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Genes
NUMB
Gene - NUMB
full name
NUMB, endocytic adaptor protein
synonyms
C14orf41, c14_5527, S171, NUMB, ENSG00000133961
HGNC
HGNC:8060
Entrez Gene
Gene:8650
ENSEMBL
ENSG00000133961
location
chr: 14
start: 73741858
stop: 73925288
strand: -
transcripts
NM_001005745.1
NM_003744.5
NM_001005744.1
NM_001005743.1
pathways
Activated NOTCH1 Transmits Signal to the Nucleus
[NCBI:1269536]
[REACTOME:R-HSA-2122948]
[PUBMED:15574878]
[PUBMED:19726682]
[PUBMED:18628966]
[PUBMED:9620803]
[PUBMED:12530964]
[PUBMED:15652348]
[PUBMED:18237417]
[PUBMED:10882063]
[PUBMED:11006133]
[PUBMED:18077452]
[PUBMED:9462510]
[PUBMED:14567914]
[PUBMED:17003037]
[PUBMED:19524514]
[PUBMED:17028573]
[PUBMED:10206645]
[PUBMED:20418862]
[PUBMED:15965470]
[PUBMED:16284625]
[PUBMED:11226752]
[PUBMED:19567869]
[PUBMED:12354787]
[PUBMED:11740940]
[PUBMED:9590294]
[PUBMED:15824097]
[PUBMED:9244301]
[PUBMED:18043734]
[PUBMED:9315665]
[PUBMED:10879540]
[PUBMED:9819428]
[PUBMED:8313469]
[PUBMED:18296446]
Axon guidance
[NCBI:83065]
[KEGG:hsa04360]
[NCBI:1270303]
[REACTOME:R-HSA-422475]
[PUBMED:14682358]
[PUBMED:15084255]
[PUBMED:11687826]
[PUBMED:15818466]
[PUBMED:15363605]
[PUBMED:12471249]
[PUBMED:15630019]
[PUBMED:11891122]
[PUBMED:15960985]
[PUBMED:12677003]
Degradation of GLI1 by the proteasome
[NCBI:1269639]
[REACTOME:R-HSA-5610780]
[PUBMED:17283082]
[PUBMED:10075717]
[PUBMED:10725236]
[PUBMED:21921029]
[PUBMED:12361967]
Developmental Biology
[NCBI:1270302]
[REACTOME:R-HSA-1266738]
Hedgehog 'off' state
[NCBI:1269636]
[REACTOME:R-HSA-5610787]
[PUBMED:21801010]
[PUBMED:20395968]
[PUBMED:23719536]
[PUBMED:21502959]
Hedgehog 'on' state
[NCBI:1269640]
[REACTOME:R-HSA-5632684]
[PUBMED:23719536]
[PUBMED:21502959]
[PUBMED:21801010]
[PUBMED:20395968]
L1CAM interactions
[NCBI:1270323]
[REACTOME:R-HSA-373760]
[PUBMED:9211984]
[PUBMED:18760361]
[PUBMED:14709786]
[PUBMED:17189949]
[PUBMED:19356150]
Notch signaling pathway
[NCBI:83062]
[KEGG:hsa04330]
[NCBI:169345]
[Pathway Interaction Database:notch_pathway]
[PUBMED:11459941]
[PUBMED:12682059]
[PUBMED:11825871]
[PUBMED:17658278]
[PUBMED:15998794]
[PUBMED:11101851]
[PUBMED:19686683]
[PUBMED:18490439]
[PUBMED:11150244]
[PUBMED:9694793]
[PUBMED:10206645]
[PUBMED:19704010]
[PUBMED:16137758]
[PUBMED:15288258]
[PUBMED:17392792]
[PUBMED:8749394]
[PUBMED:15965470]
[PUBMED:14566063]
[PUBMED:19567869]
