full name
Rho guanine nucleotide exchange factor 7
synonyms
BETA-PIX, COOL-1, COOL1, Nbla10314, P50, P50BP, P85, P85COOL1, P85SPR, PAK3, PIXB, ARHGEF7, ENSG00000102606
HGNC
HGNC:15607
Entrez Gene
Gene:8874
ENSEMBL
ENSG00000102606
location
chr: 13
start: 111767624
stop: 111958081
strand: +
transcripts
NM_001113511.1
NM_145735.2
NM_001113512.1
NM_003899.3
NM_001113513.1
pathways
Aurora A signaling
[NCBI:137925]
[Pathway Interaction Database:aurora_a_pathway]
[PUBMED:17308110]
[PUBMED:16894566]
[PUBMED:16631581]
[PUBMED:17229885]
[PUBMED:15128871]
[PUBMED:14990569]
[PUBMED:12177045]
[PUBMED:14580337]
[PUBMED:14724178]
[PUBMED:17545617]
[PUBMED:15687499]
[PUBMED:11163242]
[PUBMED:14603251]
[PUBMED:17060449]
[PUBMED:12208850]
[PUBMED:12815066]
[PUBMED:17125467]
[PUBMED:13678582]
[PUBMED:15987997]
[PUBMED:15966895]
[PUBMED:11976319]
[PUBMED:14702041]
[PUBMED:16246726]
[PUBMED:17452972]
[PUBMED:12082625]
[PUBMED:11039908]
[PUBMED:14667408]
[PUBMED:12577065]
[PUBMED:14600264]
[PUBMED:11756469]
[PUBMED:16772293]
[PUBMED:12023018]
[PUBMED:15469940]
[PUBMED:16082213]
Axon guidance
[NCBI:83065]
[KEGG:hsa04360]
[NCBI:1270303]
[REACTOME:R-HSA-422475]
[PUBMED:14682358]
[PUBMED:15084255]
[PUBMED:11687826]
[PUBMED:15818466]
[PUBMED:15363605]
[PUBMED:12471249]
[PUBMED:15630019]
[PUBMED:11891122]
[PUBMED:15960985]
[PUBMED:12677003]
CDC42 signaling events
[NCBI:137994]
[Pathway Interaction Database:cdc42_pathway]
[PUBMED:7629060]
[PUBMED:7652575]
[PUBMED:8653792]
[PUBMED:18448434]
[PUBMED:19822663]
[PUBMED:19454477]
[PUBMED:18662680]
[PUBMED:15882626]
[PUBMED:11948177]
[PUBMED:9860974]
[PUBMED:15225553]
[PUBMED:8643625]
[PUBMED:8107774]
[PUBMED:8670801]
[PUBMED:8034624]
[PUBMED:10934474]
[PUBMED:10734320]
[PUBMED:17522712]
[PUBMED:11525734]
[PUBMED:15649357]
[PUBMED:10473551]
[PUBMED:16157700]
[PUBMED:9822598]
[PUBMED:15723051]
[PUBMED:7600582]
[PUBMED:18319301]
[PUBMED:9042860]
[PUBMED:10613909]
[PUBMED:17580073]
[PUBMED:12745076]
[PUBMED:16253996]
[PUBMED:10840034]
[PUBMED:10360579]
[PUBMED:11907268]
[PUBMED:10934475]
[PUBMED:10219243]
[PUBMED:17038317]
[PUBMED:8910292]
[PUBMED:9403696]
[PUBMED:11285260]
[PUBMED:10995437]
[PUBMED:9368021]
[PUBMED:14970210]
[PUBMED:9694656]
[PUBMED:14505571]
[PUBMED:17115031]
[PUBMED:9317150]
[PUBMED:14653992]
[PUBMED:17081755]
[PUBMED:12676083]
[PUBMED:18216334]
[PUBMED:19826000]
[PUBMED:8702968]
[PUBMED:11304531]
[PUBMED:10973943]
[PUBMED:11309380]
[PUBMED:18586681]
[PUBMED:15479449]
[PUBMED:19097998]
[PUBMED:16892055]
[PUBMED:17244649]
[PUBMED:8625410]
[PUBMED:8497321]
[PUBMED:15485841]
[PUBMED:16407834]
[PUBMED:11804587]
[PUBMED:9867866]
[PUBMED:10747870]
[PUBMED:7600581]
[PUBMED:12610628]
[PUBMED:19435802]
[PUBMED:15572110]
[PUBMED:7592586]
[PUBMED:11696321]
