full name
granzyme B

synonyms
CCPI, CGL-1, CGL1, CSP-B, CSPB, CTLA1, CTSGL1, HLP, SECT, GZMB, ENSG00000100453

HGNC
HGNC:4709

Entrez Gene
Gene:3002

ENSEMBL
ENSG00000100453

location
chr: 14
start: 25100160
stop: 25103490
strand: -

transcripts
NM_004131.4

pathways
Activation, myristolyation of BID and translocation to mitochondria [NCBI:1270269] [REACTOME:R-HSA-75108] [PUBMED:9727492] [PUBMED:14634621]
Allograft rejection [NCBI:83123] [KEGG:hsa05330] [PUBMED:8835634] [PUBMED:12023610] [PUBMED:12563298] [PUBMED:17445565] [PUBMED:12216939] [PUBMED:14710779] [PUBMED:10746853] [PUBMED:10571983] [PUBMED:10331992] [PUBMED:10667806]
Apoptosis [NCBI:83060] [KEGG:hsa04210] [NCBI:1270262] [REACTOME:R-HSA-109581] [PUBMED:12189384] [PUBMED:20533903] [PUBMED:18208375] [PUBMED:22429822] [PUBMED:15218528] [PUBMED:24769728] [PUBMED:18023214] [PUBMED:25526085] [PUBMED:23070002] [PUBMED:15654015] [PUBMED:15601572] [PUBMED:14561771] [PUBMED:24278747] [PUBMED:21914490] [PUBMED:22465226] [PUBMED:21145844] [PUBMED:12838338] [PUBMED:18238895] [PUBMED:12949498] [PUBMED:18304445] [PUBMED:14737178] [PUBMED:26231733] [PUBMED:9916983] [PUBMED:14634621] [PUBMED:19770840] [PUBMED:22075987] [PUBMED:4561027] [PUBMED:20075940] [PUBMED:9894605] [PUBMED:26615431] [PUBMED:12505355] [PUBMED:11520933] [PUBMED:19148180] [PUBMED:16397578] [PUBMED:15719025] [PUBMED:15322527] [PUBMED:15725726] [PUBMED:12209154] [PUBMED:23803157]
Autoimmune thyroid disease [NCBI:83121] [KEGG:hsa05320] [PUBMED:15132715] [PUBMED:12192541] [PUBMED:17192582] [PUBMED:9534029] [PUBMED:11396701] [PUBMED:11913070] [PUBMED:15049952] [PUBMED:11577986] [PUBMED:15762980]
Caspase cascade in apoptosis [NCBI:137974] [Pathway Interaction Database:caspase_pathway] [PUBMED:7774019] [PUBMED:8626669] [PUBMED:9850096] [PUBMED:11803376] [PUBMED:15189451] [PUBMED:10564664] [PUBMED:9642276] [PUBMED:10567584] [PUBMED:12419244] [PUBMED:11423904] [PUBMED:9422506] [PUBMED:11438643] [PUBMED:9070648] [PUBMED:9588194] [PUBMED:11085743] [PUBMED:9298992] [PUBMED:9933635] [PUBMED:9528810] [PUBMED:9323209] [PUBMED:10809769] [PUBMED:8700869] [PUBMED:9463409] [PUBMED:10497198] [PUBMED:11953316] [PUBMED:9422513] [PUBMED:10409650] [PUBMED:11463840] [PUBMED:10611247] [PUBMED:8605870]
Downstream signaling in naive CD8+ T cells [NCBI:138018] [Pathway Interaction Database:cd8tcrdownstreampathway] [PUBMED:293720] [PUBMED:7935374] [PUBMED:12065418] [PUBMED:8566027] [PUBMED:12917261] [PUBMED:8394352] [PUBMED:8441422] [PUBMED:1386920] [PUBMED:8617294] [PUBMED:12732656] [PUBMED:7889942] [PUBMED:1737937] [PUBMED:1381507] [PUBMED:16210616] [PUBMED:11927626] [PUBMED:10477579] [PUBMED:10206983] [PUBMED:8376940] [PUBMED:9395475] [PUBMED:12972619] [PUBMED:8394845] [PUBMED:11485747] [PUBMED:15814665] [PUBMED:14645153] [PUBMED:2119889] [PUBMED:8208531] [PUBMED:10970869] [PUBMED:8612134] [PUBMED:8623163] [PUBMED:16237086] [PUBMED:16585578] [PUBMED:10544201] [PUBMED:8397339] [PUBMED:14605368] [PUBMED:12560487] [PUBMED:7982959]
Graft-versus-host disease [NCBI:83124] [KEGG:hsa05332] [PUBMED:14556773] [PUBMED:17784964] [PUBMED:14735553] [PUBMED:16412784] [PUBMED:17900507] [PUBMED:15372473] [PUBMED:16147539] [PUBMED:12359826] [PUBMED:15882431]
IL12-mediated signaling events [NCBI:137922] [Pathway Interaction Database:il12_2pathway] [PUBMED:12874225] [PUBMED:12221108] [PUBMED:16380506] [PUBMED:9768751] [PUBMED:17114419] [PUBMED:10358173] [PUBMED:9890938] [PUBMED:12213961] [PUBMED:11120802] [PUBMED:9202126] [PUBMED:16641133] [PUBMED:10198225] [PUBMED:16763563] [PUBMED:15728489] [PUBMED:8103068] [PUBMED:10903740] [PUBMED:10201984] [PUBMED:7638186] [PUBMED:11894097] [PUBMED:16220539] [PUBMED:10961885] [PUBMED:7594594] [PUBMED:17110450] [PUBMED:9582275] [PUBMED:10320373] [PUBMED:7528775] [PUBMED:11207258] [PUBMED:9038232] [PUBMED:15522880] [PUBMED:11175814] [PUBMED:9531298] [PUBMED:7722452] [PUBMED:8943050] [PUBMED:7553885] [PUBMED:9454765]
