Logo
full name
cyclin dependent kinase 8

synonyms
K35, CDK8, ENSG00000132964

HGNC
HGNC:1779

Entrez Gene
Gene:1024

ENSEMBL
ENSG00000132964

location
chr: 13
start: 26828262
stop: 26979375
strand: +

OMIM
OMIM:603184: CDK8
OMIM:618748: Intellectual developmental disorder with hypotonia and behavioral abnormalities

transcripts
NM_001260.1

pathways
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants [NCBI:1268891] [REACTOME:R-HSA-2894862] [PUBMED:15472075] [PUBMED:17646408] [PUBMED:17646409] [PUBMED:16738328]
Constitutive Signaling by NOTCH1 PEST Domain Mutants [NCBI:1268889] [REACTOME:R-HSA-2644606] [PUBMED:15472075] [PUBMED:17646408] [PUBMED:17646409]
Developmental Biology [NCBI:1270302] [REACTOME:R-HSA-1266738]
Disease [NCBI:1268854] [REACTOME:R-HSA-1643685]
Diseases of signal transduction [NCBI:1268855] [REACTOME:R-HSA-5663202] [PUBMED:12509752]
Fatty acid, triacylglycerol, and ketone body metabolism [NCBI:1270010] [REACTOME:R-HSA-535734]
Gene Expression [NCBI:1269649] [REACTOME:R-HSA-74160]
Generic Transcription Pathway [NCBI:1269650] [REACTOME:R-HSA-212436] [PUBMED:15175151] [PUBMED:14744435] [PUBMED:15680972] [PUBMED:11395415] [PUBMED:15896744] [PUBMED:10235266] [PUBMED:14986688] [PUBMED:12023297] [PUBMED:15680973] [PUBMED:16751179] [PUBMED:11861166] [PUBMED:16429119] [PUBMED:16719718] [PUBMED:16921404] [PUBMED:15690163]
Metabolism [NCBI:1269956] [REACTOME:R-HSA-1430728]
Metabolism of lipids and lipoproteins [NCBI:1270001] [REACTOME:R-HSA-556833]
NOTCH1 Intracellular Domain Regulates Transcription [NCBI:1269537] [REACTOME:R-HSA-2122947] [PUBMED:11044625] [PUBMED:8649374] [PUBMED:21737748] [PUBMED:9694793] [PUBMED:20972443] [PUBMED:11585921] [PUBMED:17114293] [PUBMED:8001118] [PUBMED:18094723] [PUBMED:8687460] [PUBMED:16256737] [PUBMED:16530044] [PUBMED:12050117] [PUBMED:10964718] [PUBMED:12391150] [PUBMED:7566092] [PUBMED:15546612] [PUBMED:15107403] [PUBMED:18374649] [PUBMED:14980219] [PUBMED:11461910] [PUBMED:10713164]
PPARA activates gene expression [NCBI:1270030] [REACTOME:R-HSA-1989781] [PUBMED:10529898] [PUBMED:18288277] [PUBMED:11330046] [PUBMED:20936127] [PUBMED:14999402]
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) [NCBI:1270029] [REACTOME:R-HSA-400206] [PUBMED:18288277] [PUBMED:10529898] [PUBMED:16476485] [PUBMED:16503871]
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription [NCBI:1269528] [REACTOME:R-HSA-2173796] [PUBMED:22275377] [PUBMED:18568018] [PUBMED:15150273] [PUBMED:10934479] [PUBMED:11294908] [PUBMED:12592392] [PUBMED:10022869] [PUBMED:14657019] [PUBMED:11013220] [PUBMED:11274402] [PUBMED:19914168] [PUBMED:12150994]
