Logo
full name
DNA polymerase epsilon 2, accessory subunit

synonyms
DPE2, POLE2, ENSG00000100479

HGNC
HGNC:9178

Entrez Gene
Gene:5427

ENSEMBL
ENSG00000100479

location
chr: 14
start: 50110270
stop: 50155098
strand: -

transcripts
NM_001197330.1
NM_002692.3
NM_001197331.1

pathways
Activation of the pre-replicative complex [NCBI:1269773] [REACTOME:R-HSA-68962] [PUBMED:10402192] [PUBMED:11779870] [PUBMED:10801458] [PUBMED:12169736] [PUBMED:11323433] [PUBMED:9038340] [PUBMED:9765232] [PUBMED:9829972] [PUBMED:10970868] [PUBMED:9353276] [PUBMED:7502077] [PUBMED:11459976] [PUBMED:11395502]
Base Excision Repair [NCBI:1270351] [REACTOME:R-HSA-73884] [PUBMED:11937636] [PUBMED:10583946]
Base excision repair [NCBI:83043] [KEGG:hsa03410] [PUBMED:17893748] [PUBMED:11436317] [PUBMED:17337257] [PUBMED:21665970]
Cell Cycle [NCBI:1269741] [REACTOME:R-HSA-1640170]
Cell Cycle, Mitotic [NCBI:1269763] [REACTOME:R-HSA-69278]
Chromosome Maintenance [NCBI:1269853] [REACTOME:R-HSA-73886]
DNA Damage Bypass [NCBI:1270367] [REACTOME:R-HSA-73893] [PUBMED:21605556] [PUBMED:10925197] [PUBMED:11595180] [PUBMED:12800216] [PUBMED:19225445] [PUBMED:25038291]
DNA Double-Strand Break Repair [NCBI:1309095] [REACTOME:R-HSA-5693532] [PUBMED:12897142] [PUBMED:20965415]
DNA Repair [NCBI:1270350] [REACTOME:R-HSA-73894] [PUBMED:10583946] [PUBMED:23175119]
DNA Replication [NCBI:1269875] [REACTOME:R-HSA-69306] [PUBMED:11257218] [PUBMED:12045100] [PUBMED:1536007] [PUBMED:10966477] [PUBMED:1579437] [PUBMED:8223461]
DNA Replication Pre-Initiation [NCBI:1269832] [REACTOME:R-HSA-69002]
DNA replication [NCBI:83039] [KEGG:hsa03030] [PUBMED:9759502] [PUBMED:8087839]
DNA replication initiation [NCBI:1269780] [REACTOME:R-HSA-68952] [PUBMED:6693436] [PUBMED:11395402]
Dual Incision in GG-NER [NCBI:1309115] [REACTOME:R-HSA-5696400] [PUBMED:19279666]
Dual incision in TC-NER [NCBI:1309119] [REACTOME:R-HSA-6782135] [PUBMED:19279666] [PUBMED:23906714] [PUBMED:8078911] [PUBMED:16246722] [PUBMED:19023283] [PUBMED:11904382] [PUBMED:24402227]
Extension of Telomeres [NCBI:1269857] [REACTOME:R-HSA-180786] [PUBMED:15189140]
G1/S Transition [NCBI:1269768] [REACTOME:R-HSA-69206]
Gap-filling DNA repair synthesis and ligation in GG-NER [NCBI:1309116] [REACTOME:R-HSA-5696397] [PUBMED:17643379] [PUBMED:19279666] [PUBMED:20227374]
Gap-filling DNA repair synthesis and ligation in TC-NER [NCBI:1309120] [REACTOME:R-HSA-6782210] [PUBMED:20227374] [PUBMED:19279666] [PUBMED:17643379]
Global Genome Nucleotide Excision Repair (GG-NER) [NCBI:1309112] [REACTOME:R-HSA-5696399] [PUBMED:24954209]
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA) [NCBI:1309100] [REACTOME:R-HSA-5693567] [PUBMED:20965415]
HDR through Homologous Recombination (HRR) [NCBI:1309102] [REACTOME:R-HSA-5685942] [PUBMED:20965415]
