Logo
full name
protein tyrosine phosphatase, non-receptor type 11

synonyms
BPTP3, CFC, NS1, PTP-1D, PTP2C, SH-PTP2, SH-PTP3, SHP2, PTPN11, ENSG00000179295

HGNC
HGNC:9644

Entrez Gene
Gene:5781

ENSEMBL
ENSG00000179295

location
chr: 12
start: 112856536
stop: 112947717
strand: +

OMIM
OMIM:176876: PTPN11 (Autosomal dominant inheritance)
OMIM:151100: LEOPARD syndrome 1
OMIM:607785: Leukemia, juvenile myelomonocytic, somatic
OMIM:156250: Metachondromatosis
OMIM:163950: Noonan syndrome 1

transcripts
NM_002834.3
NM_080601.1

pathways
Activated TLR4 signalling [NCBI:1269236] [REACTOME:R-HSA-166054] [PUBMED:15276183] [PUBMED:15588429] [PUBMED:15845500] [PUBMED:15596121]
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon [NCBI:1269222] [REACTOME:R-HSA-936964] [PUBMED:15210742] [PUBMED:14679297] [PUBMED:15502848] [PUBMED:17332413]
Adaptive Immune System [NCBI:1269171] [REACTOME:R-HSA-1280218] [PUBMED:16551257] [PUBMED:21682741] [PUBMED:11861602]
Adipocytokine signaling pathway [NCBI:83093] [KEGG:hsa04920] [PUBMED:12829246] [PUBMED:10905472] [PUBMED:15980064] [PUBMED:12754525] [PUBMED:12368907] [PUBMED:11557972] [PUBMED:15856064] [PUBMED:9671776] [PUBMED:10766253] [PUBMED:15733744] [PUBMED:15058305] [PUBMED:14716305] [PUBMED:11479627] [PUBMED:14679176]
Angiopoietin receptor Tie2-mediated signaling [NCBI:137917] [Pathway Interaction Database:angiopoietinreceptor_pathway] [PUBMED:9204896] [PUBMED:12609966] [PUBMED:14726409] [PUBMED:11157678] [PUBMED:10347092] [PUBMED:11967990] [PUBMED:15162796] [PUBMED:11289054] [PUBMED:12759249] [PUBMED:10051567] [PUBMED:12824293] [PUBMED:16895971] [PUBMED:10807867] [PUBMED:12933576] [PUBMED:11513602] [PUBMED:12074640] [PUBMED:8980223] [PUBMED:14665640] [PUBMED:15132996] [PUBMED:10944458] [PUBMED:11230987] [PUBMED:15242771] [PUBMED:10585289] [PUBMED:16061664] [PUBMED:10376602] [PUBMED:15350545] [PUBMED:9632797] [PUBMED:10625301] [PUBMED:9926914] [PUBMED:17189382] [PUBMED:11139469] [PUBMED:11689432] [PUBMED:11416142] [PUBMED:11166279] [PUBMED:15284220] [PUBMED:15985432] [PUBMED:16049136] [PUBMED:16157706] [PUBMED:10521483] [PUBMED:12816861] [PUBMED:9478921] [PUBMED:10376603] [PUBMED:15769741] [PUBMED:12890486] [PUBMED:14749497] [PUBMED:7561682] [PUBMED:11801735] [PUBMED:12665569] [PUBMED:12117724] [PUBMED:9764820]
Axon guidance [NCBI:83065] [KEGG:hsa04360] [NCBI:1270303] [REACTOME:R-HSA-422475] [PUBMED:14682358] [PUBMED:15084255] [PUBMED:11687826] [PUBMED:15818466] [PUBMED:15363605] [PUBMED:12471249] [PUBMED:15630019] [PUBMED:11891122] [PUBMED:15960985] [PUBMED:12677003]
CTLA4 inhibitory signaling [NCBI:1269181] [REACTOME:R-HSA-389513] [PUBMED:11905831] [PUBMED:10374692] [PUBMED:16551244] [PUBMED:12876557]
CXCR4-mediated signaling events [NCBI:137910] [Pathway Interaction Database:cxcr4_pathway] [PUBMED:18799424] [PUBMED:17537990] [PUBMED:10881171] [PUBMED:17675482] [PUBMED:11157475] [PUBMED:12077227] [PUBMED:11544290] [PUBMED:8752280] [PUBMED:12535795] [PUBMED:19380820] [PUBMED:10952719] [PUBMED:16230460] [PUBMED:12682230] [PUBMED:16503409] [PUBMED:10644702] [PUBMED:9722546] [PUBMED:11784854] [PUBMED:10491003] [PUBMED:10521508] [PUBMED:10606629] [PUBMED:15615703] [PUBMED:17568820] [PUBMED:10753828] [PUBMED:12519755] [PUBMED:12032308] [PUBMED:8752281] [PUBMED:10570282] [PUBMED:11369622] [PUBMED:15728464] [PUBMED:12590707] [PUBMED:16038794] [PUBMED:14662753] [PUBMED:18596232] [PUBMED:17056591] [PUBMED:14602072] [PUBMED:15994292] [PUBMED:16919488] [PUBMED:15872091] [PUBMED:10506573] [PUBMED:12036857] [PUBMED:15618472] [PUBMED:14704365] [PUBMED:18227351] [PUBMED:11641392] [PUBMED:18319399] [PUBMED:12133960] [PUBMED:15630457]
Cell surface interactions at the vascular wall [NCBI:1269373] [REACTOME:R-HSA-202733] [PUBMED:17525755] [PUBMED:11282294] [PUBMED:10798271] [PUBMED:8578462] [PUBMED:14615387] [PUBMED:16115029]
Cell-Cell communication [NCBI:1270231] [REACTOME:R-HSA-1500931] [PUBMED:20554646] [PUBMED:12598678] [PUBMED:17766183] [PUBMED:18837673] [PUBMED:16691243] [PUBMED:1616050]
Chronic myeloid leukemia [NCBI:83116] [KEGG:hsa05220] [PUBMED:22286129] [PUBMED:12801837] [PUBMED:11160144] [PUBMED:15719031] [PUBMED:10403855] [PUBMED:9834202] [PUBMED:11071626] [PUBMED:12244301] [PUBMED:15156182] [PUBMED:16484590] [PUBMED:14982876]
Constitutive Signaling by Aberrant PI3K in Cancer [NCBI:1268880] [REACTOME:R-HSA-2219530] [PUBMED:18317450] [PUBMED:19962665] [PUBMED:20009532] [PUBMED:20713702] [PUBMED:21478295] [PUBMED:16339315] [PUBMED:18079394] [PUBMED:17626883]
Costimulation by the CD28 family [NCBI:1269177] [REACTOME:R-HSA-388841] [PUBMED:10374692] [PUBMED:14647476] [PUBMED:11905831]
Cytokine Signaling in Immune system [NCBI:1269310] [REACTOME:R-HSA-1280215] [PUBMED:12613569]
DAP12 interactions [NCBI:1269283] [REACTOME:R-HSA-2172127] [PUBMED:19120482] [PUBMED:17220916] [PUBMED:9490415] [PUBMED:18192027] [PUBMED:15884055]
DAP12 signaling [NCBI:1269284] [REACTOME:R-HSA-2424491] [PUBMED:15884055] [PUBMED:17110943] [PUBMED:17220916]
Developmental Biology [NCBI:1270302] [REACTOME:R-HSA-1266738]
Disease [NCBI:1268854] [REACTOME:R-HSA-1643685]
Diseases of signal transduction [NCBI:1268855] [REACTOME:R-HSA-5663202] [PUBMED:12509752]
Downstream signal transduction [NCBI:1269479] [REACTOME:R-HSA-186763] [PUBMED:10508235] [PUBMED:9739761]
