full name
granzyme B
synonyms
CCPI, CGL-1, CGL1, CSP-B, CSPB, CTLA1, CTSGL1, HLP, SECT, GZMB, ENSG00000100453
HGNC
HGNC:4709
Entrez Gene
Gene:3002
ENSEMBL
ENSG00000100453
location
chr: 14
start: 25100160
stop: 25103490
strand: -
transcripts
NM_004131.4
pathways
Activation, myristolyation of BID and translocation to mitochondria
[NCBI:1270269]
[REACTOME:R-HSA-75108]
[PUBMED:9727492]
[PUBMED:14634621]
Allograft rejection
[NCBI:83123]
[KEGG:hsa05330]
[PUBMED:8835634]
[PUBMED:12023610]
[PUBMED:12563298]
[PUBMED:17445565]
[PUBMED:12216939]
[PUBMED:14710779]
[PUBMED:10746853]
[PUBMED:10571983]
[PUBMED:10331992]
[PUBMED:10667806]
Apoptosis
[NCBI:83060]
[KEGG:hsa04210]
[NCBI:1270262]
[REACTOME:R-HSA-109581]
[PUBMED:12189384]
[PUBMED:20533903]
[PUBMED:18208375]
[PUBMED:22429822]
[PUBMED:15218528]
[PUBMED:24769728]
[PUBMED:18023214]
[PUBMED:25526085]
[PUBMED:23070002]
[PUBMED:15654015]
[PUBMED:15601572]
[PUBMED:14561771]
[PUBMED:24278747]
[PUBMED:21914490]
[PUBMED:22465226]
[PUBMED:21145844]
[PUBMED:12838338]
[PUBMED:18238895]
[PUBMED:12949498]
[PUBMED:18304445]
[PUBMED:14737178]
[PUBMED:26231733]
[PUBMED:9916983]
[PUBMED:14634621]
[PUBMED:19770840]
[PUBMED:22075987]
[PUBMED:4561027]
[PUBMED:20075940]
[PUBMED:9894605]
[PUBMED:26615431]
[PUBMED:12505355]
[PUBMED:11520933]
[PUBMED:19148180]
[PUBMED:16397578]
[PUBMED:15719025]
[PUBMED:15322527]
[PUBMED:15725726]
[PUBMED:12209154]
[PUBMED:23803157]
Autoimmune thyroid disease
[NCBI:83121]
[KEGG:hsa05320]
[PUBMED:15132715]
[PUBMED:12192541]
[PUBMED:17192582]
[PUBMED:9534029]
[PUBMED:11396701]
[PUBMED:11913070]
[PUBMED:15049952]
[PUBMED:11577986]
[PUBMED:15762980]
Caspase cascade in apoptosis
[NCBI:137974]
[Pathway Interaction Database:caspase_pathway]
[PUBMED:7774019]
[PUBMED:8626669]
[PUBMED:9850096]
[PUBMED:11803376]
[PUBMED:15189451]
[PUBMED:10564664]
[PUBMED:9642276]
[PUBMED:10567584]
[PUBMED:12419244]
[PUBMED:11423904]
[PUBMED:9422506]
[PUBMED:11438643]
[PUBMED:9070648]
[PUBMED:9588194]
[PUBMED:11085743]
[PUBMED:9298992]
[PUBMED:9933635]
[PUBMED:9528810]
[PUBMED:9323209]
[PUBMED:10809769]
[PUBMED:8700869]
[PUBMED:9463409]
[PUBMED:10497198]
[PUBMED:11953316]
[PUBMED:9422513]
[PUBMED:10409650]
[PUBMED:11463840]
[PUBMED:10611247]
[PUBMED:8605870]
Downstream signaling in naive CD8+ T cells
[NCBI:138018]
[Pathway Interaction Database:cd8tcrdownstreampathway]
[PUBMED:293720]
[PUBMED:7935374]
[PUBMED:12065418]
[PUBMED:8566027]
