full name
NFKB inhibitor alpha

synonyms
IKBA, MAD-3, NFKBI, NFKBIA, ENSG00000100906

HGNC
HGNC:7797

Entrez Gene
Gene:4792

ENSEMBL
ENSG00000100906

location
chr: 14
start: 35870716
stop: 35873960
strand: -

OMIM
OMIM:164008: NFKBIA (Autosomal dominant inheritance)
OMIM:612132: Ectodermal dysplasia and immunodeficiency 2

transcripts
NM_020529.2

pathways
Activated TLR4 signalling [NCBI:1269236] [REACTOME:R-HSA-166054] [PUBMED:15276183] [PUBMED:15588429] [PUBMED:15845500] [PUBMED:15596121]
Activation of NF-kappaB in B cells [NCBI:1269186] [REACTOME:R-HSA-1169091] [PUBMED:10593898] [PUBMED:3129195] [PUBMED:7479848] [PUBMED:7809113] [PUBMED:9721103] [PUBMED:18462924] [PUBMED:8387275] [PUBMED:7628694] [PUBMED:7862124] [PUBMED:7831327] [PUBMED:7575604] [PUBMED:16356855] [PUBMED:16301747] [PUBMED:7957109] [PUBMED:11460167] [PUBMED:9914500] [PUBMED:19066035] [PUBMED:17428801] [PUBMED:7479976] [PUBMED:1756723]
Adaptive Immune System [NCBI:1269171] [REACTOME:R-HSA-1280218] [PUBMED:16551257] [PUBMED:21682741] [PUBMED:11861602]
Adipocytokine signaling pathway [NCBI:83093] [KEGG:hsa04920] [PUBMED:12829246] [PUBMED:10905472] [PUBMED:15980064] [PUBMED:12754525] [PUBMED:12368907] [PUBMED:11557972] [PUBMED:15856064] [PUBMED:9671776] [PUBMED:10766253] [PUBMED:15733744] [PUBMED:15058305] [PUBMED:14716305] [PUBMED:11479627] [PUBMED:14679176]
Apoptosis [NCBI:83060] [KEGG:hsa04210] [NCBI:1270262] [REACTOME:R-HSA-109581] [PUBMED:12189384] [PUBMED:20533903] [PUBMED:18208375] [PUBMED:22429822] [PUBMED:15218528] [PUBMED:24769728] [PUBMED:18023214] [PUBMED:25526085] [PUBMED:23070002] [PUBMED:15654015] [PUBMED:15601572] [PUBMED:14561771] [PUBMED:24278747] [PUBMED:21914490] [PUBMED:22465226] [PUBMED:21145844] [PUBMED:12838338] [PUBMED:18238895] [PUBMED:12949498] [PUBMED:18304445] [PUBMED:14737178] [PUBMED:26231733] [PUBMED:9916983] [PUBMED:14634621] [PUBMED:19770840] [PUBMED:22075987] [PUBMED:4561027] [PUBMED:20075940] [PUBMED:9894605] [PUBMED:26615431] [PUBMED:12505355] [PUBMED:11520933] [PUBMED:19148180] [PUBMED:16397578] [PUBMED:15719025] [PUBMED:15322527] [PUBMED:15725726] [PUBMED:12209154] [PUBMED:23803157]
Atypical NF-kappaB pathway [NCBI:137946] [Pathway Interaction Database:nfkappabatypicalpathway] [PUBMED:1501714] [PUBMED:9892650] [PUBMED:16308565] [PUBMED:14534291] [PUBMED:8330739] [PUBMED:8622692] [PUBMED:9724653] [PUBMED:1639070] [PUBMED:8668171] [PUBMED:8404857] [PUBMED:12711606] [PUBMED:12429743] [PUBMED:14580335] [PUBMED:12870650]
Aurora A signaling [NCBI:137925] [Pathway Interaction Database:aurora_a_pathway] [PUBMED:17308110] [PUBMED:16894566] [PUBMED:16631581] [PUBMED:17229885] [PUBMED:15128871] [PUBMED:14990569] [PUBMED:12177045] [PUBMED:14580337] [PUBMED:14724178] [PUBMED:17545617] [PUBMED:15687499] [PUBMED:11163242] [PUBMED:14603251] [PUBMED:17060449] [PUBMED:12208850] [PUBMED:12815066] [PUBMED:17125467] [PUBMED:13678582] [PUBMED:15987997] [PUBMED:15966895] [PUBMED:11976319] [PUBMED:14702041] [PUBMED:16246726] [PUBMED:17452972] [PUBMED:12082625] [PUBMED:11039908] [PUBMED:14667408] [PUBMED:12577065] [PUBMED:14600264] [PUBMED:11756469] [PUBMED:16772293] [PUBMED:12023018] [PUBMED:15469940] [PUBMED:16082213]
B cell receptor signaling pathway [NCBI:83081] [KEGG:hsa04662] [PUBMED:15626471] [PUBMED:12119152] [PUBMED:15886119] [PUBMED:12461567] [PUBMED:9697839] [PUBMED:15752555] [PUBMED:11163197] [PUBMED:18086859] [PUBMED:15364057] [PUBMED:15457440] [PUBMED:15322145] [PUBMED:15771577] [PUBMED:12033741] [PUBMED:15886112] [PUBMED:10358768]
BCR signaling pathway [NCBI:138058] [Pathway Interaction Database:bcr_5pathway] [PUBMED:7687428] [PUBMED:16200195] [PUBMED:12730099] [PUBMED:10770799] [PUBMED:14563325] [PUBMED:9763608] [PUBMED:15541657] [PUBMED:11781242] [PUBMED:11102801] [PUBMED:9586640] [PUBMED:11279148] [PUBMED:7499277] [PUBMED:7542197] [PUBMED:9820480] [PUBMED:9221755] [PUBMED:11909947] [PUBMED:9360945] [PUBMED:9058799] [PUBMED:10339589] [PUBMED:11226282] [PUBMED:9271416] [PUBMED:9620684] [PUBMED:11163197] [PUBMED:10820378] [PUBMED:11356195] [PUBMED:11080163] [PUBMED:10755621] [PUBMED:7717978] [PUBMED:7618087] [PUBMED:11577348] [PUBMED:1279802] [PUBMED:10640270] [PUBMED:11356834] [PUBMED:12867038] [PUBMED:12780340] [PUBMED:10430908] [PUBMED:7528218]