[PUBMED:11585921]
[PUBMED:18676613]
[PUBMED:12913000]
[PUBMED:10593990]
[PUBMED:15274632]
[PUBMED:11777909]
[PUBMED:12015972]
[PUBMED:10028969]
[PUBMED:18043734]
[PUBMED:17658279]
[PUBMED:17575125]
[PUBMED:10958687]
[PUBMED:15300010]
[PUBMED:10882062]
[PUBMED:12374742]
[PUBMED:11782429]
[PUBMED:9653148]
[PUBMED:9315665]
[PUBMED:8643690]
[PUBMED:17114293]
[PUBMED:10837024]
[PUBMED:15067010]
[PUBMED:17296795]
[PUBMED:10940313]
[PUBMED:18628966]
[PUBMED:12826675]
[PUBMED:12681948]
[PUBMED:16492672]
[PUBMED:12551931]
[PUBMED:15082708]
[PUBMED:12464310]
[PUBMED:12794186]
[PUBMED:16107360]
[PUBMED:19726682]
[PUBMED:11486031]
[PUBMED:16287852]
[PUBMED:12297508]
[PUBMED:16061358]
[PUBMED:17107962]
[PUBMED:9244302]
[PUBMED:11425854]
[PUBMED:9620803]
[PUBMED:15272268]
[PUBMED:18417156]
[PUBMED:16000382]
[PUBMED:11896183]
[PUBMED:11604511]
[PUBMED:16847353]
[PUBMED:11432830]
[PUBMED:15652348]
[PUBMED:12417415]
[PUBMED:14567914]
[PUBMED:11006133]
[PUBMED:18077452]
[PUBMED:16144902]
[PUBMED:15288257]
[PUBMED:15585829]
[PUBMED:12370315]
[PUBMED:15288260]
[PUBMED:17434929]
[PUBMED:12814948]
[PUBMED:10882063]
[PUBMED:11518718]
Recycling pathway of L1
[NCBI:1270324]
[REACTOME:R-HSA-437239]
[PUBMED:10804209]
[PUBMED:11717353]
[PUBMED:14709786]
Signal Transduction
[NCBI:1269379]
[REACTOME:R-HSA-162582]
[PUBMED:17604717]
[PUBMED:19648010]
[PUBMED:16260143]
[PUBMED:11742412]
[PUBMED:19536106]
[PUBMED:15863030]
[PUBMED:19379690]
[PUBMED:19458711]
[PUBMED:19935667]
[PUBMED:21252999]
[PUBMED:15520807]
[PUBMED:17496910]
[PUBMED:15450248]
[PUBMED:18043707]
[PUBMED:16939974]
[PUBMED:19762341]
[PUBMED:18483217]
[PUBMED:17084981]
[PUBMED:21781017]
[PUBMED:19619488]
Signaling by Hedgehog
[NCBI:1269633]
[REACTOME:R-HSA-5358351]
[PUBMED:19081070]
[PUBMED:21801010]
[PUBMED:15549094]
[PUBMED:23719536]
Signaling by NOTCH
[NCBI:1269530]
[REACTOME:R-HSA-157118]
Signaling by NOTCH1
[NCBI:1269535]
[REACTOME:R-HSA-1980143]
[PUBMED:20972443]
[PUBMED:8649374]
[PUBMED:11740940]
[PUBMED:15965470]
[PUBMED:16284625]
[PUBMED:9694793]
[PUBMED:19567869]
[PUBMED:12354787]
[PUBMED:11585921]
[PUBMED:20418862]
[PUBMED:11226752]
[PUBMED:9590294]
[PUBMED:9315665]
[PUBMED:17114293]
[PUBMED:18094723]
[PUBMED:10964718]
[PUBMED:10879540]
[PUBMED:8001118]
[PUBMED:12050117]
[PUBMED:18043734]
[PUBMED:9819428]
[PUBMED:15824097]
[PUBMED:9244301]
[PUBMED:16256737]
[PUBMED:8687460]
[PUBMED:19726682]
