full name
SEL1L ERAD E3 ligase adaptor subunit

synonyms
PRO1063, SEL1-LIKE, SEL1L1, SEL1L, ENSG00000071537

HGNC
HGNC:10717

Entrez Gene
Gene:6400

ENSEMBL
ENSG00000071537

location
chr: 14
start: 81937891
stop: 82000205
strand: -

transcripts
NM_005065.5
NM_001244984.1

pathways
ABC transporter disorders [NCBI:1268933] [REACTOME:R-HSA-5619084] [PUBMED:21740521] [PUBMED:16399363] [PUBMED:23415156] [PUBMED:21389634] [PUBMED:21488864] [PUBMED:21554546]
ABC-family proteins mediated transport [NCBI:1269904] [REACTOME:R-HSA-382556] [PUBMED:11435397] [PUBMED:12045106] [PUBMED:19234479]
Asparagine N-linked glycosylation [NCBI:1268714] [REACTOME:R-HSA-446203] [PUBMED:16807922] [PUBMED:19647993] [PUBMED:10580125] [PUBMED:19616933] [PUBMED:20301507] [PUBMED:20301244]
Calnexin/calreticulin cycle [NCBI:1268723] [REACTOME:R-HSA-901042] [PUBMED:18303019] [PUBMED:18337472]
Defective CFTR causes cystic fibrosis [NCBI:1268934] [REACTOME:R-HSA-5678895] [PUBMED:16126935] [PUBMED:22650116] [PUBMED:2570460] [PUBMED:21652558]
Disease [NCBI:1268854] [REACTOME:R-HSA-1643685]
Diseases of signal transduction [NCBI:1268855] [REACTOME:R-HSA-5663202] [PUBMED:12509752]
Disorders of transmembrane transporters [NCBI:1268932] [REACTOME:R-HSA-5619115] [PUBMED:16399363]
ER Quality Control Compartment (ERQC) [NCBI:1268724] [REACTOME:R-HSA-901032] [PUBMED:11408579] [PUBMED:19616933] [PUBMED:18003979] [PUBMED:20347046]
Hedgehog ligand biogenesis [NCBI:1269634] [REACTOME:R-HSA-5358346] [PUBMED:8824192] [PUBMED:11486055] [PUBMED:18585355] [PUBMED:23719536] [PUBMED:9593755] [PUBMED:21357747] [PUBMED:22902404] [PUBMED:23565096] [PUBMED:15163793] [PUBMED:11395778] [PUBMED:21257310] [PUBMED:16396909] [PUBMED:15075292]
Hh mutants abrogate ligand secretion [NCBI:1268927] [REACTOME:R-HSA-5387390] [PUBMED:19603532] [PUBMED:24784881] [PUBMED:23565096] [PUBMED:20104595]
Hh mutants that don't undergo autocatalytic processing are degraded by ERAD [NCBI:1268928] [REACTOME:R-HSA-5362768] [PUBMED:23565096] [PUBMED:20104595] [PUBMED:19603532]
Metabolism of proteins [NCBI:1268677] [REACTOME:R-HSA-392499]
N-glycan trimming in the ER and Calnexin/Calreticulin cycle [NCBI:1268722] [REACTOME:R-HSA-532668] [PUBMED:18303019]
Post-translational protein modification [NCBI:1268701] [REACTOME:R-HSA-597592]
Pre-NOTCH Expression and Processing [NCBI:1269531] [REACTOME:R-HSA-1912422] [PUBMED:21490058] [PUBMED:20805998] [PUBMED:21464368] [PUBMED:9187150] [PUBMED:11707585] [PUBMED:10669757] [PUBMED:9244302] [PUBMED:20080834] [PUBMED:18347015] [PUBMED:19773441] [PUBMED:9207795] [PUBMED:10935637] [PUBMED:19714243] [PUBMED:18243100] [PUBMED:19723635] [PUBMED:11524432] [PUBMED:9727485] [PUBMED:12486116] [PUBMED:20495621] [PUBMED:10935626] [PUBMED:20351093] [PUBMED:19701457] [PUBMED:21602795] [PUBMED:21551231] [PUBMED:9653148]
Pre-NOTCH Processing in Golgi [NCBI:1269534] [REACTOME:R-HSA-1912420] [PUBMED:9244302] [PUBMED:1764995] [PUBMED:8681805] [PUBMED:10366590] [PUBMED:10935637] [PUBMED:1295745] [PUBMED:7918097] [PUBMED:10935626] [PUBMED:20170518] [PUBMED:9727485] [PUBMED:19701457] [PUBMED:8293978] [PUBMED:20197277] [PUBMED:9653148] [PUBMED:11135303] [PUBMED:9187150] [PUBMED:11707585] [PUBMED:10459009] [PUBMED:10669757]
Protein processing in endoplasmic reticulum [NCBI:167325] [KEGG:hsa04141] [PUBMED:20347046] [PUBMED:18023214] [PUBMED:20219571] [PUBMED:19491040] [PUBMED:20112977]
Signal Transduction [NCBI:1269379] [REACTOME:R-HSA-162582] [PUBMED:17604717] [PUBMED:19648010] [PUBMED:16260143] [PUBMED:11742412] [PUBMED:19536106] [PUBMED:15863030] [PUBMED:19379690] [PUBMED:19458711] [PUBMED:19935667] [PUBMED:21252999] [PUBMED:15520807] [PUBMED:17496910] [PUBMED:15450248] [PUBMED:18043707] [PUBMED:16939974] [PUBMED:19762341] [PUBMED:18483217] [PUBMED:17084981] [PUBMED:21781017] [PUBMED:19619488]
Signaling by Hedgehog [NCBI:1269633] [REACTOME:R-HSA-5358351] [PUBMED:19081070] [PUBMED:21801010] [PUBMED:15549094] [PUBMED:23719536]
Signaling by NOTCH [NCBI:1269530] [REACTOME:R-HSA-157118]
Transmembrane transport of small molecules [NCBI:1269903] [REACTOME:R-HSA-382551]