full name
tight junction protein 1

synonyms
ZO-1, TJP1, ENSG00000104067

HGNC
HGNC:11827

Entrez Gene
Gene:7082

ENSEMBL
ENSG00000104067

location
chr: 15
start: 29992338
stop: 30261038
strand: -

transcripts
NM_175610.2
NM_003257.3

pathways
Adherens junction [NCBI:83070] [KEGG:hsa04520] [PUBMED:11703922] [PUBMED:10890911] [PUBMED:15551862] [PUBMED:15561584] [PUBMED:10959047] [PUBMED:11984870] [PUBMED:10204118] [PUBMED:15489912] [PUBMED:14623871] [PUBMED:15001769] [PUBMED:12640114] [PUBMED:12665527] [PUBMED:11171368]
Apoptosis [NCBI:83060] [KEGG:hsa04210] [NCBI:1270262] [REACTOME:R-HSA-109581] [PUBMED:12189384] [PUBMED:20533903] [PUBMED:18208375] [PUBMED:22429822] [PUBMED:15218528] [PUBMED:24769728] [PUBMED:18023214] [PUBMED:25526085] [PUBMED:23070002] [PUBMED:15654015] [PUBMED:15601572] [PUBMED:14561771] [PUBMED:24278747] [PUBMED:21914490] [PUBMED:22465226] [PUBMED:21145844] [PUBMED:12838338] [PUBMED:18238895] [PUBMED:12949498] [PUBMED:18304445] [PUBMED:14737178] [PUBMED:26231733] [PUBMED:9916983] [PUBMED:14634621] [PUBMED:19770840] [PUBMED:22075987] [PUBMED:4561027] [PUBMED:20075940] [PUBMED:9894605] [PUBMED:26615431] [PUBMED:12505355] [PUBMED:11520933] [PUBMED:19148180] [PUBMED:16397578] [PUBMED:15719025] [PUBMED:15322527] [PUBMED:15725726] [PUBMED:12209154] [PUBMED:23803157]
Apoptotic cleavage of cell adhesion proteins [NCBI:1270290] [REACTOME:R-HSA-351906] [PUBMED:11500511] [PUBMED:16286477] [PUBMED:17559062]
Apoptotic cleavage of cellular proteins [NCBI:1270288] [REACTOME:R-HSA-111465] [PUBMED:17254298] [PUBMED:17599937] [PUBMED:12655297]
Apoptotic execution phase [NCBI:1270287] [REACTOME:R-HSA-75153] [PUBMED:12655297]
E-cadherin signaling in the nascent adherens junction [NCBI:138005] [Pathway Interaction Database:ecadherin_nascentaj_pathway] [PUBMED:16371509] [PUBMED:9694656] [PUBMED:9214391] [PUBMED:17620337] [PUBMED:7969453] [PUBMED:11882288] [PUBMED:19158278] [PUBMED:11716761] [PUBMED:10402472] [PUBMED:15263019] [PUBMED:12427869] [PUBMED:11457821] [PUBMED:6976838] [PUBMED:10037790] [PUBMED:10660044] [PUBMED:15857834] [PUBMED:10202138] [PUBMED:10980705] [PUBMED:15159390] [PUBMED:2349235] [PUBMED:19114658] [PUBMED:14585958] [PUBMED:18632982] [PUBMED:12432063] [PUBMED:17261850] [PUBMED:10383446] [PUBMED:11329369] [PUBMED:14699157] [PUBMED:7954478] [PUBMED:10629228] [PUBMED:8207061] [PUBMED:15556934] [PUBMED:10473551] [PUBMED:12370292] [PUBMED:14610055] [PUBMED:16170364] [PUBMED:12770907] [PUBMED:17553930] [PUBMED:17164293] [PUBMED:2788574] [PUBMED:9512503] [PUBMED:10201395] [PUBMED:15254236] [PUBMED:15024035] [PUBMED:12447393] [PUBMED:11744701] [PUBMED:14668487] [PUBMED:18187454]
Epithelial cell signaling in Helicobacter pylori infection [NCBI:83102] [KEGG:hsa05120] [PUBMED:11389469] [PUBMED:15694859] [PUBMED:14700549] [PUBMED:12197905]
Gap junction [NCBI:83072] [KEGG:hsa04540] [PUBMED:9535909] [PUBMED:15033578] [PUBMED:12566218] [PUBMED:14506308] [PUBMED:10751659] [PUBMED:10873290] [PUBMED:15955302] [PUBMED:15033579] [PUBMED:15033580] [PUBMED:15094344]
Gap junction trafficking and regulation [NCBI:1269884] [REACTOME:R-HSA-157858] [PUBMED:15033576] [PUBMED:11737941] [PUBMED:9861669] [PUBMED:11146276]