[PUBMED:8313469]
[PUBMED:15574878]
[PUBMED:18296446]
[PUBMED:16530044]
[PUBMED:9620803]
[PUBMED:18237417]
[PUBMED:7566092]
[PUBMED:18628966]
[PUBMED:12391150]
[PUBMED:12530964]
[PUBMED:11006133]
[PUBMED:18374649]
[PUBMED:15107403]
[PUBMED:18077452]
[PUBMED:15652348]
[PUBMED:15546612]
[PUBMED:10882063]
[PUBMED:14980219]
[PUBMED:10713164]
[PUBMED:9462510]
[PUBMED:11461910]
[PUBMED:14567914]
[PUBMED:17003037]
[PUBMED:17028573]
[PUBMED:11044625]
[PUBMED:10206645]
[PUBMED:19524514]
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
[NCBI:137930]
[Pathway Interaction Database:met_pathway]
[PUBMED:10793146]
[PUBMED:8906793]
[PUBMED:11929826]
[PUBMED:10022866]
[PUBMED:11532961]
[PUBMED:12475979]
[PUBMED:1718989]
[PUBMED:1846706]
[PUBMED:10970810]
[PUBMED:10516287]
[PUBMED:12138161]
[PUBMED:11046147]
[PUBMED:18073207]
[PUBMED:12951049]
[PUBMED:15494312]
[PUBMED:9001234]
[PUBMED:11352916]
[PUBMED:11896055]
[PUBMED:9440692]
[PUBMED:8607979]
[PUBMED:12244132]
[PUBMED:11162460]
[PUBMED:11809798]
[PUBMED:9693375]
[PUBMED:14636584]
[PUBMED:17297451]
[PUBMED:17682062]
[PUBMED:19628037]
[PUBMED:11069926]
[PUBMED:18819921]
[PUBMED:16423831]
[PUBMED:10558875]
[PUBMED:16858414]
[PUBMED:10995442]
[PUBMED:20332103]
[PUBMED:11146548]
[PUBMED:18346875]
[PUBMED:17894413]
[PUBMED:9252406]
[PUBMED:17635922]
[PUBMED:11134526]
[PUBMED:2005882]
[PUBMED:19609305]
[PUBMED:8380735]
[PUBMED:16537482]
[PUBMED:10618718]
[PUBMED:9591773]
[PUBMED:12894582]
[PUBMED:9748249]
[PUBMED:11741535]
[PUBMED:17881575]
[PUBMED:10713050]
[PUBMED:1655790]
[PUBMED:11784715]
[PUBMED:10753869]
[PUBMED:10713700]
[PUBMED:11118451]
[PUBMED:16952352]
[PUBMED:15314156]
[PUBMED:19272169]
[PUBMED:12802068]
[PUBMED:17363898]
[PUBMED:7513258]
[PUBMED:1827664]
[PUBMED:2541345]
[PUBMED:8387483]
[PUBMED:16620780]
[PUBMED:11445578]
[PUBMED:10734310]
[PUBMED:16227611]
[PUBMED:12941962]
[PUBMED:15735664]
[PUBMED:19071214]
[PUBMED:7731718]
[PUBMED:19289496]
[PUBMED:11438654]
[PUBMED:11896612]
[PUBMED:11894096]
[PUBMED:11896575]
[PUBMED:7499247]
[PUBMED:12147692]
[PUBMED:11948414]
[PUBMED:19881549]
[PUBMED:19525225]
[PUBMED:14684163]
[PUBMED:17055484]
[PUBMED:9668053]
[PUBMED:10531383]
[PUBMED:9681449]
[PUBMED:1655405]
[PUBMED:12686592]
[PUBMED:19109251]
[PUBMED:10679787]
[PUBMED:9487126]
[PUBMED:9886295]
[PUBMED:12058075]
[PUBMED:15452053]
[PUBMED:9184210]
[PUBMED:10871282]
[PUBMED:17329361]
[PUBMED:2554238]