Downstream signaling events of B Cell Receptor (BCR) [NCBI:1269185] [REACTOME:R-HSA-1168372] [PUBMED:17052215] [PUBMED:19909372]
Downstream signaling of activated FGFR1 [NCBI:1269392] [REACTOME:R-HSA-5654687] [PUBMED:8752212]
Downstream signaling of activated FGFR2 [NCBI:1269403] [REACTOME:R-HSA-5654696] [PUBMED:8752212]
Downstream signaling of activated FGFR3 [NCBI:1269413] [REACTOME:R-HSA-5654708] [PUBMED:8752212]
Downstream signaling of activated FGFR4 [NCBI:1269422] [REACTOME:R-HSA-5654716] [PUBMED:8752212]
EGF receptor (ErbB1) signaling pathway [NCBI:137970] [Pathway Interaction Database:erbb1_receptor_proximal_pathway] [PUBMED:15284024] [PUBMED:15574420] [PUBMED:12024020] [PUBMED:10913131] [PUBMED:2176151] [PUBMED:8479540] [PUBMED:8386805] [PUBMED:10648629] [PUBMED:7478566] [PUBMED:9307968] [PUBMED:6090944] [PUBMED:1850098] [PUBMED:7970708] [PUBMED:12522133] [PUBMED:1537335] [PUBMED:10075741] [PUBMED:9454735] [PUBMED:9049300] [PUBMED:9642214] [PUBMED:14560030] [PUBMED:9079708] [PUBMED:12952932] [PUBMED:10806474] [PUBMED:1689011] [PUBMED:7681824] [PUBMED:9038217] [PUBMED:7525285] [PUBMED:14963038] [PUBMED:7592690] [PUBMED:1860884] [PUBMED:19401591] [PUBMED:12464621] [PUBMED:8596638] [PUBMED:7478553] [PUBMED:8626525] [PUBMED:8479541] [PUBMED:7962064] [PUBMED:10675331] [PUBMED:8106552] [PUBMED:9989831] [PUBMED:10816576] [PUBMED:7527043] [PUBMED:2171993] [PUBMED:12424235] [PUBMED:7923364] [PUBMED:2173144] [PUBMED:7993895] [PUBMED:8034616] [PUBMED:9733788] [PUBMED:2153914] [PUBMED:1322798] [PUBMED:14498832] [PUBMED:8621459] [PUBMED:7898933] [PUBMED:9121432] [PUBMED:11950594] [PUBMED:7673163] [PUBMED:7689150] [PUBMED:1623525] [PUBMED:8824201] [PUBMED:8798379] [PUBMED:8707848] [PUBMED:15550174] [PUBMED:8940013] [PUBMED:10669730] [PUBMED:8479536] [PUBMED:17635937] [PUBMED:18269246] [PUBMED:10411909] [PUBMED:7542246] [PUBMED:7488034] [PUBMED:2005883] [PUBMED:1689310] [PUBMED:7823926] [PUBMED:16055672] [PUBMED:2236073] [PUBMED:8490966] [PUBMED:18156174] [PUBMED:8628261] [PUBMED:8816994] [PUBMED:8895577] [PUBMED:11134009] [PUBMED:9355745] [PUBMED:1315766] [PUBMED:1700866] [PUBMED:9346957] [PUBMED:7518560]
EPO signaling pathway [NCBI:138051] [Pathway Interaction Database:epopathway] [PUBMED:14699131] [PUBMED:7889566] [PUBMED:8537396] [PUBMED:11124936] [PUBMED:9344843] [PUBMED:12504103] [PUBMED:7528577] [PUBMED:15329338] [PUBMED:15254422] [PUBMED:7537740] [PUBMED:9334184] [PUBMED:10882725] [PUBMED:15007095] [PUBMED:15705783] [PUBMED:10910907] [PUBMED:8343951] [PUBMED:8034732]
Epithelial cell signaling in Helicobacter pylori infection [NCBI:83102] [KEGG:hsa05120] [PUBMED:11389469] [PUBMED:15694859] [PUBMED:14700549] [PUBMED:12197905]
ErbB2/ErbB3 signaling events [NCBI:137955] [Pathway Interaction Database:erbb2erbb3pathway] [PUBMED:9677338] [PUBMED:11546794] [PUBMED:9710588] [PUBMED:11984589] [PUBMED:19474313] [PUBMED:12072561] [PUBMED:18760695] [PUBMED:18614687] [PUBMED:11027222] [PUBMED:12466964] [PUBMED:10704452] [PUBMED:19535578] [PUBMED:7556067] [PUBMED:16481445] [PUBMED:10493750] [PUBMED:17998937] [PUBMED:17210635] [PUBMED:18799465] [PUBMED:12411582] [PUBMED:15520002] [PUBMED:10531446] [PUBMED:10101228] [PUBMED:10399934] [PUBMED:8815893] [PUBMED:19179536] [PUBMED:7877996] [PUBMED:11173924] [PUBMED:12651161] [PUBMED:9362461] [PUBMED:18426980] [PUBMED:19019207] [PUBMED:9338783] [PUBMED:11312610] [PUBMED:11940572] [PUBMED:8707830] [PUBMED:11564761] [PUBMED:9049301] [PUBMED:9694850] [PUBMED:10582594] [PUBMED:9637684] [PUBMED:8702681]
FGF signaling pathway [NCBI:137989] [Pathway Interaction Database:fgf_pathway] [PUBMED:12419216] [PUBMED:16775459] [PUBMED:1656221] [PUBMED:16857743] [PUBMED:8707855] [PUBMED:17545628] [PUBMED:17623664] [PUBMED:16893902] [PUBMED:15105428] [PUBMED:16436388] [PUBMED:12370824] [PUBMED:9707175] [PUBMED:1380001] [PUBMED:15569927] [PUBMED:11241670] [PUBMED:11433297] [PUBMED:16709412] [PUBMED:12815057] [PUBMED:14966081] [PUBMED:17086194] [PUBMED:17311277] [PUBMED:14534538] [PUBMED:12398894] [PUBMED:8940113] [PUBMED:17266935] [PUBMED:10652257] [PUBMED:12604616] [PUBMED:14666721] [PUBMED:9045692] [PUBMED:15509650] [PUBMED:11353842] [PUBMED:12791257] [PUBMED:15564375] [PUBMED:12529371] [PUBMED:17409417] [PUBMED:17005551] [PUBMED:12815619] [PUBMED:11997436] [PUBMED:12110689] [PUBMED:17627937]
FRS-mediated FGFR1 signaling [NCBI:1269393] [REACTOME:R-HSA-5654693] [PUBMED:15863030] [PUBMED:18452557] [PUBMED:11447289] [PUBMED:16682955]
FRS-mediated FGFR2 signaling [NCBI:1269404] [REACTOME:R-HSA-5654700] [PUBMED:18452557] [PUBMED:11447289] [PUBMED:16682955] [PUBMED:15863030]
FRS-mediated FGFR3 signaling [NCBI:1269414] [REACTOME:R-HSA-5654706] [PUBMED:15863030] [PUBMED:18452557] [PUBMED:11447289] [PUBMED:16682955]
FRS-mediated FGFR4 signaling [NCBI:1269423] [REACTOME:R-HSA-5654712] [PUBMED:18452557] [PUBMED:11447289] [PUBMED:16682955] [PUBMED:15863030]
Fc epsilon receptor (FCERI) signaling [NCBI:1269298] [REACTOME:R-HSA-2454202] [PUBMED:15099567] [PUBMED:21799019]
Fc-epsilon receptor I signaling in mast cells [NCBI:138050] [Pathway Interaction Database:fcer1pathway] [PUBMED:9556577] [PUBMED:8629002] [PUBMED:12217401] [PUBMED:15010370] [PUBMED:15608142] [PUBMED:7561053] [PUBMED:7537741] [PUBMED:7963537] [PUBMED:8947047] [PUBMED:1384468] [PUBMED:14757742] [PUBMED:16174756] [PUBMED:10583594] [PUBMED:7513150] [PUBMED:12089510] [PUBMED:10811803] [PUBMED:9268346] [PUBMED:12640123] [PUBMED:9108083] [PUBMED:8602265] [PUBMED:11340169] [PUBMED:12953098] [PUBMED:11465115] [PUBMED:7730640] [PUBMED:9550384] [PUBMED:7518558] [PUBMED:11137136] [PUBMED:15282299] [PUBMED:14634134] [PUBMED:8534912] [PUBMED:16002993] [PUBMED:12192036] [PUBMED:7608202] [PUBMED:11714805] [PUBMED:11970986] [PUBMED:10903718] [PUBMED:15265912] [PUBMED:15477350]