[PUBMED:12917261]
[PUBMED:8394352]
[PUBMED:8441422]
[PUBMED:1386920]
[PUBMED:8617294]
[PUBMED:12732656]
[PUBMED:7889942]
[PUBMED:1737937]
[PUBMED:1381507]
[PUBMED:16210616]
[PUBMED:11927626]
[PUBMED:10477579]
[PUBMED:10206983]
[PUBMED:8376940]
[PUBMED:9395475]
[PUBMED:12972619]
[PUBMED:8394845]
[PUBMED:11485747]
[PUBMED:15814665]
[PUBMED:14645153]
[PUBMED:2119889]
[PUBMED:8208531]
[PUBMED:10970869]
[PUBMED:8612134]
[PUBMED:8623163]
[PUBMED:16237086]
[PUBMED:16585578]
[PUBMED:10544201]
[PUBMED:8397339]
[PUBMED:14605368]
[PUBMED:12560487]
[PUBMED:7982959]
Graft-versus-host disease
[NCBI:83124]
[KEGG:hsa05332]
[PUBMED:14556773]
[PUBMED:17784964]
[PUBMED:14735553]
[PUBMED:16412784]
[PUBMED:17900507]
[PUBMED:15372473]
[PUBMED:16147539]
[PUBMED:12359826]
[PUBMED:15882431]
IL12-mediated signaling events
[NCBI:137922]
[Pathway Interaction Database:il12_2pathway]
[PUBMED:12874225]
[PUBMED:12221108]
[PUBMED:16380506]
[PUBMED:9768751]
[PUBMED:17114419]
[PUBMED:10358173]
[PUBMED:9890938]
[PUBMED:12213961]
[PUBMED:11120802]
[PUBMED:9202126]
[PUBMED:16641133]
[PUBMED:10198225]
[PUBMED:16763563]
[PUBMED:15728489]
[PUBMED:8103068]
[PUBMED:10903740]
[PUBMED:10201984]
[PUBMED:7638186]
[PUBMED:11894097]
[PUBMED:16220539]
[PUBMED:10961885]
[PUBMED:7594594]
[PUBMED:17110450]
[PUBMED:9582275]
[PUBMED:10320373]
[PUBMED:7528775]
[PUBMED:11207258]
[PUBMED:9038232]
[PUBMED:15522880]
[PUBMED:11175814]
[PUBMED:9531298]
[PUBMED:7722452]
[PUBMED:8943050]
[PUBMED:7553885]
[PUBMED:9454765]
Intrinsic Pathway for Apoptosis
[NCBI:1270268]
[REACTOME:R-HSA-109606]
[PUBMED:12042762]
[PUBMED:11711427]
[PUBMED:15077149]
NOTCH2 intracellular domain regulates transcription
[NCBI:1269540]
[REACTOME:R-HSA-2197563]
[PUBMED:23362348]
[PUBMED:18724371]
[PUBMED:11986231]
[PUBMED:23362349]
[PUBMED:11866432]
[PUBMED:21898486]
[PUBMED:11101851]
Natural killer cell mediated cytotoxicity
[NCBI:83079]
[KEGG:hsa04650]
[PUBMED:12530970]
[PUBMED:15567854]
[PUBMED:8942070]
[PUBMED:11905813]
[PUBMED:9143705]
[PUBMED:9862693]
[PUBMED:11895890]
[PUBMED:12205470]
[PUBMED:11836514]
[PUBMED:15607806]
[PUBMED:16002670]
[PUBMED:15618404]
[PUBMED:11390470]
[PUBMED:11062493]
[PUBMED:14710949]
[PUBMED:12752668]
[PUBMED:15607802]
[PUBMED:16109839]
[PUBMED:12766758]
[PUBMED:16177799]
Programmed Cell Death
[NCBI:1270261]
[REACTOME:R-HSA-5357801]
[PUBMED:25236395]
Signal Transduction
[NCBI:1269379]
[REACTOME:R-HSA-162582]
[PUBMED:17604717]