HTLV-I infection [NCBI:373901] [KEGG:hsa05166] [PUBMED:17446673] [PUBMED:16436385] [PUBMED:14686485] [PUBMED:19861996] [PUBMED:19092975] [PUBMED:11325603] [PUBMED:16155602] [PUBMED:12910251] [PUBMED:16155605] [PUBMED:16036567] [PUBMED:11244044] [PUBMED:18702816] [PUBMED:15569630] [PUBMED:21114861] [PUBMED:16155611] [PUBMED:17384582] [PUBMED:16155608] [PUBMED:10602469] [PUBMED:19014483] [PUBMED:9325311]
Homology Directed Repair [NCBI:1309099] [REACTOME:R-HSA-5693538] [PUBMED:11242102] [PUBMED:20965415] [PUBMED:11376695] [PUBMED:12427531]
M/G1 Transition [NCBI:1269831] [REACTOME:R-HSA-68874]
Metabolic pathways [NCBI:132956] [KEGG:hsa01100]
Mitotic G1-G1/S phases [NCBI:1269764] [REACTOME:R-HSA-453279]
Nucleotide Excision Repair [NCBI:1309111] [REACTOME:R-HSA-5696398] [PUBMED:11900249] [PUBMED:23906714] [PUBMED:14599765] [PUBMED:10583946] [PUBMED:24954209] [PUBMED:19023283]
Nucleotide excision repair [NCBI:83044] [KEGG:hsa03420] [PUBMED:11436323] [PUBMED:18018633] [PUBMED:11436316] [PUBMED:17884153] [PUBMED:11436314] [PUBMED:17276014] [PUBMED:16922398]
PCNA-Dependent Long Patch Base Excision Repair [NCBI:1270366] [REACTOME:R-HSA-5651801] [PUBMED:9780000] [PUBMED:11601988] [PUBMED:9214649] [PUBMED:12200445] [PUBMED:10460157] [PUBMED:10559261] [PUBMED:11250913]
Purine metabolism [NCBI:82944] [KEGG:hsa00230] [NCBI:1270134] [REACTOME:R-HSA-73847] [PUBMED:4620886] [PUBMED:10986234] [PUBMED:10601204]
Pyrimidine metabolism [NCBI:82946] [KEGG:hsa00240] [NCBI:1270138] [REACTOME:R-HSA-73848] [PUBMED:16098809]
Recognition of DNA damage by PCNA-containing replication complex [NCBI:1270368] [REACTOME:R-HSA-110314] [PUBMED:15916957] [PUBMED:12226657]
Resolution of AP sites via the multiple-nucleotide patch replacement pathway [NCBI:1270364] [REACTOME:R-HSA-110373] [PUBMED:10583946] [PUBMED:9214649] [PUBMED:10559261] [PUBMED:10460157] [PUBMED:11440997] [PUBMED:11601988]
Resolution of Abasic Sites (AP sites) [NCBI:1270359] [REACTOME:R-HSA-73933] [PUBMED:11601988] [PUBMED:15260972] [PUBMED:17395641] [PUBMED:19329425] [PUBMED:9804798] [PUBMED:15556996] [PUBMED:9214649] [PUBMED:7608159] [PUBMED:11440997] [PUBMED:15871698] [PUBMED:9207062] [PUBMED:16982218] [PUBMED:8978692]
S Phase [NCBI:1269777] [REACTOME:R-HSA-69242]
Synthesis of DNA [NCBI:1269779] [REACTOME:R-HSA-69239]
Telomere C-strand (Lagging Strand) Synthesis [NCBI:1269859] [REACTOME:R-HSA-174417] [PUBMED:15189140]
Telomere C-strand synthesis initiation [NCBI:1269860] [REACTOME:R-HSA-174430] [PUBMED:11327863] [PUBMED:11395402] [PUBMED:6693436]
Telomere Maintenance [NCBI:1269856] [REACTOME:R-HSA-157579] [PUBMED:16166375] [PUBMED:4507727] [PUBMED:14685173] [PUBMED:642006] [PUBMED:15189140] [PUBMED:3907856] [PUBMED:2463488] [PUBMED:4754905]
Termination of translesion DNA synthesis [NCBI:1270374] [REACTOME:R-HSA-5656169] [PUBMED:24768535] [PUBMED:23000965]
Transcription-Coupled Nucleotide Excision Repair (TC-NER) [NCBI:1309117] [REACTOME:R-HSA-6781827] [PUBMED:24954209] [PUBMED:11823795] [PUBMED:19023283] [PUBMED:23906714] [PUBMED:3466163]
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template [NCBI:1270369] [REACTOME:R-HSA-110313] [PUBMED:10583946] [PUBMED:10856253] [PUBMED:24716551]