full name
cytochrome P450 family 1 subfamily A member 2

synonyms
CP12, P3-450, P450%28PA%29, CYP1A2, ENSG00000140505

HGNC
HGNC:2596

Entrez Gene
Gene:1544

ENSEMBL
ENSG00000140505

location
chr: 15
start: 75041184
stop: 75048941
strand: +

transcripts
NM_000761.3

pathways
Aflatoxin activation and detoxification [NCBI:1270220] [REACTOME:R-HSA-5423646] [PUBMED:23599745] [PUBMED:19514968] [PUBMED:9675258] [PUBMED:12435844]
Arachidonic acid metabolism [NCBI:82991] [KEGG:hsa00590] [NCBI:1270087] [REACTOME:R-HSA-2142753] [PUBMED:14622984] [PUBMED:15292194] [PUBMED:10908295] [PUBMED:15205388] [PUBMED:9812980] [PUBMED:14660610] [PUBMED:11328810] [PUBMED:14636671] [PUBMED:14626496] [PUBMED:11679404] [PUBMED:19244215]
Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 [NCBI:1270195] [REACTOME:R-HSA-211957]
Biological oxidations [NCBI:1270189] [REACTOME:R-HSA-211859]
Caffeine metabolism [NCBI:82945] [KEGG:hsa00232] [PUBMED:16333668] [PUBMED:14977550] [PUBMED:9705852] [PUBMED:11393735] [PUBMED:11544129]
Chemical carcinogenesis [NCBI:673221] [KEGG:hsa05204] [PUBMED:21473878] [PUBMED:15489140] [PUBMED:21255676] [PUBMED:11376689] [PUBMED:15298956] [PUBMED:17445838] [PUBMED:22705365] [PUBMED:9152590] [PUBMED:8759017] [PUBMED:20570348] [PUBMED:11275476] [PUBMED:9202760] [PUBMED:21163908] [PUBMED:10753215] [PUBMED:10913381] [PUBMED:21217854] [PUBMED:15582261] [PUBMED:16959879] [PUBMED:11092599] [PUBMED:20159989] [PUBMED:21234336] [PUBMED:17459420] [PUBMED:9275165] [PUBMED:17292678] [PUBMED:11978484] [PUBMED:11222868] [PUBMED:15660110] [PUBMED:8702479] [PUBMED:9356303] [PUBMED:20232918] [PUBMED:12435844] [PUBMED:19657920] [PUBMED:8951235] [PUBMED:15532073] [PUBMED:16084004] [PUBMED:18066431] [PUBMED:14570033] [PUBMED:16421178] [PUBMED:21154658] [PUBMED:12928348] [PUBMED:19531241] [PUBMED:20669524] [PUBMED:11467078] [PUBMED:22178655] [PUBMED:21456541]
Cytochrome P450 - arranged by substrate type [NCBI:1270191] [REACTOME:R-HSA-211897] [PUBMED:16584116] [PUBMED:15102545] [PUBMED:12369887]
Drug metabolism - cytochrome P450 [NCBI:83032] [KEGG:hsa00982] [PUBMED:16550168] [PUBMED:10575324] [PUBMED:11226815] [PUBMED:16393888] [PUBMED:12399158] [PUBMED:11504799] [PUBMED:16038189] [PUBMED:10901707] [PUBMED:18043895] [PUBMED:18463198] [PUBMED:9698084] [PUBMED:12386121] [PUBMED:10859160]
Linoleic acid metabolism [NCBI:82992] [KEGG:hsa00591] [PUBMED:12226220] [PUBMED:1634517] [PUBMED:11302930] [PUBMED:8765137] [PUBMED:12909723] [PUBMED:9694817] [PUBMED:14757320] [PUBMED:12324235]
Metabolic pathways [NCBI:132956] [KEGG:hsa01100]
Metabolism [NCBI:1269956] [REACTOME:R-HSA-1430728]
Metabolism of lipids and lipoproteins [NCBI:1270001] [REACTOME:R-HSA-556833]
Metabolism of xenobiotics by cytochrome P450 [NCBI:83031] [KEGG:hsa00980] [PUBMED:9107551] [PUBMED:10570027] [PUBMED:4395686] [PUBMED:10490505] [PUBMED:15987776] [PUBMED:15298956] [PUBMED:15319346] [PUBMED:12487150] [PUBMED:10725110]
Methylation [NCBI:1270212] [REACTOME:R-HSA-156581] [PUBMED:10898761] [PUBMED:15130560] [PUBMED:10331075]
Phase 1 - Functionalization of compounds [NCBI:1270190] [REACTOME:R-HSA-211945] [PUBMED:12369887] [PUBMED:17125408] [PUBMED:16584116]
Phase II conjugation [NCBI:1270207] [REACTOME:R-HSA-156580] [PUBMED:11805192]
Retinol metabolism [NCBI:83020] [KEGG:hsa00830] [PUBMED:17893666] [PUBMED:16968212] [PUBMED:16688755] [PUBMED:16428379] [PUBMED:17618621] [PUBMED:11093772]
Steroid hormone biosynthesis [NCBI:82940] [KEGG:hsa00140] [PUBMED:15642792] [PUBMED:16413106] [PUBMED:12832414] [PUBMED:17475203] [PUBMED:12604236] [PUBMED:10998348] [PUBMED:11469811] [PUBMED:16547389] [PUBMED:17926129] [PUBMED:17459698]
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) [NCBI:1270095] [REACTOME:R-HSA-2142816] [PUBMED:19244215] [PUBMED:10681399]
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) [NCBI:1270096] [REACTOME:R-HSA-2142670] [PUBMED:10681399] [PUBMED:19244215]
Tryptophan metabolism [NCBI:82964] [KEGG:hsa00380] [PUBMED:15749753]
Xenobiotics [NCBI:1270194] [REACTOME:R-HSA-211981] [PUBMED:12369887] [PUBMED:15102545] [PUBMED:16584116]
melatonin degradation I [NCBI:545356] [BIOCYC:HUMAN_PWY-6398] [PUBMED:18344019] [PUBMED:18717775] [PUBMED:12899443] [PUBMED:17198536] [PUBMED:16219483] [PUBMED:9181522] [PUBMED:15981996] [PUBMED:12662344] [PUBMED:11485009] [PUBMED:18155917] [PUBMED:15616152] [PUBMED:16793870]
superpathway of melatonin degradation [NCBI:545359] [BIOCYC:HUMAN_PWY-6402]
superpathway of tryptophan utilization [NCBI:835392] [BIOCYC:HUMAN_PWY66-401]