[PUBMED:10559936]
Cell death signalling via NRAGE, NRIF and NADE
[NCBI:1269447]
[REACTOME:R-HSA-204998]
[PUBMED:12787561]
Class I PI3K signaling events
[NCBI:138022]
[Pathway Interaction Database:pi3kcipathway]
[PUBMED:9072969]
[PUBMED:15296756]
[PUBMED:12780340]
[PUBMED:11154281]
[PUBMED:9326591]
[PUBMED:10357815]
[PUBMED:10586033]
[PUBMED:9824312]
[PUBMED:11001876]
[PUBMED:9593664]
[PUBMED:10770799]
[PUBMED:9442017]
[PUBMED:8643691]
[PUBMED:7627555]
[PUBMED:11102801]
[PUBMED:9307042]
[PUBMED:10506192]
[PUBMED:11804589]
[PUBMED:15879121]
[PUBMED:11226282]
[PUBMED:18024423]
[PUBMED:8629002]
[PUBMED:9550703]
[PUBMED:14688341]
[PUBMED:16418224]
[PUBMED:8945478]
[PUBMED:10333475]
[PUBMED:10764758]
[PUBMED:9417041]
[PUBMED:8052307]
Developmental Biology
[NCBI:1270302]
[REACTOME:R-HSA-1266738]
EGFR downregulation
[NCBI:1269385]
[REACTOME:R-HSA-182971]
[PUBMED:11283727]
[PUBMED:15021893]
[PUBMED:14641021]
EPH-Ephrin signaling
[NCBI:1270330]
[REACTOME:R-HSA-2682334]
[PUBMED:18281458]
[PUBMED:22120527]
Ephrin signaling
[NCBI:1270333]
[REACTOME:R-HSA-3928664]
[PUBMED:19515977]
G alpha (12/13) signalling events
[NCBI:1269579]
[REACTOME:R-HSA-416482]
[PUBMED:18814923]
[PUBMED:19212140]
GPCR downstream signaling
[NCBI:1269574]
[REACTOME:R-HSA-388396]
[PUBMED:12040175]
Internalization of ErbB1
[NCBI:138013]
[Pathway Interaction Database:erbb1_internalization_pathway]
[PUBMED:9733512]
[PUBMED:9950686]
[PUBMED:12839496]
[PUBMED:10953014]
[PUBMED:17052190]
[PUBMED:15212941]
[PUBMED:19460345]
[PUBMED:18316398]
[PUBMED:11823423]
[PUBMED:18657070]
[PUBMED:12242303]
[PUBMED:17940017]
[PUBMED:15465819]
[PUBMED:17121848]
[PUBMED:15772153]
[PUBMED:18508924]
[PUBMED:18031739]
[PUBMED:16914641]
[PUBMED:11408594]
[PUBMED:11099046]
[PUBMED:16543144]
[PUBMED:11703925]
[PUBMED:11894095]
[PUBMED:15282549]
[PUBMED:9851973]
[PUBMED:16554368]
[PUBMED:12897150]
[PUBMED:11983899]
[PUBMED:18362181]
[PUBMED:15475003]
[PUBMED:12631709]
[PUBMED:15701692]
[PUBMED:16862145]
[PUBMED:16735510]
[PUBMED:18694561]
[PUBMED:14505571]
[PUBMED:10567412]
[PUBMED:15635092]
[PUBMED:15210722]
[PUBMED:16892055]
[PUBMED:1645724]
[PUBMED:16407834]
[PUBMED:17363458]
[PUBMED:16382132]
[PUBMED:10428778]
[PUBMED:15314065]
[PUBMED:16120644]
[PUBMED:7925272]
[PUBMED:12234920]
[PUBMED:8175702]
[PUBMED:10085141]
[PUBMED:11375397]
[PUBMED:10635327]
[PUBMED:19723633]
[PUBMED:10788520]
[PUBMED:12218189]
[PUBMED:19054389]
NRAGE signals death through JNK
[NCBI:1269448]
[REACTOME:R-HSA-193648]
[PUBMED:12376548]
Regulation of CDC42 activity
[NCBI:137990]
[Pathway Interaction Database:cdc42_reg_pathway]
[PUBMED:19581296]
[PUBMED:17297291]
[PUBMED:14506234]
[PUBMED:17145773]
[PUBMED:8798610]
[PUBMED:17015620]
[PUBMED:9535855]
[PUBMED:15710388]
