full name
ubiquitin specific peptidase 8

synonyms
HumORF8, UBPY, USP8, ENSG00000138592

HGNC
HGNC:12631

Entrez Gene
Gene:9101

ENSEMBL
ENSG00000138592

location
chr: 15
start: 50716579
stop: 50793280
strand: +

OMIM
OMIM:603158: USP8
OMIM:219090: Pituitary adenoma 4, ACTH-secreting, somatic

transcripts
ENST00000433963.1
ENST00000396444.3
ENST00000307179.4

pathways
Deubiquitination [NCBI:1427860] [REACTOME:R-HSA-5688426] [PUBMED:19243136] [PUBMED:20074029] [PUBMED:15571815] [PUBMED:20418328] [PUBMED:16325574] [PUBMED:12944365] [PUBMED:23845989] [PUBMED:22201797]
Downregulation of ERBB2 signaling [NCBI:1457793] [REACTOME:R-HSA-8863795] [PUBMED:19933325] [PUBMED:21376233] [PUBMED:17210635] [PUBMED:12239347] [PUBMED:25081058]
Downregulation of ERBB2:ERBB3 signaling [NCBI:1269495] [REACTOME:R-HSA-1358803]
Endocytosis [NCBI:102279] [KEGG:hsa04144] [PUBMED:19696797] [PUBMED:19007773] [PUBMED:16203612] [PUBMED:15687999] [PUBMED:19924646] [PUBMED:15261671] [PUBMED:18647649] [PUBMED:19325624] [PUBMED:20110990] [PUBMED:22193161]
ErbB2/ErbB3 signaling events [NCBI:137955] [Pathway Interaction Database:erbb2erbb3pathway] [PUBMED:9677338] [PUBMED:11546794] [PUBMED:9710588] [PUBMED:11984589] [PUBMED:19474313] [PUBMED:12072561] [PUBMED:18760695] [PUBMED:18614687] [PUBMED:11027222] [PUBMED:12466964] [PUBMED:10704452] [PUBMED:19535578] [PUBMED:7556067] [PUBMED:16481445] [PUBMED:10493750] [PUBMED:17998937] [PUBMED:17210635] [PUBMED:18799465] [PUBMED:12411582] [PUBMED:15520002] [PUBMED:10531446] [PUBMED:10101228] [PUBMED:10399934] [PUBMED:8815893] [PUBMED:19179536] [PUBMED:7877996] [PUBMED:11173924] [PUBMED:12651161] [PUBMED:9362461] [PUBMED:18426980] [PUBMED:19019207] [PUBMED:9338783] [PUBMED:11312610] [PUBMED:11940572] [PUBMED:8707830] [PUBMED:11564761] [PUBMED:9049301] [PUBMED:9694850] [PUBMED:10582594] [PUBMED:9637684] [PUBMED:8702681]
Internalization of ErbB1 [NCBI:138013] [Pathway Interaction Database:erbb1_internalization_pathway] [PUBMED:9733512] [PUBMED:9950686] [PUBMED:12839496] [PUBMED:10953014] [PUBMED:17052190] [PUBMED:15212941] [PUBMED:19460345] [PUBMED:18316398] [PUBMED:11823423] [PUBMED:18657070] [PUBMED:12242303] [PUBMED:17940017] [PUBMED:15465819] [PUBMED:17121848] [PUBMED:15772153] [PUBMED:18508924] [PUBMED:18031739] [PUBMED:16914641] [PUBMED:11408594] [PUBMED:11099046] [PUBMED:16543144] [PUBMED:11703925] [PUBMED:11894095] [PUBMED:15282549] [PUBMED:9851973] [PUBMED:16554368] [PUBMED:12897150] [PUBMED:11983899] [PUBMED:18362181] [PUBMED:15475003] [PUBMED:12631709] [PUBMED:15701692] [PUBMED:16862145] [PUBMED:16735510] [PUBMED:18694561] [PUBMED:14505571] [PUBMED:10567412] [PUBMED:15635092] [PUBMED:15210722] [PUBMED:16892055] [PUBMED:1645724] [PUBMED:16407834] [PUBMED:17363458] [PUBMED:16382132] [PUBMED:10428778] [PUBMED:15314065] [PUBMED:16120644] [PUBMED:7925272] [PUBMED:12234920] [PUBMED:8175702] [PUBMED:10085141] [PUBMED:11375397] [PUBMED:10635327] [PUBMED:19723633] [PUBMED:10788520] [PUBMED:12218189] [PUBMED:19054389]
