full name
dynein light chain LC8-type 1

synonyms
DLC1, DLC8, DNCL1, DNCLC1, hdlc1, LC8, LC8a, PIN, DYNLL1, ENSG00000088986

HGNC
HGNC:15476

Entrez Gene
Gene:8655

ENSEMBL
ENSG00000088986

location
chr: 12
start: 120907660
stop: 120936298
strand: +

transcripts
NM_001037494.1
NM_001037495.1
NM_003746.2

pathways
AURKA Activation by TPX2 [NCBI:1383018] [REACTOME:R-HSA-8854518] [PUBMED:14580337] [PUBMED:21147853] [PUBMED:22094468] [PUBMED:21347367]
Activation of BH3-only proteins [NCBI:1270270] [REACTOME:R-HSA-114452] [PUBMED:12209154] [PUBMED:14634621]
Activation of BIM and translocation to mitochondria [NCBI:1270274] [REACTOME:R-HSA-111446] [PUBMED:14764673]
Adaptive Immune System [NCBI:1269171] [REACTOME:R-HSA-1280218] [PUBMED:16551257] [PUBMED:21682741] [PUBMED:11861602]
Anchoring of the basal body to the plasma membrane [NCBI:1268847] [REACTOME:R-HSA-5620912] [PUBMED:21816947] [PUBMED:23747070] [PUBMED:19575670] [PUBMED:13978319] [PUBMED:23348840] [PUBMED:25047614] [PUBMED:20819941] [PUBMED:5661997] [PUBMED:21422230] [PUBMED:24469809] [PUBMED:23530209] [PUBMED:21725307] [PUBMED:21680046] [PUBMED:23351793] [PUBMED:21427764] [PUBMED:11676918] [PUBMED:22653444]
Apoptosis [NCBI:83060] [KEGG:hsa04210] [NCBI:1270262] [REACTOME:R-HSA-109581] [PUBMED:12189384] [PUBMED:20533903] [PUBMED:18208375] [PUBMED:22429822] [PUBMED:15218528] [PUBMED:24769728] [PUBMED:18023214] [PUBMED:25526085] [PUBMED:23070002] [PUBMED:15654015] [PUBMED:15601572] [PUBMED:14561771] [PUBMED:24278747] [PUBMED:21914490] [PUBMED:22465226] [PUBMED:21145844] [PUBMED:12838338] [PUBMED:18238895] [PUBMED:12949498] [PUBMED:18304445] [PUBMED:14737178] [PUBMED:26231733] [PUBMED:9916983] [PUBMED:14634621] [PUBMED:19770840] [PUBMED:22075987] [PUBMED:4561027] [PUBMED:20075940] [PUBMED:9894605] [PUBMED:26615431] [PUBMED:12505355] [PUBMED:11520933] [PUBMED:19148180] [PUBMED:16397578] [PUBMED:15719025] [PUBMED:15322527] [PUBMED:15725726] [PUBMED:12209154] [PUBMED:23803157]
Asparagine N-linked glycosylation [NCBI:1268714] [REACTOME:R-HSA-446203] [PUBMED:16807922] [PUBMED:19647993] [PUBMED:10580125] [PUBMED:19616933] [PUBMED:20301507] [PUBMED:20301244]
COPI-independent Golgi-to-ER retrograde traffic [NCBI:1383043] [REACTOME:R-HSA-6811436] [PUBMED:23783758] [PUBMED:9671731] [PUBMED:25233431] [PUBMED:22130221] [PUBMED:10559986] [PUBMED:12447383] [PUBMED:10562278]
COPI-mediated anterograde transport [NCBI:1339109] [REACTOME:R-HSA-6807878] [PUBMED:9323141] [PUBMED:15632110] [PUBMED:10825291] [PUBMED:9288971] [PUBMED:23378591] [PUBMED:8334707] [PUBMED:22013193] [PUBMED:23732476]
Cell Cycle [NCBI:1269741] [REACTOME:R-HSA-1640170]
Cell Cycle, Mitotic [NCBI:1269763] [REACTOME:R-HSA-69278]
Cellular responses to stress [NCBI:1270414] [REACTOME:R-HSA-2262752] [PUBMED:15709958]
Centrosome maturation [NCBI:1269805] [REACTOME:R-HSA-380287] [PUBMED:17178454] [PUBMED:18437411]
Cilium Assembly [NCBI:1268846] [REACTOME:R-HSA-5617833] [PUBMED:21427764] [PUBMED:23351793] [PUBMED:25040720] [PUBMED:17955020] [PUBMED:22118932] [PUBMED:22653444] [PUBMED:22389062] [PUBMED:20399632] [PUBMED:25047619] [PUBMED:20395968] [PUBMED:23945166] [PUBMED:19575670] [PUBMED:24296415] [PUBMED:20145001] [PUBMED:19602418]