[PUBMED:12547822]
[PUBMED:15728722]
[PUBMED:11285260]
[PUBMED:11748279]
[PUBMED:8969170]
[PUBMED:17538024]
[PUBMED:11336673]
[PUBMED:12172552]
[PUBMED:15850391]
[PUBMED:18208356]
[PUBMED:10523665]
[PUBMED:1429634]
[PUBMED:19156867]
[PUBMED:19356586]
[PUBMED:16616186]
[PUBMED:15247287]
[PUBMED:9497316]
[PUBMED:10559246]
[PUBMED:14506284]
[PUBMED:16892055]
[PUBMED:19525225]
[PUBMED:11741931]
[PUBMED:17562871]
[PUBMED:18470881]
[PUBMED:1439791]
[PUBMED:10744696]
[PUBMED:7673236]
[PUBMED:12432077]
[PUBMED:17196961]
[PUBMED:10982832]
[PUBMED:16968698]
[PUBMED:11431473]
[PUBMED:10676816]
[PUBMED:15277544]
[PUBMED:18728402]
[PUBMED:15793564]
[PUBMED:18056264]
[PUBMED:9268338]
[PUBMED:12517963]
[PUBMED:1956381]
[PUBMED:15504743]
[PUBMED:17599059]
[PUBMED:15649357]
[PUBMED:10652228]
[PUBMED:15306850]
[PUBMED:19745154]
Regulation of RAC1 activity
[NCBI:169346]
[Pathway Interaction Database:rac1_reg_pathway]
[PUBMED:8297393]
[PUBMED:12134164]
[PUBMED:15485841]
[PUBMED:11707441]
[PUBMED:17320046]
[PUBMED:9857026]
[PUBMED:9497316]
[PUBMED:17254573]
[PUBMED:15850775]
[PUBMED:8352776]
[PUBMED:15128856]
[PUBMED:17403664]
[PUBMED:8491184]
[PUBMED:7753201]
[PUBMED:9707409]
[PUBMED:12432077]
[PUBMED:8226937]
[PUBMED:19934221]
[PUBMED:17196961]
[PUBMED:17640372]
[PUBMED:11287617]
[PUBMED:12515821]
[PUBMED:16943182]
[PUBMED:19861492]
[PUBMED:10220378]
[PUBMED:11431473]
[PUBMED:10982832]
[PUBMED:7673236]
[PUBMED:10744696]
[PUBMED:17599059]
[PUBMED:17116687]
[PUBMED:12923183]
[PUBMED:10364228]
[PUBMED:16628218]
[PUBMED:8288572]
[PUBMED:15306850]
[PUBMED:11396949]
[PUBMED:8496137]
[PUBMED:11912491]
[PUBMED:15649357]
[PUBMED:7980444]
[PUBMED:18325335]
[PUBMED:15242348]
[PUBMED:11955434]
[PUBMED:15039778]
[PUBMED:11685227]
[PUBMED:15897194]
[PUBMED:11130063]
[PUBMED:10559863]
[PUBMED:17052214]
[PUBMED:11099046]
[PUBMED:15728722]
[PUBMED:16520382]
[PUBMED:16492808]
[PUBMED:12547822]
[PUBMED:12446789]
[PUBMED:11274357]
[PUBMED:8419353]
[PUBMED:16481401]
[PUBMED:8276860]
[PUBMED:15005707]
[PUBMED:10499589]
[PUBMED:11336673]
[PUBMED:1903516]
[PUBMED:12829596]
[PUBMED:17332503]
[PUBMED:11146652]
[PUBMED:12134158]
[PUBMED:8643598]
[PUBMED:18212043]
Regulation of actin cytoskeleton
[NCBI:83089]
[KEGG:hsa04810]
[PUBMED:11152757]
[PUBMED:11082272]
[PUBMED:10574699]
[PUBMED:11082269]
[PUBMED:14657486]
[PUBMED:14744429]
[PUBMED:12700767]
Rho GTPase cycle
[NCBI:1269508]
[REACTOME:R-HSA-194840]
[PUBMED:17222083]
[PUBMED:9308960]
Signal Transduction
[NCBI:1269379]
[REACTOME:R-HSA-162582]
[PUBMED:17604717]
[PUBMED:19648010]
[PUBMED:16260143]
[PUBMED:11742412]
[PUBMED:19536106]
[PUBMED:15863030]
[PUBMED:19379690]
[PUBMED:19458711]
[PUBMED:19935667]
[PUBMED:21252999]
[PUBMED:15520807]
[PUBMED:17496910]