C-type lectin receptors (CLRs) [NCBI:1269303] [REACTOME:R-HSA-5621481] [PUBMED:19521399] [PUBMED:24330199]
CD40/CD40L signaling [NCBI:138061] [Pathway Interaction Database:cd40_pathway] [PUBMED:11967542] [PUBMED:11304555] [PUBMED:11714736] [PUBMED:17878343] [PUBMED:12354380] [PUBMED:11406619] [PUBMED:9133417] [PUBMED:7527023] [PUBMED:18997794] [PUBMED:1374165] [PUBMED:1385114] [PUBMED:12958312] [PUBMED:10764746] [PUBMED:11909853] [PUBMED:10318845] [PUBMED:7533327] [PUBMED:16260598] [PUBMED:18997792] [PUBMED:12818164] [PUBMED:10748139] [PUBMED:9718306] [PUBMED:10395671] [PUBMED:17878362] [PUBMED:7544915] [PUBMED:12370254] [PUBMED:8910514] [PUBMED:17143273] [PUBMED:10433725] [PUBMED:14981114] [PUBMED:16622006] [PUBMED:12122011] [PUBMED:12133933]
CLEC7A (Dectin-1) signaling [NCBI:1269304] [REACTOME:R-HSA-5607764] [PUBMED:12719478] [PUBMED:19223162]
Canonical NF-kappaB pathway [NCBI:138030] [Pathway Interaction Database:nfkappabcanonicalpathway] [PUBMED:7878466] [PUBMED:10688673] [PUBMED:16497931] [PUBMED:10755617] [PUBMED:9660950] [PUBMED:9346241] [PUBMED:10195894] [PUBMED:10521409] [PUBMED:12917691] [PUBMED:15620648] [PUBMED:14695475] [PUBMED:14651848] [PUBMED:11319224] [PUBMED:9150141] [PUBMED:9819420] [PUBMED:15218148] [PUBMED:7739562] [PUBMED:12657630] [PUBMED:12867425] [PUBMED:16267042]
Ceramide signaling pathway [NCBI:138023] [Pathway Interaction Database:ceramide_pathway] [PUBMED:11350735] [PUBMED:10400650] [PUBMED:9287216] [PUBMED:9488730] [PUBMED:8702918] [PUBMED:10969079] [PUBMED:10433354] [PUBMED:14739942] [PUBMED:9446561] [PUBMED:8808629] [PUBMED:8681376] [PUBMED:7477354] [PUBMED:14689449] [PUBMED:12866359] [PUBMED:9873064] [PUBMED:8933152] [PUBMED:10438487] [PUBMED:15881228] [PUBMED:10508159] [PUBMED:7519779] [PUBMED:8387486] [PUBMED:12154098] [PUBMED:7559390] [PUBMED:12486111] [PUBMED:14670935] [PUBMED:15901738] [PUBMED:15051724] [PUBMED:8393446] [PUBMED:9094715] [PUBMED:11723139] [PUBMED:10395296] [PUBMED:8681377] [PUBMED:11148216] [PUBMED:12566438] [PUBMED:15164763] [PUBMED:10026132] [PUBMED:10962008]
Chagas disease (American trypanosomiasis) [NCBI:147809] [KEGG:hsa05142] [PUBMED:12377585] [PUBMED:9794425] [PUBMED:1717552] [PUBMED:16238097] [PUBMED:10066513] [PUBMED:12874238] [PUBMED:12036740] [PUBMED:15917295] [PUBMED:12055254] [PUBMED:17651955] [PUBMED:1396957] [PUBMED:16175174] [PUBMED:2194668] [PUBMED:9190942] [PUBMED:12377942] [PUBMED:12427093] [PUBMED:10234174] [PUBMED:16030288] [PUBMED:15223603] [PUBMED:17110955]
Chemokine signaling pathway [NCBI:99051] [KEGG:hsa04062] [PUBMED:17371236] [PUBMED:19159344] [PUBMED:17169327] [PUBMED:10852130] [PUBMED:9765254] [PUBMED:15771581] [PUBMED:14607270] [PUBMED:18662984] [PUBMED:12495636] [PUBMED:15803148] [PUBMED:15046611] [PUBMED:12069927] [PUBMED:18711432] [PUBMED:17675482] [PUBMED:16144840] [PUBMED:17496928] [PUBMED:17537990] [PUBMED:11872087] [PUBMED:12051620] [PUBMED:14625285] [PUBMED:8576262] [PUBMED:11244042]
Chronic myeloid leukemia [NCBI:83116] [KEGG:hsa05220] [PUBMED:22286129] [PUBMED:12801837] [PUBMED:11160144] [PUBMED:15719031] [PUBMED:10403855] [PUBMED:9834202] [PUBMED:11071626] [PUBMED:12244301] [PUBMED:15156182] [PUBMED:16484590] [PUBMED:14982876]
Cytosolic DNA-sensing pathway [NCBI:125137] [KEGG:hsa04623] [PUBMED:18573338] [PUBMED:19665965] [PUBMED:19567913] [PUBMED:18280611] [PUBMED:18724932] [PUBMED:19497760] [PUBMED:16286919] [PUBMED:19122387] [PUBMED:19590578] [PUBMED:23258413] [PUBMED:18375758] [PUBMED:19321146] [PUBMED:19362700] [PUBMED:18941233] [PUBMED:19767723]
Cytosolic sensors of pathogen-associated DNA [NCBI:1269268] [REACTOME:R-HSA-1834949] [PUBMED:23706668] [PUBMED:21533068] [PUBMED:23706667]
Deubiquitination [NCBI:1427860] [REACTOME:R-HSA-5688426] [PUBMED:19243136] [PUBMED:20074029] [PUBMED:15571815] [PUBMED:20418328] [PUBMED:16325574] [PUBMED:12944365] [PUBMED:23845989] [PUBMED:22201797]