[PUBMED:19648010]
[PUBMED:16260143]
[PUBMED:11742412]
[PUBMED:19536106]
[PUBMED:15863030]
[PUBMED:19379690]
[PUBMED:19458711]
[PUBMED:19935667]
[PUBMED:21252999]
[PUBMED:15520807]
[PUBMED:17496910]
[PUBMED:15450248]
[PUBMED:18043707]
[PUBMED:16939974]
[PUBMED:19762341]
[PUBMED:18483217]
[PUBMED:17084981]
[PUBMED:21781017]
[PUBMED:19619488]
Signaling by NOTCH
[NCBI:1269530]
[REACTOME:R-HSA-157118]
Signaling by NOTCH2
[NCBI:1269538]
[REACTOME:R-HSA-1980145]
[PUBMED:20156974]
[PUBMED:18724371]
[PUBMED:21378989]
[PUBMED:11187898]
[PUBMED:10958687]
[PUBMED:9207788]
[PUBMED:803282]
[PUBMED:18469519]
[PUBMED:20816392]
[PUBMED:19379690]
[PUBMED:11518718]
[PUBMED:14567914]
[PUBMED:11986231]
[PUBMED:10934472]
[PUBMED:11101851]
[PUBMED:11866432]
[PUBMED:21378985]
[PUBMED:10206645]
[PUBMED:20816393]
[PUBMED:10551863]
[PUBMED:9207787]
[PUBMED:15569487]
[PUBMED:21632553]
[PUBMED:21681853]
[PUBMED:16773578]
Transcriptional misregulation in cancer
[NCBI:523016]
[KEGG:hsa05202]
[PUBMED:17327229]
[PUBMED:20190806]
[PUBMED:20145147]
[PUBMED:11313274]
[PUBMED:11863357]
[PUBMED:19472090]
[PUBMED:18330902]
[PUBMED:19738075]
[PUBMED:15024077]
[PUBMED:12032780]
[PUBMED:14630078]
[PUBMED:21765642]
[PUBMED:19564705]
[PUBMED:17101797]
[PUBMED:15160934]
[PUBMED:15688424]
[PUBMED:15985538]
[PUBMED:12527902]
[PUBMED:12511414]
[PUBMED:11607818]
[PUBMED:17222504]
[PUBMED:15826838]
[PUBMED:21747944]
[PUBMED:19406209]
[PUBMED:10350329]
[PUBMED:21779514]
[PUBMED:18563191]
[PUBMED:16946003]
[PUBMED:17250957]
[PUBMED:12670461]
[PUBMED:12529654]
[PUBMED:18855877]
[PUBMED:17505060]
[PUBMED:20153925]
[PUBMED:20490326]
[PUBMED:12130514]
[PUBMED:18648544]
[PUBMED:19855079]
[PUBMED:10717473]
[PUBMED:20478527]
[PUBMED:11340171]
[PUBMED:16169901]
[PUBMED:14998494]
[PUBMED:19233641]
[PUBMED:19133982]
[PUBMED:12393465]
[PUBMED:19059936]
[PUBMED:18172298]
[PUBMED:10500199]
[PUBMED:19141473]
[PUBMED:10537274]
[PUBMED:15156184]
[PUBMED:14701735]
[PUBMED:19422821]
[PUBMED:21518926]
[PUBMED:18850010]
[PUBMED:19075677]
[PUBMED:18457914]
[PUBMED:12527906]
[PUBMED:15644444]
[PUBMED:10784387]
[PUBMED:17024155]
[PUBMED:19075268]
[PUBMED:15826834]
[PUBMED:21849159]
[PUBMED:21123453]
[PUBMED:20974671]
[PUBMED:20863376]
Type I diabetes mellitus
[NCBI:83095]
[KEGG:hsa04940]
[PUBMED:11507694]
[PUBMED:8072542]
[PUBMED:15889095]
[PUBMED:15889096]
[PUBMED:12796471]
[PUBMED:14617043]
[PUBMED:8786033]
[PUBMED:9719467]
[PUBMED:12752668]