[PUBMED:15450248]
[PUBMED:18043707]
[PUBMED:16939974]
[PUBMED:19762341]
[PUBMED:18483217]
[PUBMED:17084981]
[PUBMED:21781017]
[PUBMED:19619488]
Signaling by EGFR
[NCBI:1269380]
[REACTOME:R-HSA-177929]
[PUBMED:10459005]
[PUBMED:10404636]
[PUBMED:12297041]
[PUBMED:15142631]
Signaling by GPCR
[NCBI:1269543]
[REACTOME:R-HSA-372790]
[PUBMED:16902930]
[PUBMED:10202136]
[PUBMED:18043707]
Signaling by Rho GTPases
[NCBI:1269507]
[REACTOME:R-HSA-194315]
[PUBMED:16212495]
[PUBMED:15630019]
Signaling events mediated by focal adhesion kinase
[NCBI:169348]
[Pathway Interaction Database:fak_pathway]
[PUBMED:18793427]
[PUBMED:15340073]
[PUBMED:16054026]
[PUBMED:12932330]
[PUBMED:20038548]
[PUBMED:7542255]
[PUBMED:8939916]
[PUBMED:16000375]
[PUBMED:10856236]
[PUBMED:17164291]
[PUBMED:9148935]
[PUBMED:10893408]
[PUBMED:10512882]
[PUBMED:11839772]
[PUBMED:11553710]
[PUBMED:7566154]
[PUBMED:20018869]
[PUBMED:12839996]
[PUBMED:11799111]
[PUBMED:16308318]
[PUBMED:11331870]
[PUBMED:12681445]
[PUBMED:11369769]
[PUBMED:11739801]
[PUBMED:9860979]
[PUBMED:8947559]
[PUBMED:11017882]
[PUBMED:7509446]
[PUBMED:10791986]
[PUBMED:9128257]
[PUBMED:19297531]
[PUBMED:17325207]
[PUBMED:17093062]
[PUBMED:10593973]
[PUBMED:20308429]
[PUBMED:8922390]
[PUBMED:19776348]
[PUBMED:9374537]
[PUBMED:10976102]
[PUBMED:10373530]
[PUBMED:19883375]
[PUBMED:10430888]
[PUBMED:12820964]
[PUBMED:9425168]
[PUBMED:14743221]
[PUBMED:18854312]
[PUBMED:12952943]
[PUBMED:15962308]
[PUBMED:11927607]
[PUBMED:15657076]
[PUBMED:15039571]
[PUBMED:18303050]
[PUBMED:11799401]
[PUBMED:15247219]
[PUBMED:12702722]
[PUBMED:10998418]
[PUBMED:7615549]
[PUBMED:18195107]
[PUBMED:9032297]
[PUBMED:10873807]
[PUBMED:10777511]
[PUBMED:12502711]
[PUBMED:9566877]
[PUBMED:8649427]
[PUBMED:19473962]
[PUBMED:9808620]
[PUBMED:15914540]
[PUBMED:1385445]
[PUBMED:18223254]
[PUBMED:11909938]
[PUBMED:15166238]
[PUBMED:7622520]
[PUBMED:8824286]
[PUBMED:8662921]
[PUBMED:8707856]
[PUBMED:10330411]
[PUBMED:10446223]
[PUBMED:20150423]
[PUBMED:11604500]
[PUBMED:9234699]
[PUBMED:18773890]
[PUBMED:18757826]
[PUBMED:9864370]
[PUBMED:7983066]
[PUBMED:18322799]
[PUBMED:12006652]
[PUBMED:16461767]
[PUBMED:10385525]
[PUBMED:14676198]
[PUBMED:9858476]
[PUBMED:18070912]
[PUBMED:11058585]
[PUBMED:12890755]
[PUBMED:9184223]
[PUBMED:12058076]
[PUBMED:12226752]
[PUBMED:19435801]
[PUBMED:10212207]
[PUBMED:10521463]
[PUBMED:16159962]
[PUBMED:7579684]
[PUBMED:18362184]
[PUBMED:7997267]
[PUBMED:8816475]
[PUBMED:11279163]
[PUBMED:7537852]
[PUBMED:11418135]
[PUBMED:12167697]
[PUBMED:12615911]
[PUBMED:12876277]
Signalling by NGF
[NCBI:1269443]
[REACTOME:R-HSA-166520]
p75 NTR receptor-mediated signalling
[NCBI:1269445]
[REACTOME:R-HSA-193704]
[PUBMED:16699811]
[PUBMED:16939974]
[PUBMED:12671646]
