Logo
full name
general transcription factor IIH subunit 3

synonyms
BTF2, P34, TFB4, TFIIH, GTF2H3, ENSG00000111358

HGNC
HGNC:4657

Entrez Gene
Gene:2967

ENSEMBL
ENSG00000111358

location
chr: 12
start: 124118286
stop: 124147151
strand: +

transcripts
NM_001516.4
NM_001271866.1
NM_001271868.1
NM_001271867.1

pathways
Basal transcription factors [NCBI:83038] [KEGG:hsa03022] [PUBMED:12516863] [PUBMED:10838567] [PUBMED:16858867] [PUBMED:19308322]
DNA Repair [NCBI:1270350] [REACTOME:R-HSA-73894] [PUBMED:10583946] [PUBMED:23175119]
Disease [NCBI:1268854] [REACTOME:R-HSA-1643685]
Dual Incision in GG-NER [NCBI:1309115] [REACTOME:R-HSA-5696400] [PUBMED:19279666]
Dual incision in TC-NER [NCBI:1309119] [REACTOME:R-HSA-6782135] [PUBMED:19279666] [PUBMED:23906714] [PUBMED:8078911] [PUBMED:16246722] [PUBMED:19023283] [PUBMED:11904382] [PUBMED:24402227]
Epigenetic regulation of gene expression [NCBI:1269734] [REACTOME:R-HSA-212165] [PUBMED:12610534]
Formation of HIV elongation complex in the absence of HIV Tat [NCBI:1269080] [REACTOME:R-HSA-167152]
Formation of HIV-1 elongation complex containing HIV-1 Tat [NCBI:1269077] [REACTOME:R-HSA-167200] [PUBMED:7853496] [PUBMED:14701750] [PUBMED:9491887] [PUBMED:15564463] [PUBMED:10757782]
Formation of Incision Complex in GG-NER [NCBI:1309114] [REACTOME:R-HSA-5696395] [PUBMED:17948053] [PUBMED:17466626] [PUBMED:11511374] [PUBMED:9716411] [PUBMED:17000769] [PUBMED:15590680] [PUBMED:19940136] [PUBMED:14517266] [PUBMED:16491090] [PUBMED:23038248]
Formation of RNA Pol II elongation complex [NCBI:1269684] [REACTOME:R-HSA-112382] [PUBMED:12676794]
Formation of TC-NER Pre-Incision Complex [NCBI:1309118] [REACTOME:R-HSA-6781823] [PUBMED:12208738] [PUBMED:16916636] [PUBMED:17290000] [PUBMED:25435140] [PUBMED:22466611] [PUBMED:10944529] [PUBMED:22902626] [PUBMED:16751180] [PUBMED:22466610] [PUBMED:8876179] [PUBMED:12660172] [PUBMED:25154395] [PUBMED:8078911]
Formation of the Early Elongation Complex [NCBI:1269683] [REACTOME:R-HSA-113418] [PUBMED:11940650] [PUBMED:10916156]
Formation of the HIV-1 Early Elongation Complex [NCBI:1269075] [REACTOME:R-HSA-167158] [PUBMED:12653964] [PUBMED:12370301] [PUBMED:11940650]
Gap-filling DNA repair synthesis and ligation in TC-NER [NCBI:1309120] [REACTOME:R-HSA-6782210] [PUBMED:20227374] [PUBMED:19279666] [PUBMED:17643379]
Gene Expression [NCBI:1269649] [REACTOME:R-HSA-74160]
Generic Transcription Pathway [NCBI:1269650] [REACTOME:R-HSA-212436] [PUBMED:15175151] [PUBMED:14744435] [PUBMED:15680972] [PUBMED:11395415] [PUBMED:15896744] [PUBMED:10235266] [PUBMED:14986688] [PUBMED:12023297] [PUBMED:15680973] [PUBMED:16751179] [PUBMED:11861166] [PUBMED:16429119] [PUBMED:16719718] [PUBMED:16921404] [PUBMED:15690163]
Global Genome Nucleotide Excision Repair (GG-NER) [NCBI:1309112] [REACTOME:R-HSA-5696399] [PUBMED:24954209]
HIV Infection [NCBI:1269057] [REACTOME:R-HSA-162906] [PUBMED:16354571] [PUBMED:9759480]
HIV Life Cycle [NCBI:1269058] [REACTOME:R-HSA-162587] [PUBMED:9188609] [PUBMED:9759480]