Disease [NCBI:1268854] [REACTOME:R-HSA-1643685]
Diseases associated with the TLR signaling cascade [NCBI:1269157] [REACTOME:R-HSA-5602358] [PUBMED:23622315] [PUBMED:21734245] [PUBMED:22610250] [PUBMED:16176658]
Diseases of Immune System [NCBI:1269156] [REACTOME:R-HSA-5260271] [PUBMED:24795713] [PUBMED:22165913]
Downstream TCR signaling [NCBI:1269176] [REACTOME:R-HSA-202424] [PUBMED:15084594]
Downstream signaling events of B Cell Receptor (BCR) [NCBI:1269185] [REACTOME:R-HSA-1168372] [PUBMED:17052215] [PUBMED:19909372]
Epithelial cell signaling in Helicobacter pylori infection [NCBI:83102] [KEGG:hsa05120] [PUBMED:11389469] [PUBMED:15694859] [PUBMED:14700549] [PUBMED:12197905]
Epstein-Barr virus infection [NCBI:585562] [KEGG:hsa05169] [PUBMED:1658397] [PUBMED:10683340] [PUBMED:19375142] [PUBMED:12438576] [PUBMED:12910248] [PUBMED:10400785] [PUBMED:16007144] [PUBMED:14576817] [PUBMED:18559925] [PUBMED:16352731] [PUBMED:7895172] [PUBMED:15510157] [PUBMED:21518914] [PUBMED:10891508] [PUBMED:14673102] [PUBMED:17159145] [PUBMED:15542638] [PUBMED:18786993] [PUBMED:16603506] [PUBMED:10644367] [PUBMED:15021898] [PUBMED:10666279] [PUBMED:9565632]
FCERI mediated NF-kB activation [NCBI:1269301] [REACTOME:R-HSA-2871837] [PUBMED:17336609] [PUBMED:16432253]
Fc epsilon receptor (FCERI) signaling [NCBI:1269298] [REACTOME:R-HSA-2454202] [PUBMED:15099567] [PUBMED:21799019]
HIV-1 Nef: Negative effector of Fas and TNF-alpha [NCBI:137995] [Pathway Interaction Database:hivnefpathway] [PUBMED:9740801] [PUBMED:10224289] [PUBMED:10940292] [PUBMED:9915703] [PUBMED:9564042] [PUBMED:9743501] [PUBMED:9873064] [PUBMED:12748303] [PUBMED:9867840] [PUBMED:11298454] [PUBMED:9184224] [PUBMED:9294162] [PUBMED:9727492] [PUBMED:9244310] [PUBMED:10318789] [PUBMED:12887920] [PUBMED:9230442] [PUBMED:9020361] [PUBMED:9108473] [PUBMED:9215629] [PUBMED:9384571]
HTLV-I infection [NCBI:373901] [KEGG:hsa05166] [PUBMED:17446673] [PUBMED:16436385] [PUBMED:14686485] [PUBMED:19861996] [PUBMED:19092975] [PUBMED:11325603] [PUBMED:16155602] [PUBMED:12910251] [PUBMED:16155605] [PUBMED:16036567] [PUBMED:11244044] [PUBMED:18702816] [PUBMED:15569630] [PUBMED:21114861] [PUBMED:16155611] [PUBMED:17384582] [PUBMED:16155608] [PUBMED:10602469] [PUBMED:19014483] [PUBMED:9325311]
Hepatitis B [NCBI:694606] [KEGG:hsa05161] [PUBMED:19854353] [PUBMED:11604508] [PUBMED:11325602] [PUBMED:18931690] [PUBMED:16891440] [PUBMED:17158882] [PUBMED:11099494] [PUBMED:9325306] [PUBMED:18024894] [PUBMED:11483993] [PUBMED:15107488] [PUBMED:11278872] [PUBMED:21647825] [PUBMED:11287574] [PUBMED:18481805] [PUBMED:17188775] [PUBMED:19784739] [PUBMED:19263472] [PUBMED:16203685] [PUBMED:18605975] [PUBMED:10454581] [PUBMED:22504921] [PUBMED:21334391] [PUBMED:20657822] [PUBMED:18046710] [PUBMED:9843511] [PUBMED:15542625] [PUBMED:21618535] [PUBMED:15132991] [PUBMED:15173177] [PUBMED:12771941] [PUBMED:21994545] [PUBMED:8764004] [PUBMED:16459163] [PUBMED:9738022] [PUBMED:11821950] [PUBMED:12839924]
Hepatitis C [NCBI:173973] [KEGG:hsa05160] [PUBMED:19708811] [PUBMED:16314558] [PUBMED:17467654] [PUBMED:19515018] [PUBMED:18514579] [PUBMED:16107833] [PUBMED:19074178] [PUBMED:12691459] [PUBMED:15302943] [PUBMED:20537953] [PUBMED:11991644] [PUBMED:19148799] [PUBMED:19187070] [PUBMED:12655344]
Herpes simplex infection [NCBI:377873] [KEGG:hsa05168] [PUBMED:12224518] [PUBMED:17913820] [PUBMED:12844494] [PUBMED:10998601] [PUBMED:15163721] [PUBMED:19694546] [PUBMED:16297150] [PUBMED:14747533] [PUBMED:12826401] [PUBMED:14963113] [PUBMED:15056211] [PUBMED:12797447] [PUBMED:21107701] [PUBMED:10918307] [PUBMED:10696424] [PUBMED:16076403] [PUBMED:10364308] [PUBMED:17222692] [PUBMED:9621021] [PUBMED:12224508] [PUBMED:19879619] [PUBMED:11070032] [PUBMED:9499021] [PUBMED:18596690] [PUBMED:12525427] [PUBMED:12224517] [PUBMED:10196275] [PUBMED:15047834] [PUBMED:18508584] [PUBMED:20036979]
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) [NCBI:1269166] [REACTOME:R-HSA-5603027] [PUBMED:18851874] [PUBMED:15229184] [PUBMED:11242109]
