full name
apurinic/apyrimidinic endodeoxyribonuclease 1

synonyms
APE, APE1, APEN, APEX, APX, HAP1, REF1, APEX1, ENSG00000100823

HGNC
HGNC:587

Entrez Gene
Gene:328

ENSEMBL
ENSG00000100823

location
chr: 14
start: 20923290
stop: 20925931
strand: +

transcripts
NM_001641.3
NM_001244249.1
NM_080649.2
NM_080648.2

pathways
Abasic sugar-phosphate removal via the single-nucleotide replacement pathway [NCBI:1270362] [REACTOME:R-HSA-73930] [PUBMED:10583946]
Base Excision Repair [NCBI:1270351] [REACTOME:R-HSA-73884] [PUBMED:11937636] [PUBMED:10583946]
Base excision repair [NCBI:83043] [KEGG:hsa03410] [PUBMED:17893748] [PUBMED:11436317] [PUBMED:17337257] [PUBMED:21665970]
DNA Repair [NCBI:1270350] [REACTOME:R-HSA-73894] [PUBMED:10583946] [PUBMED:23175119]
Displacement of DNA glycosylase by APEX1 [NCBI:1270360] [REACTOME:R-HSA-110357] [PUBMED:9724657]
HIF-2-alpha transcription factor network [NCBI:137956] [Pathway Interaction Database:hif2pathway] [PUBMED:10671489] [PUBMED:11983697] [PUBMED:11823643] [PUBMED:15039136] [PUBMED:19352007] [PUBMED:18356544] [PUBMED:17097563] [PUBMED:16740701] [PUBMED:19541651] [PUBMED:17873906] [PUBMED:12080085] [PUBMED:11292862] [PUBMED:16510872] [PUBMED:19498162] [PUBMED:10353251] [PUBMED:18625704] [PUBMED:15247232] [PUBMED:9079689] [PUBMED:19204094] [PUBMED:17322295] [PUBMED:17804822] [PUBMED:9113979] [PUBMED:12464608] [PUBMED:18434321] [PUBMED:15592504] [PUBMED:10878807] [PUBMED:17324924] [PUBMED:15192019] [PUBMED:9000051] [PUBMED:16611993] [PUBMED:10823831]
PCNA-Dependent Long Patch Base Excision Repair [NCBI:1270366] [REACTOME:R-HSA-5651801] [PUBMED:9780000] [PUBMED:11601988] [PUBMED:9214649] [PUBMED:12200445] [PUBMED:10460157] [PUBMED:10559261] [PUBMED:11250913]
POLB-Dependent Long Patch Base Excision Repair [NCBI:1270365] [REACTOME:R-HSA-110362] [PUBMED:15561706] [PUBMED:11440997] [PUBMED:15135726] [PUBMED:9214649] [PUBMED:11554294] [PUBMED:12200445] [PUBMED:11340072] [PUBMED:9685411]
Resolution of AP sites via the multiple-nucleotide patch replacement pathway [NCBI:1270364] [REACTOME:R-HSA-110373] [PUBMED:10583946] [PUBMED:9214649] [PUBMED:10559261] [PUBMED:10460157] [PUBMED:11440997] [PUBMED:11601988]
Resolution of AP sites via the single-nucleotide replacement pathway [NCBI:1270361] [REACTOME:R-HSA-110381] [PUBMED:10583946]
Resolution of Abasic Sites (AP sites) [NCBI:1270359] [REACTOME:R-HSA-73933] [PUBMED:11601988] [PUBMED:15260972] [PUBMED:17395641] [PUBMED:19329425] [PUBMED:9804798] [PUBMED:15556996] [PUBMED:9214649] [PUBMED:7608159] [PUBMED:11440997] [PUBMED:15871698] [PUBMED:9207062] [PUBMED:16982218] [PUBMED:8978692]