Metabolism of proteins [NCBI:1268677] [REACTOME:R-HSA-392499]
Mitophagy - animal [NCBI:1496831] [KEGG:hsa04137] [PUBMED:26611876] [PUBMED:27443527] [PUBMED:25995186] [PUBMED:25611507] [PUBMED:27021519] [PUBMED:25999423] [PUBMED:27701735] [PUBMED:26882551]
Negative regulation of MET activity [NCBI:1457805] [REACTOME:R-HSA-6807004] [PUBMED:24828152] [PUBMED:11894096] [PUBMED:14684163] [PUBMED:12475979] [PUBMED:23208509] [PUBMED:9001234] [PUBMED:11420688] [PUBMED:18819921] [PUBMED:11741535] [PUBMED:15314156]
Post-translational protein modification [NCBI:1268701] [REACTOME:R-HSA-597592]
Regulation of FZD by ubiquitination [NCBI:1269607] [REACTOME:R-HSA-4641263] [PUBMED:17908284] [PUBMED:22575959] [PUBMED:23058807] [PUBMED:22965053] [PUBMED:20495530] [PUBMED:22617469]
Signal Transduction [NCBI:1269379] [REACTOME:R-HSA-162582] [PUBMED:17604717] [PUBMED:19648010] [PUBMED:16260143] [PUBMED:11742412] [PUBMED:19536106] [PUBMED:15863030] [PUBMED:19379690] [PUBMED:19458711] [PUBMED:19935667] [PUBMED:21252999] [PUBMED:15520807] [PUBMED:17496910] [PUBMED:15450248] [PUBMED:18043707] [PUBMED:16939974] [PUBMED:19762341] [PUBMED:18483217] [PUBMED:17084981] [PUBMED:21781017] [PUBMED:19619488]
Signaling by ERBB2 [NCBI:1269489] [REACTOME:R-HSA-1227986]
Signaling by MET [NCBI:1457794] [REACTOME:R-HSA-6806834] [PUBMED:1846706] [PUBMED:12948444] [PUBMED:16782899] [PUBMED:15249655] [PUBMED:22270953] [PUBMED:15167892] [PUBMED:7708691] [PUBMED:11081636] [PUBMED:8384622] [PUBMED:21102609] [PUBMED:16461907] [PUBMED:9407027] [PUBMED:7854453] [PUBMED:7651534] [PUBMED:9070211] [PUBMED:8208547] [PUBMED:24518591] [PUBMED:6590967] [PUBMED:15180923] [PUBMED:20802513] [PUBMED:10521801] [PUBMED:9038378] [PUBMED:17403932] [PUBMED:1655790] [PUBMED:12006644] [PUBMED:7513258] [PUBMED:18614017] [PUBMED:10753869] [PUBMED:17662939] [PUBMED:14685170] [PUBMED:10734310] [PUBMED:1827664] [PUBMED:7731718] [PUBMED:19996456] [PUBMED:11430831] [PUBMED:8302603] [PUBMED:15218027] [PUBMED:9140397] [PUBMED:2423252] [PUBMED:16113677] [PUBMED:12147692] [PUBMED:10648629] [PUBMED:7854452] [PUBMED:15070743] [PUBMED:15301554] [PUBMED:19881549] [PUBMED:25992381] [PUBMED:10871282] [PUBMED:12726861]
Signaling by Wnt [NCBI:1269594] [REACTOME:R-HSA-195721] [PUBMED:19530173] [PUBMED:23256519] [PUBMED:22952392] [PUBMED:19204114] [PUBMED:19365405] [PUBMED:19619488] [PUBMED:17143292] [PUBMED:17230199] [PUBMED:18710302] [PUBMED:16099039] [PUBMED:20576942] [PUBMED:10858654] [PUBMED:12967557]
TCF dependent signaling in response to WNT [NCBI:1269599] [REACTOME:R-HSA-201681] [PUBMED:19619488] [PUBMED:23256519] [PUBMED:23343194]
Ub-specific processing proteases [NCBI:1427862] [REACTOME:R-HSA-5689880] [PUBMED:16325574]