Intrinsic Pathway for Apoptosis [NCBI:1270268] [REACTOME:R-HSA-109606] [PUBMED:12042762] [PUBMED:11711427] [PUBMED:15077149]
NOTCH2 intracellular domain regulates transcription [NCBI:1269540] [REACTOME:R-HSA-2197563] [PUBMED:23362348] [PUBMED:18724371] [PUBMED:11986231] [PUBMED:23362349] [PUBMED:11866432] [PUBMED:21898486] [PUBMED:11101851]
Natural killer cell mediated cytotoxicity [NCBI:83079] [KEGG:hsa04650] [PUBMED:12530970] [PUBMED:15567854] [PUBMED:8942070] [PUBMED:11905813] [PUBMED:9143705] [PUBMED:9862693] [PUBMED:11895890] [PUBMED:12205470] [PUBMED:11836514] [PUBMED:15607806] [PUBMED:16002670] [PUBMED:15618404] [PUBMED:11390470] [PUBMED:11062493] [PUBMED:14710949] [PUBMED:12752668] [PUBMED:15607802] [PUBMED:16109839] [PUBMED:12766758] [PUBMED:16177799]
Programmed Cell Death [NCBI:1270261] [REACTOME:R-HSA-5357801] [PUBMED:25236395]
Signal Transduction [NCBI:1269379] [REACTOME:R-HSA-162582] [PUBMED:17604717] [PUBMED:19648010] [PUBMED:16260143] [PUBMED:11742412] [PUBMED:19536106] [PUBMED:15863030] [PUBMED:19379690] [PUBMED:19458711] [PUBMED:19935667] [PUBMED:21252999] [PUBMED:15520807] [PUBMED:17496910] [PUBMED:15450248] [PUBMED:18043707] [PUBMED:16939974] [PUBMED:19762341] [PUBMED:18483217] [PUBMED:17084981] [PUBMED:21781017] [PUBMED:19619488]
Signaling by NOTCH [NCBI:1269530] [REACTOME:R-HSA-157118]
Signaling by NOTCH2 [NCBI:1269538] [REACTOME:R-HSA-1980145] [PUBMED:20156974] [PUBMED:18724371] [PUBMED:21378989] [PUBMED:11187898] [PUBMED:10958687] [PUBMED:9207788] [PUBMED:803282] [PUBMED:18469519] [PUBMED:20816392] [PUBMED:19379690] [PUBMED:11518718] [PUBMED:14567914] [PUBMED:11986231] [PUBMED:10934472] [PUBMED:11101851] [PUBMED:11866432] [PUBMED:21378985] [PUBMED:10206645] [PUBMED:20816393] [PUBMED:10551863] [PUBMED:9207787] [PUBMED:15569487] [PUBMED:21632553] [PUBMED:21681853] [PUBMED:16773578]
Transcriptional misregulation in cancer [NCBI:523016] [KEGG:hsa05202] [PUBMED:17327229] [PUBMED:20190806] [PUBMED:20145147] [PUBMED:11313274] [PUBMED:11863357] [PUBMED:19472090] [PUBMED:18330902] [PUBMED:19738075] [PUBMED:15024077] [PUBMED:12032780] [PUBMED:14630078] [PUBMED:21765642] [PUBMED:19564705] [PUBMED:17101797] [PUBMED:15160934] [PUBMED:15688424] [PUBMED:15985538] [PUBMED:12527902] [PUBMED:12511414] [PUBMED:11607818] [PUBMED:17222504] [PUBMED:15826838] [PUBMED:21747944] [PUBMED:19406209] [PUBMED:10350329] [PUBMED:21779514] [PUBMED:18563191] [PUBMED:16946003] [PUBMED:17250957] [PUBMED:12670461] [PUBMED:12529654] [PUBMED:18855877] [PUBMED:17505060] [PUBMED:20153925] [PUBMED:20490326] [PUBMED:12130514] [PUBMED:18648544] [PUBMED:19855079] [PUBMED:10717473] [PUBMED:20478527] [PUBMED:11340171] [PUBMED:16169901] [PUBMED:14998494] [PUBMED:19233641] [PUBMED:19133982] [PUBMED:12393465] [PUBMED:19059936] [PUBMED:18172298] [PUBMED:10500199] [PUBMED:19141473] [PUBMED:10537274] [PUBMED:15156184] [PUBMED:14701735] [PUBMED:19422821] [PUBMED:21518926] [PUBMED:18850010] [PUBMED:19075677] [PUBMED:18457914] [PUBMED:12527906] [PUBMED:15644444] [PUBMED:10784387] [PUBMED:17024155] [PUBMED:19075268] [PUBMED:15826834] [PUBMED:21849159] [PUBMED:21123453] [PUBMED:20974671] [PUBMED:20863376]
Type I diabetes mellitus [NCBI:83095] [KEGG:hsa04940] [PUBMED:11507694] [PUBMED:8072542] [PUBMED:15889095] [PUBMED:15889096] [PUBMED:12796471] [PUBMED:14617043] [PUBMED:8786033] [PUBMED:9719467] [PUBMED:12752668]