full name
4-hydroxyphenylpyruvate dioxygenase

synonyms
4-HPPD, 4HPPD, GLOD3, HPPDASE, PPD, HPD, ENSG00000158104

HGNC
HGNC:5147

Entrez Gene
Gene:3242

ENSEMBL
ENSG00000158104

location
chr: 12
start: 122277433
stop: 122326517
strand: -

OMIM
OMIM:609695: HPD (Autosomal dominant inheritance)
OMIM:140350: Hawkinsinuria
OMIM:276710: Tyrosinemia, type III

transcripts
NM_001171993.1
ENST00000289004.4

pathways
Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism [NCBI:1309221] [REACTOME:R-HSA-6788656]
Metabolic pathways [NCBI:132956] [KEGG:hsa01100]
Metabolism [NCBI:1269956] [REACTOME:R-HSA-1430728]
Metabolism of amino acids and derivatives [NCBI:1270158] [REACTOME:R-HSA-71291]
Phenylalanine and tyrosine catabolism [NCBI:1270164] [REACTOME:R-HSA-71182]
Phenylalanine metabolism [NCBI:82960] [KEGG:hsa00360] [PUBMED:19016485] [PUBMED:10537203] [PUBMED:20660314] [PUBMED:9098055] [PUBMED:9603882]
Tyrosine degradation, tyrosine => homogentisate [NCBI:522534] [KEGG:hsa_M00044]
Tyrosine metabolism [NCBI:82959] [KEGG:hsa00350] [PUBMED:8550403] [PUBMED:1194238] [PUBMED:11171088] [PUBMED:18435614]
Ubiquinone and other terpenoid-quinone biosynthesis [NCBI:82939] [KEGG:hsa00130] [PUBMED:18284213] [PUBMED:11470786] [PUBMED:17760421] [PUBMED:17956107] [PUBMED:12615349] [PUBMED:18801996] [PUBMED:23113660] [PUBMED:14499605] [PUBMED:14508009] [PUBMED:16989822] [PUBMED:12523993] [PUBMED:12721307] [PUBMED:21239697] [PUBMED:12232327] [PUBMED:12908086] [PUBMED:11583838]
tyrosine degradation [NCBI:142386] [BIOCYC:HUMAN_TYRFUMCAT-PWY] [PUBMED:3298976]