GAB1 signalosome [NCBI:1269384] [REACTOME:R-HSA-180292] [PUBMED:15550174]
GPVI-mediated activation cascade [NCBI:1269357] [REACTOME:R-HSA-114604] [PUBMED:16102042] [PUBMED:11943772]
Hemostasis [NCBI:1269340] [REACTOME:R-HSA-109582]
Herpes simplex infection [NCBI:377873] [KEGG:hsa05168] [PUBMED:12224518] [PUBMED:17913820] [PUBMED:12844494] [PUBMED:10998601] [PUBMED:15163721] [PUBMED:19694546] [PUBMED:16297150] [PUBMED:14747533] [PUBMED:12826401] [PUBMED:14963113] [PUBMED:15056211] [PUBMED:12797447] [PUBMED:21107701] [PUBMED:10918307] [PUBMED:10696424] [PUBMED:16076403] [PUBMED:10364308] [PUBMED:17222692] [PUBMED:9621021] [PUBMED:12224508] [PUBMED:19879619] [PUBMED:11070032] [PUBMED:9499021] [PUBMED:18596690] [PUBMED:12525427] [PUBMED:12224517] [PUBMED:10196275] [PUBMED:15047834] [PUBMED:18508584] [PUBMED:20036979]
IFN-gamma pathway [NCBI:138040] [Pathway Interaction Database:ifngpathway] [PUBMED:9724754] [PUBMED:10657627] [PUBMED:10067896] [PUBMED:9271410] [PUBMED:8608598] [PUBMED:15878863] [PUBMED:11971965] [PUBMED:11438544] [PUBMED:15051500] [PUBMED:17032168] [PUBMED:11909529] [PUBMED:11171987] [PUBMED:7514165] [PUBMED:12817007] [PUBMED:8232552] [PUBMED:10485906] [PUBMED:8755534] [PUBMED:10490100] [PUBMED:8156998] [PUBMED:11972023] [PUBMED:8986769] [PUBMED:12438563] [PUBMED:10022928] [PUBMED:12270932] [PUBMED:7510216] [PUBMED:15311277] [PUBMED:14670297] [PUBMED:12048245] [PUBMED:10777554] [PUBMED:12138178] [PUBMED:9336467] [PUBMED:7690989] [PUBMED:1281555] [PUBMED:17606919] [PUBMED:10805787] [PUBMED:12050152] [PUBMED:8608597] [PUBMED:15879117] [PUBMED:12855578] [PUBMED:10995751] [PUBMED:10490099] [PUBMED:7777519]
IGF1 pathway [NCBI:137992] [Pathway Interaction Database:igf1_pathway] [PUBMED:15003536] [PUBMED:10576742] [PUBMED:8621590] [PUBMED:9346240] [PUBMED:16932738] [PUBMED:8662827] [PUBMED:15976035] [PUBMED:11572799] [PUBMED:14550766] [PUBMED:15070696] [PUBMED:9346905] [PUBMED:10490655] [PUBMED:1378290] [PUBMED:9480911] [PUBMED:9442079] [PUBMED:7534289] [PUBMED:8265614] [PUBMED:9748296] [PUBMED:11884618] [PUBMED:12538620] [PUBMED:8798417] [PUBMED:8764099] [PUBMED:8505282] [PUBMED:7540132] [PUBMED:12048182] [PUBMED:15611085] [PUBMED:14604996] [PUBMED:7642582] [PUBMED:11836447] [PUBMED:8776723] [PUBMED:7513703] [PUBMED:9506989]
IGF1R signaling cascade [NCBI:1269618] [REACTOME:R-HSA-2428924] [PUBMED:17598937] [PUBMED:20975071] [PUBMED:22649417] [PUBMED:21042815] [PUBMED:18927274] [PUBMED:20098959]
IL2 signaling events mediated by PI3K [NCBI:137938] [Pathway Interaction Database:il2_pi3kpathway] [PUBMED:15271800] [PUBMED:8617294] [PUBMED:7543780] [PUBMED:9092570] [PUBMED:9162082] [PUBMED:7737351] [PUBMED:9108028] [PUBMED:11486019] [PUBMED:1614535] [PUBMED:15843522] [PUBMED:7760801] [PUBMED:9029085] [PUBMED:1652056] [PUBMED:11994454] [PUBMED:12393431] [PUBMED:9771966] [PUBMED:10373522] [PUBMED:12525482] [PUBMED:3523754] [PUBMED:7736574] [PUBMED:10982827] [PUBMED:7589144] [PUBMED:7528328]
IL2 signaling events mediated by STAT5 [NCBI:137988] [Pathway Interaction Database:il2_stat5pathway] [PUBMED:11160217] [PUBMED:16645171] [PUBMED:9121484] [PUBMED:17182565] [PUBMED:14607901] [PUBMED:9104808] [PUBMED:11485747] [PUBMED:14614860] [PUBMED:10679091] [PUBMED:12196288] [PUBMED:10072077] [PUBMED:10544201] [PUBMED:15004274] [PUBMED:9390691] [PUBMED:9395528] [PUBMED:10514006] [PUBMED:14500638] [PUBMED:16757175] [PUBMED:9541574] [PUBMED:8617294]
IL2-mediated signaling events [NCBI:137976] [Pathway Interaction Database:il2_1pathway] [PUBMED:7568005] [PUBMED:10962026] [PUBMED:1545122] [PUBMED:10602027] [PUBMED:15170389] [PUBMED:9092570] [PUBMED:7509794] [PUBMED:15356145] [PUBMED:9973481] [PUBMED:10899310] [PUBMED:9195132] [PUBMED:7544001] [PUBMED:7777534] [PUBMED:12681450] [PUBMED:7665592] [PUBMED:8702919] [PUBMED:1708096] [PUBMED:8643566] [PUBMED:7988557] [PUBMED:7737351] [PUBMED:1532814] [PUBMED:8262551] [PUBMED:8025955] [PUBMED:10993906] [PUBMED:3095922] [PUBMED:8805624] [PUBMED:9391116] [PUBMED:7973658] [PUBMED:11331873] [PUBMED:10421845] [PUBMED:8119884] [PUBMED:7781605] [PUBMED:12543077] [PUBMED:9133424] [PUBMED:1618313] [PUBMED:1940342] [PUBMED:9382798] [PUBMED:10514520] [PUBMED:7973659] [PUBMED:1639773] [PUBMED:9029085] [PUBMED:7760801] [PUBMED:1460037] [PUBMED:9202126] [PUBMED:1652056] [PUBMED:12393431] [PUBMED:8397196] [PUBMED:2047859] [PUBMED:7688728] [PUBMED:8700888] [PUBMED:7528668] [PUBMED:9305919] [PUBMED:2303462] [PUBMED:7568001] [PUBMED:9822600] [PUBMED:7543676] [PUBMED:7499365] [PUBMED:10843677] [PUBMED:7600304] [PUBMED:7719937] [PUBMED:9590209] [PUBMED:9794391] [PUBMED:10849428] [PUBMED:8294403] [PUBMED:10373548] [PUBMED:2590941] [PUBMED:9512511] [PUBMED:6434688] [PUBMED:9697832] [PUBMED:10982827] [PUBMED:10214954] [PUBMED:10825200] [PUBMED:1535827] [PUBMED:10369681] [PUBMED:7719938] [PUBMED:1655887] [PUBMED:8376945] [PUBMED:1996324] [PUBMED:7479881] [PUBMED:10962581] [PUBMED:7973657] [PUBMED:1631559] [PUBMED:10066828] [PUBMED:9169478] [PUBMED:8552611] [PUBMED:8483935] [PUBMED:2106566] [PUBMED:16199887]
