Logo
full name
protein phosphatase, Mg2+/Mn2+ dependent 1A

synonyms
PP2C-ALPHA, PP2CA, PP2Calpha, PPM1A, ENSG00000100614

HGNC
HGNC:9275

Entrez Gene
Gene:5494

ENSEMBL
ENSG00000100614

location
chr: 14
start: 60712470
stop: 60765805
strand: +

transcripts
NM_177952.2
NM_021003.4
NM_177951.2

pathways
BMP receptor signaling [NCBI:137948] [Pathway Interaction Database:bmppathway] [PUBMED:9136927] [PUBMED:12857866] [PUBMED:11158580] [PUBMED:10748465] [PUBMED:11401399] [PUBMED:9442019] [PUBMED:10814522] [PUBMED:8752214] [PUBMED:9660951] [PUBMED:17085434] [PUBMED:11714695] [PUBMED:7644468] [PUBMED:15671031] [PUBMED:8065329] [PUBMED:16604073] [PUBMED:8006002] [PUBMED:9436979] [PUBMED:9689081] [PUBMED:9335505] [PUBMED:17289590] [PUBMED:8893010] [PUBMED:16931515] [PUBMED:10748100] [PUBMED:15020244] [PUBMED:11121043] [PUBMED:15975920] [PUBMED:7937936] [PUBMED:11016919] [PUBMED:8752213] [PUBMED:7673243] [PUBMED:10519551] [PUBMED:8662721] [PUBMED:9878061] [PUBMED:17356069] [PUBMED:7791754] [PUBMED:8653785] [PUBMED:10504300] [PUBMED:10458166]
Downregulation of SMAD2/3:SMAD4 transcriptional activity [NCBI:1269529] [REACTOME:R-HSA-2173795] [PUBMED:19917253] [PUBMED:11389444] [PUBMED:10535941] [PUBMED:10199400] [PUBMED:16751101] [PUBMED:17591695] [PUBMED:10485843] [PUBMED:21095583] [PUBMED:11427533] [PUBMED:19135894] [PUBMED:10531062] [PUBMED:22045334] [PUBMED:10549282]
Energy dependent regulation of mTOR by LKB1-AMPK [NCBI:1269439] [REACTOME:R-HSA-380972] [PUBMED:17613433] [PUBMED:17712357] [PUBMED:17010524]
Gene Expression [NCBI:1269649] [REACTOME:R-HSA-74160]
Generic Transcription Pathway [NCBI:1269650] [REACTOME:R-HSA-212436] [PUBMED:15175151] [PUBMED:14744435] [PUBMED:15680972] [PUBMED:11395415] [PUBMED:15896744] [PUBMED:10235266] [PUBMED:14986688] [PUBMED:12023297] [PUBMED:15680973] [PUBMED:16751179] [PUBMED:11861166] [PUBMED:16429119] [PUBMED:16719718] [PUBMED:16921404] [PUBMED:15690163]
IGF1R signaling cascade [NCBI:1269618] [REACTOME:R-HSA-2428924] [PUBMED:17598937] [PUBMED:20975071] [PUBMED:22649417] [PUBMED:21042815] [PUBMED:18927274] [PUBMED:20098959]
IRS-mediated signalling [NCBI:1269431] [REACTOME:R-HSA-112399]
IRS-related events triggered by IGF1R [NCBI:1269620] [REACTOME:R-HSA-2428928] [PUBMED:17598937] [PUBMED:20975071] [PUBMED:22649417] [PUBMED:18927274] [PUBMED:21042815] [PUBMED:20098959]
Insulin receptor signalling cascade [NCBI:1269429] [REACTOME:R-HSA-74751] [PUBMED:9677303] [PUBMED:11282018]
MAPK signaling pathway [NCBI:83048] [KEGG:hsa04010] [PUBMED:11749383] [PUBMED:12566928] [PUBMED:12849693] [PUBMED:12676795] [PUBMED:12947395] [PUBMED:14597384] [PUBMED:11369511] [PUBMED:12191611] [PUBMED:12390245]
PI3K Cascade [NCBI:1269432] [REACTOME:R-HSA-109704]
PKB-mediated events [NCBI:1269434] [REACTOME:R-HSA-109703]
Regulation of cytoplasmic and nuclear SMAD2/3 signaling [NCBI:138015] [Pathway Interaction Database:smad2_3pathway] [PUBMED:8893010] [PUBMED:12740389] [PUBMED:12193595] [PUBMED:11294908] [PUBMED:10085121] [PUBMED:9620846] [PUBMED:12592392] [PUBMED:14750902] [PUBMED:12917407] [PUBMED:12374795] [PUBMED:16751101] [PUBMED:9346908] [PUBMED:10197981] [PUBMED:12621041] [PUBMED:9214508] [PUBMED:11278302] [PUBMED:17035229] [PUBMED:12191473]
Signal Transduction [NCBI:1269379] [REACTOME:R-HSA-162582] [PUBMED:17604717] [PUBMED:19648010] [PUBMED:16260143] [PUBMED:11742412] [PUBMED:19536106] [PUBMED:15863030] [PUBMED:19379690] [PUBMED:19458711] [PUBMED:19935667] [PUBMED:21252999] [PUBMED:15520807] [PUBMED:17496910] [PUBMED:15450248] [PUBMED:18043707] [PUBMED:16939974] [PUBMED:19762341] [PUBMED:18483217] [PUBMED:17084981] [PUBMED:21781017] [PUBMED:19619488]
Signaling by Insulin receptor [NCBI:1269428] [REACTOME:R-HSA-74752] [PUBMED:8276779]
Signaling by TGF-beta Receptor Complex [NCBI:1269523] [REACTOME:R-HSA-170834] [PUBMED:19648010]
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) [NCBI:1269617] [REACTOME:R-HSA-2404192] [PUBMED:21042815] [PUBMED:18927274] [PUBMED:20098959] [PUBMED:17598937] [PUBMED:20975071] [PUBMED:22044904] [PUBMED:22649417]
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer [NCBI:1269527] [REACTOME:R-HSA-2173793] [PUBMED:12150994] [PUBMED:16751101] [PUBMED:10199400] [PUBMED:18568018] [PUBMED:19135894] [PUBMED:10531062]
mTOR signalling [NCBI:1269436] [REACTOME:R-HSA-165159] [PUBMED:21157483]