Membrane Trafficking [NCBI:1269877] [REACTOME:R-HSA-199991] [PUBMED:11031247]
Nephrin/Neph1 signaling in the kidney podocyte [NCBI:138072] [Pathway Interaction Database:nephrin_neph1_pathway] [PUBMED:12660326] [PUBMED:18212058] [PUBMED:12832477] [PUBMED:10504499] [PUBMED:12846735] [PUBMED:18385666] [PUBMED:12668668] [PUBMED:19142224] [PUBMED:14633607] [PUBMED:16525419] [PUBMED:10514378] [PUBMED:17923684] [PUBMED:18274541] [PUBMED:17079490] [PUBMED:11733557] [PUBMED:16968782] [PUBMED:15200416] [PUBMED:12424224] [PUBMED:11562357] [PUBMED:18715943] [PUBMED:11549599] [PUBMED:15339792] [PUBMED:10742096] [PUBMED:14570703] [PUBMED:19179337] [PUBMED:19497968] [PUBMED:12578837] [PUBMED:18562307] [PUBMED:18046313] [PUBMED:12646566] [PUBMED:15579503] [PUBMED:18033240] [PUBMED:16543952]
Programmed Cell Death [NCBI:1270261] [REACTOME:R-HSA-5357801] [PUBMED:25236395]
Regulation of gap junction activity [NCBI:1269893] [REACTOME:R-HSA-191650]
Salmonella infection [NCBI:375172] [KEGG:hsa05132] [PUBMED:18407067] [PUBMED:18411289] [PUBMED:18778407] [PUBMED:20123714] [PUBMED:20158475] [PUBMED:19779561] [PUBMED:18026123] [PUBMED:19930040] [PUBMED:12675800] [PUBMED:11755407] [PUBMED:11489966] [PUBMED:19775254] [PUBMED:20943123] [PUBMED:17690885] [PUBMED:16938850] [PUBMED:20526845] [PUBMED:11567004] [PUBMED:17074883] [PUBMED:11825778] [PUBMED:17071592] [PUBMED:16800847] [PUBMED:16611232] [PUBMED:10499590]
Signal Transduction [NCBI:1269379] [REACTOME:R-HSA-162582] [PUBMED:17604717] [PUBMED:19648010] [PUBMED:16260143] [PUBMED:11742412] [PUBMED:19536106] [PUBMED:15863030] [PUBMED:19379690] [PUBMED:19458711] [PUBMED:19935667] [PUBMED:21252999] [PUBMED:15520807] [PUBMED:17496910] [PUBMED:15450248] [PUBMED:18043707] [PUBMED:16939974] [PUBMED:19762341] [PUBMED:18483217] [PUBMED:17084981] [PUBMED:21781017] [PUBMED:19619488]
Signaling by Hippo [NCBI:1269616] [REACTOME:R-HSA-2028269] [PUBMED:20850437] [PUBMED:20951342] [PUBMED:20598891] [PUBMED:20439427] [PUBMED:11278283] [PUBMED:20452772] [PUBMED:21224387] [PUBMED:20412773] [PUBMED:21233212] [PUBMED:20868367]
Tight junction [NCBI:83071] [KEGG:hsa04530] [PUBMED:25152334] [PUBMED:16650994] [PUBMED:22892070] [PUBMED:18946474] [PUBMED:12042308] [PUBMED:23885123] [PUBMED:16771626] [PUBMED:17182900] [PUBMED:21283798] [PUBMED:25757376] [PUBMED:22928510] [PUBMED:22169974] [PUBMED:25469537] [PUBMED:24651541] [PUBMED:15820555] [PUBMED:17525755] [PUBMED:27353478] [PUBMED:17950242] [PUBMED:18005931] [PUBMED:24548561] [PUBMED:21781017] [PUBMED:20094051] [PUBMED:20134025] [PUBMED:22896795] [PUBMED:18094055] [PUBMED:25483301]
Vesicle-mediated transport [NCBI:1269876] [REACTOME:R-HSA-5653656]
Vibrio cholerae infection [NCBI:83101] [KEGG:hsa05110] [PUBMED:12671039] [PUBMED:17464284] [PUBMED:17156122] [PUBMED:11207565] [PUBMED:13679513] [PUBMED:11032799] [PUBMED:14659695] [PUBMED:11953326] [PUBMED:10942706] [PUBMED:12102686] [PUBMED:11349009] [PUBMED:11292584] [PUBMED:12403808] [PUBMED:11454785] [PUBMED:15204437]
c-src mediated regulation of Cx43 function and closure of gap junctions [NCBI:1269894] [REACTOME:R-HSA-191647] [PUBMED:11124251] [PUBMED:10085299] [PUBMED:14638725] [PUBMED:15492000] [PUBMED:12807735]