IL6-mediated signaling events [NCBI:137932] [Pathway Interaction Database:il6_7pathway] [PUBMED:8559663] [PUBMED:8662591] [PUBMED:11689697] [PUBMED:11727828] [PUBMED:10383440] [PUBMED:10777583] [PUBMED:16774741] [PUBMED:12754507] [PUBMED:9295319] [PUBMED:15722452] [PUBMED:10859312] [PUBMED:9590172] [PUBMED:9880505] [PUBMED:12445202] [PUBMED:8134389] [PUBMED:10409724] [PUBMED:8164674] [PUBMED:8272872] [PUBMED:9794795] [PUBMED:7678052] [PUBMED:8511589] [PUBMED:8668165] [PUBMED:9724754] [PUBMED:8083235] [PUBMED:12754505] [PUBMED:8621622] [PUBMED:16254248] [PUBMED:12361954] [PUBMED:10605021] [PUBMED:9388184] [PUBMED:15935617] [PUBMED:11120832] [PUBMED:7875298] [PUBMED:9973404] [PUBMED:11335711] [PUBMED:9632795] [PUBMED:11468294] [PUBMED:7898939] [PUBMED:8626374] [PUBMED:8670868] [PUBMED:7537214] [PUBMED:15677447] [PUBMED:2261637] [PUBMED:9874564] [PUBMED:12829785] [PUBMED:8537375] [PUBMED:8272873] [PUBMED:7523403] [PUBMED:11251120] [PUBMED:9163525] [PUBMED:3136546] [PUBMED:10727406] [PUBMED:10023775] [PUBMED:12754506] [PUBMED:12456685] [PUBMED:2788034] [PUBMED:10446219] [PUBMED:15572665] [PUBMED:1662392] [PUBMED:15010462] [PUBMED:8140422] [PUBMED:8467812]
IRS-mediated signalling [NCBI:1269431] [REACTOME:R-HSA-112399]
IRS-related events triggered by IGF1R [NCBI:1269620] [REACTOME:R-HSA-2428928] [PUBMED:17598937] [PUBMED:20975071] [PUBMED:22649417] [PUBMED:18927274] [PUBMED:21042815] [PUBMED:20098959]
Immune System [NCBI:1269170] [REACTOME:R-HSA-168256]
Innate Immune System [NCBI:1269203] [REACTOME:R-HSA-168249]
Insulin Pathway [NCBI:138026] [Pathway Interaction Database:insulin_pathway] [PUBMED:8491186] [PUBMED:9111325] [PUBMED:7629070] [PUBMED:10499514] [PUBMED:11121405] [PUBMED:10660596] [PUBMED:8196603] [PUBMED:11096081] [PUBMED:8524328] [PUBMED:9891043] [PUBMED:12242347] [PUBMED:2123524] [PUBMED:9369444] [PUBMED:1375946] [PUBMED:9348199] [PUBMED:8826975] [PUBMED:8316835] [PUBMED:8999839] [PUBMED:8449939] [PUBMED:10807907] [PUBMED:1599438] [PUBMED:8265614] [PUBMED:11171109] [PUBMED:11821390] [PUBMED:12687004] [PUBMED:7806540] [PUBMED:11154281] [PUBMED:8244979] [PUBMED:8798417] [PUBMED:1381348] [PUBMED:7581368] [PUBMED:15787604] [PUBMED:8385105] [PUBMED:11551902] [PUBMED:8114695] [PUBMED:11997497] [PUBMED:11001060] [PUBMED:11309621] [PUBMED:9109420] [PUBMED:8383963] [PUBMED:12147684] [PUBMED:8144662] [PUBMED:12036959] [PUBMED:14734537] [PUBMED:7983051] [PUBMED:9083103] [PUBMED:15210700] [PUBMED:9065430] [PUBMED:11297536] [PUBMED:10544179] [PUBMED:1321126] [PUBMED:11502760] [PUBMED:8978681] [PUBMED:8999972] [PUBMED:14690593] [PUBMED:11832334] [PUBMED:9447983] [PUBMED:15192089] [PUBMED:8524413] [PUBMED:7685165] [PUBMED:10329736] [PUBMED:11287630] [PUBMED:15486046] [PUBMED:10330191] [PUBMED:8626723]
Insulin receptor signalling cascade [NCBI:1269429] [REACTOME:R-HSA-74751] [PUBMED:9677303] [PUBMED:11282018]
Insulin resistance [NCBI:1272486] [KEGG:hsa04931] [PUBMED:17130651] [PUBMED:20466550] [PUBMED:16364488] [PUBMED:12765939] [PUBMED:15166380] [PUBMED:7666792] [PUBMED:16756496] [PUBMED:23647930] [PUBMED:10923637] [PUBMED:17141630] [PUBMED:9886945] [PUBMED:8048519] [PUBMED:18309108] [PUBMED:15107844] [PUBMED:20526383] [PUBMED:22360800] [PUBMED:16186396] [PUBMED:22675355] [PUBMED:22677645]
Integrins in angiogenesis [NCBI:137999] [Pathway Interaction Database:avb3_integrin_pathway] [PUBMED:10837460] [PUBMED:9182576] [PUBMED:12642872] [PUBMED:15711558] [PUBMED:10037797] [PUBMED:10196194] [PUBMED:11877390] [PUBMED:16418218] [PUBMED:16600665] [PUBMED:16982628] [PUBMED:15479743] [PUBMED:16720645] [PUBMED:11684710] [PUBMED:10821695] [PUBMED:12237112] [PUBMED:12750158] [PUBMED:11551924] [PUBMED:8794870] [PUBMED:10022831] [PUBMED:15187087] [PUBMED:16195423] [PUBMED:16760434] [PUBMED:12682293] [PUBMED:9420328] [PUBMED:15247219] [PUBMED:9490736] [PUBMED:11313365]
Interferon Signaling [NCBI:1269311] [REACTOME:R-HSA-913531] [PUBMED:18929502] [PUBMED:15607020] [PUBMED:15864272] [PUBMED:14525967] [PUBMED:19059436]
Interferon alpha/beta signaling [NCBI:1269312] [REACTOME:R-HSA-909733] [PUBMED:8621447] [PUBMED:8605876] [PUBMED:8702790] [PUBMED:17969444]
Interferon gamma signaling [NCBI:1269314] [REACTOME:R-HSA-877300] [PUBMED:9462485] [PUBMED:18929502] [PUBMED:9143700] [PUBMED:14525967]
Interleukin-3, 5 and GM-CSF signaling [NCBI:1269323] [REACTOME:R-HSA-512988] [PUBMED:10450743] [PUBMED:9766809]
Interleukin-6 family signaling [NCBI:1339142] [REACTOME:R-HSA-6783589] [PUBMED:9685167] [PUBMED:8666978] [PUBMED:12773095] [PUBMED:9143707] [PUBMED:9716487] [PUBMED:7632928]
Interleukin-6 signaling [NCBI:1269325] [REACTOME:R-HSA-1059683] [PUBMED:20410258]
Jak-STAT signaling pathway [NCBI:83077] [KEGG:hsa04630] [PUBMED:21034406] [PUBMED:22339650] [PUBMED:16204702] [PUBMED:25587654] [PUBMED:24069565] [PUBMED:22383755] [PUBMED:24606160] [PUBMED:10851053] [PUBMED:23735217] [PUBMED:25217450] [PUBMED:21372217]
Leukocyte transendothelial migration [NCBI:83083] [KEGG:hsa04670] [PUBMED:15629883] [PUBMED:10975856] [PUBMED:14976004] [PUBMED:15265790] [PUBMED:15173832] [PUBMED:12540948] [PUBMED:15771581] [PUBMED:15604886] [PUBMED:14977592]
MAPK family signaling cascades [NCBI:1269501] [REACTOME:R-HSA-5683057] [PUBMED:21167873] [PUBMED:17161475] [PUBMED:22535895] [PUBMED:21372320]