HIV Transcription Elongation [NCBI:1269074] [REACTOME:R-HSA-167169] [PUBMED:10550206] [PUBMED:15049426]
HIV Transcription Initiation [NCBI:1269071] [REACTOME:R-HSA-167161]
Infectious disease [NCBI:1269056] [REACTOME:R-HSA-5663205]
Late Phase of HIV Life Cycle [NCBI:1269069] [REACTOME:R-HSA-162599] [PUBMED:2825027] [PUBMED:10550206] [PUBMED:10562489] [PUBMED:15719065] [PUBMED:15183343] [PUBMED:3031512] [PUBMED:9891806] [PUBMED:2784194]
Negative epigenetic regulation of rRNA expression [NCBI:1269737] [REACTOME:R-HSA-5250941] [PUBMED:23063748] [PUBMED:23150253] [PUBMED:18616426]
NoRC negatively regulates rRNA expression [NCBI:1269739] [REACTOME:R-HSA-427413] [PUBMED:17439825] [PUBMED:17613545] [PUBMED:23063748] [PUBMED:11583633] [PUBMED:18631128] [PUBMED:18616426]
Nucleotide Excision Repair [NCBI:1309111] [REACTOME:R-HSA-5696398] [PUBMED:11900249] [PUBMED:23906714] [PUBMED:14599765] [PUBMED:10583946] [PUBMED:24954209] [PUBMED:19023283]
Nucleotide excision repair [NCBI:83044] [KEGG:hsa03420] [PUBMED:11436323] [PUBMED:18018633] [PUBMED:11436316] [PUBMED:17884153] [PUBMED:11436314] [PUBMED:17276014] [PUBMED:16922398]
RNA Pol II CTD phosphorylation and interaction with CE [NCBI:1269681] [REACTOME:R-HSA-77075]
RNA Pol II CTD phosphorylation and interaction with CE during HIV infection [NCBI:1269073] [REACTOME:R-HSA-167160]
RNA Polymerase I Chain Elongation [NCBI:1269662] [REACTOME:R-HSA-73777]
RNA Polymerase I Promoter Clearance [NCBI:1269658] [REACTOME:R-HSA-73854]
RNA Polymerase I Promoter Escape [NCBI:1269661] [REACTOME:R-HSA-73772]
RNA Polymerase I Transcription [NCBI:1269657] [REACTOME:R-HSA-73864]
RNA Polymerase I Transcription Initiation [NCBI:1269660] [REACTOME:R-HSA-73762]
RNA Polymerase I Transcription Termination [NCBI:1269663] [REACTOME:R-HSA-73863]
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription [NCBI:1269656] [REACTOME:R-HSA-504046]
RNA Polymerase II HIV Promoter Escape [NCBI:1269072] [REACTOME:R-HSA-167162]
RNA Polymerase II Pre-transcription Events [NCBI:1269676] [REACTOME:R-HSA-674695]
RNA Polymerase II Promoter Escape [NCBI:1269680] [REACTOME:R-HSA-73776] [PUBMED:9405375]
RNA Polymerase II Transcription [NCBI:1269675] [REACTOME:R-HSA-73857]
RNA Polymerase II Transcription Elongation [NCBI:1269682] [REACTOME:R-HSA-75955] [PUBMED:11018013] [PUBMED:12676794] [PUBMED:14550628]
RNA Polymerase II Transcription Initiation [NCBI:1269679] [REACTOME:R-HSA-75953] [PUBMED:7601352] [PUBMED:8612591] [PUBMED:11784853] [PUBMED:3667620] [PUBMED:9405375]
RNA Polymerase II Transcription Initiation And Promoter Clearance [NCBI:1269678] [REACTOME:R-HSA-76042]
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening [NCBI:1269677] [REACTOME:R-HSA-73779] [PUBMED:8946909]
TP53 Regulates Transcription of DNA Repair Genes [NCBI:1383075] [REACTOME:R-HSA-6796648] [PUBMED:10984493] [PUBMED:25712099] [PUBMED:22988298] [PUBMED:12771027] [PUBMED:23139867] [PUBMED:11971958] [PUBMED:22012619] [PUBMED:11988847] [PUBMED:9858527] [PUBMED:26773055] [PUBMED:15781865] [PUBMED:11350971] [PUBMED:25429106] [PUBMED:12170774] [PUBMED:20096807] [PUBMED:18187580] [PUBMED:9063748] [PUBMED:24662513]
