBMED:11805142] [PUBMED:10637471] [PUBMED:9872323] [PUBMED:11809791] [PUBMED:11520784] [PUBMED:12691919] [PUBMED:10397721] [PUBMED:15611091] [PUBMED:12356726] [PUBMED:9528781] [PUBMED:1381360] [PUBMED:9651683] [PUBMED:10849422] [PUBMED:9355737]