MAPK1 (ERK2) activation [NCBI:1269505] [REACTOME:R-HSA-112411] [PUBMED:22177953] [PUBMED:8131746]
MAPK1/MAPK3 signaling [NCBI:1269502] [REACTOME:R-HSA-5684996] [PUBMED:25378393] [PUBMED:18199641] [PUBMED:17496909] [PUBMED:21779496] [PUBMED:15520807] [PUBMED:16393692] [PUBMED:19520853] [PUBMED:17496910] [PUBMED:22569528]
MAPK3 (ERK1) activation [NCBI:1269504] [REACTOME:R-HSA-110056]
MET activates PTPN11 [NCBI:1457798] [REACTOME:R-HSA-8865999] [PUBMED:10871282] [PUBMED:24951116] [PUBMED:16765027]
MyD88-independent TLR3/TLR4 cascade [NCBI:1269220] [REACTOME:R-HSA-166166] [PUBMED:15276183]
NGF signalling via TRKA from the plasma membrane [NCBI:1269460] [REACTOME:R-HSA-187037] [PUBMED:11520933] [PUBMED:12676795] [PUBMED:10851172] [PUBMED:10579918]
Natural killer cell mediated cytotoxicity [NCBI:83079] [KEGG:hsa04650] [PUBMED:12530970] [PUBMED:15567854] [PUBMED:8942070] [PUBMED:11905813] [PUBMED:9143705] [PUBMED:9862693] [PUBMED:11895890] [PUBMED:12205470] [PUBMED:11836514] [PUBMED:15607806] [PUBMED:16002670] [PUBMED:15618404] [PUBMED:11390470] [PUBMED:11062493] [PUBMED:14710949] [PUBMED:12752668] [PUBMED:15607802] [PUBMED:16109839] [PUBMED:12766758] [PUBMED:16177799]
Negative regulation of FGFR1 signaling [NCBI:1269397] [REACTOME:R-HSA-5654726] [PUBMED:18452557] [PUBMED:11997436] [PUBMED:20940169] [PUBMED:12815057]
Negative regulation of FGFR2 signaling [NCBI:1269408] [REACTOME:R-HSA-5654727] [PUBMED:12815057] [PUBMED:18452557] [PUBMED:11997436] [PUBMED:20940169]
Negative regulation of FGFR3 signaling [NCBI:1269418] [REACTOME:R-HSA-5654732] [PUBMED:12815057] [PUBMED:18452557] [PUBMED:11997436] [PUBMED:20940169]
Negative regulation of FGFR4 signaling [NCBI:1269427] [REACTOME:R-HSA-5654733] [PUBMED:12815057] [PUBMED:18452557] [PUBMED:11997436] [PUBMED:20940169]
Negative regulation of the PI3K/AKT network [NCBI:1269191] [REACTOME:R-HSA-199418]
Netrin mediated repulsion signals [NCBI:1270316] [REACTOME:R-HSA-418886]
Netrin-1 signaling [NCBI:1270314] [REACTOME:R-HSA-373752] [PUBMED:18269208] [PUBMED:10499167]
Neurotrophic factor-mediated Trk receptor signaling [NCBI:137977] [Pathway Interaction Database:trkrpathway] [PUBMED:1849459] [PUBMED:8226808] [PUBMED:11163269] [PUBMED:7510697] [PUBMED:11027277] [PUBMED:15758069] [PUBMED:11425862] [PUBMED:11238898] [PUBMED:11251075] [PUBMED:8344249] [PUBMED:9356464] [PUBMED:11150291] [PUBMED:10092678] [PUBMED:1280261] [PUBMED:11150334] [PUBMED:11244088] [PUBMED:10985348] [PUBMED:15753086] [PUBMED:1653651] [PUBMED:11466412] [PUBMED:15167895] [PUBMED:1831195] [PUBMED:10490030] [PUBMED:8384556] [PUBMED:16697063] [PUBMED:17003042] [PUBMED:15520226] [PUBMED:15632082] [PUBMED:16611639] [PUBMED:16187212] [PUBMED:9182757] [PUBMED:1604323] [PUBMED:16284401] [PUBMED:8356095] [PUBMED:10329710] [PUBMED:9927421] [PUBMED:9856458] [PUBMED:10691301] [PUBMED:1375038] [PUBMED:10679771] [PUBMED:15122257] [PUBMED:15513915] [PUBMED:16701206] [PUBMED:1710174] [PUBMED:8155326] [PUBMED:8288573] [PUBMED:7972023] [PUBMED:7512734] [PUBMED:10601297] [PUBMED:16203995] [PUBMED:12510192] [PUBMED:16481401] [PUBMED:8106527] [PUBMED:11278445] [PUBMED:9099755] [PUBMED:1850821] [PUBMED:9632781] [PUBMED:10235685] [PUBMED:15917464] [PUBMED:9285826] [PUBMED:12446789] [PUBMED:7657612] [PUBMED:1850549] [PUBMED:12879077] [PUBMED:16157584] [PUBMED:10207144] [PUBMED:12006576] [PUBMED:8052307] [PUBMED:8382740] [PUBMED:10629055]
Neurotrophin signaling pathway [NCBI:101143] [KEGG:hsa04722] [PUBMED:16699811] [PUBMED:10812966] [PUBMED:12676795] [PUBMED:16939974] [PUBMED:10851172] [PUBMED:15499580] [PUBMED:14704852] [PUBMED:11399424] [PUBMED:10764727] [PUBMED:10985348] [PUBMED:16856873] [PUBMED:11529497]
PD-1 signaling [NCBI:1269182] [REACTOME:R-HSA-389948] [PUBMED:18759926] [PUBMED:18173375]
PDGFR-beta signaling pathway [NCBI:138071] [Pathway Interaction Database:pdgfrbpathway] [PUBMED:7545675] [PUBMED:16769879] [PUBMED:12652307] [PUBMED:10463951] [PUBMED:9742401] [PUBMED:8086421] [PUBMED:10391677] [PUBMED:7739538] [PUBMED:9989826] [PUBMED:10734138] [PUBMED:15753096] [PUBMED:7692233] [PUBMED:11489946] [PUBMED:10837138] [PUBMED:10229199] [PUBMED:10821867] [PUBMED:11709084] [PUBMED:11389443] [PUBMED:12958184] [PUBMED:10734113] [PUBMED:15161943] [PUBMED:12149261] [PUBMED:16456542] [PUBMED:16224065] [PUBMED:8619809] [PUBMED:15494217] [PUBMED:1849073] [PUBMED:11085978] [PUBMED:2544881] [PUBMED:7622571] [PUBMED:10779329] [PUBMED:15944146] [PUBMED:11027258] [PUBMED:1708307] [PUBMED:8940081] [PUBMED:11854295] [PUBMED:8195171] [PUBMED:12424235] [PUBMED:7935392] [PUBMED:14966296] [PUBMED:16537894]
PECAM1 interactions [NCBI:1269375] [REACTOME:R-HSA-210990] [PUBMED:12681475] [PUBMED:14619965]
PI-3K cascade:FGFR1 [NCBI:1269396] [REACTOME:R-HSA-5654689] [PUBMED:15863030] [PUBMED:11057895] [PUBMED:12089343] [PUBMED:12558974] [PUBMED:10918587]
PI-3K cascade:FGFR2 [NCBI:1269407] [REACTOME:R-HSA-5654695] [PUBMED:10918587] [PUBMED:15863030] [PUBMED:11057895] [PUBMED:12558974] [PUBMED:12089343]
PI-3K cascade:FGFR3 [NCBI:1269417] [REACTOME:R-HSA-5654710] [PUBMED:10918587] [PUBMED:15863030] [PUBMED:11057895] [PUBMED:12089343] [PUBMED:12558974]
PI-3K cascade:FGFR4 [NCBI:1269426] [REACTOME:R-HSA-5654720] [PUBMED:10918587] [PUBMED:15863030] [PUBMED:11057895] [PUBMED:12558974] [PUBMED:12089343]
PI3K Cascade [NCBI:1269432] [REACTOME:R-HSA-109704]
