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Genes
POLE2
Gene - POLE2
full name
DNA polymerase epsilon 2, accessory subunit
synonyms
DPE2, POLE2, ENSG00000100479
HGNC
HGNC:9178
Entrez Gene
Gene:5427
ENSEMBL
ENSG00000100479
location
chr: 14
start: 50110270
stop: 50155098
strand: -
transcripts
NM_001197330.1
NM_002692.3
NM_001197331.1
pathways
Activation of the pre-replicative complex
[NCBI:1269773]
[REACTOME:R-HSA-68962]
[PUBMED:10402192]
[PUBMED:11779870]
[PUBMED:10801458]
[PUBMED:12169736]
[PUBMED:11323433]
[PUBMED:9038340]
[PUBMED:9765232]
[PUBMED:9829972]
[PUBMED:10970868]
[PUBMED:9353276]
[PUBMED:7502077]
[PUBMED:11459976]
[PUBMED:11395502]
Base Excision Repair
[NCBI:1270351]
[REACTOME:R-HSA-73884]
[PUBMED:11937636]
[PUBMED:10583946]
Base excision repair
[NCBI:83043]
[KEGG:hsa03410]
[PUBMED:17893748]
[PUBMED:11436317]
[PUBMED:17337257]
[PUBMED:21665970]
Cell Cycle
[NCBI:1269741]
[REACTOME:R-HSA-1640170]
Cell Cycle, Mitotic
[NCBI:1269763]
[REACTOME:R-HSA-69278]
Chromosome Maintenance
[NCBI:1269853]
[REACTOME:R-HSA-73886]
DNA Damage Bypass
[NCBI:1270367]
[REACTOME:R-HSA-73893]
[PUBMED:21605556]
[PUBMED:10925197]
[PUBMED:11595180]
[PUBMED:12800216]
[PUBMED:19225445]
[PUBMED:25038291]
DNA Double-Strand Break Repair
[NCBI:1309095]
[REACTOME:R-HSA-5693532]
[PUBMED:12897142]
[PUBMED:20965415]
DNA Repair
[NCBI:1270350]
[REACTOME:R-HSA-73894]
[PUBMED:10583946]
[PUBMED:23175119]
DNA Replication
[NCBI:1269875]
[REACTOME:R-HSA-69306]
[PUBMED:11257218]
[PUBMED:12045100]
[PUBMED:1536007]
[PUBMED:10966477]
[PUBMED:1579437]
[PUBMED:8223461]
DNA Replication Pre-Initiation
[NCBI:1269832]
[REACTOME:R-HSA-69002]
DNA replication
[NCBI:83039]
[KEGG:hsa03030]
[PUBMED:9759502]
[PUBMED:8087839]
DNA replication initiation
[NCBI:1269780]
[REACTOME:R-HSA-68952]
[PUBMED:6693436]
[PUBMED:11395402]
Dual Incision in GG-NER
[NCBI:1309115]
[REACTOME:R-HSA-5696400]
[PUBMED:19279666]
Dual incision in TC-NER
[NCBI:1309119]
[REACTOME:R-HSA-6782135]
[PUBMED:19279666]
[PUBMED:23906714]
[PUBMED:8078911]
[PUBMED:16246722]
[PUBMED:19023283]
[PUBMED:11904382]
[PUBMED:24402227]
Extension of Telomeres
[NCBI:1269857]
[REACTOME:R-HSA-180786]
[PUBMED:15189140]
G1/S Transition
[NCBI:1269768]
[REACTOME:R-HSA-69206]
Gap-filling DNA repair synthesis and ligation in GG-NER
[NCBI:1309116]
[REACTOME:R-HSA-5696397]
[PUBMED:17643379]
[PUBMED:19279666]
[PUBMED:20227374]
Gap-filling DNA repair synthesis and ligation in TC-NER
[NCBI:1309120]
[REACTOME:R-HSA-6782210]
[PUBMED:20227374]
[PUBMED:19279666]
[PUBMED:17643379]
Global Genome Nucleotide Excision Repair (GG-NER)
[NCBI:1309112]
[REACTOME:R-HSA-5696399]
[PUBMED:24954209]
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)
[NCBI:1309100]
[REACTOME:R-HSA-5693567]
[PUBMED:20965415]
HDR through Homologous Recombination (HRR)
[NCBI:1309102]
[REACTOME:R-HSA-5685942]
[PUBMED:20965415]
HTLV-I infection
[NCBI:373901]
[KEGG:hsa05166]
[PUBMED:17446673]
[PUBMED:16436385]
[PUBMED:14686485]
[PUBMED:19861996]
[PUBMED:19092975]
[PUBMED:11325603]
[PUBMED:16155602]