Signal Transduction [NCBI:1269379] [REACTOME:R-HSA-162582] [PUBMED:17604717] [PUBMED:19648010] [PUBMED:16260143] [PUBMED:11742412] [PUBMED:19536106] [PUBMED:15863030] [PUBMED:19379690] [PUBMED:19458711] [PUBMED:19935667] [PUBMED:21252999] [PUBMED:15520807] [PUBMED:17496910] [PUBMED:15450248] [PUBMED:18043707] [PUBMED:16939974] [PUBMED:19762341] [PUBMED:18483217] [PUBMED:17084981] [PUBMED:21781017] [PUBMED:19619488]
Signaling by NOTCH [NCBI:1269530] [REACTOME:R-HSA-157118]
Signaling by NOTCH1 [NCBI:1269535] [REACTOME:R-HSA-1980143] [PUBMED:20972443] [PUBMED:8649374] [PUBMED:11740940] [PUBMED:15965470] [PUBMED:16284625] [PUBMED:9694793] [PUBMED:19567869] [PUBMED:12354787] [PUBMED:11585921] [PUBMED:20418862] [PUBMED:11226752] [PUBMED:9590294] [PUBMED:9315665] [PUBMED:17114293] [PUBMED:18094723] [PUBMED:10964718] [PUBMED:10879540] [PUBMED:8001118] [PUBMED:12050117] [PUBMED:18043734] [PUBMED:9819428] [PUBMED:15824097] [PUBMED:9244301] [PUBMED:16256737] [PUBMED:8687460] [PUBMED:19726682] [PUBMED:8313469] [PUBMED:15574878] [PUBMED:18296446] [PUBMED:16530044] [PUBMED:9620803] [PUBMED:18237417] [PUBMED:7566092] [PUBMED:18628966] [PUBMED:12391150] [PUBMED:12530964] [PUBMED:11006133] [PUBMED:18374649] [PUBMED:15107403] [PUBMED:18077452] [PUBMED:15652348] [PUBMED:15546612] [PUBMED:10882063] [PUBMED:14980219] [PUBMED:10713164] [PUBMED:9462510] [PUBMED:11461910] [PUBMED:14567914] [PUBMED:17003037] [PUBMED:17028573] [PUBMED:11044625] [PUBMED:10206645] [PUBMED:19524514]
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer [NCBI:1268890] [REACTOME:R-HSA-2894858] [PUBMED:15472075]
Signaling by NOTCH1 PEST Domain Mutants in Cancer [NCBI:1268888] [REACTOME:R-HSA-2644602] [PUBMED:17646408] [PUBMED:15472075] [PUBMED:17646409]
Signaling by NOTCH1 in Cancer [NCBI:1268883] [REACTOME:R-HSA-2644603] [PUBMED:17646409] [PUBMED:10367900] [PUBMED:16738328] [PUBMED:15951812] [PUBMED:22399357] [PUBMED:15546612] [PUBMED:11461910] [PUBMED:9118226] [PUBMED:15951813] [PUBMED:17646408] [PUBMED:15472075] [PUBMED:11585921] [PUBMED:17909001] [PUBMED:16612405] [PUBMED:1831692] [PUBMED:15187027]
Signaling by TGF-beta Receptor Complex [NCBI:1269523] [REACTOME:R-HSA-170834] [PUBMED:19648010]
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer [NCBI:1269527] [REACTOME:R-HSA-2173793] [PUBMED:12150994] [PUBMED:16751101] [PUBMED:10199400] [PUBMED:18568018] [PUBMED:19135894] [PUBMED:10531062]
Transcriptional regulation of white adipocyte differentiation [NCBI:1270345] [REACTOME:R-HSA-381340] [PUBMED:21082419] [PUBMED:17956727] [PUBMED:17475546] [PUBMED:1840554] [PUBMED:17139329] [PUBMED:15860371] [PUBMED:18518822] [PUBMED:10603305] [PUBMED:7531665] [PUBMED:20054179] [PUBMED:7838715] [PUBMED:16054042] [PUBMED:17060461] [PUBMED:17011499] [PUBMED:16380219] [PUBMED:8970730]