PI3K/AKT Signaling in Cancer [NCBI:1268879] [REACTOME:R-HSA-2219528] [PUBMED:20713702] [PUBMED:10555148] [PUBMED:19644473] [PUBMED:17611497] [PUBMED:21478295] [PUBMED:17626883] [PUBMED:16339315] [PUBMED:18317450] [PUBMED:18079394] [PUBMED:9467011] [PUBMED:17604717] [PUBMED:9326929] [PUBMED:18954143] [PUBMED:20009532] [PUBMED:19962665] [PUBMED:21430697] [PUBMED:19487573] [PUBMED:10866302]
PI3K/AKT activation [NCBI:1269473] [REACTOME:R-HSA-198203] [PUBMED:10579926] [PUBMED:12123609]
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling [NCBI:1383020] [REACTOME:R-HSA-6811558] [PUBMED:12422219] [PUBMED:16979564] [PUBMED:19805105] [PUBMED:17200115] [PUBMED:21827948] [PUBMED:19576174] [PUBMED:18753295] [PUBMED:19896968] [PUBMED:16456541] [PUBMED:25495341] [PUBMED:15464023] [PUBMED:23758345] [PUBMED:9367159] [PUBMED:9211928] [PUBMED:17245604]
PIP3 activates AKT signaling [NCBI:1269188] [REACTOME:R-HSA-1257604]
Phospholipase D signaling pathway [NCBI:1311074] [KEGG:hsa04072] [PUBMED:9310372] [PUBMED:9119890] [PUBMED:15310762] [PUBMED:18936782] [PUBMED:24990952] [PUBMED:14769825] [PUBMED:21936578] [PUBMED:10666319] [PUBMED:17210675] [PUBMED:19264150] [PUBMED:23076158] [PUBMED:17054901] [PUBMED:16622417] [PUBMED:10807766] [PUBMED:12217395] [PUBMED:11042115] [PUBMED:19815110] [PUBMED:24995811] [PUBMED:16143829] [PUBMED:8135758] [PUBMED:11991733] [PUBMED:19410013] [PUBMED:17245604]
Platelet activation, signaling and aggregation [NCBI:1269350] [REACTOME:R-HSA-76002] [PUBMED:16543958] [PUBMED:8704248] [PUBMED:2018971] [PUBMED:1672265] [PUBMED:17059469] [PUBMED:12681240] [PUBMED:12411949] [PUBMED:11511514]
Platelet homeostasis [NCBI:1269341] [REACTOME:R-HSA-418346] [PUBMED:10798271]
Platelet sensitization by LDL [NCBI:1269348] [REACTOME:R-HSA-432142] [PUBMED:12038793] [PUBMED:12775720] [PUBMED:15459198]
Prolactin receptor signaling [NCBI:1269328] [REACTOME:R-HSA-1170546] [PUBMED:9626554] [PUBMED:11356125] [PUBMED:11826263]
Proteoglycans in cancer [NCBI:782000] [KEGG:hsa05205] [PUBMED:19433454] [PUBMED:20655987] [PUBMED:18798267] [PUBMED:10633082] [PUBMED:10687947] [PUBMED:22735579] [PUBMED:24412155] [PUBMED:9346940] [PUBMED:22087031] [PUBMED:22194599] [PUBMED:14711376] [PUBMED:19255147] [PUBMED:15655247] [PUBMED:11717317] [PUBMED:17971838] [PUBMED:18413366] [PUBMED:20974860] [PUBMED:11830493] [PUBMED:23058688] [PUBMED:18450475] [PUBMED:12748184] [PUBMED:19733083] [PUBMED:18812315] [PUBMED:12509413] [PUBMED:21155971] [PUBMED:11931647] [PUBMED:18949819] [PUBMED:12729888] [PUBMED:15994311] [PUBMED:23305321] [PUBMED:18505598] [PUBMED:22563565] [PUBMED:22033227]
RAF-independent MAPK1/3 activation [NCBI:1269503] [REACTOME:R-HSA-112409] [PUBMED:21135874] [PUBMED:22569528] [PUBMED:23954936]
RET signaling [NCBI:1427866] [REACTOME:R-HSA-8853659] [PUBMED:15013219] [PUBMED:17036197]
Ras signaling pathway [NCBI:868085] [KEGG:hsa04014] [PUBMED:23506953] [PUBMED:18437264] [PUBMED:15062121] [PUBMED:22189424] [PUBMED:22233291] [PUBMED:12778136] [PUBMED:11313946] [PUBMED:17428555] [PUBMED:19091743] [PUBMED:18568040] [PUBMED:20420946] [PUBMED:12217381] [PUBMED:14663478] [PUBMED:21686117] [PUBMED:12642680] [PUBMED:21196257] [PUBMED:16869784] [PUBMED:21111786] [PUBMED:16966426] [PUBMED:10712923] [PUBMED:22020205] [PUBMED:17384584] [PUBMED:15572660] [PUBMED:18413813]
Regulation of IFNA signaling [NCBI:1269313] [REACTOME:R-HSA-912694] [PUBMED:16710296] [PUBMED:16311601] [PUBMED:10526574]
Regulation of IFNG signaling [NCBI:1269315] [REACTOME:R-HSA-877312] [PUBMED:10526574] [PUBMED:18031232] [PUBMED:12645661]
Renal cell carcinoma [NCBI:83107] [KEGG:hsa05211] [PUBMED:12351585] [PUBMED:17211469] [PUBMED:16339096] [PUBMED:17287871] [PUBMED:14634372] [PUBMED:15611513] [PUBMED:14685170] [PUBMED:15122209]
Role of LAT2/NTAL/LAB on calcium mobilization [NCBI:1269302] [REACTOME:R-HSA-2730905] [PUBMED:17993265] [PUBMED:20643813] [PUBMED:17420272]
Signal Transduction [NCBI:1269379] [REACTOME:R-HSA-162582] [PUBMED:17604717] [PUBMED:19648010] [PUBMED:16260143] [PUBMED:11742412] [PUBMED:19536106] [PUBMED:15863030] [PUBMED:19379690] [PUBMED:19458711] [PUBMED:19935667] [PUBMED:21252999] [PUBMED:15520807] [PUBMED:17496910] [PUBMED:15450248] [PUBMED:18043707] [PUBMED:16939974] [PUBMED:19762341] [PUBMED:18483217] [PUBMED:17084981] [PUBMED:21781017] [PUBMED:19619488]
Signal regulatory protein (SIRP) family interactions [NCBI:1270241] [REACTOME:R-HSA-391160] [PUBMED:16339511] [PUBMED:11792697] [PUBMED:16691243] [PUBMED:12023008] [PUBMED:19144521]
Signaling by EGFR [NCBI:1269380] [REACTOME:R-HSA-177929] [PUBMED:10459005] [PUBMED:10404636] [PUBMED:12297041] [PUBMED:15142631]
Signaling by FGFR [NCBI:1269386] [REACTOME:R-HSA-190236] [PUBMED:15863038] [PUBMED:12080084] [PUBMED:20602996] [PUBMED:15863030] [PUBMED:15567848] [PUBMED:7917292] [PUBMED:19247306] [PUBMED:16597617]
Signaling by FGFR1 [NCBI:1269387] [REACTOME:R-HSA-5654736] [PUBMED:16597617] [PUBMED:19247306] [PUBMED:12080084] [PUBMED:15863038] [PUBMED:15567848] [PUBMED:20602996] [PUBMED:7917292] [PUBMED:15863030]
Signaling by FGFR2 [NCBI:1269399] [REACTOME:R-HSA-5654738] [PUBMED:19247306] [PUBMED:16597617] [PUBMED:15863038] [PUBMED:12080084] [PUBMED:15863030] [PUBMED:20602996] [PUBMED:15567848] [PUBMED:7917292]
Signaling by FGFR3 [NCBI:1269409] [REACTOME:R-HSA-5654741] [PUBMED:16597617] [PUBMED:19247306] [PUBMED:15863038] [PUBMED:12080084] [PUBMED:20602996] [PUBMED:15567848] [PUBMED:7917292] [PUBMED:15863030]