[PUBMED:12910251]
[PUBMED:16155605]
[PUBMED:16036567]
[PUBMED:11244044]
[PUBMED:18702816]
[PUBMED:15569630]
[PUBMED:21114861]
[PUBMED:16155611]
[PUBMED:17384582]
[PUBMED:16155608]
[PUBMED:10602469]
[PUBMED:19014483]
[PUBMED:9325311]
Homology Directed Repair
[NCBI:1309099]
[REACTOME:R-HSA-5693538]
[PUBMED:11242102]
[PUBMED:20965415]
[PUBMED:11376695]
[PUBMED:12427531]
M/G1 Transition
[NCBI:1269831]
[REACTOME:R-HSA-68874]
Metabolic pathways
[NCBI:132956]
[KEGG:hsa01100]
Mitotic G1-G1/S phases
[NCBI:1269764]
[REACTOME:R-HSA-453279]
Nucleotide Excision Repair
[NCBI:1309111]
[REACTOME:R-HSA-5696398]
[PUBMED:11900249]
[PUBMED:23906714]
[PUBMED:14599765]
[PUBMED:10583946]
[PUBMED:24954209]
[PUBMED:19023283]
Nucleotide excision repair
[NCBI:83044]
[KEGG:hsa03420]
[PUBMED:11436323]
[PUBMED:18018633]
[PUBMED:11436316]
[PUBMED:17884153]
[PUBMED:11436314]
[PUBMED:17276014]
[PUBMED:16922398]
PCNA-Dependent Long Patch Base Excision Repair
[NCBI:1270366]
[REACTOME:R-HSA-5651801]
[PUBMED:9780000]
[PUBMED:11601988]
[PUBMED:9214649]
[PUBMED:12200445]
[PUBMED:10460157]
[PUBMED:10559261]
[PUBMED:11250913]
Purine metabolism
[NCBI:82944]
[KEGG:hsa00230]
[NCBI:1270134]
[REACTOME:R-HSA-73847]
[PUBMED:4620886]
[PUBMED:10986234]
[PUBMED:10601204]
Pyrimidine metabolism
[NCBI:82946]
[KEGG:hsa00240]
[NCBI:1270138]
[REACTOME:R-HSA-73848]
[PUBMED:16098809]
Recognition of DNA damage by PCNA-containing replication complex
[NCBI:1270368]
[REACTOME:R-HSA-110314]
[PUBMED:15916957]
[PUBMED:12226657]
Resolution of AP sites via the multiple-nucleotide patch replacement pathway
[NCBI:1270364]
[REACTOME:R-HSA-110373]
[PUBMED:10583946]
[PUBMED:9214649]
[PUBMED:10559261]
[PUBMED:10460157]
[PUBMED:11440997]
[PUBMED:11601988]
Resolution of Abasic Sites (AP sites)
[NCBI:1270359]
[REACTOME:R-HSA-73933]
[PUBMED:11601988]
[PUBMED:15260972]
[PUBMED:17395641]
[PUBMED:19329425]
[PUBMED:9804798]
[PUBMED:15556996]
[PUBMED:9214649]
[PUBMED:7608159]
[PUBMED:11440997]
[PUBMED:15871698]
[PUBMED:9207062]
[PUBMED:16982218]
[PUBMED:8978692]
S Phase
[NCBI:1269777]
[REACTOME:R-HSA-69242]
Synthesis of DNA
[NCBI:1269779]
[REACTOME:R-HSA-69239]
Telomere C-strand (Lagging Strand) Synthesis
[NCBI:1269859]
[REACTOME:R-HSA-174417]
[PUBMED:15189140]
Telomere C-strand synthesis initiation
[NCBI:1269860]
[REACTOME:R-HSA-174430]
[PUBMED:11327863]
[PUBMED:11395402]
[PUBMED:6693436]
Telomere Maintenance
[NCBI:1269856]
[REACTOME:R-HSA-157579]
[PUBMED:16166375]
[PUBMED:4507727]
[PUBMED:14685173]
[PUBMED:642006]
[PUBMED:15189140]
[PUBMED:3907856]
[PUBMED:2463488]
[PUBMED:4754905]
Termination of translesion DNA synthesis
[NCBI:1270374]
[REACTOME:R-HSA-5656169]
[PUBMED:24768535]
[PUBMED:23000965]
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
[NCBI:1309117]
[REACTOME:R-HSA-6781827]
[PUBMED:24954209]
[PUBMED:11823795]
[PUBMED:19023283]
[PUBMED:23906714]
[PUBMED:3466163]
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template
[NCBI:1270369]
[REACTOME:R-HSA-110313]
[PUBMED:10583946]
[PUBMED:10856253]
[PUBMED:24716551]