full name
purine nucleoside phosphorylase

synonyms
NP, PRO1837, PUNP, PNP, ENSG00000198805

HGNC
HGNC:7892

Entrez Gene
Gene:4860

ENSEMBL
ENSG00000198805

location
chr: 14
start: 20937538
stop: 20946165
strand: +

OMIM
OMIM:164050: PNP (Autosomal recessive inheritance)
OMIM:613179: Immunodeficiency due to purine nucleoside phosphorylase deficiency

transcripts
NM_000270.3

pathways
Immune System [NCBI:1269170] [REACTOME:R-HSA-168256]
Innate Immune System [NCBI:1269203] [REACTOME:R-HSA-168249]
Metabolic pathways [NCBI:132956] [KEGG:hsa01100]
Metabolism [NCBI:1269956] [REACTOME:R-HSA-1430728]
Metabolism of nucleotides [NCBI:1270133] [REACTOME:R-HSA-15869] [PUBMED:17266529] [PUBMED:8283301] [PUBMED:20494131]
Neutrophil degranulation [NCBI:1457780] [REACTOME:R-HSA-6798695] [PUBMED:20338884] [PUBMED:1378856] [PUBMED:17627888] [PUBMED:23650620] [PUBMED:8692836]
Nicotinate and nicotinamide metabolism [NCBI:83014] [KEGG:hsa00760] [PUBMED:16894175] [PUBMED:11514508] [PUBMED:5835946] [PUBMED:16321959] [PUBMED:13475371] [PUBMED:21953451]
Purine catabolism [NCBI:1270137] [REACTOME:R-HSA-74259] [PUBMED:4620886]
Purine metabolism [NCBI:82944] [KEGG:hsa00230] [NCBI:1270134] [REACTOME:R-HSA-73847] [PUBMED:4620886] [PUBMED:10986234] [PUBMED:10601204]
Purine salvage [NCBI:1270136] [REACTOME:R-HSA-74217] [PUBMED:4620886]
Pyrimidine metabolism [NCBI:82946] [KEGG:hsa00240] [NCBI:1270138] [REACTOME:R-HSA-73848] [PUBMED:16098809]
adenine and adenosine salvage III [NCBI:547495] [BIOCYC:HUMAN_PWY-6609] [PUBMED:15812856]
adenosine nucleotides degradation [NCBI:142279] [BIOCYC:HUMAN_SALVADEHYPOX-PWY]
arsenate detoxification I (glutaredoxin) [NCBI:142442] [BIOCYC:HUMAN_PWY-4202] [PUBMED:15276412] [PUBMED:9131259] [PUBMED:10328340] [PUBMED:518594] [PUBMED:6750413] [PUBMED:367316] [PUBMED:12505313] [PUBMED:15808521] [PUBMED:11790780]
guanine and guanosine salvage [NCBI:547497] [BIOCYC:HUMAN_PWY-6620] [PUBMED:8089153]
guanosine nucleotides degradation [NCBI:545363] [BIOCYC:HUMAN_PWY-6608] [PUBMED:14725335] [PUBMED:2372926] [PUBMED:6094556]
purine deoxyribonucleosides degradation [NCBI:1108783] [BIOCYC:HUMAN_PWY-7179-1] [PUBMED:12180982]
purine nucleotides degradation [NCBI:545362] [BIOCYC:HUMAN_PWY-6353]
purine ribonucleosides degradation to ribose-1-phosphate [NCBI:142432] [BIOCYC:HUMAN_PWY0-1296]
superpathway of purine nucleotide salvage [NCBI:907942] [BIOCYC:HUMAN_PWY66-409] [PUBMED:18712276] [PUBMED:18365665] [PUBMED:16176880] [PUBMED:23575936] [PUBMED:1301916]
urate biosynthesis/inosine 5'-phosphate degradation [NCBI:545323] [BIOCYC:HUMAN_PWY-5695]