IL-17 signaling pathway [NCBI:1474301] [KEGG:hsa04657] [PUBMED:17921324] [PUBMED:24011563] [PUBMED:21349428] [PUBMED:20383173] [PUBMED:20514051] [PUBMED:20177959] [PUBMED:18178098] [PUBMED:21074482] [PUBMED:21130872] [PUBMED:17027518] [PUBMED:23917206] [PUBMED:23116200] [PUBMED:18701318] [PUBMED:26252407] [PUBMED:22851696] [PUBMED:21155836] [PUBMED:25145755] [PUBMED:17177681] [PUBMED:19575028] [PUBMED:23557798] [PUBMED:21852080] [PUBMED:22324470]
IL23-mediated signaling events [NCBI:138000] [Pathway Interaction Database:il23pathway] [PUBMED:16200068] [PUBMED:12023338] [PUBMED:17030949] [PUBMED:16670770] [PUBMED:17074928] [PUBMED:15583831] [PUBMED:16919486] [PUBMED:12417590] [PUBMED:16622035] [PUBMED:16698929] [PUBMED:14978083] [PUBMED:12610626] [PUBMED:15308705] [PUBMED:16200070] [PUBMED:15657292] [PUBMED:16648837] [PUBMED:11114383] [PUBMED:12023369] [PUBMED:9038232]
IkBA variant leads to EDA-ID [NCBI:1269168] [REACTOME:R-HSA-5603029] [PUBMED:18412279] [PUBMED:23708964]
Immune System [NCBI:1269170] [REACTOME:R-HSA-168256]
Influenza A [NCBI:217173] [KEGG:hsa05164] [PUBMED:17267598] [PUBMED:18049471] [PUBMED:16882036] [PUBMED:11907320] [PUBMED:17944269] [PUBMED:20629046] [PUBMED:17072332] [PUBMED:18588994] [PUBMED:19864182] [PUBMED:19290913] [PUBMED:19420020] [PUBMED:17213831] [PUBMED:9060654] [PUBMED:19481124] [PUBMED:16494716] [PUBMED:21147034] [PUBMED:18980544] [PUBMED:20020828] [PUBMED:15502848] [PUBMED:19782761]
Innate Immune System [NCBI:1269203] [REACTOME:R-HSA-168249]
Insulin resistance [NCBI:1272486] [KEGG:hsa04931] [PUBMED:17130651] [PUBMED:20466550] [PUBMED:16364488] [PUBMED:12765939] [PUBMED:15166380] [PUBMED:7666792] [PUBMED:16756496] [PUBMED:23647930] [PUBMED:10923637] [PUBMED:17141630] [PUBMED:9886945] [PUBMED:8048519] [PUBMED:18309108] [PUBMED:15107844] [PUBMED:20526383] [PUBMED:22360800] [PUBMED:16186396] [PUBMED:22675355] [PUBMED:22677645]
LPA receptor mediated events [NCBI:137928] [Pathway Interaction Database:lysophospholipid_pathway] [PUBMED:10601262] [PUBMED:16289596] [PUBMED:7809106] [PUBMED:10342794] [PUBMED:15928312] [PUBMED:16769764] [PUBMED:11243883] [PUBMED:14688263] [PUBMED:10551845] [PUBMED:16687414] [PUBMED:9819398] [PUBMED:7527052] [PUBMED:9600933] [PUBMED:2551506] [PUBMED:15988003] [PUBMED:10644509] [PUBMED:16199135] [PUBMED:15728708] [PUBMED:1637305] [PUBMED:7476905] [PUBMED:7510708] [PUBMED:8647803] [PUBMED:10420989] [PUBMED:12880866] [PUBMED:10766839] [PUBMED:12181443] [PUBMED:15461590] [PUBMED:16452634] [PUBMED:16197369] [PUBMED:10779388] [PUBMED:10506190] [PUBMED:9305878] [PUBMED:16904289] [PUBMED:15878967] [PUBMED:15143197] [PUBMED:11948806] [PUBMED:11040035] [PUBMED:12393875] [PUBMED:9407095] [PUBMED:15280372] [PUBMED:16890224] [PUBMED:8805276]
Legionellosis [NCBI:469200] [KEGG:hsa05134] [PUBMED:19021631] [PUBMED:19157961] [PUBMED:20375353] [PUBMED:19478083] [PUBMED:18284575] [PUBMED:19386084] [PUBMED:19666608] [PUBMED:15972519] [PUBMED:18549456] [PUBMED:1721820] [PUBMED:17124169] [PUBMED:19687203] [PUBMED:18363881] [PUBMED:19343209] [PUBMED:20941588] [PUBMED:16824952] [PUBMED:18281405] [PUBMED:18048909] [PUBMED:16495539] [PUBMED:12427954]
Leishmaniasis [NCBI:144181] [KEGG:hsa05140] [PUBMED:11890722] [PUBMED:7916951] [PUBMED:10417174] [PUBMED:11298294] [PUBMED:10586030] [PUBMED:15322192] [PUBMED:15831826] [PUBMED:11728310] [PUBMED:15039466] [PUBMED:10462516] [PUBMED:10608501] [PUBMED:15721837] [PUBMED:15639739] [PUBMED:14762510] [PUBMED:18793215] [PUBMED:7591091] [PUBMED:12438359] [PUBMED:18070909] [PUBMED:17543969] [PUBMED:15983048] [PUBMED:16848789] [PUBMED:10770277] [PUBMED:9504340]
Measles [NCBI:213306] [KEGG:hsa05162] [PUBMED:16237742] [PUBMED:12804771] [PUBMED:19198562] [PUBMED:20376484] [PUBMED:11385511] [PUBMED:16963735] [PUBMED:19198566] [PUBMED:18922877] [PUBMED:19203114] [PUBMED:12620806] [PUBMED:16690907] [PUBMED:17720800] [PUBMED:20636817] [PUBMED:12410527] [PUBMED:11582511] [PUBMED:19203109] [PUBMED:19203113] [PUBMED:14585342] [PUBMED:12805463]
Metabolism of proteins [NCBI:1268677] [REACTOME:R-HSA-392499]