Signaling by FGFR4 [NCBI:1269419] [REACTOME:R-HSA-5654743] [PUBMED:15863038] [PUBMED:12080084] [PUBMED:15567848] [PUBMED:20602996] [PUBMED:7917292] [PUBMED:15863030] [PUBMED:19247306] [PUBMED:16597617]
Signaling by Insulin receptor [NCBI:1269428] [REACTOME:R-HSA-74752] [PUBMED:8276779]
Signaling by Interleukins [NCBI:1269318] [REACTOME:R-HSA-449147] [PUBMED:19302047] [PUBMED:12445398]
Signaling by Leptin [NCBI:1269632] [REACTOME:R-HSA-2586552] [PUBMED:22211890] [PUBMED:23562747] [PUBMED:20600241] [PUBMED:21622208] [PUBMED:23579596] [PUBMED:22458591] [PUBMED:21489811] [PUBMED:19724019] [PUBMED:21331644] [PUBMED:22448029] [PUBMED:21147620] [PUBMED:20198122] [PUBMED:21677426] [PUBMED:20029269] [PUBMED:22249808] [PUBMED:22991412] [PUBMED:21527729] [PUBMED:17937601] [PUBMED:20553370] [PUBMED:21713385] [PUBMED:23565489] [PUBMED:22289780]
Signaling by MET [NCBI:1457794] [REACTOME:R-HSA-6806834] [PUBMED:1846706] [PUBMED:12948444] [PUBMED:16782899] [PUBMED:15249655] [PUBMED:22270953] [PUBMED:15167892] [PUBMED:7708691] [PUBMED:11081636] [PUBMED:8384622] [PUBMED:21102609] [PUBMED:16461907] [PUBMED:9407027] [PUBMED:7854453] [PUBMED:7651534] [PUBMED:9070211] [PUBMED:8208547] [PUBMED:24518591] [PUBMED:6590967] [PUBMED:15180923] [PUBMED:20802513] [PUBMED:10521801] [PUBMED:9038378] [PUBMED:17403932] [PUBMED:1655790] [PUBMED:12006644] [PUBMED:7513258] [PUBMED:18614017] [PUBMED:10753869] [PUBMED:17662939] [PUBMED:14685170] [PUBMED:10734310] [PUBMED:1827664] [PUBMED:7731718] [PUBMED:19996456] [PUBMED:11430831] [PUBMED:8302603] [PUBMED:15218027] [PUBMED:9140397] [PUBMED:2423252] [PUBMED:16113677] [PUBMED:12147692] [PUBMED:10648629] [PUBMED:7854452] [PUBMED:15070743] [PUBMED:15301554] [PUBMED:19881549] [PUBMED:25992381] [PUBMED:10871282] [PUBMED:12726861]
Signaling by PDGF [NCBI:1269478] [REACTOME:R-HSA-186797] [PUBMED:15207811] [PUBMED:10508235] [PUBMED:9739761]
Signaling by SCF-KIT [NCBI:1269487] [REACTOME:R-HSA-1433557] [PUBMED:17350321] [PUBMED:16483568] [PUBMED:7688988] [PUBMED:19540337] [PUBMED:16475976] [PUBMED:15526160]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) [NCBI:1269617] [REACTOME:R-HSA-2404192] [PUBMED:21042815] [PUBMED:18927274] [PUBMED:20098959] [PUBMED:17598937] [PUBMED:20975071] [PUBMED:22044904] [PUBMED:22649417]
Signaling by the B Cell Receptor (BCR) [NCBI:1269183] [REACTOME:R-HSA-983705] [PUBMED:1702903] [PUBMED:2011584] [PUBMED:1081164] [PUBMED:19065780] [PUBMED:16849466] [PUBMED:1375264] [PUBMED:7538118] [PUBMED:11901194] [PUBMED:8580068] [PUBMED:19249086] [PUBMED:18596693] [PUBMED:10648173] [PUBMED:4589993] [PUBMED:8163536] [PUBMED:1376928] [PUBMED:7688784] [PUBMED:6335036] [PUBMED:17052215] [PUBMED:18818202] [PUBMED:20206686] [PUBMED:7592958] [PUBMED:7524079] [PUBMED:15489917] [PUBMED:15509800] [PUBMED:18187424] [PUBMED:7927516] [PUBMED:803528] [PUBMED:19909372] [PUBMED:20192804] [PUBMED:8306975]
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) [NCBI:137930] [Pathway Interaction Database:met_pathway] [PUBMED:10793146] [PUBMED:8906793] [PUBMED:11929826] [PUBMED:10022866] [PUBMED:11532961] [PUBMED:12475979] [PUBMED:1718989] [PUBMED:1846706] [PUBMED:10970810] [PUBMED:10516287] [PUBMED:12138161] [PUBMED:11046147] [PUBMED:18073207] [PUBMED:12951049] [PUBMED:15494312] [PUBMED:9001234] [PUBMED:11352916] [PUBMED:11896055] [PUBMED:9440692] [PUBMED:8607979] [PUBMED:12244132] [PUBMED:11162460] [PUBMED:11809798] [PUBMED:9693375] [PUBMED:14636584] [PUBMED:17297451] [PUBMED:17682062] [PUBMED:19628037] [PUBMED:11069926] [PUBMED:18819921] [PUBMED:16423831] [PUBMED:10558875] [PUBMED:16858414] [PUBMED:10995442] [PUBMED:20332103] [PUBMED:11146548] [PUBMED:18346875] [PUBMED:17894413] [PUBMED:9252406] [PUBMED:17635922] [PUBMED:11134526] [PUBMED:2005882] [PUBMED:19609305] [PUBMED:8380735] [PUBMED:16537482] [PUBMED:10618718] [PUBMED:9591773] [PUBMED:12894582] [PUBMED:9748249] [PUBMED:11741535] [PUBMED:17881575] [PUBMED:10713050] [PUBMED:1655790] [PUBMED:11784715] [PUBMED:10753869] [PUBMED:10713700] [PUBMED:11118451] [PUBMED:16952352] [PUBMED:15314156] [PUBMED:19272169] [PUBMED:12802068] [PUBMED:17363898] [PUBMED:7513258] [PUBMED:1827664] [PUBMED:2541345] [PUBMED:8387483] [PUBMED:16620780] [PUBMED:11445578] [PUBMED:10734310] [PUBMED:16227611] [PUBMED:12941962] [PUBMED:15735664] [PUBMED:19071214] [PUBMED:7731718] [PUBMED:19289496] [PUBMED:11438654] [PUBMED:11896612] [PUBMED:11894096] [PUBMED:11896575] [PUBMED:7499247] [PUBMED:12147692] [PUBMED:11948414] [PUBMED:19881549] [PUBMED:19525225] [PUBMED:14684163] [PUBMED:17055484] [PUBMED:9668053] [PUBMED:10531383] [PUBMED:9681449] [PUBMED:1655405] [PUBMED:12686592] [PUBMED:19109251] [PUBMED:10679787] [PUBMED:9487126] [PUBMED:9886295] [PUBMED:12058075] [PUBMED:15452053] [PUBMED:9184210] [PUBMED:10871282] [PUBMED:17329361] [PUBMED:2554238]
Signaling events mediated by Stem cell factor receptor (c-Kit) [NCBI:138068] [Pathway Interaction Database:kitpathway] [PUBMED:12909618] [PUBMED:10364466] [PUBMED:10673502] [PUBMED:15315962] [PUBMED:12192036] [PUBMED:12444928] [PUBMED:15504549] [PUBMED:8950973] [PUBMED:11071635] [PUBMED:12149208] [PUBMED:11369651] [PUBMED:9038210] [PUBMED:10679268] [PUBMED:15465815] [PUBMED:10523831] [PUBMED:8611693] [PUBMED:15676208] [PUBMED:11805142] [PUBMED:10637471] [PUBMED:9872323] [PUBMED:11809791] [PUBMED:11520784] [PUBMED:12691919] [PUBMED:10397721] [PUBMED:15611091] [PUBMED:12356726] [PUBMED:9528781] [PUBMED:1381360] [PUBMED:9651683] [PUBMED:10849422] [PUBMED:9355737]
