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Genes
EIF2S1
Gene - EIF2S1
full name
eukaryotic translation initiation factor 2 subunit alpha
synonyms
EIF-2, EIF-2A, EIF-2alpha, EIF2, EIF2A, EIF2S1, ENSG00000134001
HGNC
HGNC:3265
Entrez Gene
Gene:1965
ENSEMBL
ENSG00000134001
location
chr: 14
start: 67827034
stop: 67853233
strand: +
transcripts
NM_004094.4
pathways
ABC-family proteins mediated transport
[NCBI:1269904]
[REACTOME:R-HSA-382556]
[PUBMED:11435397]
[PUBMED:12045106]
[PUBMED:19234479]
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
[NCBI:1268683]
[REACTOME:R-HSA-72662]
[PUBMED:9732867]
[PUBMED:592399]
[PUBMED:641056]
[PUBMED:6853548]
Apoptosis
[NCBI:83060]
[KEGG:hsa04210]
[NCBI:1270262]
[REACTOME:R-HSA-109581]
[PUBMED:12189384]
[PUBMED:20533903]
[PUBMED:18208375]
[PUBMED:22429822]
[PUBMED:15218528]
[PUBMED:24769728]
[PUBMED:18023214]
[PUBMED:25526085]
[PUBMED:23070002]
[PUBMED:15654015]
[PUBMED:15601572]
[PUBMED:14561771]
[PUBMED:24278747]
[PUBMED:21914490]
[PUBMED:22465226]
[PUBMED:21145844]
[PUBMED:12838338]
[PUBMED:18238895]
[PUBMED:12949498]
[PUBMED:18304445]
[PUBMED:14737178]
[PUBMED:26231733]
[PUBMED:9916983]
[PUBMED:14634621]
[PUBMED:19770840]
[PUBMED:22075987]
[PUBMED:4561027]
[PUBMED:20075940]
[PUBMED:9894605]
[PUBMED:26615431]
[PUBMED:12505355]
[PUBMED:11520933]
[PUBMED:19148180]
[PUBMED:16397578]
[PUBMED:15719025]
[PUBMED:15322527]
[PUBMED:15725726]
[PUBMED:12209154]
[PUBMED:23803157]
Autophagy - animal
[NCBI:83058]
[KEGG:hsa04140]
[PUBMED:16200202]
[PUBMED:15325588]
[PUBMED:24343578]
[PUBMED:15978794]
[PUBMED:19802558]
[PUBMED:16099218]
[PUBMED:11099404]
[PUBMED:19653858]
[PUBMED:15325584]
[PUBMED:20034776]
[PUBMED:15928708]
[PUBMED:21801009]
[PUBMED:25948417]
[PUBMED:16125113]
[PUBMED:21187343]
Cap-dependent Translation Initiation
[NCBI:1268680]
[REACTOME:R-HSA-72737]
Eukaryotic Translation Initiation
[NCBI:1268679]
[REACTOME:R-HSA-72613]
[PUBMED:20444697]
Formation of the ternary complex, and subsequently, the 43S complex
[NCBI:1268682]
[REACTOME:R-HSA-72695]
[PUBMED:641056]
[PUBMED:1104615]
[PUBMED:592399]
[PUBMED:429297]
GTP hydrolysis and joining of the 60S ribosomal subunit
[NCBI:1268686]
[REACTOME:R-HSA-72706]
[PUBMED:11018020]
[PUBMED:1095581]
[PUBMED:429297]
[PUBMED:641056]
[PUBMED:1856230]
[PUBMED:592398]
[PUBMED:10659855]
[PUBMED:592399]
Gene Expression
[NCBI:1269649]
[REACTOME:R-HSA-74160]
Hepatitis C
[NCBI:173973]
[KEGG:hsa05160]
[PUBMED:19708811]
[PUBMED:16314558]
[PUBMED:17467654]
[PUBMED:19515018]
[PUBMED:18514579]
[PUBMED:16107833]
[PUBMED:19074178]
[PUBMED:12691459]
[PUBMED:15302943]
[PUBMED:20537953]
[PUBMED:11991644]
[PUBMED:19148799]
[PUBMED:19187070]
[PUBMED:12655344]
Herpes simplex infection
[NCBI:377873]
[KEGG:hsa05168]
[PUBMED:12224518]
[PUBMED:17913820]
[PUBMED:12844494]
[PUBMED:10998601]
[PUBMED:15163721]
[PUBMED:19694546]
[PUBMED:16297150]
[PUBMED:14747533]
[PUBMED:12826401]
[PUBMED:14963113]
[PUBMED:15056211]
[PUBMED:12797447]
[PUBMED:21107701]
[PUBMED:10918307]
[PUBMED:10696424]
[PUBMED:16076403]
[PUBMED:10364308]
[PUBMED:17222692]
[PUBMED:9621021]
[PUBMED:12224508]
[PUBMED:19879619]
[PUBMED:11070032]
[PUBMED:9499021]
[PUBMED:18596690]
[PUBMED:12525427]
[PUBMED:12224517]
[PUBMED:10196275]
[PUBMED:15047834]
[PUBMED:18508584]
[PUBMED:20036979]
Influenza A
[NCBI:217173]
[KEGG:hsa05164]
[PUBMED:17267598]
[PUBMED:18049471]
[PUBMED:16882036]
[PUBMED:11907320]
[PUBMED:17944269]
[PUBMED:20629046]
[PUBMED:17072332]
[PUBMED:18588994]
[PUBMED:19864182]
[PUBMED:19290913]
[PUBMED:19420020]
[PUBMED:17213831]
[PUBMED:9060654]
[PUBMED:19481124]
[PUBMED:16494716]
[PUBMED:21147034]
[PUBMED:18980544]
