full name
coagulation factor V

synonyms
FVL, PCCF, RPRGL1, THPH2, F5, ENSG00000198734

HGNC
HGNC:3542

Entrez Gene
Gene:2153

ENSEMBL
ENSG00000198734

location
chr: 1
start: 169481192
stop: 169555769
strand: -

OMIM
OMIM:612309: F5 (Autosomal recessive inheritance)
OMIM:227400: Factor V deficiency
OMIM:188055: Thrombophilia due to activated protein C resistance
OMIM:600880: {Budd-Chiari syndrome}
OMIM:614389: {Pregnancy loss, recurrent, susceptibility to, 1}
OMIM:601367: {Stroke, ischemic, susceptibility to}
OMIM:188055: {Thrombophilia, susceptibility to, due to factor V Leiden}

transcripts
ENST00000367797

pathways
Asparagine N-linked glycosylation [NCBI:1268714] [REACTOME:R-HSA-446203] [PUBMED:19647993] [PUBMED:10580125] [PUBMED:16807922] [PUBMED:19616933] [PUBMED:20301507] [PUBMED:20301244]
Blood Clotting Cascade [NCBI:198840] [WikiPathways:WP272] [PUBMED:7741998]
COPII (Coat Protein 2) Mediated Vesicle Transport [NCBI:1268727] [REACTOME:R-HSA-204005] [PUBMED:17316621] [PUBMED:11252894]
Cargo concentration in the ER [NCBI:1309087] [REACTOME:R-HSA-5694530] [PUBMED:18843296] [PUBMED:20533886] [PUBMED:22013193] [PUBMED:12426382] [PUBMED:12941277] [PUBMED:23378591] [PUBMED:12819131] [PUBMED:21878990] [PUBMED:12941276] [PUBMED:25619253]
Common Pathway of Fibrin Clot Formation [NCBI:1269371] [REACTOME:R-HSA-140875] [PUBMED:1931959]
Complement and Coagulation Cascades [NCBI:198880] [WikiPathways:WP558]
Complement and coagulation cascades [NCBI:83073] [KEGG:hsa04610] [PUBMED:25309880] [PUBMED:25568220] [PUBMED:23110467] [PUBMED:20027185] [PUBMED:21811895] [PUBMED:26324800] [PUBMED:25705421] [PUBMED:23911436] [PUBMED:24924409] [PUBMED:23564578] [PUBMED:26489954] [PUBMED:17635716] [PUBMED:23564577] [PUBMED:26082779]
ER to Golgi Anterograde Transport [NCBI:1268726] [REACTOME:R-HSA-199977] [PUBMED:11252894]
Formation of Fibrin Clot (Clotting Cascade) [NCBI:1269368] [REACTOME:R-HSA-140877] [PUBMED:1931959] [PUBMED:12524220]
Hemostasis [NCBI:1269340] [REACTOME:R-HSA-109582]
Membrane Trafficking [NCBI:1269877] [REACTOME:R-HSA-199991] [PUBMED:11031247]
Metabolism of proteins [NCBI:1268677] [REACTOME:R-HSA-392499]
Platelet activation, signaling and aggregation [NCBI:1269350] [REACTOME:R-HSA-76002] [PUBMED:16543958] [PUBMED:2018971] [PUBMED:1672265] [PUBMED:12681240] [PUBMED:11511514] [PUBMED:8704248] [PUBMED:17059469] [PUBMED:12411949]
Platelet degranulation [NCBI:1269367] [REACTOME:R-HSA-114608] [PUBMED:14630798]
Post-translational protein modification [NCBI:1268701] [REACTOME:R-HSA-597592]
Response to elevated platelet cytosolic Ca2+ [NCBI:1269365] [REACTOME:R-HSA-76005] [PUBMED:8424766]
Transport to the Golgi and subsequent modification [NCBI:1268725] [REACTOME:R-HSA-948021] [PUBMED:12717434] [PUBMED:3594573] [PUBMED:10412983]
Vesicle-mediated transport [NCBI:1269876] [REACTOME:R-HSA-5653656]