Signaling events mediated by VEGFR1 and VEGFR2 [NCBI:137940] [Pathway Interaction Database:vegfr1_2_pathway] [PUBMED:9398617] [PUBMED:9405464] [PUBMED:11494124] [PUBMED:12963813] [PUBMED:11756651] [PUBMED:10744763] [PUBMED:15060076] [PUBMED:9600074] [PUBMED:10376603] [PUBMED:11425855] [PUBMED:16337972] [PUBMED:12154000] [PUBMED:11978735] [PUBMED:10692392] [PUBMED:16763158] [PUBMED:10361126] [PUBMED:10748121] [PUBMED:12598525] [PUBMED:15026417] [PUBMED:11948691] [PUBMED:16966330] [PUBMED:16835467] [PUBMED:10409677] [PUBMED:10908731] [PUBMED:8903320] [PUBMED:15962004] [PUBMED:16633338] [PUBMED:11387210] [PUBMED:16839566] [PUBMED:11312102] [PUBMED:10207622] [PUBMED:16787925] [PUBMED:12171920] [PUBMED:12509223] [PUBMED:16760434] [PUBMED:14724572] [PUBMED:11704645] [PUBMED:12821150] [PUBMED:12881528] [PUBMED:9790910] [PUBMED:10376602] [PUBMED:15247219] [PUBMED:11333271] [PUBMED:12214271] [PUBMED:9804796] [PUBMED:11986311] [PUBMED:9182576] [PUBMED:15217908] [PUBMED:10749680] [PUBMED:16763549]
Signaling events regulated by Ret tyrosine kinase [NCBI:137915] [Pathway Interaction Database:ret_pathway] [PUBMED:11002419] [PUBMED:17050626] [PUBMED:11360177] [PUBMED:7478523] [PUBMED:12176011] [PUBMED:12771945] [PUBMED:14607833] [PUBMED:7665556] [PUBMED:8631863] [PUBMED:11470823] [PUBMED:15966897] [PUBMED:12087092] [PUBMED:16820412] [PUBMED:15657578] [PUBMED:10208419] [PUBMED:9182757] [PUBMED:8662982] [PUBMED:9047383] [PUBMED:12063395] [PUBMED:15569713] [PUBMED:15286081] [PUBMED:10448070] [PUBMED:16227613] [PUBMED:11390647] [PUBMED:15351743] [PUBMED:8674117] [PUBMED:11313948] [PUBMED:2181380] [PUBMED:9047384] [PUBMED:8570170] [PUBMED:11886862] [PUBMED:9632781] [PUBMED:16153436] [PUBMED:11000521]
Signalling by NGF [NCBI:1269443] [REACTOME:R-HSA-166520]
Spry regulation of FGF signaling [NCBI:1269398] [REACTOME:R-HSA-1295596] [PUBMED:9458049] [PUBMED:16893902] [PUBMED:19690147] [PUBMED:19570949]
TCR signaling in naive CD4+ T cells [NCBI:137998] [Pathway Interaction Database:tcr_pathway] [PUBMED:11376344] [PUBMED:9094314] [PUBMED:8083187] [PUBMED:11994416] [PUBMED:16365455] [PUBMED:10072079] [PUBMED:12361955] [PUBMED:12755691] [PUBMED:8642247] [PUBMED:15125833] [PUBMED:7509360] [PUBMED:11353765] [PUBMED:12941616] [PUBMED:8700169] [PUBMED:11120819] [PUBMED:15899849] [PUBMED:8990121] [PUBMED:8702662] [PUBMED:8164687] [PUBMED:2141684] [PUBMED:11567141] [PUBMED:9846481] [PUBMED:9489702] [PUBMED:10811803] [PUBMED:11368773] [PUBMED:14557276] [PUBMED:2548204] [PUBMED:10318843] [PUBMED:15536066] [PUBMED:10652356] [PUBMED:7568038] [PUBMED:11175263] [PUBMED:9438848] [PUBMED:9692882] [PUBMED:10209031] [PUBMED:7509083] [PUBMED:12874226] [PUBMED:8673706] [PUBMED:16733527] [PUBMED:9822663] [PUBMED:12738795] [PUBMED:11904433] [PUBMED:8084588] [PUBMED:8114715] [PUBMED:9312162] [PUBMED:8790380] [PUBMED:9677202] [PUBMED:15802604] [PUBMED:14702343] [PUBMED:10903746] [PUBMED:10807788] [PUBMED:8176201] [PUBMED:9207119] [PUBMED:10790433] [PUBMED:8892604] [PUBMED:9665884] [PUBMED:1639064] [PUBMED:12421919] [PUBMED:8246987] [PUBMED:9710204] [PUBMED:8146197] [PUBMED:2190221] [PUBMED:10229072] [PUBMED:10021361] [PUBMED:9924026] [PUBMED:12186560] [PUBMED:16649996] [PUBMED:11287959] [PUBMED:12917261] [PUBMED:7545666] [PUBMED:11250890] [PUBMED:12842872] [PUBMED:15879121] [PUBMED:11567140] [PUBMED:10209041] [PUBMED:10556826] [PUBMED:8183372] [PUBMED:12397360] [PUBMED:10506192] [PUBMED:10861059] [PUBMED:12507424] [PUBMED:12845325] [PUBMED:10745081] [PUBMED:8195151] [PUBMED:12024036] [PUBMED:7524075] [PUBMED:1464315] [PUBMED:12138205] [PUBMED:7544353] [PUBMED:16906149] [PUBMED:9637919] [PUBMED:2470098] [PUBMED:3919143] [PUBMED:16005298] [PUBMED:10918068] [PUBMED:8636141] [PUBMED:16921383] [PUBMED:8479536] [PUBMED:7556092] [PUBMED:16582901] [PUBMED:8805223] [PUBMED:15933714] [PUBMED:10224278] [PUBMED:9819387] [PUBMED:12881521] [PUBMED:14988727] [PUBMED:16849481] [PUBMED:11390650]
TRIF-mediated TLR3/TLR4 signaling [NCBI:1269221] [REACTOME:R-HSA-937061] [PUBMED:15814722] [PUBMED:12855817] [PUBMED:14739303]
Tie2 Signaling [NCBI:1269374] [REACTOME:R-HSA-210993] [PUBMED:11566266] [PUBMED:11969368] [PUBMED:9764820] [PUBMED:11191051]
Toll Like Receptor 3 (TLR3) Cascade [NCBI:1269219] [REACTOME:R-HSA-168164] [PUBMED:19627256] [PUBMED:15733829] [PUBMED:18202435]
Toll Like Receptor 4 (TLR4) Cascade [NCBI:1269234] [REACTOME:R-HSA-166016]
Toll-Like Receptors Cascades [NCBI:1269204] [REACTOME:R-HSA-168898] [PUBMED:15950447] [PUBMED:12893815] [PUBMED:15976490] [PUBMED:15585605] [PUBMED:14751757]
VEGFR1 specific signals [NCBI:137924] [Pathway Interaction Database:vegfr1_pathway] [PUBMED:9299537] [PUBMED:9751730] [PUBMED:9722576] [PUBMED:14633857] [PUBMED:11978735] [PUBMED:11278319] [PUBMED:12649282] [PUBMED:16839566] [PUBMED:12598525] [PUBMED:12171920] [PUBMED:12796773] [PUBMED:16633338] [PUBMED:11312102] [PUBMED:9295307] [PUBMED:10908731] [PUBMED:16787925] [PUBMED:11704645] [PUBMED:9790910] [PUBMED:10376602] [PUBMED:9804796] [PUBMED:11986311] [PUBMED:10749680] [PUBMED:12214271] [PUBMED:9398617] [PUBMED:8621427] [PUBMED:11425855] [PUBMED:15001553] [PUBMED:10376603] [PUBMED:7824266] [PUBMED:10842181] [PUBMED:9600074]