[PUBMED:20020828]
[PUBMED:15502848]
[PUBMED:19782761]
L13a-mediated translational silencing of Ceruloplasmin expression
[NCBI:1268688]
[REACTOME:R-HSA-156827]
[PUBMED:14567916]
Measles
[NCBI:213306]
[KEGG:hsa05162]
[PUBMED:16237742]
[PUBMED:12804771]
[PUBMED:19198562]
[PUBMED:20376484]
[PUBMED:11385511]
[PUBMED:16963735]
[PUBMED:19198566]
[PUBMED:18922877]
[PUBMED:19203114]
[PUBMED:12620806]
[PUBMED:16690907]
[PUBMED:17720800]
[PUBMED:20636817]
[PUBMED:12410527]
[PUBMED:11582511]
[PUBMED:19203109]
[PUBMED:19203113]
[PUBMED:14585342]
[PUBMED:12805463]
Metabolism of proteins
[NCBI:1268677]
[REACTOME:R-HSA-392499]
Non-alcoholic fatty liver disease (NAFLD)
[NCBI:862188]
[KEGG:hsa04932]
[PUBMED:21038418]
[PUBMED:17498512]
[PUBMED:19352614]
[PUBMED:23299992]
[PUBMED:22570745]
[PUBMED:9285483]
[PUBMED:12891546]
[PUBMED:18061659]
[PUBMED:22705006]
[PUBMED:16364488]
[PUBMED:18242193]
[PUBMED:16374858]
[PUBMED:22940046]
[PUBMED:20619513]
[PUBMED:20303879]
[PUBMED:14685853]
[PUBMED:16406828]
[PUBMED:23545492]
[PUBMED:21145844]
PERK regulates gene expression
[NCBI:1268761]
[REACTOME:R-HSA-381042]
[PUBMED:18048764]
[PUBMED:17956313]
[PUBMED:18038217]
[PUBMED:18436705]
Protein processing in endoplasmic reticulum
[NCBI:167325]
[KEGG:hsa04141]
[PUBMED:20347046]
[PUBMED:18023214]
[PUBMED:20219571]
[PUBMED:19491040]
[PUBMED:20112977]
RNA transport
[NCBI:177876]
[KEGG:hsa03013]
[PUBMED:10872469]
[PUBMED:17401408]
[PUBMED:20733056]
[PUBMED:11018020]
[PUBMED:15519698]
[PUBMED:16314458]
[PUBMED:15901496]
[PUBMED:9548260]
[PUBMED:18313922]
Recycling of eIF2:GDP
[NCBI:1268687]
[REACTOME:R-HSA-72731]
[PUBMED:7063012]
Ribosomal scanning and start codon recognition
[NCBI:1268685]
[REACTOME:R-HSA-72702]
[PUBMED:9732867]
[PUBMED:7000367]
[PUBMED:592399]
[PUBMED:641056]
Translation
[NCBI:1268678]
[REACTOME:R-HSA-72766]
Translation initiation complex formation
[NCBI:1268684]
[REACTOME:R-HSA-72649]
[PUBMED:6853548]
[PUBMED:641056]
[PUBMED:9732867]
[PUBMED:592399]
Transmembrane transport of small molecules
[NCBI:1269903]
[REACTOME:R-HSA-382551]
Unfolded Protein Response (UPR)
[NCBI:1268756]
[REACTOME:R-HSA-381119]
[PUBMED:18436705]
[PUBMED:18038217]
[PUBMED:27067637]
[PUBMED:16365312]
[PUBMED:18048764]
[PUBMED:15952902]
Validated targets of C-MYC transcriptional activation
[NCBI:169351]
[Pathway Interaction Database:myc_activpathway]
[PUBMED:18987359]
[PUBMED:16537449]
[PUBMED:9924025]
[PUBMED:17643117]
[PUBMED:8356088]
[PUBMED:10688915]
[PUBMED:1562593]
[PUBMED:19020761]
[PUBMED:10823814]
[PUBMED:12637527]
[PUBMED:9178906]
[PUBMED:17967894]
[PUBMED:15723053]
[PUBMED:16508012]
[PUBMED:8700224]
[PUBMED:12091391]
[PUBMED:20173740]
[PUBMED:11522645]
[PUBMED:15774466]
[PUBMED:12776737]
[PUBMED:12011429]
[PUBMED:12138190]
[PUBMED:10022128]
[PUBMED:11511539]
[PUBMED:12177005]
[PUBMED:17599065]
[PUBMED:6438521]
[PUBMED:19745813]
[PUBMED:8196628]
[PUBMED:10891489]
[PUBMED:8934531]
[PUBMED:15723054]
[PUBMED:9192621]
[PUBMED:18042711]
[PUBMED:10779353]
[PUBMED:1989881]
[PUBMED:8861962]
[PUBMED:12529648]
[PUBMED:16269333]
[PUBMED:16172399]
[PUBMED:8494784]
[PUBMED:15282543]
[PUBMED:8297793]
[PUBMED:12776177]
[PUBMED:9811896]
[PUBMED:11103792]
[PUBMED:17170079]
[PUBMED:18593934]
[PUBMED:11673469]
[PUBMED:18408012]
[PUBMED:1340466]
[PUBMED:17088530]
[PUBMED:8327497]
[PUBMED:16423995]
[PUBMED:12816956]
[PUBMED:11598121]
[PUBMED:14724288]
[PUBMED:17848523]
[PUBMED:10508165]
[PUBMED:12695333]
[PUBMED:17822678]
[PUBMED:10606642]
[PUBMED:9869632]
[PUBMED:9212167]
[PUBMED:19211792]
[PUBMED:16287840]
[PUBMED:18978814]
[PUBMED:11511535]
[PUBMED:15944709]
[PUBMED:11604407]
[PUBMED:11909865]