MyD88 cascade initiated on plasma membrane [NCBI:1269207] [REACTOME:R-HSA-975871] [PUBMED:15728506] [PUBMED:16239509]
MyD88 dependent cascade initiated on endosome [NCBI:1269228] [REACTOME:R-HSA-975155] [PUBMED:20237413] [PUBMED:15276183] [PUBMED:18652679]
MyD88-independent TLR3/TLR4 cascade [NCBI:1269220] [REACTOME:R-HSA-166166] [PUBMED:15276183]
MyD88:Mal cascade initiated on plasma membrane [NCBI:1269237] [REACTOME:R-HSA-166058] [PUBMED:15276183]
NF-kB is activated and signals survival [NCBI:1269454] [REACTOME:R-HSA-209560] [PUBMED:16187223]
NF-kappa B signaling pathway [NCBI:634527] [KEGG:hsa04064] [PUBMED:22119011] [PUBMED:16264088] [PUBMED:21187855] [PUBMED:15546385] [PUBMED:17607554] [PUBMED:21135871] [PUBMED:16984817] [PUBMED:17047224] [PUBMED:19203223] [PUBMED:20300215] [PUBMED:14657271] [PUBMED:17431096] [PUBMED:15134788] [PUBMED:16356770] [PUBMED:21772278] [PUBMED:12654254] [PUBMED:22390971] [PUBMED:22017435] [PUBMED:17183360] [PUBMED:21173796] [PUBMED:15905862] [PUBMED:19302050] [PUBMED:17098202] [PUBMED:21872579] [PUBMED:22152226] [PUBMED:18613837] [PUBMED:19489733] [PUBMED:11875461] [PUBMED:19726767] [PUBMED:22017430] [PUBMED:21232019] [PUBMED:18832076]
NOD-like receptor signaling pathway [NCBI:122191] [KEGG:hsa04621] [PUBMED:25330206] [PUBMED:21575908] [PUBMED:23846113] [PUBMED:26549800] [PUBMED:16493424] [PUBMED:23124073] [PUBMED:24840700] [PUBMED:27291964] [PUBMED:27012466] [PUBMED:24707857] [PUBMED:19767725] [PUBMED:25879280] [PUBMED:23215645] [PUBMED:22819539] [PUBMED:23702978] [PUBMED:20643110] [PUBMED:25879288] [PUBMED:26655628] [PUBMED:25145756] [PUBMED:24718315] [PUBMED:26482951] [PUBMED:25526305] [PUBMED:26121197] [PUBMED:22430786]
Neurotrophin signaling pathway [NCBI:101143] [KEGG:hsa04722] [PUBMED:16699811] [PUBMED:10812966] [PUBMED:12676795] [PUBMED:16939974] [PUBMED:10851172] [PUBMED:15499580] [PUBMED:14704852] [PUBMED:11399424] [PUBMED:10764727] [PUBMED:10985348] [PUBMED:16856873] [PUBMED:11529497]
Osteoclast differentiation [NCBI:193147] [KEGG:hsa04380] [PUBMED:17633024] [PUBMED:18382763] [PUBMED:18329366] [PUBMED:17869613] [PUBMED:18722561] [PUBMED:15122243] [PUBMED:20703218] [PUBMED:12748652] [PUBMED:12110142] [PUBMED:19585227] [PUBMED:15546140] [PUBMED:16184196] [PUBMED:15817678] [PUBMED:20392226] [PUBMED:16313349] [PUBMED:16313342] [PUBMED:17380158] [PUBMED:18451259]
Osteopontin-mediated events [NCBI:137960] [Pathway Interaction Database:avb3_opn_pathway] [PUBMED:9727056] [PUBMED:9585425] [PUBMED:16888388] [PUBMED:16474180] [PUBMED:15757900] [PUBMED:9682033] [PUBMED:12529435] [PUBMED:15142256] [PUBMED:14624447] [PUBMED:15711558] [PUBMED:9988732] [PUBMED:12730217] [PUBMED:11600576] [PUBMED:8744948] [PUBMED:16691505] [PUBMED:11940607] [PUBMED:16006560] [PUBMED:10766830] [PUBMED:10559185]
Pathways in cancer [NCBI:83105] [KEGG:hsa05200] [PUBMED:12244301] [PUBMED:15156182] [PUBMED:16899407] [PUBMED:12621137] [PUBMED:21193867] [PUBMED:16001072] [PUBMED:11707511] [PUBMED:11253051] [PUBMED:11071626] [PUBMED:17251915] [PUBMED:11736900] [PUBMED:16557281] [PUBMED:16699851] [PUBMED:16189702] [PUBMED:11902573] [PUBMED:16555243] [PUBMED:8069858] [PUBMED:15310786] [PUBMED:9834202] [PUBMED:16700615] [PUBMED:12545153] [PUBMED:15656799] [PUBMED:12154354] [PUBMED:11895903] [PUBMED:11527574] [PUBMED:16326109] [PUBMED:16339096] [PUBMED:11160144] [PUBMED:15724144] [PUBMED:12951584] [PUBMED:10647931] [PUBMED:16881963] [PUBMED:15557758] [PUBMED:11477132] [PUBMED:15721476] [PUBMED:15625120] [PUBMED:16236521] [PUBMED:14967450] [PUBMED:15942304] [PUBMED:17287871] [PUBMED:14634372] [PUBMED:15573119] [PUBMED:15009714] [PUBMED:16112428] [PUBMED:15611513] [PUBMED:16001050] [PUBMED:15349822] [PUBMED:16551846] [PUBMED:15978322] [PUBMED:15774796] [PUBMED:16352814] [PUBMED:12951588] [PUBMED:10944551] [PUBMED:10740269] [PUBMED:15639402] [PUBMED:12407699] [PUBMED:11130178] [PUBMED:15109562] [PUBMED:11170304] [PUBMED:11276000] [PUBMED:9643506] [PUBMED:16248975] [PUBMED:16242838] [PUBMED:12946833] [PUBMED:11559746] [PUBMED:9196022] [PUBMED:12079267] [PUBMED:15468170] [PUBMED:16064