ER to Golgi Anterograde Transport [NCBI:1268726] [REACTOME:R-HSA-199977] [PUBMED:11252894]
G2/M Transition [NCBI:1269799] [REACTOME:R-HSA-69275]
Golgi-to-ER retrograde transport [NCBI:1383041] [REACTOME:R-HSA-8856688] [PUBMED:23732476] [PUBMED:23378591] [PUBMED:25233431]
Immune System [NCBI:1269170] [REACTOME:R-HSA-168256]
Innate Immune System [NCBI:1269203] [REACTOME:R-HSA-168249]
Intra-Golgi and retrograde Golgi-to-ER traffic [NCBI:1383038] [REACTOME:R-HSA-6811442] [PUBMED:11756463] [PUBMED:23839779] [PUBMED:21436057] [PUBMED:22013193] [PUBMED:21421921] [PUBMED:25233431] [PUBMED:16157178] [PUBMED:12121415] [PUBMED:25343031] [PUBMED:24068461] [PUBMED:19575639]
Intraflagellar transport [NCBI:1268853] [REACTOME:R-HSA-5620924] [PUBMED:21427764] [PUBMED:17574030] [PUBMED:17314406] [PUBMED:16049494] [PUBMED:15231740] [PUBMED:22118932] [PUBMED:19450523] [PUBMED:16229832] [PUBMED:23945166] [PUBMED:16775004] [PUBMED:24296415] [PUBMED:16061793] [PUBMED:18327258]
Intrinsic Pathway for Apoptosis [NCBI:1270268] [REACTOME:R-HSA-109606] [PUBMED:12042762] [PUBMED:11711427] [PUBMED:15077149]
Loss of Nlp from mitotic centrosomes [NCBI:1269809] [REACTOME:R-HSA-380259] [PUBMED:12852856]
Loss of proteins required for interphase microtubule organization from the centrosome [NCBI:1269808] [REACTOME:R-HSA-380284] [PUBMED:12140259] [PUBMED:12852856]
MHC class II antigen presentation [NCBI:1269200] [REACTOME:R-HSA-2132295] [PUBMED:19703008] [PUBMED:9316394] [PUBMED:11684289] [PUBMED:19217269] [PUBMED:8689559]
Macroautophagy [NCBI:1270432] [REACTOME:R-HSA-1632852] [PUBMED:24296784]
Membrane Trafficking [NCBI:1269877] [REACTOME:R-HSA-199991] [PUBMED:11031247]
Metabolism of proteins [NCBI:1268677] [REACTOME:R-HSA-392499]
Mitotic G2-G2/M phases [NCBI:1269797] [REACTOME:R-HSA-453274]
Neutrophil degranulation [NCBI:1457780] [REACTOME:R-HSA-6798695] [PUBMED:20338884] [PUBMED:1378856] [PUBMED:17627888] [PUBMED:23650620] [PUBMED:8692836]
Organelle biogenesis and maintenance [NCBI:1268838] [REACTOME:R-HSA-1852241] [PUBMED:8608592] [PUBMED:16103713]
Post-translational protein modification [NCBI:1268701] [REACTOME:R-HSA-597592]
Programmed Cell Death [NCBI:1270261] [REACTOME:R-HSA-5357801] [PUBMED:25236395]
Recruitment of mitotic centrosome proteins and complexes [NCBI:1269806] [REACTOME:R-HSA-380270] [PUBMED:18437411] [PUBMED:17178454]
Regulation of PLK1 Activity at G2/M Transition [NCBI:1269803] [REACTOME:R-HSA-2565942] [PUBMED:12207013] [PUBMED:18615013] [PUBMED:13678582] [PUBMED:18378770] [PUBMED:18566290] [PUBMED:18477460] [PUBMED:22365832]
Transport to the Golgi and subsequent modification [NCBI:1268725] [REACTOME:R-HSA-948021] [PUBMED:12717434] [PUBMED:10412983] [PUBMED:3594573]
Vasopressin-regulated water reabsorption [NCBI:143700] [KEGG:hsa04962] [PUBMED:14586738] [PUBMED:17956998] [PUBMED:11001488] [PUBMED:10073616] [PUBMED:18566824] [PUBMED:18431594] [PUBMED:11773613] [PUBMED:18655910] [PUBMED:10070156] [PUBMED:15522987] [PUBMED:10099706]
Vesicle-mediated transport [NCBI:1269876] [REACTOME:R-HSA-5653656]