Tat-mediated elongation of the HIV-1 transcript [NCBI:1269076] [REACTOME:R-HSA-167246] [PUBMED:2825027] [PUBMED:9450929] [PUBMED:11940650] [PUBMED:2476805] [PUBMED:10866664] [PUBMED:10757782] [PUBMED:10550206] [PUBMED:10199401] [PUBMED:15719065] [PUBMED:10562489] [PUBMED:15183343] [PUBMED:14701750] [PUBMED:7853496] [PUBMED:9491887]
Transcription of the HIV genome [NCBI:1269070] [REACTOME:R-HSA-167172] [PUBMED:10550206] [PUBMED:9791012]
Transcription-Coupled Nucleotide Excision Repair (TC-NER) [NCBI:1309117] [REACTOME:R-HSA-6781827] [PUBMED:24954209] [PUBMED:11823795] [PUBMED:19023283] [PUBMED:23906714] [PUBMED:3466163]
Transcriptional Regulation by TP53 [NCBI:1269654] [REACTOME:R-HSA-3700989] [PUBMED:26122615] [PUBMED:19410540]
Viral carcinogenesis [NCBI:658418] [KEGG:hsa05203] [PUBMED:9990017] [PUBMED:15173177] [PUBMED:16036567] [PUBMED:16581947] [PUBMED:9060639] [PUBMED:17457345] [PUBMED:15956361] [PUBMED:21421561] [PUBMED:18391203] [PUBMED:21040832] [PUBMED:9837909] [PUBMED:17645777] [PUBMED:15967719] [PUBMED:12686421] [PUBMED:17049016] [PUBMED:21152115] [PUBMED:11160754] [PUBMED:21966251] [PUBMED:17979705] [PUBMED:8617242] [PUBMED:12925958] [PUBMED:10873631] [PUBMED:21250384] [PUBMED:15614436] [PUBMED:10354594] [PUBMED:20494113] [PUBMED:18702816] [PUBMED:9651361] [PUBMED:16459163] [PUBMED:11278402] [PUBMED:15510157] [PUBMED:19956178] [PUBMED:18251977] [PUBMED:11766888] [PUBMED:10824878] [PUBMED:21372216] [PUBMED:11244044] [PUBMED:17894800] [PUBMED:11905817] [PUBMED:21347341] [PUBMED:12186904] [PUBMED:9374493] [PUBMED:16352731] [PUBMED:12770701] [PUBMED:17384582] [PUBMED:14506283] [PUBMED:11091847] [PUBMED:17267064] [PUBMED:11886269] [PUBMED:21177815] [PUBMED:10400746] [PUBMED:19156753] [PUBMED:9882379] [PUBMED:14559998] [PUBMED:15767449] [PUBMED:22110506] [PUBMED:20534855] [PUBMED:15542638] [PUBMED:9343405] [PUBMED:10405893] [PUBMED:19400863] [PUBMED:9349482] [PUBMED:14747563] [PUBMED:21647825] [PUBMED:12970441] [PUBMED:11669605] [PUBMED:15795286] [PUBMED:21994562] [PUBMED:14530271] [PUBMED:9594662] [PUBMED:22566809] [PUBMED:19651473] [PUBMED:8756622] [PUBMED:15105524] [PUBMED:15452270] [PUBMED:18948197] [PUBMED:16760382] [PUBMED:10793105] [PUBMED:21084867] [PUBMED:16308315] [PUBMED:16155604] [PUBMED:16381817] [PUBMED:16828973] [PUBMED:15342967] [PUBMED:15692053] [PUBMED:10855768] [PUBMED:19078975] [PUBMED:12379483] [PUBMED:15310405] [PUBMED:8223437] [PUBMED:16939421] [PUBMED:12910250] [PUBMED:16039586] [PUBMED:18201576] [PUBMED:21102637] [PUBMED:21743832] [PUBMED:20592731] [PUBMED:10644344] [PUBMED:10074132] [PUBMED:19715458] [PUBMED:16155601] [PUBMED:11604508] [PUBMED:15919895] [PUBMED:11099494] [PUBMED:18385245] [PUBMED:19854353] [PUBMED:12101418]
mRNA Capping [NCBI:1269687] [REACTOME:R-HSA-72086] [PUBMED:11909521] [PUBMED:3326038] [PUBMED:10395561] [PUBMED:11017188]