138] [PUBMED:14580692] [PUBMED:15082523] [PUBMED:15551095] [PUBMED:17062879] [PUBMED:17211469] [PUBMED:11720739] [PUBMED:12588368] [PUBMED:11057895] [PUBMED:9422516] [PUBMED:12894244] [PUBMED:15479695] [PUBMED:16189154] [PUBMED:12878745] [PUBMED:11900250] [PUBMED:11103787] [PUBMED:15122209] [PUBMED:12711111] [PUBMED:12243753] [PUBMED:16306523] [PUBMED:16702400] [PUBMED:15270885] [PUBMED:14685170] [PUBMED:14586404] [PUBMED:11078609] [PUBMED:15284264] [PUBMED:10505543] [PUBMED:11223406] [PUBMED:14982876] [PUBMED:12648469] [PUBMED:12867060] [PUBMED:15711891] [PUBMED:12094241] [PUBMED:16642045] [PUBMED:11463388] [PUBMED:12762887] [PUBMED:15746962] [PUBMED:15823750] [PUBMED:16750612] [PUBMED:16484590] [PUBMED:11459867] [PUBMED:16146838] [PUBMED:14556242] [PUBMED:15947972] [PUBMED:12563308] [PUBMED:16946003] [PUBMED:15948971] [PUBMED:11407945] [PUBMED:12737309] [PUBMED:16095998] [PUBMED:12351585] [PUBMED:24508914] [PUBMED:12084351] [PUBMED:11807782] [PUBMED:14695152] [PUBMED:10453277] [PUBMED:17554387] [PUBMED:15841168] [PUBMED:12616528] [PUBMED:10403855] [PUBMED:16054233] [PUBMED:16474624] [PUBMED:16822996] [PUBMED:17028294] [PUBMED:11224709] [PUBMED:11750244] [PUBMED:11905738] [PUBMED:15719031] [PUBMED:10843728] [PUBMED:16110317] [PUBMED:11721960] [PUBMED:12741677] [PUBMED:7585656] [PUBMED:12801837] [PUBMED:16551847] [PUBMED:12459728] [PUBMED:11431710] [PUBMED:12468433] [PUBMED:11165748] [PUBMED:16042571] [PUBMED:16508724] [PUBMED:15000146] [PUBMED:17149381] [PUBMED:15948711] [PUBMED:14747944] [PUBMED:14737121] [PUBMED:12379883] [PUBMED:17158541] [PUBMED:12850530] [PUBMED:10835690] [PUBMED:16870043]
Post-translational protein modification [NCBI:1268701] [REACTOME:R-HSA-597592]
Prostate cancer [NCBI:83111] [KEGG:hsa05215] [PUBMED:12878745] [PUBMED:11900250] [PUBMED:11527574] [PUBMED:11750244] [PUBMED:16551847] [PUBMED:10835690] [PUBMED:8069858] [PUBMED:15724144] [PUBMED:10453277] [PUBMED:15082523] [PUBMED:9422516]
RIG-I-like receptor signaling pathway [NCBI:117292] [KEGG:hsa04622] [PUBMED:19224920] [PUBMED:19076341] [PUBMED:18549796] [PUBMED:18591413] [PUBMED:19615405] [PUBMED:19120475] [PUBMED:18439848] [PUBMED:19120476] [PUBMED:15208624] [PUBMED:19539500] [PUBMED:18272355] [PUBMED:18984593]
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways [NCBI:1269259] [REACTOME:R-HSA-168928] [PUBMED:17395582] [PUBMED:17942531] [PUBMED:18701081] [PUBMED:17683970] [PUBMED:18989317] [PUBMED:16214811]
RIP-mediated NFkB activation via ZBP1 [NCBI:1269271] [REACTOME:R-HSA-1810476] [PUBMED:18941233] [PUBMED:19590578]
Shigellosis [NCBI:83104] [KEGG:hsa05131] [PUBMED:11379633] [PUBMED:10491394] [PUBMED:17173036] [PUBMED:18202440] [PUBMED:17095701] [PUBMED:16622194] [PUBMED:16413487] [PUBMED:18005683] [PUBMED:15731041] [PUBMED:15073367] [PUBMED:12856283] [PUBMED:16939534] [PUBMED:17060328] [PUBMED:12065406] [PUBMED:8376337] [PUBMED:11207560] [PUBMED:8642302] [PUBMED:12356723] [PUBMED:15694852] [PUBMED:10369666] [PUBMED:14638419] [PUBMED:16441429] [PUBMED:16162672] [PUBMED:17719540] [PUBMED:7665485] [PUBMED:18059288] [PUBMED:18005697] [PUBMED:19165331] [PUBMED:12828640] [PUBMED:17662586] [PUBMED:9176079] [PUBMED:7591128] [PUBMED:15318166] [PUBMED:15950937]
Signal Transduction [NCBI:1269379] [REACTOME:R-HSA-162582] [PUBMED:17604717] [PUBMED:19648010] [PUBMED:16260143] [PUBMED:11742412] [PUBMED:19536106] [PUBMED:15863030] [PUBMED:19379690] [PUBMED:19458711] [PUBMED:19935667] [PUBMED:21252999] [PUBMED:15520807] [PUBMED:17496910] [PUBMED:15450248] [PUBMED:18043707] [PUBMED:16939974] [PUBMED:19762341] [PUBMED:18483217] [PUBMED:17084981] [PUBMED:21781017] [PUBMED:19619488]
Signaling by the B Cell Receptor (BCR) [NCBI:1269183] [REACTOME:R-HSA-983705] [PUBMED:1702903] [PUBMED:2011584] [PUBMED:1081164] [PUBMED:19065780] [PUBMED:16849466] [PUBMED:1375264] [PUBMED:7538118] [PUBMED:11901194] [PUBMED:8580068] [PUBMED:19249086] [PUBMED:18596693] [PUBMED:10648173] [PUBMED:4589993] [PUBMED:8163536] [PUBMED:1376928] [PUBMED:7688784] [PUBMED:6335036] [PUBMED:17052215] [PUBMED:18818202] [PUBMED:20206686] [PUBMED:7592958] [PUBMED:7524079] [PUBMED:15489917] [PUBMED:15509800] [PUBMED:18187424] [PUBMED:7927516] [PUBMED:803528] [PUBMED:19909372] [PUBMED:20192804] [PUBMED:8306975]
