full name
exosome component 8

synonyms
bA421P11.3, CIP3, EAP2, OIP2, p9, RP11-421P11.3, RRP43, Rrp43p, EXOSC8, ENSG00000120699

HGNC
HGNC:17035

Entrez Gene
Gene:11340

ENSEMBL
ENSG00000120699

location
chr: 13
start: 37574678
stop: 37583751
strand: +

OMIM
OMIM:606019: EXOSC8
OMIM:616081: Pontocerebellar hypoplasia, type 1C

transcripts
NM_181503.2

pathways
ATF4 activates genes [NCBI:1268762] [REACTOME:R-HSA-380994] [PUBMED:18840095] [PUBMED:16931790] [PUBMED:16687408] [PUBMED:14742429] [PUBMED:16912112] [PUBMED:20022965] [PUBMED:18426796] [PUBMED:14630918]
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA [NCBI:1269727] [REACTOME:R-HSA-450385] [PUBMED:12440953] [PUBMED:12704645] [PUBMED:11719186] [PUBMED:15687258] [PUBMED:16391004]
Deadenylation-dependent mRNA decay [NCBI:1269712] [REACTOME:R-HSA-429914] [PUBMED:19239894] [PUBMED:14749774] [PUBMED:17245413] [PUBMED:15475613] [PUBMED:11283721] [PUBMED:16141059]
Gene Expression [NCBI:1269649] [REACTOME:R-HSA-74160]
KSRP (KHSRP) binds and destabilizes mRNA [NCBI:1269729] [REACTOME:R-HSA-450604] [PUBMED:12440953] [PUBMED:16391004] [PUBMED:12704645]
Major pathway of rRNA processing in the nucleolus [NCBI:1383086] [REACTOME:R-HSA-6791226] [PUBMED:25346433] [PUBMED:23412654] [PUBMED:12150911] [PUBMED:25877921] [PUBMED:23973377] [PUBMED:11862453] [PUBMED:21956940] [PUBMED:22342225] [PUBMED:21318072] [PUBMED:12068309]
Metabolism of proteins [NCBI:1268677] [REACTOME:R-HSA-392499]
PERK regulates gene expression [NCBI:1268761] [REACTOME:R-HSA-381042] [PUBMED:17956313] [PUBMED:18436705] [PUBMED:18038217] [PUBMED:18048764]
RNA degradation [NCBI:117291] [KEGG:hsa03018] [PUBMED:16939780] [PUBMED:17471261] [PUBMED:16968219] [PUBMED:16766188] [PUBMED:17447862] [PUBMED:19239894] [PUBMED:17560162]
Regulation of mRNA stability by proteins that bind AU-rich elements [NCBI:1269725] [REACTOME:R-HSA-450531] [PUBMED:12440953] [PUBMED:12704645] [PUBMED:15460540] [PUBMED:16391004]
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA [NCBI:1269728] [REACTOME:R-HSA-450513] [PUBMED:18481987] [PUBMED:16391004] [PUBMED:12704645] [PUBMED:12440953]
Unfolded Protein Response (UPR) [NCBI:1268756] [REACTOME:R-HSA-381119] [PUBMED:18436705] [PUBMED:18038217] [PUBMED:16365312] [PUBMED:15952902] [PUBMED:18048764]
mRNA decay by 3' to 5' exoribonuclease [NCBI:1269714] [REACTOME:R-HSA-429958] [PUBMED:19239894] [PUBMED:14749774] [PUBMED:15475613] [PUBMED:11283721] [PUBMED:16141059] [PUBMED:17245413]
rRNA processing [NCBI:1383085] [REACTOME:R-HSA-72312] [PUBMED:20174677] [PUBMED:21956940] [PUBMED:25346433] [PUBMED:15193314] [PUBMED:25590339] [PUBMED:11862453] [PUBMED:19917616] [PUBMED:24490730]