Signaling events mediated by HDAC Class I [NCBI:137997] [Pathway Interaction Database:hdac_classi_pathway] [PUBMED:9885572] [PUBMED:14701748] [PUBMED:10888618] [PUBMED:12393750] [PUBMED:9804427] [PUBMED:9139820] [PUBMED:12408818] [PUBMED:16809764] [PUBMED:12788099] [PUBMED:11533489] [PUBMED:15831498] [PUBMED:15701600] [PUBMED:11532945] [PUBMED:12183469] [PUBMED:16428440] [PUBMED:9150134] [PUBMED:12972430] [PUBMED:11486036] [PUBMED:15920470] [PUBMED:9150135] [PUBMED:9651585] [PUBMED:11960997] [PUBMED:9326634] [PUBMED:11278251] [PUBMED:14521922] [PUBMED:9197243] [PUBMED:9346952] [PUBMED:16371367] [PUBMED:10444591] [PUBMED:15653507] [PUBMED:15920471] [PUBMED:11919195]
Signalling by NGF [NCBI:1269443] [REACTOME:R-HSA-166520]
Small cell lung cancer [NCBI:83118] [KEGG:hsa05222] [PUBMED:12711111] [PUBMED:11463388] [PUBMED:12741677] [PUBMED:11905738] [PUBMED:11807782] [PUBMED:12379883] [PUBMED:12243753] [PUBMED:12616528] [PUBMED:11720739] [PUBMED:15109562] [PUBMED:12407699] [PUBMED:10944551] [PUBMED:16112428] [PUBMED:11559746] [PUBMED:16064138] [PUBMED:11902573]
T cell receptor signaling pathway [NCBI:83080] [KEGG:hsa04660] [PUBMED:17395537] [PUBMED:15308211] [PUBMED:15928679] [PUBMED:14656980] [PUBMED:17187070] [PUBMED:15084594] [PUBMED:16799472] [PUBMED:12669022] [PUBMED:15286727] [PUBMED:15122199] [PUBMED:19132916] [PUBMED:15489916] [PUBMED:11905831] [PUBMED:12195013] [PUBMED:15343367] [PUBMED:12133805] [PUBMED:14647476] [PUBMED:15771581] [PUBMED:15099566] [PUBMED:14617194] [PUBMED:19290929] [PUBMED:15345216]
TAK1 activates NFkB by phosphorylation and activation of IKKs complex [NCBI:1269210] [REACTOME:R-HSA-445989] [PUBMED:15837794] [PUBMED:11460167]
TCR signaling [NCBI:1269172] [REACTOME:R-HSA-202403] [PUBMED:10375551] [PUBMED:12876557] [PUBMED:9989491]
TNF signaling pathway [NCBI:812256] [KEGG:hsa04668] [PUBMED:20489699] [PUBMED:14532286] [PUBMED:21232019] [PUBMED:11897488] [PUBMED:22296764] [PUBMED:10581243] [PUBMED:23085193] [PUBMED:23531747]
TRAF6 mediated NF-kB activation [NCBI:1269263] [REACTOME:R-HSA-933542] [PUBMED:18984593]
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation [NCBI:1269229] [REACTOME:R-HSA-975138] [PUBMED:22511786] [PUBMED:18794297]
TRIF-mediated TLR3/TLR4 signaling [NCBI:1269221] [REACTOME:R-HSA-937061] [PUBMED:15814722] [PUBMED:12855817] [PUBMED:14739303]
Th1 and Th2 cell differentiation [NCBI:1458885] [KEGG:hsa04658] [PUBMED:15819694] [PUBMED:12171942] [PUBMED:19165228] [PUBMED:23336087] [PUBMED:26044597] [PUBMED:19151746] [PUBMED:19362457] [PUBMED:22044277] [PUBMED:11752608] [PUBMED:23405903] [PUBMED:19375293] [PUBMED:24113868] [PUBMED:19151747] [PUBMED:23624818] [PUBMED:22566933] [PUBMED:11121747] [PUBMED:20969597] [PUBMED:20065998]
Th17 cell differentiation [NCBI:1469482] [KEGG:hsa04659] [PUBMED:23325835] [PUBMED:23036716] [PUBMED:20488727] [PUBMED:21151104] [PUBMED:21084214] [PUBMED:20054607] [PUBMED:22754770] [PUBMED:22640807] [PUBMED:19379825] [PUBMED:22133865] [PUBMED:22324470] [PUBMED:17768419] [PUBMED:18408735] [PUBMED:21776333] [PUBMED:26253381] [PUBMED:16200068] [PUBMED:18362914] [PUBMED:24325586] [PUBMED:19381306] [PUBMED:18166487]
Toll Like Receptor 10 (TLR10) Cascade [NCBI:1269206] [REACTOME:R-HSA-168142] [PUBMED:15728506] [PUBMED:18332149]
Toll Like Receptor 2 (TLR2) Cascade [NCBI:1269238] [REACTOME:R-HSA-181438] [PUBMED:10820283]
Toll Like Receptor 3 (TLR3) Cascade [NCBI:1269219] [REACTOME:R-HSA-168164] [PUBMED:19627256] [PUBMED:15733829] [PUBMED:18202435]
Toll Like Receptor 4 (TLR4) Cascade [NCBI:1269234] [REACTOME:R-HSA-166016]
Toll Like Receptor 5 (TLR5) Cascade [NCBI:1269226] [REACTOME:R-HSA-168176] [PUBMED:11489966] [PUBMED:11323673]
Toll Like Receptor 7/8 (TLR7/8) Cascade [NCBI:1269227] [REACTOME:R-HSA-168181] [PUBMED:14976262]
Toll Like Receptor 9 (TLR9) Cascade [NCBI:1269233] [REACTOME:R-HSA-168138] [PUBMED:14751759]
Toll Like Receptor TLR1:TLR2 Cascade [NCBI:1269239] [REACTOME:R-HSA-168179] [PUBMED:12975352]
Toll Like Receptor TLR6:TLR2 Cascade [NCBI:1269240] [REACTOME:R-HSA-168188] [PUBMED:14977973]
Toll-Like Receptors Cascades [NCBI:1269204] [REACTOME:R-HSA-168898] [PUBMED:15950447] [PUBMED:12893815] [PUBMED:15976490] [PUBMED:15585605] [PUBMED:14751757]
Toll-like receptor signaling pathway [NCBI:83076] [KEGG:hsa04620] [PUBMED:16924467] [PUBMED:17395581] [PUBMED:17637696] [PUBMED:12734364] [PUBMED:17507094] [PUBMED:14698224] [PUBMED:11101877] [PUBMED:16497588] [PUBMED:14751764] [PUBMED:17275323] [PUBMED:17457343] [PUBMED:16932750]
Toxoplasmosis [NCBI:169642] [KEGG:hsa05145] [PUBMED:18617274] [PUBMED:19400868] [PUBMED:17024357] [PUBMED:19744886] [PUBMED:19891610] [PUBMED:17110955] [PUBMED:12106793] [PUBMED:12580944] [PUBMED:12857995] [PUBMED:10234174] [PUBMED:18327664] [PUBMED:10525166] [PUBMED:18059289] [PUBMED:18775432] [PUBMED:14642303] [PUBMED:15361242] [PUBMED:16339966] [PUBMED:14987366] [PUBMED:15639739]
Ub-specific processing proteases [NCBI:1427862] [REACTOME:R-HSA-5689880] [PUBMED:16325574]
Viral carcinogenesis [NCBI:658418] [KEGG:hsa05203] [PUBMED:9990017] [PUBMED:15173177] [PUBMED:16036567] [PUBMED:16581947] [PUBMED:9060639] [PUBMED:17457345] [PUBMED:15956361] [PUBMED:21421561] [PUBMED:18391203] [PUBMED:21040832] [PUBMED:9837909] [PUBMED:17645777] [PUBMED:15967719] [PUBMED:12686421] [PUBMED:17049016] [PUBMED:21152115] [PUBMED:11160754] [PUBMED:21966251] [PUBMED:17979705] [PUBMED:8617242] [PUBMED:12925958] [PUBMED:10873631] [PUBMED:21250384] [PUBMED:15614436] [PUBMED:10354594] [PUBMED:20494113] [PUBMED:18702816] [PUBMED:9651361] [PUBMED:16459163] [PUBMED:11278402] [PUBMED:15510157] [PUBMED:19956178] [PUBMED:18251977] [PUBMED:11766888] [PUBMED:10824878] [PUBMED:21372216] [PUBMED:11244044] [PUBMED:17894800] [PUBMED:11905817] [PUBMED:21347341] [PUBMED:12186904] [PUBMED:9374493] [PUBMED:16352731] [PUBMED:12770701] [PUBMED:17384582] [PUBMED:14506283] [PUBMED:11091847] [PUBMED:17267064] [PUBMED:11886269] [PUBMED:21177815] [PUBMED:10400746] [PUBMED:19156753] [PUBMED:9882379] [PUBMED:14559998] [PUBMED:15767449] [PUBMED:22110506] [PUBMED:20534855] [PUBMED:15542638] [PUBMED:9343405] [PUBMED:10405893] [PUBMED:19400863] [PUBMED:9349482] [PUBMED:14747563] [PUBMED:21647825] [PUBMED:12970441] [PUBMED:11669605] [PUBMED:15795286] [PUBMED:21994562] [PUBMED:14530271] [PUBMED:9594662] [PUBMED:22566809] [PUBMED:19651473] [PUBMED:8756622] [PUBMED:15105524] [PUBMED:15452270] [PUBMED:18948197] [PUBMED:16760382] [PUBMED:10793105] [PUBMED:21084867] [PUBMED:16308315] [PUBMED:16155604] [PUBMED:16381817] [PUBMED:16828973] [PUBMED:15342967] [PUBMED:15692053] [PUBMED:10855768] [PUBMED:19078975] [PUBMED:12379483] [PUBMED:15310405] [PUBMED:8223437] [PUBMED:16939421] [PUBMED:12910250] [PUBMED:16039586] [PUBMED:18201576] [PUBMED:21102637] [PUBMED:21743832] [PUBMED:20592731] [PUBMED:10644344] [PUBMED:10074132] [PUBMED:19715458] [PUBMED:16155601] [PUBMED:11604508] [PUBMED:15919895] [PUBMED:11099494] [PUBMED:18385245] [PUBMED:19854353] [PUBMED:12101418]
ZBP1(DAI) mediated induction of type I IFNs [NCBI:1269269] [REACTOME:R-HSA-1606322] [PUBMED:18375758] [PUBMED:18941233] [PUBMED:11842111] [PUBMED:19590578] [PUBMED:17618271] [PUBMED:18771559] [PUBMED:19846511]
cAMP signaling pathway [NCBI:1017634] [KEGG:hsa04024] [PUBMED:10880354] [PUBMED:9204709] [PUBMED:21693691] [PUBMED:24062645] [PUBMED:24450633] [PUBMED:21346730] [PUBMED:24613710] [PUBMED:21744067] [PUBMED:22082266] [PUBMED:16460276] [PUBMED:18176800] [PUBMED:14715909] [PUBMED:7688165] [PUBMED:24281338] [PUBMED:11117527] [PUBMED:16765984] [PUBMED:18323530] [PUBMED:18064650] [PUBMED:21852968] [PUBMED:11493633] [PUBMED:21212391] [PUBMED:15142747] [PUBMED:17077866] [PUBMED:19460777] [PUBMED:19874988] [PUBMED:16571352] [PUBMED:22022314]
p75 NTR receptor-mediated signalling [NCBI:1269445] [REACTOME:R-HSA-193704] [PUBMED:16699811] [PUBMED:16939974] [PUBMED:12671646]
p75NTR signals via NF-kB [NCBI:1269452] [REACTOME:R-HSA-193639] [PUBMED:16997282]